Category: 80382-23-6

The dynamic chemical diversity of the numerous elements, ions and molecules that constitute the basis of life provides wide challenges and opportunities for research. In an article, author is Bian, Ming, once mentioned the application of 80382-23-6, Name is Sodium 2-(4-((2-oxocyclopentyl)methyl)phenyl)propanoate, molecular formula is C15H17NaO3, molecular weight is 268.2835, MDL number is MFCD00941425, category is phthalazine. Now introduce a scientific discovery about this category, Product Details of 80382-23-6.

With the aim of finding new anticonvulsant drugs, new 6-substituted-[1,2,4] triazolo[3,4-a] (tetrazolo[5,1-a]) phthalazine derivatives (1-34) have been designed and synthesized. All the compounds were evaluated for their anticonvulsant activities using the maximal electroshock test (MES). Most of the synthesized compounds exhibited potent anticonvulsant activities in the MES. The most promising compound 14 showed significant anticonvulsant activity in MES test with ED50 value of 9.3 mg/kg. It displayed a wide margin of safety with protective index much higher than the standard drug Carbamazepine. And the potency of compound 14 against seizures induced by Pentylenetetrazole, Isoniazid, Thiosemicarbazide and 3-Mercaptopropionic acid in the chemical-induced seizure tests suggested that compound 14 displayed wide spectrum of activity in several models.

We’ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, 80382-23-6. The above is the message from the blog manager. Recommanded Product: Sodium 2-(4-((2-oxocyclopentyl)methyl)phenyl)propanoate.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Redox catalysis has been broadly utilized in electrochemical synthesis due to its kinetic advantages over direct electrolysis. 80382-23-6, Name is Sodium 2-(4-((2-oxocyclopentyl)methyl)phenyl)propanoate, molecular formula is , belongs to phthalazine compound. In a document, author is El-Helby, Abdel-Ghany A., Application of 80382-23-6.

Background: Extensive studies were reported in the synthesis of several phthalazine derivatives as promising anticancer agents as potent VEGFR-2 inhibitors. Vatalanib (PTK787) was the first anilinophthalazine published derivative as a potent inhibitor of VEGFR. The discovery of vatalanib as a clinical candidate led to the design and synthesis of different anilinophthalazine derivatives as potent inhibitors for VEGFR-2. The objective of present research work is the synthesis of new agents with the same essential pharmacophoric features of the reported and clinically used VEGFR-2 inhibitors (e.g vatalanib and sorafenib). The main core of our molecular design rationale comprised bioisosteric modification strategies of VEGFR-2 inhibitors at four different positions. Material and Methods: A correlation between structure and biological activity of our designed phthalazines was established using molecular docking and VEGFR-2 kinase assay. Results and Discussion: In view of their expected anticancer activity, novel triazolo[3,4-a]phthalazine derivatives 5-6a-o and 3-substituted-bis([1,2,41triazolo)[3,4-a:4′,3′-c]phthalazines 9a-b were designed, synthesized and evaluated for their anti-proliferative activity against two human tumor cell lines HCT-116 human colon adenocarcinoma and MCF-7 breast cancer. It was found that, compound 6o the most potent derivative against both HCT116 and MCF-7 cancer cell lines. Compounds 6o, 6m, 6d and 9b showed the highest anticancer activities against HCT116 human colon adenocarcinoma with IC50 of 7 +/- 0.06, 13 +/- 0.11, 15 +/- 0.14 and 23 +/- 0.22 mu M respectively while compounds 6o, 6d, 6a and 6n showed the highest anticancer activities against MCF-7 breast cancer with IC50 of 16.98 +/- 0.15, 18.2 +/- 0.17, 57.54 +/- 0.53 and 66.45 +/- 0.67 mu M respectively. Sorafenib as a highly potent VEGFR-2 inhibitor was used as a reference drug with IC50 of 5.47 +/- 0.3 and 7.26 +/- 0.3 mu M respectively. Nine compounds were further evaluated for their VEGFR-2 inhibitory activity. Compounds 6o, 6m, 6d and 9b emerged as the most active counterparts against VEGFR-2 with IC50 values of 0.1 +/- 0.01, 0.15 +/- 0.02, 0.28 +/- 0.03 and 0.38 +/- 0.04 mu M, respectively comparable to that of sorafenib (IC50 = 0.1+0.02) mu M. Furthermore, molecular docking studies were carried out for all synthesized compounds to investigate their binding pattern and predict their binding affinities towards VEGFR-2 active site. In silico ADMET studies were calculated for the tested compounds. Most of our designed compounds exhibited good ADMET profile. Conclusion: The obtained results showed that, the most active compounds could be useful as a template for future design, optimization, adaptation and investigation to produce more potent and selective VEGFR-2 inhibitors with higher anticancer analogs.

Application of 80382-23-6, One of the oldest and most widely used commercial enzyme inhibitors is aspirin, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 80382-23-6.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Quality Control of Sodium 2-(4-((2-oxocyclopentyl)methyl)phenyl)propanoate, Academic researchers, R&D teams, teachers, students, policy makers and the media all rely on us to share knowledge that is reliable, accurate and cutting-edge. 80382-23-6, Name is Sodium 2-(4-((2-oxocyclopentyl)methyl)phenyl)propanoate, SMILES is CC(C1=CC=C(CC2C(CCC2)=O)C=C1)C([O-])=O.[Na+], belongs to phthalazine compound. In a article, author is Turhan, K., introduce new discover of the category.

In this study, substituted 2H-indazolo[2,1-b]phthalazine-1,6,11-triones, that may possess biological activity, have been synthesized via one-pot three-component cyclocondensation reaction of aromatic aldehydes, cyclic 1,3-dione and phthalhydrazide in ethanol catalyzed by Y(OTf)(3) with good to excellent yields. The structures of all synthesized compounds, 3,4-dihydro-13-phenyl-2H-indazolo[2,1-b]phthalazine-1,6,11(13H)-trione (4a), 13-(4-cyanophenyl)-3,4-dihydro-2H-indazolo[2,1-b]phthalazine-1,6,11(13H)-trione (4b), 3,4-dihydro-3,3-dimethyl-13-(4-cyanophenyl)-2H-indazolo[2,1-b]phthalazine-1,6,11(13H)-trione (4c), 3,4-dihydro-3,3-dimethyl-13-phenyl-2H-indazolo[2,1-b]phthalazine-1,6,11(13H)-trione (4d), and 3,4-dihydro-13-(4-isopropylphenyl)-3,3-dimethyl-2H-indazolo[2,1-b]phthalazine-1,6,11(13H)-trione (4e) have been elucidated from IR, NMR and mass spectral data.

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Chemistry is traditionally divided into organic and inorganic chemistry. The former is the study of compounds containing at least one carbon-hydrogen bonds. 80382-23-6, Name is Sodium 2-(4-((2-oxocyclopentyl)methyl)phenyl)propanoate, molecular formula is C15H17NaO3, belongs to phthalazine compound, is a common compound. In a patnet, author is Bian, Ming, once mentioned the new application about 80382-23-6, Safety of Sodium 2-(4-((2-oxocyclopentyl)methyl)phenyl)propanoate.

With the aim of finding new anticonvulsant drugs, new 6-substituted-[1,2,4] triazolo[3,4-a] (tetrazolo[5,1-a]) phthalazine derivatives (1-34) have been designed and synthesized. All the compounds were evaluated for their anticonvulsant activities using the maximal electroshock test (MES). Most of the synthesized compounds exhibited potent anticonvulsant activities in the MES. The most promising compound 14 showed significant anticonvulsant activity in MES test with ED50 value of 9.3 mg/kg. It displayed a wide margin of safety with protective index much higher than the standard drug Carbamazepine. And the potency of compound 14 against seizures induced by Pentylenetetrazole, Isoniazid, Thiosemicarbazide and 3-Mercaptopropionic acid in the chemical-induced seizure tests suggested that compound 14 displayed wide spectrum of activity in several models.

We’ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, 80382-23-6. The above is the message from the blog manager. Safety of Sodium 2-(4-((2-oxocyclopentyl)methyl)phenyl)propanoate.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Electric Literature of 80382-23-6, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C–H bond functionalisation has revolutionised modern synthetic chemistry. 80382-23-6, Name is Sodium 2-(4-((2-oxocyclopentyl)methyl)phenyl)propanoate, SMILES is CC(C1=CC=C(CC2C(CCC2)=O)C=C1)C([O-])=O.[Na+], belongs to phthalazine compound. In a article, author is Hofmann, Jonas D., introduce new discover of the category.

To enable cost-efficient stationary energy storage, organic active materials are the subject of current investigations with regard to their application in aqueous redox flow batteries. Especially quinones quinones with their beneficial electrochemical properties and natural abundance pose a promising class of compounds for this challenging endeavor. Yet, there are not many active materials available for the catholyte side to realize solely quinone-based systems. Herein we introduce the novel hydroquinone 5,8-dihydroxy-2,3-phthalazine together with two of its derivatives and propose it as a promising active material for the catholyte side of aqueous redox flow batteries. We systematically investigate the electrochemical properties as well as the structure-property relationship of this class of compounds. The unmodified dihydroxyphthalazine exhibits a favorably high redox potential of 796 mV vs SHE in acidic solution that is competitive with benzoquinone compounds. Moreover, the introduced dihydroxyphthalazines feature a high electron transfer rate surpassing benzoquinone species by almost one order of magnitude. With regard to stable cycling performance, we further achieved a high resilience against detrimental side reactions such as Michael addition by adding methyl substituents to the base structure. Our experimental findings are supported and extended by theoretical considerations in terms of density functional theory calculations. With this combined approach we outline further promising dihydroxyphthalazine-based materials with regard to performance-relevant quantities like redox potential, cycling stability, and water solubility. This study aims to propel further research in the field of quinone-based active materials for the catholyte of future aqueous redox flow batteries.

Electric Literature of 80382-23-6, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. I hope my blog about 80382-23-6 is helpful to your research.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Chemistry can be defined as the study of matter and the changes it undergoes. You’ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology. 80382-23-6, Name is Sodium 2-(4-((2-oxocyclopentyl)methyl)phenyl)propanoate, molecular formula is , belongs to phthalazine compound. In a document, author is Chegeni, Mahnaz Mahmoodi Fard, Category: phthalazines.

Experimental and computational studies were carried out for the synthesis of 2H-indazolo[2,1-b]phthalazine-triones using gamma-Al2O3/BF3/Fe3O4 as a nanocatalyst in optimized and solvent-free conditions. The most significant features of the existing protocol are easy preparation of the catalyst, short reaction times, environmentally benign, and milder reaction conditions. The analysis data were reported using the experimental results of this investigation, such as: H-NMR, FT-IR (Fourier-transform infrared spectroscopy), X-ray diffraction, vibrating-sample magnetometer, Thermal gravimetric analysis (TG-DTG), nitrogen adsorption isotherm, Field Emission Scanning Electron Microscopy, and Transmission electron microscopy images of nanocatalyst. In this study, 2H-indazolo[2,1-b]phthalazine-triones have also been theoretically investigated using DFT-B3LYP/6-31G method. Also, some of the physical chemistry properties have examined for conformers of products, which there was good agreement between the computational results and obtained experimental for the products.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 80382-23-6, in my other articles. Category: phthalazines.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

In an article, author is Turhan, K., once mentioned the application of 80382-23-6, Quality Control of Sodium 2-(4-((2-oxocyclopentyl)methyl)phenyl)propanoate, Name is Sodium 2-(4-((2-oxocyclopentyl)methyl)phenyl)propanoate, molecular formula is C15H17NaO3, molecular weight is 268.2835, MDL number is MFCD00941425, category is phthalazine. Now introduce a scientific discovery about this category.

In this study, substituted 2H-indazolo[2,1-b]phthalazine-1,6,11-triones, that may possess biological activity, have been synthesized via one-pot three-component cyclocondensation reaction of aromatic aldehydes, cyclic 1,3-dione and phthalhydrazide in ethanol catalyzed by Y(OTf)(3) with good to excellent yields. The structures of all synthesized compounds, 3,4-dihydro-13-phenyl-2H-indazolo[2,1-b]phthalazine-1,6,11(13H)-trione (4a), 13-(4-cyanophenyl)-3,4-dihydro-2H-indazolo[2,1-b]phthalazine-1,6,11(13H)-trione (4b), 3,4-dihydro-3,3-dimethyl-13-(4-cyanophenyl)-2H-indazolo[2,1-b]phthalazine-1,6,11(13H)-trione (4c), 3,4-dihydro-3,3-dimethyl-13-phenyl-2H-indazolo[2,1-b]phthalazine-1,6,11(13H)-trione (4d), and 3,4-dihydro-13-(4-isopropylphenyl)-3,3-dimethyl-2H-indazolo[2,1-b]phthalazine-1,6,11(13H)-trione (4e) have been elucidated from IR, NMR and mass spectral data.

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 80382-23-6, Name is Sodium 2-(4-((2-oxocyclopentyl)methyl)phenyl)propanoate, molecular formula is C15H17NaO3. In an article, author is Mohamadpour, Farzaneh,once mentioned of 80382-23-6, Formula: https://www.ambeed.com/products/80382-23-6.html.

An efficient and convenient zinc acetate dihydrate (Zn(OAc)(2)center dot 2H(2)O) catalyzed synthesis of 1H-pyrazolo[1,2-b]phthalazine-5,10-dione derivatives has been accomplished via one-pot four-condensation of phthalic anhydride, hydrazine monohydrate, aromatic aldehydes derivatives and malononitrile under solvent-free conditions. The notable advantages of the present procedure are: operational simplicity, eco-friendly, environmentally benign nature, low-cost and non-toxic catalyst, no necessity of chromatographic purification steps, short reaction times and good to high yields.

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Reference of 80382-23-6, Catalysts allow a reaction to proceed via a pathway that has a lower activation energy than the uncatalyzed reaction. 80382-23-6, Name is Sodium 2-(4-((2-oxocyclopentyl)methyl)phenyl)propanoate, SMILES is CC(C1=CC=C(CC2C(CCC2)=O)C=C1)C([O-])=O.[Na+], belongs to phthalazine compound. In a article, author is El-Helby, Abdel-Ghany A., introduce new discover of the category.

Background: Extensive studies were reported in the synthesis of several phthalazine derivatives as promising anticancer agents as potent VEGFR-2 inhibitors. Vatalanib (PTK787) was the first anilinophthalazine published derivative as a potent inhibitor of VEGFR. The discovery of vatalanib as a clinical candidate led to the design and synthesis of different anilinophthalazine derivatives as potent inhibitors for VEGFR-2. The objective of present research work is the synthesis of new agents with the same essential pharmacophoric features of the reported and clinically used VEGFR-2 inhibitors (e.g vatalanib and sorafenib). The main core of our molecular design rationale comprised bioisosteric modification strategies of VEGFR-2 inhibitors at four different positions. Material and Methods: A correlation between structure and biological activity of our designed phthalazines was established using molecular docking and VEGFR-2 kinase assay. Results and Discussion: In view of their expected anticancer activity, novel triazolo[3,4-a]phthalazine derivatives 5-6a-o and 3-substituted-bis([1,2,41triazolo)[3,4-a:4′,3′-c]phthalazines 9a-b were designed, synthesized and evaluated for their anti-proliferative activity against two human tumor cell lines HCT-116 human colon adenocarcinoma and MCF-7 breast cancer. It was found that, compound 6o the most potent derivative against both HCT116 and MCF-7 cancer cell lines. Compounds 6o, 6m, 6d and 9b showed the highest anticancer activities against HCT116 human colon adenocarcinoma with IC50 of 7 +/- 0.06, 13 +/- 0.11, 15 +/- 0.14 and 23 +/- 0.22 mu M respectively while compounds 6o, 6d, 6a and 6n showed the highest anticancer activities against MCF-7 breast cancer with IC50 of 16.98 +/- 0.15, 18.2 +/- 0.17, 57.54 +/- 0.53 and 66.45 +/- 0.67 mu M respectively. Sorafenib as a highly potent VEGFR-2 inhibitor was used as a reference drug with IC50 of 5.47 +/- 0.3 and 7.26 +/- 0.3 mu M respectively. Nine compounds were further evaluated for their VEGFR-2 inhibitory activity. Compounds 6o, 6m, 6d and 9b emerged as the most active counterparts against VEGFR-2 with IC50 values of 0.1 +/- 0.01, 0.15 +/- 0.02, 0.28 +/- 0.03 and 0.38 +/- 0.04 mu M, respectively comparable to that of sorafenib (IC50 = 0.1+0.02) mu M. Furthermore, molecular docking studies were carried out for all synthesized compounds to investigate their binding pattern and predict their binding affinities towards VEGFR-2 active site. In silico ADMET studies were calculated for the tested compounds. Most of our designed compounds exhibited good ADMET profile. Conclusion: The obtained results showed that, the most active compounds could be useful as a template for future design, optimization, adaptation and investigation to produce more potent and selective VEGFR-2 inhibitors with higher anticancer analogs.

Reference of 80382-23-6, One of the oldest and most widely used commercial enzyme inhibitors is aspirin, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 80382-23-6.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Reactions catalyzed within inorganic and organic materials and at electrochemical interfaces commonly occur at high coverage and in condensed media, causing turnover rates to depend strongly on interfacial structure and composition, 80382-23-6, Name is Sodium 2-(4-((2-oxocyclopentyl)methyl)phenyl)propanoate, SMILES is CC(C1=CC=C(CC2C(CCC2)=O)C=C1)C([O-])=O.[Na+], in an article , author is Norman, Peter, once mentioned of 80382-23-6, Computed Properties of https://www.ambeed.com/products/80382-23-6.html.

Novel 1-anilino-4-phenylphthalazine derivatives, compositions containing them, and their use as JAK1 inhibitors and for the treatment of cancer, inflammatory and autoimmune diseases are claimed. This represents a novel scaffold for JAK inhibitors and is highly distinct from the JAK1 inhibitors previously described, although the same scaffold has been employed in other kinase inhibitors.

But sometimes, even after several years of basic chemistry education, it is not easy to form a clear picture on how they govern reactivity! 80382-23-6, you can contact me at any time and look forward to more communication. Computed Properties of https://www.ambeed.com/products/80382-23-6.html.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem