Category: 81-16-3

In an article, author is Malinowski, Zbigniew, once mentioned the application of 81-16-3, HPLC of Formula: C10H9NO3S, Name is 2-Aminonaphthalene-1-sulfonic acid, molecular formula is C10H9NO3S, molecular weight is 223.25, MDL number is MFCD00003988, category is phthalazines. Now introduce a scientific discovery about this category.

Synthesis of 4-alkylsulfanylphthalazin-1(2H)-ones via palladium catalyzed sulfanylation of substituted 4-bromophthalazin-1 (2H)-ones

The synthesis of a series of new alkylsulfanyl phthalazinone and phthalazine derivatives is described. The target compounds were efficiently synthesized in a four step sequence, consisting of (1) cyclization of 2-formylbenzoic acid with hydrazine hydrate to form phthalazinone, (2) the direct bromination of phthalazinone core with KBr3, (3) alkylation of the obtained 4-bromolactam (Mitsunobu procedure) to make N- and also O-alkyl derivatives and finally (4) palladium-catalyzed coupling reactions of 2-alkyl-4bromophthalazinone and 1-allcyloxy-4-bromophthalazine derivatives with aliphatic mercaptanes. Furthermore, the synthesis of 2-methyl-8-(propan-2-yl)sulfanyl-pyrido[3,44pyridazin-1(2H)-one from 2methyl-pyrido[3,4-d]pyridazin-1(2H)-one via bromination reaction with KBr3 and subsequent sulfanylation by isopropyl mercaptan under catalyzed coupling reaction conditions is also described. (C) 2016 Elsevier Ltd. All rights reserved.

If you are interested in 81-16-3, you can contact me at any time and look forward to more communication. HPLC of Formula: C10H9NO3S.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. , SDS of cas: 81-16-3, 81-16-3, Name is 2-Aminonaphthalene-1-sulfonic acid, molecular formula is C10H9NO3S, belongs to phthalazines compound. In a document, author is Shalkouhi, Somaye Nikzad, introduce the new discover.

Synthesis of novel spiro[chromeno[4 ‘,3 ‘:3,4]pyrazolo[1,2-b]phthalazine-7,3 ‘-indoline]-2 ‘,6,9,14-tetraone

Fe3O4@Cys-SO3H magnetic nanocatalyst has been used as an effective and reusable solid acid catalyst for the one pot synthesis of novel spiro[chromeno[4′,3′:3,4]pyrazolo[1,2-b]phthalazine-7,3′-indoline]-2’,6,9,14-tetraone via a three-component reaction of phthalhydrazide, 4-hydroxycoumarin and isatin derivatives. Easy separation of catalyst, good yields of reaction and synthesis of novel heterocyclic compound are some advantages of this procedure.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 81-16-3. SDS of cas: 81-16-3.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

In an article, author is Shaterian, Hamid Reza, once mentioned the application of 81-16-3, COA of Formula: C10H9NO3S, Name is 2-Aminonaphthalene-1-sulfonic acid, molecular formula is C10H9NO3S, molecular weight is 223.25, MDL number is MFCD00003988, category is phthalazines. Now introduce a scientific discovery about this category.

One-pot, four-component synthesis of 2H-indazolo[2,1-b]phthalazine-triones catalyzed by cellulose-SO3H as a reusable heterogeneous and efficient catalyst

A practical and green method for the synthesis of 2H-indazolo[2,1-b]phthalazine-1,6,11(13H)-trione derivatives using cellulose-SO3H as a solid acidic catalyst for the four-component condensation reaction of hydrazinium hydroxide, phthalic anhydride, dimedone, and aromatic aldehydes under thermal solvent-free conditions is described. Cellulose-SO3H as a recyclable green chemical compound has been demonstrated as a new catalyst for the synthesis of this class of compounds.

If you are interested in 81-16-3, you can contact me at any time and look forward to more communication. COA of Formula: C10H9NO3S.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. , Category: phthalazines, 81-16-3, Name is 2-Aminonaphthalene-1-sulfonic acid, molecular formula is C10H9NO3S, belongs to phthalazines compound. In a document, author is Wang Wang, introduce the new discover.

An improved procedure for the three-component synthesis of 1H-pyrazolo[1,2-b]phthalazine-5,10-dione derivatives using basic ionic liquid

An efficient and green method for the synthesis of 1H-pyrazolo[1,2-b]phthalazine-5,10-dione derivatives has been achieved through the one-pot, three-component condensation of aromatic aldehydes, malononitrile or ethyl cyanoacetate, and phthalhydrazide in the presence of 1-butyl-3-methyl imidazolium hydroxide ([bmim]OH) as catalyst in EtOH. This reaction does not involve any hazardous organic solvent and toxic catalyst. The ionic liquid can be recovered and recycled for subsequent reactions. Moreover, this protocol has the advantages of easy work-up, short reaction time, mild reaction conditions and environmentally benign procedures compared with the reported methods.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 81-16-3. Category: phthalazines.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Reactions catalyzed within inorganic and organic materials and at electrochemical interfaces commonly occur at high coverage and in condensed media, causing turnover rates to depend strongly on interfacial structure and composition, 81-16-3, Name is 2-Aminonaphthalene-1-sulfonic acid, SMILES is O=S(C1=C2C=CC=CC2=CC=C1N)(O)=O, in an article , author is Maheswari, Cinnathambi Subramani, once mentioned of 81-16-3, Recommanded Product: 81-16-3.

Antibacterial Evaluation of Some 3-Amino-1H-Pyrazolo[1,2-b]Phthalazine-2-Carboxamides by using Fish Scale Hydroxyapatite as a Heterogeneous Catalyst

Fish scale hydroxyapatite (FS-HAP) has been used as an efficient catalyst for the synthesis of 3-amino-1H-pyrazolo[1,2-b]phthalazine-2-carboxamide derivatives via the one-pot, three-component cyclocondensation reactions of aromatic aldehydes with cyanoacetamide and phthalhydrazide under solvent-free condition. FS-HAP has been characterized by FT-IR, XRD, SEM and EDS techniques. The synthesized compounds were evaluated for their in vitro antibacterial activity against gram-positive (Bacillus cereus, Bacillus aryabhattai, Bacillus megaterium, Staphylococcus aureus) and gram-negative (Serratia marcescens, Bacillus Pseudomonas putida, Escherichia coli, Enterobacter cloacae) bacteria. Tetracycline and erythromycin were used as standard antibiotics in this investigation. In the present protocol, we have achieved remarkable yields of the product in shorter reaction time and the catalyst was easily recovered and reused.

But sometimes, even after several years of basic chemistry education, it is not easy to form a clear picture on how they govern reactivity! 81-16-3, you can contact me at any time and look forward to more communication. Recommanded Product: 81-16-3.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Electric Literature of 81-16-3, As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 81-16-3, Name is 2-Aminonaphthalene-1-sulfonic acid, SMILES is O=S(C1=C2C=CC=CC2=CC=C1N)(O)=O, belongs to phthalazines compound. In a article, author is Wei, Cheng-Xi, introduce new discover of the category.

The regulating inotropic activity of 6-substituted-oxy-[1,2,4]triazolo[3,4-a]phthalazine

In a previous research, we synthesized and evaluated the anticonvulsant activity of a series of 6-substituted-oxy-[1,2,4] triazolo[3,4-a] phthalazine compounds. Reference to other studies, we deduce that the compounds may be useful for regulating inotropic activity by effecting stroke volume, so in this study, we evaluated 20 compounds (15a-t) for their changed inotropic activity by measuring the left atrium stroke volume in heart preparations isolated from Wistar rats. Among the 20 compounds, 15j was the most potent with an increased stroke volume of 27.39 +/- 3.16 % at the concentration of 50 mu M, compound 15m was identified as the most potent with an decreased stroke volume of -95.59 +/- 0.50 % at the same concentration which is much more effective than referenced drug Nifedipine (-55.22 +/- 1.87% at the concentration of 1 mu M).

Electric Literature of 81-16-3, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. I hope my blog about 81-16-3 is helpful to your research.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 81-16-3, Name is 2-Aminonaphthalene-1-sulfonic acid, molecular formula is C10H9NO3S, belongs to phthalazines compound. In a document, author is Maleki, Behrooz, introduce the new discover, Quality Control of 2-Aminonaphthalene-1-sulfonic acid.

Lewis acid free synthesis of 3,4-dihydro-1H-indazolo[1,2-b]phthalazine-1,6,11(2H,13H)-triones promoted by 1,1,1,3,3,3-hexafluoro-2-propanol

A convenient, environmentally friendly and efficient procedure for the synthesis 3,4-dihydro-1H-indazolo[1,2-b]phthalazine-1,6,11(2H,13H)-trione derivatives has been developed via multi-component and one-pot reactions of various aldehydes with cyclic 1,3-diketones and phthalhydrazide 1,1,1,3,3,3-hexafluoro-2-propanol (HFIP). In simple and mild reaction conditions, the use of HFIP is explored as an easy workup and a green catalyst for the one-pot three-component synthesis of 3,4-dihydro-1H-indazolo[1,2-b]phthalazine-1,6,11(2H, 13H)-triones. Thus, this practical method is developed as a notable medium for these derivatives via a multicomponent reaction.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 81-16-3. Quality Control of 2-Aminonaphthalene-1-sulfonic acid.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 81-16-3, Name is 2-Aminonaphthalene-1-sulfonic acid, molecular formula is C10H9NO3S, belongs to phthalazines compound. In a document, author is Taslimi, Parham, introduce the new discover, COA of Formula: C10H9NO3S.

Cholinesterases, alpha-glycosidase, and carbonic anhydrase inhibition properties of 1H-pyrazolo[1,2-b]phthalazine-5,10-dione derivatives: Synthetic analogues for the treatment of Alzheimer’s disease and diabetes mellitus

In this study, using the Cu(OTf)(2) catalyst, 1H-pyrazolo[1,2-b]phthalazine-5,10-dione derivative molecules were carried out in one step and with high yield (86-91%). The previously synthesized 1H-pyrazolo [1,2-b]phthalazine-5,10-dione derivatives, carbonic anhydrase I and II isozymes (hCA I and II), acetylcholinesterase (AChE), butyrylcholinesterase (BChE) and alpha-glycosidase (alpha-Gly) enzymes with K-i values in the range of 4.88-15.94 nM for hCA I, 7.04-20.83 nM for hCA II, 68.25-158.27 for AChE, 60.17-91.27 for BChE and 0.36-2.36 nM for alpha-Gly, respectively. In silico studies were performed on the molecules inhibiting hCA I, hCA II, AChE, BChE and alpha-Gly receptors. When we evaluated the data obtained in this work, we determined the inhibition type of the 1H-pyrazolo[1,2-b]phthalazine-5,10-dione derivatives at the receptors. Reference inhibitors were used for all enzymes.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 81-16-3. COA of Formula: C10H9NO3S.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Electric Literature of 81-16-3, Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, 81-16-3, Name is 2-Aminonaphthalene-1-sulfonic acid, SMILES is O=S(C1=C2C=CC=CC2=CC=C1N)(O)=O, belongs to phthalazines compound. In a article, author is Berber, Nurcan, introduce new discover of the category.

Synthesis and evaluation of new phthalazine substituted beta-lactam derivatives as carbonic anhydrase inhibitors

A new series of phthalazine substituted beta-lactam derivatives were synthesized and their inhibitory effects on the activity of purified human carbonic anhydrase (hCA I and II) were evaluated. 2H-Indazolo[2,1-b]phthalazine-trione derivative was prepared with 4-nitrobenzaldehyde, dimedone, and phthalhydrazide in the presence of TFA in DMF, and the nitro group was reduced to 13-(4-aminophenyl)-3,3-dimethyl-3,4-dihydro-2H-indazolo[1,2-b]phthalazine-1,6,11(13H)-trione with SnCl2 center dot 2H(2)O. The reduced compound was reacted with different aromatic aldehydes, and phthalazine substituted imines were synthesized. The imine compounds undergo (2+2) cycloaddition reactions with ketenes to produce 2H-indazolo[2,1-b]phthalazine-trione substituted beta-lactam derivatives. The beta-lactam compounds were tested as inhibitors of the CA isoenzyme activity. The results showed that all the synthesized compounds inhibited the CA isoenzyme activity. 1-(4-(3,3-dimethyl-1,6,11-trioxo-2,3,4,6,11,13-hexahydro-1H-indazolo[1,2b]phthalazin-13-yl)phenyl)-2-oxo-4-p-tolylazetidin-3-yl acetate (IC50 = 6.97 A mu M for hCA I and 8.48 A mu M for hCA II) had the most inhibitory effect.

Electric Literature of 81-16-3, Consequently, the presence of a catalyst will permit a system to reach equilibrium more quickly, but it has no effect on the position of the equilibrium as reflected in the value of its equilibrium constant.I hope my blog about 81-16-3 is helpful to your research.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem