Category: 875-74-1

Synthetic Route of 875-74-1, As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 875-74-1, Name is H-D-Phg-OH, SMILES is O=C(O)[C@H](N)C1=CC=CC=C1, belongs to phthalazines compound. In a article, author is Slawinski, Jaroslaw, introduce new discover of the category.

Synthesis and Anti-Yeast Evaluation of Novel 2-Alkylthio-4-chloro-5-methyl-N-[imino-(1-oxo-(1H)-phthalazin-2-yl)methyl]benzenesulfonamide Derivatives

Pathogenic fungi are one of the main causes of hospital-related infections. Since conventional antifungals have become less effective because of the increasing fungal resistance to the standard drugs, the need for new agents is becoming urgent. Herein we report a synthesis of a series of novel N-[imino-(1-oxo-(1H)-phthalazin-2-yl) methyl]benzenesulfonamide derivatives with in vitro activity against yeast-like fungi isolated from the oral cavity and respiratory tract of patients with candidiasis. These compounds were synthesized by the one-step or two-step reactions of 1-(2-alkylthiobenzensulfonyl)-2aminoguanidines with the appropriate ortho-carbonyl benzoic acids. The biological study revealed that new derivatives have shown significant growth-inhibitory activity, superior or comparable, than those of the reference drug fluconazole. The most promising activities were observed against Candida albicans, with inhibition at least 1-3 (12.5%-37.5%) of the eight tested strains at the low MIC level of <= 6.2-25 mu g/mL. Synthetic Route of 875-74-1, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. I hope my blog about 875-74-1 is helpful to your research.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

875-74-1, Name is H-D-Phg-OH, molecular formula is C8H9NO2, belongs to phthalazines compound, is a common compound. In a patnet, author is Kokunov, Yu. V., once mentioned the new application about 875-74-1, Formula: C8H9NO2.

Binuclear complex of silver(I) perrhenate with phthalazine: Synthesis, crystal structure, and luminescence properties

Silver compound Ag-2(Phtz)(4)](ReO4)(2) (I) (Phtz is phthalazine, C8H6N2) is synthesized, and its crystal structure is determined. The crystals are triclinic: space group , a = 9.651(2), b = 9.655(2), c = 10.884(2) , alpha = 115.752(2)A degrees, beta = 94.582(2)A degrees, gamma = 106.000(2)A degrees, V = 854.3(2) (3), Z = 1, rho(calcd) = 2.404 g/cm(3). The Ag atom forms a triangular coordination mode (Ag(1)-N(11) 2.34(2), Ag(1)-N(12AEuro) 2.24(2), and Ag(1)-N(21) 2.28(1) ) by the nitrogen atoms of one monodentate and two bridging phthalazine molecules. Their interaction results in the formation of an almost planar centrosymmetric binuclear cationic complex [Ag-2(Phtz)(4)](2+) (Ag(1)a <-Ag(1A) 3.452(7) ). The oxygen atoms of the ReO (4) (-) anion are randomly disordered over three positions each. The luminescence spectrum contains an emission band in the green region. We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, 875-74-1. The above is the message from the blog manager. Formula: C8H9NO2.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 875-74-1, Name is H-D-Phg-OH, SMILES is O=C(O)[C@H](N)C1=CC=CC=C1, belongs to phthalazines compound. In a document, author is Moustafa, Ahmed H., introduce the new discover, SDS of cas: 875-74-1.

Synthesis, Antiviral, and Antimicrobial Activity of N- and S-Alkylated Phthalazine Derivatives

A series of N-alkylphthalazinone were synthesized by the reaction of phthalazin-1(2H)-one derivatives 1a-c with alkylating agents namely, propargyl, allyl bromide, epichlorohydrin, 1,3-dichloro-2-propanol, 4-bromobutylacetate, and 1-(bromomethoxy) ethyl acetate to give the corresponding N-alkylphthalazinone 2a-c, 3a-c, 5a-c, 6a-c, 7a-c, and 9a-c. Alkylation of phthalazin-1(2H)-thione to give a series from S-alkylphthalazine 12-14 and thioglycosides 15 and 17 was performed. Deprotection of compounds 7a-c, 9a-c, 15, and 17 resulted in the formation of the corresponding products 8a-c, 10a-c, 16, and 18. The structure of newly synthesized compounds was assigned by IR, H-1, C-13 NMR, and elemental analysis. Some of these compounds were screened for antiviral and antimicrobial activity.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 875-74-1 is helpful to your research. SDS of cas: 875-74-1.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Related Products of 875-74-1, Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. 875-74-1, Name is H-D-Phg-OH, SMILES is O=C(O)[C@H](N)C1=CC=CC=C1, belongs to phthalazines compound. In a article, author is Aly, M. R. E., introduce new discover of the category.

Synthesis, Insecticidal, and Fungicidal Screening of Some New Quinoline Derivatives

This paper describes the synthesis of a series of quinolines graphted with hydrazones, pyrazoles, pyridazine, phthalazine, triazepinone, semicarbazide, and thiomorpholide moieties and four metal complexes. These derivatives were screened against Fusarium oxysporum and the red palm weevil (RPW) Rhynchophorus ferrugineus Oliver (coleopteran: Curculionidae) as palm pathogens. Only chlorinated quinolines were active against these organisms with hydrazones being good fungicides, while those modified with pyrazoles and pyrazines showed moderate insecticidal activity. A unique trihydroxylated hydrazone was active against both organisms, while another hydrazone, the most potent fungicide in this series, exhibited insecticidal activity only upon complexation with Zn2+ ions.

Related Products of 875-74-1, Because enzymes can increase reaction rates by enormous factors and tend to be very specific, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 875-74-1.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 875-74-1, Name is H-D-Phg-OH, SMILES is O=C(O)[C@H](N)C1=CC=CC=C1, belongs to phthalazines compound. In a document, author is Atar, Amol B., introduce the new discover, Application In Synthesis of H-D-Phg-OH.

beta-Cyclodextrine-SO3H: the most efficient catalyst for one-pot synthesis of 2H-indazolo[2,1-b]phthalazine-triones under solvent-free conditions

An environmentally benign and efficient method has been developed for the synthesis of a series of 2H-indazolo[2,1-b]phthalazine-triones derivatives with beta-cyclodextrine-SO3H as a recyclable catalyst by simply combining of various aldehydes with cyclic 1,3-diketones and phthalhydrazide under solvent free condition. The advantageous features of this methodology are high atom-economy, operational simplicity, shorter reaction time, convergence, and facile automation. A greener, efficient, and expeditious method has been developed for the synthesis of 2H-indazolo [2,1-b] phthalazine-triones derivatives with beta-cyclodextrine-SO3H as a recyclable catalyst for the first time. [GRAPHICS] .

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 875-74-1 is helpful to your research. Application In Synthesis of H-D-Phg-OH.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics, 875-74-1, Name is H-D-Phg-OH, SMILES is O=C(O)[C@H](N)C1=CC=CC=C1, belongs to phthalazines compound. In a document, author is Insuasty, Alberto, introduce the new discover, Category: phthalazines.

A Family of Heterocyclic Naphthalene Diimide (NDI) Analogues: Comparing Parent Isoquinoline Diimides and Phthalazine Diimides with NDI

Parent isoquinoline diimide (IQDI) and phthalazine diimide (PTDI), as two new heterocyclic analogues of naphthalene diimides (NDIs), have been synthesized through an oxidative strategy in 35-79 % yield. X-ray crystallography has been used to support the formation of IQDI, which also show fluorescence quantum yields of 3.5 %. The electrochemical and electrical properties of these molecules have been studied. The electrochemical results show an interesting trend in first reduction potential PTDICategory: phthalazines.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, such as the rate of change in the concentration of reactants or products with time. 875-74-1, Name is H-D-Phg-OH, formurla is C8H9NO2. In a document, author is Nfor, Emmanuel N., introducing its new discovery. Category: phthalazines.

Synthesis, crystal structure and antifungal activity of a Ni(II) complex of a new hydrazone derived from antihypertensive drug hydralazine hydrochloride

A new complex of nickel(II) with 1-(2-[(5-methylfuran-2yl)methylene)] hydrazono) phthalazine HL (1) has been synthesized and characterized by elemental analysis, IR, electronic spectra, TGA, H-1 and C-13 NMR spectroscopy. The crystal structures of the free ligand and its complex have been determined by single crystal X-ray diffraction techniques. In the complex the hydrazone ligand chelates to the nickel(II) through nitrogen atoms in a bidentate manner. The antifungal activity of the ligand and its nickel(II) complex 3 was studied against Aspergillus niger, Aspergillus flavus and Candida albicans. The results revealed modest activity of the complex (3) against the tested organisms with inhibition zones of 14, 14 and 13 mm, compared to the free ligand 1 with inhibition zones of 11 mm each for A. niger, A. flavus and C. albicans respectively. (C) 2013 Elsevier Ltd. All rights reserved.

If you are hungry for even more, make sure to check my other article about 875-74-1, Category: phthalazines.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem