Category: phthalazine

An article Copper nitrate-mediated synthesis of 3-aryl isoxazolines and isoxazoles from olefinic azlactones WOS:000482917600008 published article about AMINO-ACIDS; 1,3-DIPOLAR CYCLOADDITION; SELECTIVE INHIBITOR; DIRECT CONVERSION; NITRILE OXIDES; ALKENES; ALKYNES; POTENT; DIPOLAROPHILES; CONSTRUCTION in [Lin, Yifan; Zhang, Ke; Gao, Mingchun; Jiang, Zheyi; Liu, Jiajie; Ma, Yurui; Wang, Haoyu; Tan, Qitao; Xiao, Junjie; Xu, Bin] Shanghai Univ, Qianweichang Coll, Sch Life Sci, Innovat Drug Res Ctr,Dept Chem, Shanghai 200444, Peoples R China; [Xu, Bin] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China in 2019.0, Cited 61.0. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7. Formula: C7H5NO4

A copper nitrate-mediated [2 + 2 + 1] cycloaddition reaction was developed for the expedient synthesis of pharmacologically interesting 3-aryl substituted isoxazolines and isoxazoles through C = C bond cleavage. Copper nitrate is employed as a reaction promoter and precursor of nitrile oxides. The given approach features a new mode of cycloaddition from olefinic azlactones, copper nitrate and unsaturated compounds with wide substrate scope, good functional group tolerance and operational simplicity.

Bye, fridends, I hope you can learn more about C7H5NO4, If you have any questions, you can browse other blog as well. See you lster.. Formula: C7H5NO4

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Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

HPLC of Formula: C7H5NO4. Lu, LX; Zhang, HY; Liu, J; Liu, Y; Wang, YW; Xu, ST; Zhu, ZY; Xu, JY in [Lu, Lixue; Zhang, Hengyuan; Liu, Yang; Wang, Yiwei; Xu, Shengtao; Xu, Jinyi] China Pharmaceut Univ, State Key Lab Nat Med, 24 Tong Jia Xiang, Nanjing 210009, Jiangsu, Peoples R China; [Lu, Lixue; Zhang, Hengyuan; Liu, Yang; Wang, Yiwei; Xu, Shengtao; Xu, Jinyi] China Pharmaceut Univ, Dept Med Chem, 24 Tong Jia Xiang, Nanjing 210009, Jiangsu, Peoples R China; [Lu, Lixue; Liu, Jie] China Pharmaceut Univ, Dept Organ Chem, 24 Tong Jia Xiang, Nanjing 210009, Jiangsu, Peoples R China; [Zhu, Zheying] Univ Nottingham, Sch Pharm, Div Mol Therapeut & Formulat, Univ Pk Campus, Nottingham NG7 2RD, England published Synthesis, biological evaluation and mechanism studies of C-23 modified 23-hydroxybetulinic acid derivatives as anticancer agents in 2019, Cited 18. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7.

A series of C-23 modified 23-hydroxybetulinic acid (HBA) derivatives were synthesized and evaluated for their antiproliferative activity against a panel of cancer cell lines (A2780, A375, B16, MCF-7 and HepG2). The biological screening results showed that most of the derivatives exhibited more potent antiproliferative activity than HBA, and compound 6e exhibited the most potent activity with IC50 values of 2.14 mu M, 2.89 mu M, and 3.97 mu M against A2780, B16, and MCF-7 cells, respectively. Further anticancer mechanism studies revealed that compound 6e induced the generation of intracellular reactive oxygen species (ROS) and reduction of mitochondrial membrane potential (MMP) of B16 cells in a dose-dependent manner. Moreover, western blot analysis indicated that compound 6e downregulated the expression of anti-apoptotic protein Bcl-2 and upregulated the expression of proapoptotic protein Bax, activation of caspase 3 to induce cell apoptosis. Meanwhile, compound 6e significantly inhibited the phosphorylation of MEK, ERK, and Akt without affecting the expression of MEK, ERK, and Akt. Furthermore, the in vivo anti-tumor activity of 6e was validated (tumor inhibitory ratio of 68.4% at the dose of 30 mg/kg) in mice with B16 melanoma. (C) 2019 Elsevier Masson SAS. All rights reserved.

About 4-Nitrobenzoic acid, If you have any questions, you can contact Lu, LX; Zhang, HY; Liu, J; Liu, Y; Wang, YW; Xu, ST; Zhu, ZY; Xu, JY or concate me.. HPLC of Formula: C7H5NO4

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

HPLC of Formula: C7H5NO4. Ma, HP; Bai, CLM; Bao, YS in [Ma, Hongpeng; Bai, Chaolumen; Bao, Yong-Sheng] Inner Mongolia Normal Univ, Coll Chem & Environm Sci, Inner Mongolia Key Lab Green Catalysis, Hohhot 010022, Peoples R China published Heterogeneous Suzuki-Miyaura coupling of heteroaryl ester via chemoselective C(acyl)-O bond activation in 2019, Cited 47. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7.

A site-selective supported palladium nanoparticle catalyzed Suzuki-Miyaura cross-coupling reaction with heteroaryl esters and arylboronic acids as coupling partners was developed. This methodology provides a heterogeneous catalytic route for aryl ketone formation via C(acyl)-O bond activation of esters by successful suppression of the undesired decarbonylation phenomenon. The catalyst can be reused and shows high activity after eight cycles. The XPS analysis of the catalyst before and after the reaction suggested that the reaction might be performed via a Pd-0/Pd-II catalytic cycle that began with Pd-0.

HPLC of Formula: C7H5NO4. Welcome to talk about 62-23-7, If you have any questions, you can contact Ma, HP; Bai, CLM; Bao, YS or send Email.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

An article Amide Synthesis through the In Situ Generation of Chloro- and Imido-Phosphonium Salts WOS:000546100300092 published article about N-C CLEAVAGE; CARBOXYLIC-ACIDS; CATALYZED AMINOCARBONYLATION; AMINO-ACIDS; OXIDATIVE AMIDATION; FREE TRANSAMIDATION; SECONDARY AMIDES; ARYL IODIDES; METAL-FREE; ALDEHYDES in [Irving, Charles D.; Floreancig, Jack T.; Laulhe, Sebastien] Indiana Univ Purdue Univ Indianapolis IUPUI, Dept Chem & Chem Biol, Indianapolis, IN 46202 USA in 2020, Cited 84. SDS of cas: 62-23-7. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7

We describe a methodology for the amidation of carboxylic acids by generating phosphonium salts in situ from N-chlorophthalimide and triphenylphosphine. Aliphatic, benzylic, and aromatic carboxylic acids can be transformed into their amide counter parts using primary and secondary amines. This functional group interconversion is achieved at room temperature in good to excellent yields. Mechanistic work shows the in situ formation of chloro- and imido-phosphonium salts that react as activating agents for carboxylic acids and generate an acyloxyphosphonium species.

SDS of cas: 62-23-7. Bye, fridends, I hope you can learn more about C7H5NO4, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Name: 4-Nitrobenzoic acid. In 2019.0 TETRAHEDRON published article about FACILE SYNTHESIS; RECEPTOR ANTAGONIST; EFFICIENT SYNTHESIS; COUPLING REACTION; DERIVATIVES; CYCLIZATION; ACCESS; SERIES; ROUTE; CELLS in [Xiong, Jun; Wei, Xiao; Wan, Yu-Chen; Ding, Ming-Wu] Cent China Normal Univ, Key Lab Pesticide & Chem Biol, Minist Educ, Hubei Int Sci & Technol Cooperat Base Pesticide &, Wuhan, Hubei, Peoples R China; [Xiong, Jun] Hubei Univ Sci & Technol, Coll Pharm, Xianning 437100, Hubei, Peoples R China in 2019.0, Cited 59.0. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7.

An efficient one-pot and regioselective synthesis of 3,4-dihydroquinazolines and 4,5-dihydro-3H-1,4-benzodiazepin-3-ones by Ugi/Staudinger/aza-Wittig sequence has been developed. The Ugi reactions of 2-azidobenzylamines, aldehydes, acids (or alpha-keto acids) and isocyanides produced the azide intermediates, which were then treated with tributylphosphine or triphenylphosphine to give poly-substituted 3,4-dihydroquinazolines or 4,5-dihydro-3H-1,4-benzodiazepin-3-ones in moderate to good yields by tandem Standinger/aza-Wittig reactions. (C) 2019 Elsevier Ltd. All rights reserved.

Welcome to talk about 62-23-7, If you have any questions, you can contact Xiong, J; Wei, X; Wan, YC; Ding, MW or send Email.. Name: 4-Nitrobenzoic acid

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

An article Chemical modifications of G418 (geneticin): Synthesis of novel readthrough aminoglycosides results in an improved in vitro safety window but no improvements in vivo WOS:000560727400005 published article about ZEBRAFISH; LINE in [Baiazitov, Ramil Y.; Friesen, Westley; Johnson, Briana; Mollin, Anna; Sheedy, Josephine; Sierra, Jairo; Weetall, Marla; Branstrom, Arthur; Welch, Ellen; Moon, Young-Choon] PTC Therapeut Inc, 100 Corp Court, South Plainfield, NJ 07080 USA in 2020.0, Cited 23.0. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7. Quality Control of 4-Nitrobenzoic acid

G418 is currently the most potent and active aminoglycoside to promote readthrough of eukaryotic nonsense mutations. However, owing to its toxicity G418 cannot be used in vivo to study readthrough activity A robust and scalable method for selective derivatization of G418 was developed to study the biological activity and toxicity of a series of analogs. Despite our synthetic efforts, an improvement in readthrough potency was not achieved. We discovered several analogs that demonstrated reduced zebra fish hair cell toxicity (a surrogate for ototoxicity), but this reduction in cellular toxicity did not translate to reduced in vivo toxicity in rats.

Quality Control of 4-Nitrobenzoic acid. Welcome to talk about 62-23-7, If you have any questions, you can contact Baiazitov, RY; Friesen, W; Johnson, B; Mollin, A; Sheedy, J; Sierra, J; Weetall, M; Branstrom, A; Welch, E; Moon, YC or send Email.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Recently I am researching about CROSS-COUPLINGS; ENANTIOSELECTIVE ADDITION; ESTERIFICATION; ACTIVATION; CONVERSION; REAGENTS; ALKENES, Saw an article supported by the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21931010]; National Key Research and Development Program of China [2017YFA0207302]; Program for Changjiang Scholars and Innovative Research Team in University of the Ministry of Education, China. Published in SCIENCE PRESS in BEIJING ,Authors: Chen, H; Chen, DH; Huang, PQ. The CAS is 62-23-7. Through research, I have a further understanding and discovery of 4-Nitrobenzoic acid. Formula: C7H5NO4

N-Acylpyrrole-type amides are a class of versatile building blocks in asymmetric synthesis. We report that by employing Ni(COD)(2)/2,2 ‘-bipyridine (5 mol%) catalytic system, the direct, catalytic alcoholysis of N-acylpyrrole-type aromatic and aliphatic amides with both primary and secondary alcohols can be achieved efficiently under very mild conditions (rt, 1 h) even at gram scale. By increasing the catalyst loading to 10 mol%, prolonging reaction time (18 h), and/or elevating reaction temperature to 50 degrees C/80 degrees C, the reaction could be extended to both complex and hindered N-acylpyrroles as well as to N-acylpyrazoles, Nacylindoles, and to other (functionalized) primary and secondary alcohols. In all cases, only 1.5 equiv. of alcohol were used. The value of the method has been demonstrated by the racemization-free, catalytic alcoholysis of chiral amides yielded from other asymmetric methodologies.

Formula: C7H5NO4. About 4-Nitrobenzoic acid, If you have any questions, you can contact Chen, H; Chen, DH; Huang, PQ or concate me.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

An article Synthesis of Dithiolethiones and Identification of Potential Neuroprotective Agents via Activation of Nrf2-Driven Antioxidant Enzymes WOS:000515216200046 published article about CUL3-BASED E3 LIGASE; OXIDATIVE STRESS; THERAPEUTIC TARGET; PC12 CELLS; NEURODEGENERATIVE DISEASES; MITOCHONDRIAL DYSFUNCTION; KEAP1-NRF2-ARE PATHWAY; BIOLOGICAL EVALUATION; HYDROGEN-PEROXIDE; CANCER PREVENTION in [Song, Zi-Long; Bai, Feifei; Zhang, Baoxin; Fang, Jianguo] Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China; [Song, Zi-Long; Bai, Feifei; Zhang, Baoxin; Fang, Jianguo] Lanzhou Univ, Coll Chem & Chem Engn, Lanzhou 730000, Peoples R China in 2020, Cited 70. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7. Safety of 4-Nitrobenzoic acid

Oxidative stress is implicated in the pathogenesis of a wide variety of neurodegenerative disorders, and accordingly, dietary supplement of exogenous antioxidants or/and upregulation of the endogenous antioxidant defense system are promising for therapeutic intervention or chemoprevention of neurodegenerative diseases. Nrf2, a master regulator of the cellular antioxidant machinery, cardinally participates in the transcription of cytoprotective genes against oxidative/electrophilic stresses. Herein, we report the synthesis of 59 structurally diverse dithiolethiones and evaluation of their neuroprotection against 6-hydroxydopamine- or H2O2 -induced oxidative damages in PC12 cells, a neuron-like rat pheochromocytoma cell line. Initial screening identified compounds 10 and 11 having low cytotoxicity but conferring remarkable protection on PC12 cells from oxidative-mediated damages. Further studies demonstrated that both compounds upregulated a battery of antioxidant genes as well as corresponding genes’ products. Significantly, silence of Nrf2 expression abolishes cytoprotection of 10 and 11, indicating targeting Nrf2 activation is pivotal for their cellular functions. Taken together, the two lead compounds discovered here with potent neuroprotective functions against oxidative stress via Nrf2 activation merit further development as therapeutic or chemopreventive candidates for neurodegenerative disorders.

Safety of 4-Nitrobenzoic acid. About 4-Nitrobenzoic acid, If you have any questions, you can contact Song, ZL; Bai, FF; Zhang, BX; Fang, JG or concate me.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Safety of 4-Nitrobenzoic acid. Recently I am researching about CHARGE-TRANSPORT PROPERTIES; PLATELET-AGGREGATION; MOLECULAR DOCKING; CROSS-TALK; ANTIOXIDANTS; RESONANCE; ASPIRIN; DRUGS, Saw an article supported by the Higher Education Commission of PakistanHigher Education Commission of Pakistan; Deanship of Scientific Research at King KhalidUniversity [R.G.P.2/15/40]. Published in WALTER DE GRUYTER GMBH in BERLIN ,Authors: Ramzan, A; Nazeer, A; Irfan, A; Al-Sehemi, AG; Verpoort, F; Khatak, ZA; Ahmad, A; Munawar, MA; Khan, MA; Basra, MAR. The CAS is 62-23-7. Through research, I have a further understanding and discovery of 4-Nitrobenzoic acid

A novel series of 2-(3-methyl-1,6-diphenyl-1H-pyrazolo[3,4-b]pyridin4-yl)-5-aryl-1,3,4-oxadiazoles (4a-4h) has been synthesized from corresponding hydrazones (3a-3h) and evaluated their antiplatelet aggregation effect induced by arachidonic acid and collagen. Spectral data and elemental evaluation were used to confirm the structure of the compounds while molecular docking against cyclooxygenase 1 and 2 (COX1 & COX2) and quantitative structure-activity relationship (QSAR) were performed in describing their antiplatelet potential. All synthesized compound exhibited more than 50% platelet aggregation inhibition against both arachidonic acid and collagen. Antiplatelet activities results showed that 4b and 4f compounds have highest % inhibition against arachidonic acid. High Egap and ionization potential values showed that the compound 4d, 4e and 4f were supposed to be more active and good electron donor while 4b, 4c, 4d, 4e, 4g and 4h might be more active due to more electrophilic sites. Interaction with more than one residues in the binding pocket of COX-1 in comparison with aspirin and ligand efficacy (LE) consequences showed that compounds have excellent action potential for COX-1. Computational evaluations are in good agreement with antiplatelet activities of the compounds. All compounds might be promising antiplatelet agents especially 4b, 4f and helpful in the synthesis of new drugs for the treatment of cardiovascular diseases (CVDs).

Safety of 4-Nitrobenzoic acid. Welcome to talk about 62-23-7, If you have any questions, you can contact Ramzan, A; Nazeer, A; Irfan, A; Al-Sehemi, AG; Verpoort, F; Khatak, ZA; Ahmad, A; Munawar, MA; Khan, MA; Basra, MAR or send Email.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

An article Synthetic aluminosilicate based geopolymers – Second generation geopolymer HPLC stationary phases WOS:000482179800023 published article about INTERACTION LIQUID-CHROMATOGRAPHY; POROUS GRAPHITIC CARBON; RETENTION BEHAVIOR; PERFORMANCE; METAKAOLIN; COLUMNS; SELECTIVITY; SUSPENSION; PACKING; MODE in [Thakur, Nimisha; Wahab, M. Farooq; Khanal, Durga D.; Armstrong, Daniel W.] Univ Arlington, Dept Chem & Biochem, Arlington, TX 76019 USA in 2019.0, Cited 46.0. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7. Quality Control of 4-Nitrobenzoic acid

A survey of existing stationary phases classified by the United States Pharmacopeia reveals that 120 groups of chromatographic supports mostly utilize silica-silane chemistry, polymeric materials along with some niche metal oxides. In this work, the synthesis and characterization of transition-metal free geopolymers as a new class of stationary phases for hydrophilic interaction liquid chromatography and normal phase separations is reported. The geopolymers were synthesized by reaction of synthetic aluminosilicate with potassium silicate (fumed silica dissolved in KOH) in a water-in-oil emulsion. For comparative purposes of peak shapes, a geopolymer from natural metakaolin was also synthesized. The geopolymers were examined by X-ray diffraction, energy dispersive spectroscopy, laser diffraction, and N-2-adsorption isotherms. This two-step approach gives spherical microparticles with surface area and pore size comparable to silica phases (150 m(2)/g and 120 angstrom respectively). Both synthetic aluminosilicates based and natural metakaolin based geopolymers occupy a unique spot in the HILIC selectivity chart when compared to 35 HILIC phases. An additional promising feature of geopolymers is high pH and temperature stability which are used to tune selectivity for small polar analytes. High pH separations are shown with carboxylic acids. Geopolymers also show mixed mode behavior in retention with ion-exchange properties in purely aqueous mobile phases. The separation of derivatized sugars is demonstrated and compared with porous graphitic carbon (Hypercarb (TM)) as another pH-stable stationary phase. (C) 2019 Elsevier B.V. All rights reserved.

Quality Control of 4-Nitrobenzoic acid. About 4-Nitrobenzoic acid, If you have any questions, you can contact Thakur, N; Wahab, MF; Khanal, DD; Armstrong, DW or concate me.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem