Category: phthalazine

Application In Synthesis of 4-Nitrobenzoic acid. I found the field of Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Chemistry very interesting. Saw the article Synthesis of ureido thioglycosides as novel insect beta-N-acetylhexosaminidase OfHex1 inhibitors published in 2020.0, Reprint Addresses Zhang, JJ (corresponding author), China Agr Univ, Coll Sci, Dept Pesticide Chem, Beijing, Peoples R China.; Yang, Q (corresponding author), Chinese Acad Agr Sci, State Key Lab Biol Plant Dis & Insect Pests, Inst Plant Protect, Beijing, Peoples R China.; Yang, Q (corresponding author), Chinese Acad Agr Sci, Shenzhen Agr Genome Res Inst, Beijing, Peoples R China.. The CAS is 62-23-7. Through research, I have a further understanding and discovery of 4-Nitrobenzoic acid.

The insect beta-N-acetylhexosaminidase OfHex1 from Ostrinia furnacalis (one of the most destructive agricultural pests) has been considered as a promising pesticide target. In this study, a series of novel and readily available ureido thioglycosides were designed and synthesized based on the catalytic mechanism and the co-crystal structures of OfHex1 with substrates. After evaluation via enzyme inhibition experiments, thioglycosides 11c and 15k were found to have inhibitory activities against OfHex1 with the K-i values of 25.6 mu M and 53.8 mu M, respectively. In addition, all these ureido thioglycosides exhibited high selectivity toward OfHex1 over hOGA and HsHexB (K-i > 100 mu M). Furthermore, to investigate the inhibitory mechanism, the possible binding modes of 11c and 15k with OfHex1 were deduced based on molecular docking analysis. This work may provide useful structural starting points for further rational design of potent inhibitors of OfHex1.

Application In Synthesis of 4-Nitrobenzoic acid. About 4-Nitrobenzoic acid, If you have any questions, you can contact Shen, SQ; Dong, LL; Lu, HZ; Dong, YH; Yang, Q; Zhang, JJ or concate me.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

In 2020 CHEM BIODIVERS published article about ANTIOXIDANT ACTIVITIES; ANTIMICROBIAL ACTIVITY; THIOUREA DERIVATIVES; OXIDATIVE STRESS; L. in [Aziz, Hamid; Saeed, Aamer] Quaid I Azam Univ, Dept Chem, Islamabad 45320, Pakistan; [Khan, Muhammad Aslam; Afridi, Shakeeb] Quaid I Azam Univ, Dept Biotechnol, Islamabad 45320, Pakistan; [Jabeen, Farukh] Laurentian Univ, Dept Biol, 935 Ramsey Lake Rd, Sudbury, ON P3E 2C6, Canada; [Jabeen, Farukh] Computat Sci Res & Dev Org, 1401,2485 Hurontraio St, Mississauga, ON L5A 2G6, Canada; [Ashfaq-ur-Rehman] Abdul Wali Khan Univ, Dept Biochem, Shankar Campus, Mardan 23200, Khyber Pukhtoon, Pakistan; [Ashfaq-ur-Rehman] Shanghai Jiao Tong Univ, Dept Bioinformat & Biostat, 800 Dongchuan Rd, Shanghai 200240, Peoples R China; [Hashim, Muhammad] Quaid I Azam Univ, Dept Biochem, Islamabad 45320, Pakistan in 2020, Cited 47. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7. Recommanded Product: 62-23-7

The present study reports the convenient synthesis, spectroscopic characterization, bio-assays and computational evaluation of a novel series of N-acyl-1H-imidazole-1-carbothioamides. The screened derivatives displayed excellent antioxidant activity, moderate antibacterial and antifungal potential. The screened derivatives were found to be highly biocompatible against hRBCs. Molecular docking ascertained the mechanism and mode of action towards the molecular target delineating that ligands and complexes were stabilized at the active site by electrostatic and hydrophobic forces in accordance to the corresponding experimental results. Docking simulation provided additional information about the possibilities of inhibitory potential of the compounds against RNA. Computational evaluation predicted that N-acyl-1H-imidazole-1-carbothioamides 5c and 5g can serve as potential surrogates for hit to lead generation and design of novel antioxidant and antibacterial agents.

Recommanded Product: 62-23-7. About 4-Nitrobenzoic acid, If you have any questions, you can contact Aziz, H; Saeed, A; Khan, MA; Afridi, S; Jabeen, F; Ashfaq-ur-Rehman; Hashim, M or concate me.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Recently I am researching about HIGHLY SELECTIVE OXIDATION; PLATINUM CATALYST; MOLECULAR-OXYGEN; ALLYLIC ALCOHOLS; PORE STRUCTURE; POROUS CARBON; ALDEHYDES; EFFICIENT; NANOPARTICLES; SURFACE, Saw an article supported by the Institute for Advanced Studies in Basic Science (IASBS) Research Council [G2019IASBS31100]. Published in ROYAL SOC CHEMISTRY in CAMBRIDGE ,Authors: Ganji, N; Karimi, B; Najafvand-Derikvandi, S; Vali, H. The CAS is 62-23-7. Through research, I have a further understanding and discovery of 4-Nitrobenzoic acid. Product Details of 62-23-7

Preparation of an ordered mesoporous polypyrrole/carbon (PPy/OMC) composite has been described through a two-step nanocasting process using KIT-6 as a template. Characterization of the PPy/OMC nanocomposite by various analysis methods such as TEM, XRD, TGA, SEM and N-2 sorption confirmed the preparation of a material with ordered mesoporous structure, uniform pore size distribution, high surface area and high stability. This nanocomposite was then used for the immobilization of palladium nanoparticles. The nanoparticles were almost uniformly distributed on the support with a narrow particle size of 20-25 nm, confirmed by various analysis methods. Performance of the Pd@PPy/OMC catalyst was evaluated in the aerobic oxidation of various primary and secondary alcohols on water as a green solvent, giving the corresponding carboxylic acids and ketones in high yields and excellent selectivity. The catalyst could also be reused for at least 10 reaction runs without losing its catalytic activity and selectivity. High catalytic efficiency of the catalyst can be attributed to a strong synergism between the PPy/OMC and that of supported Pd nanoparticles.

About 4-Nitrobenzoic acid, If you have any questions, you can contact Ganji, N; Karimi, B; Najafvand-Derikvandi, S; Vali, H or concate me.. Product Details of 62-23-7

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Quality Control of 4-Nitrobenzoic acid. I found the field of Chemistry very interesting. Saw the article Dichloromethane as a methylene synthon for regioselective linkage of diverse carboxylic acids: Direct access to methylene diesters under metal-free conditions published in 2019.0, Reprint Addresses Fu, ZJ; Cai, H (corresponding author), Nanchang Univ, Coll Chem, Nanchang 330031, Jiangxi, Peoples R China.. The CAS is 62-23-7. Through research, I have a further understanding and discovery of 4-Nitrobenzoic acid.

A metal-free cross coupling between common CH2Cl2 and carboxylic acids has been achieved with K2CO3 as the sole additive. This simple protocol is a convenient and cost-effective route to synthesize methylene diesters from a wide scope of carboxylic acids substrates with good functional group tolerance. Several gram-scale reactions have been performed to evaluate the effectiveness and practicality of this protocol. (C) 2019 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.

Quality Control of 4-Nitrobenzoic acid. About 4-Nitrobenzoic acid, If you have any questions, you can contact Wang, SL; Fu, ZJ; Huang, ZC; Jiang, YQ; Guo, SM; Cai, H or concate me.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

An article Synthesis and anticancer evaluation of new lipophilic 1,2,4 and 1,3,4-oxadiazoles WOS:000459358600003 published article about BIOLOGICAL EVALUATION; DERIVATIVES SYNTHESIS; MOLECULAR DOCKING; INHIBITORS; APOPTOSIS; MOIETY; TOXICITY; ANALOGS; GROWTH; POTENT in [Caneschi, Wiliam; Enes, Karine Braga; de Mendonca, Camille Carvalho; Fernandes, Fabio de Souza; Miguel, Fabio Balbino; Le Hyaric, Mireille; Duarte, Lucas Mattos; Leal de Oliveira, Marcone Augusto; Dos Santos, Hello F.; Costa Couri, Mara Rubia] Univ Fed Juiz de Fora, Dept Quim, ICE, Campus Martelo, BR-36036330 Juiz De Fora, MG, Brazil; [Martins, Jefferson da Silva; Pinho, Roberto Rosas] Univ Fed Juiz de Fora, Dept Fis, ICE, Campus Martelo, BR-36036330 Juiz De Fora, MG, Brazil; [Paz Lopes, Miriam Teresa; Dittz, Dalton] Univ Fed Minas Gerais, ICB, Dept Farmacol, BR-31270901 Belo Horizonte, MG, Brazil; [Silva, Heveline] Univ Fed Minas Gerais, Dept Quim, BR-31270901 Belo Horizonte, MG, Brazil in 2019.0, Cited 37.0. Application In Synthesis of 4-Nitrobenzoic acid. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7

A series of1,2,4- and 1,3,4-oxadiazole derivatives were synthesized and evaluated for their anticancer activity. Halogenated 1,2,4-oxadiazoles were obtained from benzonitrile and coupled either lipophilic amines or with aminoalcohols. Lipophilic 1,3,4-oxadiazole derivatives were obtained through the Mannich reactions between 5-(aryl)-1,3,4-oxadiazole-2-thiol and alkylated or acylated amines. The in vitro cytotoxic effects were evaluated against 4T1- mammary carcinoma and CT26 – colon cancer cells. The best results were obtained for the 1,3,4-oxadiazole coupled to alkylated piperazine with 10-14 carbon chain moiety, with IC50 values ranging from 1.6 to 3.55 mu M for the 4T1 cell line, and from 1.6 to 3.9 mu M for the CT26.WT cell line, and selectivity index up to 19. The most potent compounds were investigated with AnnexinV and PI staining as indicative of apoptosis induction. (C) 2019 Published by Elsevier Masson SAS.

About 4-Nitrobenzoic acid, If you have any questions, you can contact Caneschi, W; Enes, KB; de Mendonca, CC; Fernandes, FD; Miguel, FB; Martins, JD; Le Hyaric, M; Pinho, RR; Duarte, LM; de Oliveira, MAL; Dos Santos, HF; Lopes, MTP; Dittz, D; Silva, H; Couri, MRC or concate me.. Application In Synthesis of 4-Nitrobenzoic acid

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Recently I am researching about MARKOVNIKOV-SELECTIVE HYDROFUNCTIONALIZATION; HETEROATOM BOND FORMATION; UNACTIVATED OLEFINS; ELECTRON-TRANSFER; CARBOXYLIC-ACIDS; OXIDATION; HYDROAMINATION; COMPLEXES; FE; ORGANOCOBALT(IV), Saw an article supported by the College of Chemistry and Molecular Engineering, Peking University; BNLMS. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Zhou, XL; Yang, F; Sun, HL; Yin, YN; Ye, WT; Zhu, R. The CAS is 62-23-7. Through research, I have a further understanding and discovery of 4-Nitrobenzoic acid. Product Details of 62-23-7

A functional group tolerant cobalt-catalyzed method for the intermolecular hydrofunctionalization of alkenes with oxygen- and nitrogen-based nucleophiles is reported. This protocol features a strategic use of hypervalent iodine(III) reagents that enables a mechanistic shift from conventional cobalt-hydride catalysis. Key evidence was found supporting a unique bimetallic-mediated rate-limiting step involving two distinct cobalt(III) species, from which a new carbon-heteroatom bond is formed.

Product Details of 62-23-7. About 4-Nitrobenzoic acid, If you have any questions, you can contact Zhou, XL; Yang, F; Sun, HL; Yin, YN; Ye, WT; Zhu, R or concate me.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Yang, JS; Hu, X; Liu, ZJ; Li, XY; Dong, Y; Liu, G in [Yang, Jingshu; Hu, Xiao; Li, Xueyuan; Liu, Gang] Tsinghua Univ, Sch Pharmaceut Sci, Beijing 100084, Peoples R China; [Liu, Zijie; Dong, Yi] Chinese Acad Med Sci & Peking Union Med Coll, State Key Lab Bioact Subst & Funct Nat Med, Inst Mat Med, Beijing 100050, Peoples R China; [Liu, Zijie; Dong, Yi] Chinese Acad Med Sci & Peking Union Med Coll, Beijing Key Lab Active Subst Discovery & Druggabi, Inst Mat Med, Beijing 100050, Peoples R China published Cp*Co-III-catalyzed formal [4+2] cycloaddition of benzamides to afford quinazolinone derivatives in 2019, Cited 83. Application In Synthesis of 4-Nitrobenzoic acid. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7.

A Cp*Co-III-catalyzed arene C-H bond amidation/annulation of benzamides was developed to afford quinazolinone derivatives in one-pot with high yields and broad substrate scope. This method could be applied to the synthesis of quinazolinone drugs and late-stage modification of natural products.

About 4-Nitrobenzoic acid, If you have any questions, you can contact Yang, JS; Hu, X; Liu, ZJ; Li, XY; Dong, Y; Liu, G or concate me.. Application In Synthesis of 4-Nitrobenzoic acid

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Product Details of 62-23-7. In 2020 MOLECULES published article about DERIVATIVES; 2-AMINO-1,3,4-THIADIAZOLE; THIOSEMICARBAZONES; REDUCTION in [Kudelko, Agnieszka; Olesiejuk, Monika; Luczynski, Marcin] Silesian Tech Univ, Dept Chem Organ Technol & Petrochem, Krzywoustego 4, PL-44100 Gliwice, Poland; [Swiatkowski, Marcin; Sieranski, Tomasz; Kruszynski, Rafal] Lodz Univ Technol, Inst Gen & Ecol Chem, Dept Xray Crystallog & Crystal Chem, Zeromskiego 116, PL-90924 Lodz, Poland in 2020, Cited 44. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7.

Three series of azo dyes derived from 2-amino-5-aryl-1,3,4-thiadiazoles and aniline,N,N-dimethylaniline and phenol were synthesized in high yields by a conventional diazotization-coupling sequence. The chemical structures of the prepared compounds were confirmed by(1)H-NMR,C-13-NMR, IR, UV-Vis spectroscopy, mass spectrometry and elemental analysis. In addition, the X-ray single crystal structure of a representative azo dye was presented. For explicit determination of the influence of a substituent on radiation absorption in UV-Vis range, time-dependent density functional theory calculations were performed.

About 4-Nitrobenzoic acid, If you have any questions, you can contact Kudelko, A; Olesiejuk, M; Luczynski, M; Swiatkowski, M; Sieranski, T; Kruszynski, R or concate me.. Product Details of 62-23-7

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Mohammadpour, P; Safaei, E in [Mohammadpour, Pegah; Safaei, Elham] Shiraz Univ, Coll Sci, Dept Chem, Shiraz 7194684795, Iran published Catalytic C-H aerobic and oxidant-induced oxidation of alkylbenzenes (including toluene derivatives) over VO2+ immobilized on core-shell Fe3O4@SiO2 at room temperature in water in 2020.0, Cited 78.0. Formula: C7H5NO4. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7.

Direct C-H bond oxidation of organic materials, and producing the necessary oxygenated compounds under mild conditions, has attracted increasing interest. The selective oxidation of various alkylbenzenes was carried out by means of a new catalyst containing VO2+ species supported on silica-coated Fe3O4 nanoparticles usingt-butyl hydroperoxide as an oxidant at room temperature in H2O or solvent-free media. The chemical and structural characterization of the catalyst using several methods such as FTIR spectroscopy, XRD, FETEM, FESEM, SAED, EDX and XPS showed that VO2+ is covalently bonded to the silica surface. High selectivity and excellent conversion of various toluene derivatives, with less reactive aliphatic (sp(3)) C-H bonds, to related benzoic acids were quite noticeable. The aerobic oxygenation reaction of these alkylbenzenes was studied under the same conditions. All the results accompanied by sustainability of the inexpensive and simple magnetically separable heterogeneous catalyst proved the important criteria for commercial applications.

Formula: C7H5NO4. About 4-Nitrobenzoic acid, If you have any questions, you can contact Mohammadpour, P; Safaei, E or concate me.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

An article Effect of Cp-Ligand Methylation on Rhodium(III)-Catalyzed Annulations of Aromatic Carboxylic Acids with Alkynes: Synthesis of Isocoumarins and PAHs for Organic Light-Emitting Devices WOS:000516845200010 published article about INTERNAL ALKYNES; BENZOIC-ACIDS; CATALYZED ANNULATION; OXIDATIVE ANNULATION; ARYL IODIDES; COMPLEXES; ELECTRON; ARENE in [Molotkov, Alexander P.; Arsenov, Mikhail A.; Kapustin, Daniil A.; Muratov, Dmitry, V; Shepel’, Nikolay E.; Fedorov, Yury, V; Smol’yakov, Alexander F.; Loginov, Dmitry A.] Russian Acad Sci, AN Nesmeyanov Inst Organoelement Cpds, 28 Ul Vavilova, Moscow 119991, Russia; [Smol’yakov, Alexander F.; Knyazeva, Elena, I] RUDN Univ, Fac Sci, 6 Miklukho Maklaya St, Moscow 117198, Russia; [Smol’yakov, Alexander F.] Plekhanov Russian Univ Econ, Stremyanny Per 36, Moscow 117997, Russia; [Lypenko, Dmitry A.; Dmitriev, Artem, V; Aleksandrov, Alexey E.; Maltsev, Eugeny, I] Russian Acad Sci, AN Frumkin Inst Phys Chem & Electrochem, Leninsky Prosp 31,Bld 4, Moscow 119071, Russia in 2020.0, Cited 72.0. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7. Recommanded Product: 4-Nitrobenzoic acid

An efficient protocol was developed for the synthesis of pi-extended isocoumarins and polycyclic aromatic hydrocarbons based on the oxidative coupling of aromatic carboxylic acids with internal alkynes catalyzed by (cyclopentadienyl)rhodium complexes. The coupling chemoselectivity strongly depends on whether Cp or the methylated Cp* ligands are used. The pentamethyl derivative [Cp*RhCl2](2) predominantly gives isocoumarins, while the non-methylated complex [CpRhI2](n) produces naphthalene derivatives. The polyaromatic carboxylic acids (such as 1-naphthoic acid, 1-pyrenecarboxylic acid, fluorene-1-carboxylic acid, and dibenzofuran-4-carboxylic acid) are suitable for this approach. A mixture of Cp*H/RhCl3 can be used as a catalyst instead of [Cp*RhCl2](2). The structures of 3,4-diphenylindeno[1,2-h]isochromen-1(11H)-one and 7,10-dimethyl-8,9-diphenylbenzo[pqr]tetraphene were determined by X-ray diffraction. In addition, the optical properties of the prepared compounds were studied. 7,8-Diphenyl-10H-phenaleno[1,9-gh]isochromen-10-one was employed as an emissive layer for OLED manufacturing. The OLED emits yellow-green light with a maximum intensity 1740 cd . m(-2) at 15 V.

Recommanded Product: 4-Nitrobenzoic acid. About 4-Nitrobenzoic acid, If you have any questions, you can contact Molotkov, AP; Arsenov, MA; Kapustin, DA; Muratov, DV; Shepel’, NE; Fedorov, YV; Smol’yakov, AF; Knyazeva, EI; Lypenko, DA; Dmitriev, AV; Aleksandrov, AE; Maltsev, EI; Loginov, DA or concate me.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem