Category: phthalazine

Electric Literature of 13001-40-6, In classical electrochemical theory, both the electron transfer rate and the adsorption of reactants at the electrode control the electrochemical reaction. 13001-40-6, Name is 4,4′-(1,4-Phenylenebis(ethene-2,1-diyl))dibenzonitrile, SMILES is N#CC1=CC=C(/C=C/C2=CC=C(/C=C/C3=CC=C(C=C3)C#N)C=C2)C=C1, belongs to phthalazine compound. In a article, author is Elmi-Mehr, M., introduce new discover of the category.

Some new derivatives of 3-amino-1-aryl-N-butyl-5,10-dioxo-5,10-dihydro-1H-pyrazolo[1,2-b]- phthalazine-2-carboxamide are synthesized via in situ Knoevenagel condensation of aromatic aldehydes with N-butyl-2-cyanoacetamide, which leads to 3-aryl-N-butyl-2-cyanoacrylamides. This is followed by the reaction with phthalhydrazide upon refluxing in ethanol under catalyst-free conditions. The products are characterized on the basis of IR, H-1 and C-13 NMR spectral data.

Electric Literature of 13001-40-6, The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 13001-40-6 is helpful to your research.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Having gained chemical understanding at molecular level, chemistry graduates may choose to apply this knowledge in almost unlimited ways, as it can be used to analyze all matter and therefore our entire environment., Product Details of 1571-08-0, 1571-08-0, Name is Methyl 4-formylbenzoate, SMILES is C1=C(C(OC)=O)C=CC(=C1)C=O, belongs to phthalazine compound. In a document, author is Kiasat, Ali Reza, introduce the new discover.

A simple, efficient, and high yielding one-pot protocol for the synthesis of 2H-indazolo[2,1-b]phthalazine-trione derivatives has been developed by three-component coupling of phthalhydrazide, dimedone and some aromatic aldehydes in ecofriendly neat conditions promoted by nano-gamma-alumina sulforic acid. This protocol avoids the use of expensive catalysts, toxic solvents and chromatographic separation. Also the proposed protocol was extended to the linear beta-diketone (acetylaceton) instead of cyclic diketone (dimedone). The generality and functional tolerance of this convergent and environmentally benign method is demonstrated. The nature of each step of the suggested mechanism for this condensation reaction is also identified through Density Functional Theory (DFT) calculations using B3LYP/6-31G** level of theory. It is shown that the first step is charge controlled; whereas the second one is controlled by frontier molecular orbitals. The H-1 and C-13 chemical shift values together with the structural parameters of the title compound have been also computed and the scaled values have been compared with the corresponding experimental NMR and X-ray spectra. As a result, the calculated spectroscopic data and optimized geometry show a good agreement with the experimental results. (C) 2012 Elsevier B.V. All rights reserved.

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Chemical engineers work across a number of sectors, processes differ within each of these areas, but chemistry and chemical engineering roles are found throughout, creation and manufacturing process of chemical products and materials. Recommanded Product: Chlorhexidine Diacetate, 56-95-1, Name is Chlorhexidine Diacetate, SMILES is N=C(NCCCCCCNC(NC(NC1=CC=C(Cl)C=C1)=N)=N)NC(NC2=CC=C(Cl)C=C2)=N.CC(O)=O.CC(O)=O, in an article , author is Shalkouhi, Somaye Nikzad, once mentioned of 56-95-1.

Fe3O4@Cys-SO3H magnetic nanocatalyst has been used as an effective and reusable solid acid catalyst for the one pot synthesis of novel spiro[chromeno[4′,3′:3,4]pyrazolo[1,2-b]phthalazine-7,3′-indoline]-2′,6,9,14-tetraone via a three-component reaction of phthalhydrazide, 4-hydroxycoumarin and isatin derivatives. Easy separation of catalyst, good yields of reaction and synthesis of novel heterocyclic compound are some advantages of this procedure.

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

You could be based in a university, combining chemical research with teaching; in a pharmaceutical company, working on developing and trialing new drugs; helping to ensure national healthcare provision keeps pace with new discoveries. 122-03-2, Name is p-Isopropylbenzenecarboxaldehyde, SMILES is CC(C)C1=CC=C(C=O)C=C1, belongs to phthalazine compound. In a document, author is Hamidinasab, Mahdia, introduce the new discover, Product Details of 122-03-2.

One-pot pseudo five-component synthesis of some new, vital and pharmaceutically important bis 1H-Indazolo [1,2-b]phthalazine-triones has been considered in presence of prepared NiFe2O4@TiO2-DEA-OSO3H nanostructure as an efficient magnetic nanocatalyst. The synthesized compounds can be good candidates to have diverse biological potency and efficacy. The geometry, electronic structure, natural bond orbitals (NBO) and molecular electrostatic potential (MEP) surface analysis were carried out for some bis 1H-Indazolo [1,2-b]phthalazine-triones using HF/3-21G computational method. The theoretical studies revealed the existense of intramoleculare hydrogen bonds and high HOMO-LUMO energy gap for the products structures. Some advantages of this protocol are high yields, short reaction times, simple purification, and environmentally mild reaction conditions. Furthermore, the catalyst was reused at least six times without substantial loss of catalytic activity. (C) 2019 Elsevier B.V. All rights reserved.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 122-03-2, in my other articles. Product Details of 122-03-2.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Synthetic Route of 80382-23-6, As a society publisher, everything we do is to support the scientific community – so you can trust us to always act in your best interests, and get your work the international recognition that it deserves. 80382-23-6, Name is Sodium 2-(4-((2-oxocyclopentyl)methyl)phenyl)propanoate, SMILES is CC(C1=CC=C(CC2C(CCC2)=O)C=C1)C([O-])=O.[Na+], belongs to phthalazine compound. In a article, author is Zare, Mohammad Reza, introduce new discover of the category.

Sulfonated magnetic nanoparticles (SO3H-Fe3O4@SiO2 MNPs) have been explored as an efficient, cost-effective, and recyclable nanocatalyst for the facile synthesis of 3,4-dihydro-2H-indazolo[1,2-b]phthalazin-1,6,11(13H)-triones through a one-pot three-component reaction between aldehydes, dimedone, and phthalhydrazide under mild and green (solvent-free) conditions. Simple separation of the catalyst using an external magnet, efficient recyclability of the developed magnetic nanocatalyst up to five fresh runs without significant loss in its catalytic activity, excellent yields of the designed reactions (88 to 98%), low reaction times as well as solvent-free and facial reaction condition are some advantages of the present procedure that qualified the fabricated magnetic nanocatalyst for industrial applications.

Synthetic Route of 80382-23-6, Consequently, the presence of a catalyst will permit a system to reach equilibrium more quickly, but it has no effect on the position of the equilibrium as reflected in the value of its equilibrium constant.I hope my blog about 80382-23-6 is helpful to your research.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Recommanded Product: Boc-D-Phenylglycinol, While the job of a research scientist varies, most chemistry careers in research are based in laboratories, where research is conducted by teams following scientific methods and standards. 102089-74-7, Name is Boc-D-Phenylglycinol, SMILES is [C@@H](NC(OC(C)(C)C)=O)(C1=CC=CC=C1)CO, belongs to phthalazine compound. In a article, author is Khaleghi Abbasabadi, Masoud, introduce new discover of the category.

In this research, we report a novel synthesis of magnetic beta-alanine-functionalized-graphene oxide quantum dots Fe3O4@GOQDs-N-(beta-alanine) as a recyclable and eco-friendly heterogeneous nanocatalyst. The catalytic efficiency of these nanosheets was explored as a basic catalyst for a one-pot three-component synthesis of various 1H-pyrazolo[1,2-b]phthalazine-5,10-dione and 2,3-dihydroquinazolin-4(1H)-one derivatives. The reactions proceeded smoothly under mild and green conditions to afford the respected products in excellent yields. The structure of this newly fabricated catalyst was successfully confirmed by different analytical techniques such as Fourier transform infrared spectroscopy, X-ray diffraction, field emission-scanning electron microscopy, high-resolution transmission electron microscopy, energy-dispersive X-ray spectroscopy, vibrating sample magnetometry, and thermogravimetric analysis. The stability and recyclability of the catalyst were examined by performing the model reaction in six consecutive runs. The recovered catalyst from the first run was directly used for the next runs with no significant loss of catalytic activity.

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Electric Literature of 81-16-3, While the job of a research scientist varies, most chemistry careers in research are based in laboratories, where research is conducted by teams following scientific methods and standards. 81-16-3, Name is 2-Aminonaphthalene-1-sulfonic acid, SMILES is O=S(C1=C2C=CC=CC2=CC=C1N)(O)=O, belongs to phthalazine compound. In a article, author is Amirmahani, Najmeh, introduce new discover of the category.

Tetrabutyl phosphonium sulfate ([TBP](2)SO4), as novel room-temperature ionic liquid (RTIL), was synthesized by a simple cost-effective method, characterized by H-1, C-13, P-31 NMR and FT-IR spectrophotometry. The newly prepared catalyst was used as an efficient catalyst in some four multicomponent reactions (4MCRs) e. g., to synthesis pyridazino[1,2-a]indazole, indazolo[2,1-b]phthalazine and pyrazolo[1,2-b]phthalazine. This green method has several advantages such as short reaction time, using simple methods to prepare catalysts and products, easy operation and high efficiency of products. In addition, the catalyst can be easily recovered and reused several times with reduced average activity. Graphic abstract

Electric Literature of 81-16-3, Because enzymes can increase reaction rates by enormous factors and tend to be very specific, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 81-16-3.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Quality Control of Sodium 2-formylbenzenesulfonate, In classical electrochemical theory, both the electron transfer rate and the adsorption of reactants at the electrode control the electrochemical reaction. 1008-72-6, Name is Sodium 2-formylbenzenesulfonate, SMILES is O=S(C1=CC=CC=C1C=O)([O-])=O.[Na+], belongs to phthalazine compound. In a article, author is Ji, Dezhong, introduce new discover of the category.

A series of anthranilamide derivatives were designed and synthesized as novel smoothened (SMO) inhibitors based on the SMO inhibitor taladegib (LY2940680), which can also inhibit the SMO-D473H mutant, via a ring-opening strategy. The phthalazine core in LY2940680 was replaced with anthranilamide, which retained the inhibitory activity towards the hedgehog (Hh) signaling pathway as evidenced by a dual luciferase reporter gene assay. Compound 12a displayed the best inhibitory activity against the Hh signaling pathway with IC50 value of 34.09 nM, and exhibited better proliferation inhibitory activity towards the Daoy cell line (IC50=0.48 mu M) than LY2940680 (IC50=0.79 mu M).

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Recommanded Product: 1-(Bromomethyl)-4-(trifluoromethyl)benzene, Reactions catalyzed within inorganic and organic materials and at electrochemical interfaces commonly occur at high coverage and in condensed media, causing turnover rates to depend strongly on interfacial structure and composition. 402-49-3, Name is 1-(Bromomethyl)-4-(trifluoromethyl)benzene, SMILES is FC(C1=CC=C(CBr)C=C1)(F)F, belongs to phthalazine compound. In a article, author is Mousapour, Maryam, introduce new discover of the category.

In this work, poly(vinylpyrrolidonium) perchlorate {[PVPH]ClO4}, a newly reported modified polymeric catalyst, is used as an efficient and reusable solid acid catalyst for the promotion of the synthesis of 2H-indazolo[2,1-b]phthalazine-trione derivatives. All reactions were performed under mild conditions and the products were formed over short reaction times in excellent yields. It is important to note that this solid acid catalyst can be reused several times without any appreciable loss in its activity.

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

The prevalence of solvent effects in heterogeneous catalysis in condensed media has motivated developing quantitative kinetic, and theoretical assessments of solvent structures and their interactions with reaction intermediates and transition states. 1439-36-7, Name is 1-(Triphenylphosphoranylidene)propan-2-one, molecular formula is C21H19OP, belongs to phthalazine compound. In a document, author is De Abreu, Maxime, introduce the new discover, Synthetic Route of 1439-36-7.

Phosphoramidates are for the first time presented as efficient N-Centered Radical (NCR) precursors under visible-light irradiation. More precisely among this class of phosphorus-derived compounds, we studied the radical reactivity of phosphonohydrazones, under mild reaction conditions, which allowed the synthesis of a wide and diversified library of the scarcely reported phthalazine scaffold. Mechanistic investigations confirmed the formation of a NCR from these brand-new phosphonohydrazones (derivatived from phosphoramidates), which were further engaged in an intramolecular 6-exo-dig cyclization to provide phthalazines. Compared to other pre-activated moieties, the phosphoramidate group is self-immolative, thus enhancing its attractiveness for the C-N bond formation.

Synthetic Route of 1439-36-7, Consequently, the presence of a catalyst will permit a system to reach equilibrium more quickly, but it has no effect on the position of the equilibrium as reflected in the value of its equilibrium constant.I hope my blog about 1439-36-7 is helpful to your research.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem