Category: phthalazine

The dynamic chemical diversity of the numerous elements, ions and molecules that constitute the basis of life provides wide challenges and opportunities for research. In an article, author is Jimenez, Iosu, once mentioned the application of 495-69-2, Name is 2-Benzamidoacetic acid, molecular formula is C9H9NO3, molecular weight is 179.1727, MDL number is MFCD00002692, category is phthalazine. Now introduce a scientific discovery about this category, Recommanded Product: 2-Benzamidoacetic acid.

Differential scanning calorimetry (DSC) and thermogravimetry (TG) are analytical and quantitative methods capable of providing reliable, fast and reproducible results. These data allow establishing the thermal stability, purity degree and the polymorphic behavior of organic compounds. Thermal analysis of fusion and degradation processes was carried out on organonitrogen, organosulfur and organoselenium phthalazine derivatives to establish thermal stability criteria. Decomposition and fusion temperatures of 27 biological active compounds, synthesized by our research group were determined using TG and DSC. Analysis of the thermal data indicated that: (a) in general, nitrogen compounds are more stable than sulfur and selenium compounds; (b) thioderivatives possess degradation temperatures higher than selenium compounds; (c) the presence of selenium atoms in molecular structure has associated a minor thermal stability; (d) sulfide derivatives decomposition process have higher T-onset values than disulfide compounds; (e) there are differences in the stability due to groups selenol, methylseleno, and cyanoseleno; (f) the nature of the substituent located on the benzyl ring has no effects on selenophthalazines thermal stability.

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Electric Literature of 143-66-8, Reactions catalyzed within inorganic and organic materials and at electrochemical interfaces commonly occur at high coverage and in condensed media, causing turnover rates to depend strongly on interfacial structure and composition. 143-66-8, Name is Sodium tetraphenylborate, SMILES is C1([B-](C2=CC=CC=C2)(C3=CC=CC=C3)C4=CC=CC=C4)=CC=CC=C1.[Na+], belongs to phthalazine compound. In a article, author is Romero, Angel H., introduce new discover of the category.

A series of twenty phthalazinyl-hydrazones were synthesized and tested as potential anti-Trypanosoma cruzi agents. The phthalazines containing 5-nitroheteroaryl moiety 3l and 3m displayed an excellent in vitro antitrypanosomal profile, exhibiting low micromolar EC50 values against proliferative epimastigote of T. cruzi and minimal toxicity toward Vero cells. These derivatives were more potent than the reference drug benznidazole against the epimastigote stage of the parasite. Structure-property analysis indicates that the highly conjugated 5-nitroheteroaryl moiety connected to the phthalazin scaffold play an important role in the antichagasic activity of these phthalazines. The decrease on the mitochondrial dehydrogenase activity and significant ROS production found for the parasites treated with 3l and 3m suggest that both nitro-derivatives can act through an oxidative stress mechanism. (C) 2017 Elsevier Inc. All rights reserved.

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Researchers are common within chemical engineering and are often tasked with creating and developing new chemical techniques, frequently combining other advanced and emerging scientific areas. Formula: https://www.ambeed.com/products/369-34-6.html, 369-34-6, Name is 3,4-Difluoronitrobenzene, SMILES is C1=C(C=CC(=C1F)F)[N+](=O)[O-], in an article , author is Rostamnia, Sadegh, once mentioned of 369-34-6.

The channels of mesoporous (SBA-15) represent a straightforward reactor for the rapid synthesis of indazolophthalazinetrione skeletons via three-component coupling reactions in 2,2,2-trifluoroethanol. The solid SBA-15 and TFE could be recovered and reused. The present method carries the advantage of being performed under neutral conditions and requires no activation or modification of the substrates. (C) 2014 Elsevier Ltd. All rights reserved.

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Recommanded Product: 2-(6-Methoxynaphthalen-2-yl)acetic acid, Chemistry graduates have much scope to use their knowledge in a range of research sectors, including roles within chemical engineering, chemical and related industries, healthcare and more. 23981-47-7, Name is 2-(6-Methoxynaphthalen-2-yl)acetic acid, SMILES is O=C(O)CC1=CC=C2C=C(OC)C=CC2=C1, belongs to phthalazine compound. In a article, author is Liu, Da-Chuan, introduce new discover of the category.

The transcription factor nuclear factor-kappa B (NF-kappa B) controls many physiological processes including inflammation, immunity, and apoptosis. In this study, a novel series of 6-phenoxy-[1,2,4] triazolo[3,4-a] phthalazine-3-carboxamide derivatives were synthesized as potent anti-inflammatory agents, which acted on tumor necrosis factor (TNF-alpha) as inhibitors of NF-kappa B activation. We showed that compounds 6h (6-(2,4-dichlorophenoxy)-[1,2,4] triazolo[3,4-a] phthalazine-3-carboxamide) and 6i (6-(3-tolyloxy)[1,2,4] triazolo[3,4-a]phthalazine-3-carboxamide) showed more prominent anti-inflammatory activity than other compounds, with similar activities as the reference drug dihydrotanshinone; compound 6i showed the lowest cellular toxicity among the tested compounds. In vivo evaluation of the anti-inflammatory activity showed that compound 6i exhibited excellent anti-inflammatory activity with 58.19% inhibition at 50 mg/kg intraperitoneal (i.p.), with equal efficacy as the positive control indomethacin (100 mg/kg i.p.; 59.21% inhibition). (C) 2016 Elsevier Ltd. All rights reserved.

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Redox catalysis has been broadly utilized in electrochemical synthesis due to its kinetic advantages over direct electrolysis. 838-88-0, Name is 4,4′-Methylenebis(2-methylaniline), molecular formula is , belongs to phthalazine compound. In a document, author is Goli-Jolodar, Omid, Formula: https://www.ambeed.com/products/838-88-0.html.

In this research work, 4,4′-(butane-1,4-diyl) bis(1-sulfo-1,4-diazabicyclo[2.2.2]octane-1,4-diium) tetrachloride (NS-C4(DABCO-SO3H)(2)center dot 4Cl) as a new nano-sized N-sulfonic acid was prepared and characterized using different types of spectroscopic methods including FT-IR, H-1 NMR, C-13 NMR, XRD, TGA and SEM analysis. This new reagent was efficiently used as catalyst for the promotion of the one-pot synthesis of 2H-indazolo[2,1-b] phthalazine-1,6,11(13H)-triones derivatives, as a class of biologically active compounds with important pharmaceutical properties, under solvent-free conditions during short reaction times in high yields.

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

With the volume and accessibility of scientific research increasing across the world, it has never been more important to continue building the reputation for quality and ethical publishing we’ve spent the past two centuries establishing. 3648-20-2, Name is Diundecyl phthalate, SMILES is O=C(OCCCCCCCCCCC)C1=CC=CC=C1C(OCCCCCCCCCCC)=O, in an article , author is Shaterian, Hamid Reza, once mentioned of 3648-20-2, Name: Diundecyl phthalate.

An efficient synthesis of 2H-indazolo[2,1-b]phthalazine-1,6,11(13H)-trione derivatives from the four-component condensation of dimedone, arylaldehyde, hydrazine monohydrate, and phthalic anhydride using reusable ionic liquids, 2-pyrrolidonium hydrogensulfate, (4-sulfobutyl)tris(4-sulfophenyl)phosphonium hydrogensulfate and triphenyl(propyl-3-sulphonyl)phosphonium toluenesulfonate as acidic catalysts have been investigated. (C) 2012 Academie des sciences. Published by Elsevier Masson SAS. All rights reserved.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 3648-20-2, in my other articles. Name: Diundecyl phthalate.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

SDS of cas: 24324-17-2, As a society publisher, everything we do is to support the scientific community – so you can trust us to always act in your best interests, and get your work the international recognition that it deserves. 24324-17-2, Name is 9-Fluorenemethanol, SMILES is C1=CC=CC3=C1C2=CC=CC=C2C3CO, belongs to phthalazine compound. In a article, author is Dong, Yong Ping, introduce new discover of the category.

Chemiluminescence (CL) of a cyclometallated iridium (III) complex {tris[1-(2,6-dimethylphenoxy)-4-(4-chlorophenyl)phthalazine]iridium(III)} in the presence of potassium permanganate and oxalic acid is reported for the first time. Cysteine exhibits sufficient enhancing effect on the CL generated from the cyclometallated iridium(III) complex, which make it possible for the sensitive detection of cysteine using a flow-injectionchemiluminescence (FICL) method. The optimum conditions for the chemiluminescence emission were investigated. Under the optimal condition, the linear range for the determination of cysteine was 1.0?x?1095.0?x?106?mol/L with a detection limit of 6.9?x?1010?mol/L. A relative standard deviation of 1.6% was obtained for eight replicate determinations. The mechanisms of CL are proposed and the emitting species was identified as the metal-to-ligand charge-transfer (MLCT) excited states of the iridium complex. Copyright (c) 2011 John Wiley & Sons, Ltd.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 24324-17-2. SDS of cas: 24324-17-2.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Reference of 696-63-9, While the job of a research scientist varies, most chemistry careers in research are based in laboratories, where research is conducted by teams following scientific methods and standards. 696-63-9, Name is 4-Methoxythiophenol, SMILES is SC1=CC=C(OC)C=C1, belongs to phthalazine compound. In a article, author is Hasaninejed, Alireza, introduce new discover of the category.

A green practical method for the efficient synthesis of 2H-indazolo[2,1-b]phthalazine-1,6,11(13H)-triones using sulfuric acid-modified polyethylene glycol-6000 (PEG-OSO3H) as an eco-friendly polymeric catalyst from the four-component condensation reaction of phthalic anhydride, hydrazinium hydroxide, 1,3-cyclohexanedione or 5,5-dimethyl 1,3-cyclohexanedione (dimedone) and aromatic aldehydes under solvent-free conditions at 80 degrees C is described. This approach allowed the environmental impact factor (E-factor) to be minimized. (C) 2012 Elsevier B. V. All rights reserved.

Reference of 696-63-9, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. I hope my blog about 696-63-9 is helpful to your research.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Some examples of the diverse research done by chemistry experts include discovery of new medicines and vaccines, improving understanding of environmental issues, and development of new chemical products and materials. 4271-30-1, Name is (S)-2-(4-Aminobenzamido)pentanedioic acid, molecular formula is C12H14N2O5, Name: (S)-2-(4-Aminobenzamido)pentanedioic acid, belongs to phthalazine compound, is a common compound. In a patnet, author is Zare, Abdolkarim, once mentioned the new application about 4271-30-1.

A novel BrOnsted acidic ionic liquid namely N,N-diethyl-N-sulfoethanamminium hydrogen sulfate ([Et3N-SO3H]HSO4) was synthesized, and characterized using FT-IR, H-1 NMR, C-13 NMR, and mass data. Then, its catalytic activity was examined for the preparation of triazolo[1,2-a]-indazole-triones and 2H-indazolo[2,1-b]phthalazine-triones by the one-pot multi-component condensation of arylaldehydes with dimedone and 4-phenylurazole/2,3-dihydrophthalazine-1,4-dione under solvent-free conditions. [Et3N-SO3H]HSO4 efficiently promoted the reaction to afford the products in high yields and in short reaction times.

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Chemical research careers are more diverse than they might first appear, as there are many different reasons to conduct research and many possible environments. , Reference of 696-63-9, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 696-63-9, Name is 4-Methoxythiophenol, molecular formula is C7H8OS, belongs to phthalazine compound. In a document, author is Dmitrienko, Anton.

The aluminum(I) compound NacNacAl (NacNac=[ArNC(Me)CHC(Me)NAr](-), Ar=2,6-iPr(2)C(6)H(3),1) shows diverse and substrate-controlled reactivity in reactions with N-heterocycles. 4-Dimethylaminopyridine (DMAP), a basic substrate in which the 4-position is blocked, induces rearrangement of NacNacAl by shifting a hydrogen atom from the methyl group of the NacNac backbone to the aluminum center. In contrast, C-H activation of the methyl group of 4-picoline takes place to produce a species with a reactive terminal methylene. Reaction of1with 3,5-lutidine results in the first example of an uncatalyzed, room-temperature cleavage of an sp(2)C-H bond (in the 4-position) by an Al(I)species. Another reactivity mode was observed for quinoline, which undergoes 2,2 ‘-coupling. Finally, the reaction of1with phthalazine produces the product of N-N bond cleavage.

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem