Category: phthalazine

Kanojia, SV; Chatterjee, S; Chattopadhyay, S; Goswami, D in [Kanojia, Seema V.; Chatterjee, Sucheta; Chattopadhyay, Subrata; Goswami, Dibakar] Bhabha Atom Res Ctr, Bioorgan Div, Mumbai 400085, Maharashtra, India; [Goswami, Dibakar] Homi Bhabha Natl Inst, Training Sch Complex, Mumbai 400094, Maharashtra, India published A chemoenzymatic synthesis of ceramide trafficking inhibitor HPA-12 in 2019.0, Cited 55.0. Computed Properties of C7H5NO4. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7.

A chemoenzymatic synthesis of the title compound has been developed using an efficient and highly enantioselective lipase-catalyzed acylation in a hydrophobic ionic liquid, [bmim][PF6], followed by a diastereoselective asymmetric dihydroxylation as the key steps for incorporating the stereogenic centers. The further conversion to the appropriate intermediates and subsequent acylation with lauric acid furnished the target compound.

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Phthalazine – Wikipedia,
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Thakur, N; Wahab, MF; Khanal, DD; Armstrong, DW in [Thakur, Nimisha; Wahab, M. Farooq; Khanal, Durga D.; Armstrong, Daniel W.] Univ Arlington, Dept Chem & Biochem, Arlington, TX 76019 USA published Synthetic aluminosilicate based geopolymers – Second generation geopolymer HPLC stationary phases in 2019.0, Cited 46.0. HPLC of Formula: C7H5NO4. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7.

A survey of existing stationary phases classified by the United States Pharmacopeia reveals that 120 groups of chromatographic supports mostly utilize silica-silane chemistry, polymeric materials along with some niche metal oxides. In this work, the synthesis and characterization of transition-metal free geopolymers as a new class of stationary phases for hydrophilic interaction liquid chromatography and normal phase separations is reported. The geopolymers were synthesized by reaction of synthetic aluminosilicate with potassium silicate (fumed silica dissolved in KOH) in a water-in-oil emulsion. For comparative purposes of peak shapes, a geopolymer from natural metakaolin was also synthesized. The geopolymers were examined by X-ray diffraction, energy dispersive spectroscopy, laser diffraction, and N-2-adsorption isotherms. This two-step approach gives spherical microparticles with surface area and pore size comparable to silica phases (150 m(2)/g and 120 angstrom respectively). Both synthetic aluminosilicates based and natural metakaolin based geopolymers occupy a unique spot in the HILIC selectivity chart when compared to 35 HILIC phases. An additional promising feature of geopolymers is high pH and temperature stability which are used to tune selectivity for small polar analytes. High pH separations are shown with carboxylic acids. Geopolymers also show mixed mode behavior in retention with ion-exchange properties in purely aqueous mobile phases. The separation of derivatized sugars is demonstrated and compared with porous graphitic carbon (Hypercarb (TM)) as another pH-stable stationary phase. (C) 2019 Elsevier B.V. All rights reserved.

HPLC of Formula: C7H5NO4. Bye, fridends, I hope you can learn more about C7H5NO4, If you have any questions, you can browse other blog as well. See you lster.

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Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

An article Total syntheses of several iridolactones and the putative structure of noriridoid scholarein A: an intramolecular Pauson-Khand reaction based one-stop synthetic solution WOS:000476549400014 published article about NATURALLY-OCCURRING IRIDOIDS; ENANTIOSELECTIVE TOTAL-SYNTHESIS; SOLVOMERCURATION-DEMERCURATION; ISOIRIDOMYRMECIN; STEREOCHEMISTRY; IRIDOMYRMECIN; SECOIRIDOIDS; OXIDATION; ACID in [Salam, Abdus; Ray, Sayan; Abu Zaid, Md; Kumar, Dileep; Khan, Tabrez] Indian Inst Technol Bhubaneswar, Sch Basic Sci, Organ Synth Lab, Khurdha 752050, Odisha, India in 2019.0, Cited 55.0. Quality Control of 4-Nitrobenzoic acid. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7

A simple and general approach towards the total syntheses of several iridolactones such as (+/-)-boschnialactone, (+/-)-7-epi-boschnialactone, (+/-)-teucriumlactone, (+/-)-iridomyrmecin, (+/-)-isoboonein, (+/-)-7-epi-argyol, (+/-)-scabrol A, (+/-)-7-epi-scabrol A, and (+/-)-patriscabrol as well as the putative structure of scholarein A is delineated. The synthetic strategy features a diastereoselective intramolecular Pauson-Khand reaction (IPKR) to construct the iridoid framework followed by some strategic synthetic manipulations to access the targeted monoterpenes including those having diverse oxy-functionalization patterns and with 3-5 contiguous stereogenic centres in a highly stereocontrolled manner. Also, the present endeavour includes the first total synthesis of scabrol A.

Quality Control of 4-Nitrobenzoic acid. About 4-Nitrobenzoic acid, If you have any questions, you can contact Salam, A; Ray, S; Abu Zaid, M; Kumar, D; Khan, T or concate me.

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Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Authors Dhanju, S; Upadhyaya, K; Rice, CA; Pegan, SD; Media, J; Valeriote, FA; Crich, D in AMER CHEMICAL SOC published article about MOLECULAR MOIETIES; STEPWISE REDUCTION; CHEMICAL SPACE; KALKITOXIN; (+)-KALKITOXIN; ACTIVATION; COMPLEX; DAST; BOND in [Dhanju, Sandeep; Crich, David] Wayne State Univ, Dept Chem, Detroit, MI 48202 USA; [Crich, David] Univ Georgia, Dept Chem, Dept Pharmaceut & Biomed Sci, Athens, GA 30602 USA; [Crich, David] Univ Georgia, Complex Carbohydrate Res Ctr, Athens, GA 30602 USA; [Media, Joseph; Valeriote, Frederick A.] Henry Ford Canc Inst, Dept Internal Med, Div Hematol & Oncol, Detroit, MI 48202 USA; [Upadhyaya, Kapil; Rice, Christopher A.; Pegan, Scott D.] Univ Georgia, Dept Pharmaceut & Biomed Sci, Athens, GA 30602 USA in 2020.0, Cited 58.0. Recommanded Product: 4-Nitrobenzoic acid. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7

We describe the synthesis of 10-aza-9-oxakalkitoxin, an N,N,O-trisubstituted hydroxylamine-based analog, or hydroxalog, of the cytotoxic marine natural product kalkitoxin in which the -NMe-O- moiety replaces a -CHMe-CH2- unit in the backbone of the natural product. 10-Aza-9-oxakalkitoxin displays potent and selective cytotoxicity (IC50 2.4 ng mL(-1)) comparable to that of kalkitoxin itself (IC50 3.2 ng mL(-1)) against the human hepato-carcinoma cell line HepG2 over both the human leukemia cell line CEM and the normal hematopoietic CFU-GM. Like kalkitoxin, and contrary to the common expectation for hydroxylamines, 10-aza-9-oxakalkitoxin is not mutagenic.

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Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

An article Ruthenium-Catalyzed Regioselective Direct Ortho-Acyloxylation of Azoarenes with Carboxylic Acids via C-H Bond Activation WOS:000458273900018 published article about AROMATIC AZO-COMPOUNDS; DECARBOXYLATIVE ORTHO-ACYLATION; C(SP(2))-H BONDS; DIRECT ACCESS; AZOBENZENES; ACETOXYLATION; HYDROXYLATION; OXYGENATIONS; ARYLATION; ANILINES in [Kianmehr, Ebrahim; Nasab, Sepideh Bahrami] Univ Tehran, Sch Chem, Coll Sci, Tehran, Iran in 2019, Cited 73. Formula: C7H5NO4. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7

A Ru-II-catalyzed highly regioselective C-H acyloxylation of azoarenes with inexpensive alkyl and aryl carboxylic acids as an acyloxylation agent is described. The reaction demonstrates a broad substrate scope and good functional group tolerance. This method provides a facile procedure to synthesize ortho-acyloxylated azoarene derivatives.

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Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

In 2019.0 RES CHEM INTERMEDIAT published article about SONOGASHIRA COUPLING REACTION; REUSABLE HETEROGENEOUS CATALYST; COPPER-FREE SONOGASHIRA; PALLADIUM NANOPARTICLES; PD NANOPARTICLES; NITROBENZENE HYDROGENATION; SELECTIVE HYDROGENATION; VERSATILE CATALYST; EFFICIENT SUPPORT; CARBON NANOTUBE in [Sadjadi, Samahe] Iran Polymer & Petrochem Inst, Fac Petrochem, Gas Convers Dept, POB 14975-112, Tehran, Iran; [Malmir, Masoumeh; Pourmohammad, Nargess; Heravi, Majid M.] Alzahra Univ, Sch Sci, Dept Chem, POB 1993891176, Tehran, Iran; [Ahmadi, Shervin] Iran Polymer & Petrochem Inst, Dept Polymer Proc, Tehran, Iran in 2019.0, Cited 61.0. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7. Computed Properties of C7H5NO4

A covalent hybrid of halloysite-poly(methyl methacrylate-co-maleic anhydride) was prepared and applied for the immobilization of Pd nanoparticles. The hybrid system, Pd@Hal-Gua-Poly, was then characterized via TEM, TGA, ICP, BET, FTIR and XRD and successfully used as a heterogeneous catalyst for promoting two main Pd-catalyzed reactions, i.e. hydrogenation of nitro-arenes and Suzuki coupling reaction under mild and eco-friendly conditions. The study of recyclability of the catalyst confirmed high recyclability and low Pd leaching of Pd@Hal-Gua-Poly. Moreover, the hot-filtration test showed the heterogeneous nature of the catalysts. Notably, the comparison of the activity of the catalyst with that of Pd@Hal and Pd@Poly confirmed the superior catalytic activity of the former, indicating that the hybridization of Hal and Poly could lead to the improvement of the catalytic activity. [GRAPHICS] .

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Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

An article A nano-reactor based on PtNi@metal-organic framework composites loaded with polyoxometalates for hydrogenation-esterification tandem reactions WOS:000459580000021 published article about SELECTIVE HYDROGENATION; CATALYST; BENZOCAINE; NANOPARTICLES; PERFORMANCE; CHEMISTRY; DRIVEN; FLOW in [Kuang, Qin] Xiamen Univ, State Key Lab Phys Chem Solid Surfaces, Coll Chem & Chem Engn, Xiamen 361005, Peoples R China; Xiamen Univ, Dept Chem, Coll Chem & Chem Engn, Xiamen 361005, Peoples R China in 2019.0, Cited 47.0. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7. Quality Control of 4-Nitrobenzoic acid

Tandem catalysis (i.e., a process in which a desirable product is synthesized by a one-step process consisting of sequential reactions) has attracted intensive attention owing to its sustainable green and atom-economical characteristics. In this process, the utilization of a high-efficiency multifunctional catalyst is key. However, different functional sites integrated within the catalyst are required to be rationally designed and precisely engineered to guarantee the synergy between the catalytic reactions. Herein, a novel kind of hydrogenation-esterification tandem catalyst with metal/acid (alloy/polyoxometalates) active sites integrated within the metal-organic frameworks (MOFs) was prepared by a facile self-sacrificial template route. In this tandem catalyst, the MOF cavities served as tandem reactors, the PtNi alloy sites encapsulated within the MOF material acted as hydrogenation sites, and the solid phosphotungstic acid embedded in the MOF cavities provided esterification sites. This well-designed tandem catalyst showed outstanding activity and selectivity towards the one-step synthesis of amino-ester-type anesthetics (e.g., benzocaine) owing to the synergistic catalysis of the metal and acid sites. Clearly, this novel tandem catalyst simplifies the traditional industry process and provides a new method to rationally construct new tandem catalysts.

Quality Control of 4-Nitrobenzoic acid. Welcome to talk about 62-23-7, If you have any questions, you can contact Chen, LN; Zhang, XB; Zhou, JH; Xie, ZX; Kuang, Q; Zheng, LS or send Email.

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Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Recently I am researching about MATRIX-METALLOPROTEINASE INHIBITORS; CANCER-CELL INVASION; BREAST-CANCER; MATRIX-METALLOPROTEINASE-9 ACTIVITY; CRYSTAL-STRUCTURES; TUMOR-GROWTH; DESIGN; ROLES; MULTICOMPONENT; OVEREXPRESSION, Saw an article supported by the . Published in ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER in ISSY-LES-MOULINEAUX ,Authors: Ayoup, MS; Fouad, MA; Abdel-Hamid, H; Ramadan, E; Abu-Serie, MM; Noby, A; Teleb, M. The CAS is 62-23-7. Through research, I have a further understanding and discovery of 4-Nitrobenzoic acid. COA of Formula: C7H5NO4

Matrix metalloproteinases (MMPs) are major modulators of the tumor microenvironment. They participate in extracellular matrix turnover, tumor growth, angiogenesis and metastasis. Accordingly, MMPs inhibition seems to be ideal solution to control cancer. Many MMPs inhibitors have been introduced ranging from hydroxamate-based peptidomimetics to the next generation non-hydroxamate inhibitors. Among MMPs, MMP-9 is attractive druggable anticancer target. Studies showed that inhibiting AKT, the central signaling node of MMP-9 upregulation, provides additional MMP-9 blockade. Furthermore, caspase-dependent AKT cleavage leads to cell death. Herein, Ugi MCR was utilized as a rapid combinatorial approach to generate various decorated bis-amide scaffolds as dual MMP-9/AKT inhibitors endowed with caspase 3/7 activation potential. The target adducts were designed to mimic the thematic structural features of non-hydroxamate MMP inhibitors. p-Nitrophenyl isonitrile 1 was utilized as structure entry to Ugi products with some structural similarities to amide-based caspase 3/7 activators. Besides, various acids, amines and aldehydes were employed as Ugi educts to enrich the SAR data. All adducts were screened for cytotoxicity against normal fibroblasts and three cancer cell lines; MCF-7, NFS-60 and HepG-2 utilizing MTT assay. 8,11 and 28 were more active and safer than doxorubicin with single-digit nM IC50 and promising selectivity. Mechanistically, they exhibited dual MMP-9/AKT inhibition at single-digit nM IC50 with excellent selectivity over MMP-1,-2 and -13, and induced >51% caspase 3/7 activation. Consequently, they induced >49% apoptosis as detected by flow cytometric analysis, and inhibited cell migration (metastasis) up to 97% in cancer cells. Docking simulations were nearly consistent with enzymatic evaluation, also declared possible binding modes and essential structure features of active compounds. In silico physicochemical properties, ligand efficiency and drug-likeness metrics were reasonable for all adducts. Interestingly, 8 and 28 can be considered as drug-like candidates. (C) 2019 Elsevier Masson SAS. All rights reserved.

COA of Formula: C7H5NO4. Bye, fridends, I hope you can learn more about C7H5NO4, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

An article Synthesis, Cytotoxic and Heparanase Inhibition Studies of 5-oxo-1-arylpyrrolidine-3-carboxamides of Hydrazides and 4-amino-5-ary1-4H-1,2,4-triazole-3-thiol WOS:000540735800007 published article about ANTICANCER ACTIVITY; TRIAZOLE DERIVATIVES; MOLECULAR DOCKING; IN-VITRO; SULFATE in [Hari, Swetha; Preetham, Habbanakuppe D.; Rangappa, Kanchugarakoppal S.] Univ Mysore, Dept Studies Chem, Mysuru 570006, Karnataka, India; [Swaroop, Toreshettahally R.; Basappa, Salundi] Univ Mysore, Dept Studies Organ Chem, Mysuru 570006, Karnataka, India; [Mohan, Chakrabhavi D.] Univ Mysore, Dept Studies Mol Biol, Mysuru 570006, Karnataka, India; [Muddegowda, Umashakara] Karnataka State Open Univ, Dept Studies Chem, Mysuru 570006, Karnataka, India; [Vlodavsky, Israel] Technion, Canc & Vasc Biol Res Ctr, Bruce Rappaport Fac Med, Haifa, Israel; [Sethi, Gautam] Natl Univ Singapore, Dept Pharmacol, Yong Loo Lin Sch Med, Singapore 117600, Singapore in 2020, Cited 38. Name: 4-Nitrobenzoic acid. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7

Design of chemically novel, biologically potent small heterocyclic molecules with anticancer activities, which targets the enzyme heparanase has gained prominent clinical interest. We have synthesized a novel class of carboxamide derivatives by coupling various substituted aromatic acid hydrazides and triazoleamine with pyrrolidine carboxylic acid by using coupling agents. The synthesized compounds are characterized by spectroscopic techniques such as FT-IR, DIMS and NMR. These compounds arc investigated for cytotoxicity on different cancer cell lines and heparanase inhibitory activity. Most of them showed moderate heparanase inhibitory activity and good cytotoxicity.

Name: 4-Nitrobenzoic acid. About 4-Nitrobenzoic acid, If you have any questions, you can contact Hari, S; Swaroop, TR; Preetham, HD; Mohan, CD; Muddegowda, U; Basappa, S; Vlodavsky, I; Sethi, G; Rangappa, KS or concate me.

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Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Authors Sagara, PS; Siril, PF; Ravikumar, PC in AMER CHEMICAL SOC published article about COBALT; FUNCTIONALIZATION; ALKENYLATION; HYDRAZINES; AMINATION; ARYLATION; CLEAVAGE; INDOLES in [Sagara, Prateep Singh; Siril, Prem Felix] Indian Inst Technol Mandi, Sch Basic Sci, Mandi 175005, Himachal Prades, India; [Ravikumar, Ponneri Chandrababu] Natl Inst Sci Educ & Res NISER Bhubaneswar, Sch Chem Sci, Jatani Campus, Bhubaneswar 752050, Odisha, India in 2019, Cited 29. Application In Synthesis of 4-Nitrobenzoic acid. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7

We report a new application of N-amino-7-azaindole as a new bidentate-directing group for [Ru(p-cymene)Cl-2](2)-catalyzed C(sp(2))-H alkenylation/annulation of N-(1H-pyrrolo[2,3-b]pyridin-1-yl)benzamides with internal alkynes to afford N-isoquinolono-7-azaindole via the formation of C-C and C-N bonds. The reaction shows a wide range of substrate scope with different symmetrical and unsymmetrical alkynes, affording the desired product in good to excellent yields. In the case of unsymmetrical alkynes, a highly regioselective product was obtained, which was confirmed by single-crystal X-ray crystallography. A new ruthenium-4-methyl-N-(1H-pyrrolo[2,3-b]pyridin-1-yl)benzamide complex was isolated, and its structure was confirmed by single-crystal X-ray crystallography.

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem