Category: phthalazine

SDS of cas: 482-05-3, As a society publisher, everything we do is to support the scientific community – so you can trust us to always act in your best interests, and get your work the international recognition that it deserves. 482-05-3, Name is [1,1′-Biphenyl]-2,2′-dicarboxylic acid, SMILES is O=C(C1=CC=CC=C1C2=CC=CC=C2C(O)=O)O, belongs to phthalazine compound. In a article, author is Davarpanah, Jamal, introduce new discover of the category.

In the present work, amorphous silica nanoparticles were synthesized from low-cost rice husk ash (RH-SiO2). The nanoparticles were later modified by an acidic ionic liquid containing double-charged diazoniabi-cyclo[2.2.2]octane chloride using sol-gel method (RH@[SiPrDABCO@BuSO3H]HSO4). The structural properties of this Bronsted solid acid were systematically investigated by Fourier transform infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), thermal gravimetric analysis-derivative thermogravimetric analysis (TGA-DTG), and Brunauer-Emmett-Teller (BET) measurements. The catalytic activity of this nanocomposite was successfully tested through the one-pot synthesis of 1H-pyrazolo[1,2-b]phthalazine-5,10-diones via three-component couplings of phthalhydrazide, aromatic aldehydes, and malononitrile. The heterogeneous catalyst could be recovered easily and reused without significant loss of its catalytic activity.

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Related Products of 66-99-9, Academic researchers, R&D teams, teachers, students, policy makers and the media all rely on us to share knowledge that is reliable, accurate and cutting-edge. 66-99-9, Name is 2-Naphthaldehyde, SMILES is O=CC1=CC=C2C=CC=CC2=C1, belongs to phthalazine compound. In a article, author is Wang, Haitao, introduce new discover of the category.

Novel amino-acid-derived phthalazine reagents have been designed and synthesized for the enantioselective fluorocyclizations of prochiral indoles. The scope of reaction is evidenced by 28 examples of fluorinated furoindole and pyrroloindole heterocycles bearing various functionalities with up to 99% ee. The resulting enantioenriched fluorinated products are found to be potent AChE inhibitors. Advantages of the current new chiral reagents include ease in the synthesis of analogues and readily tunable steric/electronic demands.

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Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Quality Control of N-Cbz-D-Asparagine, As a society publisher, everything we do is to support the scientific community – so you can trust us to always act in your best interests, and get your work the international recognition that it deserves. 4474-86-6, Name is N-Cbz-D-Asparagine, SMILES is O=C(N)C[C@H](C(O)=O)NC(OCC1=CC=CC=C1)=O, belongs to phthalazine compound. In a article, author is Jahanshahi, Parivash, introduce new discover of the category.

A novel one-pot four-component, highly efficient and environmentally benign approach for the synthesis of a wide range of 1H-pyrazolo[1,2-b]phthalazine-5,10-dione derivatives in the presence of acetic acid functionalized imidazolium salt (1-carboxymethyl-2,3-dimethylimidazolium iodide {[cmdmim]I}) as a newly synthesized BrOnsted acid catalyst is described. The reaction occurs via tandem Knoevenagel-cyclocondensation of phthalic anhydride, hydrazine hydrate, aromatic aldehydes and 3-(1-methyl-1H-pyrrol-2-yl)-3-oxopropanenitrile (or 3-(1H-indol-3-yl)-3-oxopropanenitrile) in the presence of acetic acid functionalized imidazolium salt {[cmdmim]I} in ethanol under reflux conditions. This adequate procedure possesses some advantages like atom economy, cost-effectiveness, operational simplicity, short reaction times, straightforward work-up procedure, high yields, and reusability of the catalyst in 5 consecutive runs without any appreciable decrease in activity.

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Reference of 1679-64-7, In classical electrochemical theory, both the electron transfer rate and the adsorption of reactants at the electrode control the electrochemical reaction. 1679-64-7, Name is 4-(Methoxycarbonyl)benzoic acid, SMILES is C1=CC(=CC=C1C(O)=O)C(OC)=O, belongs to phthalazine compound. In a article, author is Xue, Jie, introduce new discover of the category.

Despite the great potential for applications spanning, from military night-vision displays and information-secured devices to civilian medical diagnostics and phototherapy, the development of highly efficient, stable, and low-cost near-infrared (NIR) emitting lumophores is still a formidable challenge. Herein, we report two novel NIR-emitting homoleptic facial Ir(III) complexes based on extended pi-conjugated benzo[g]phthalazine ligands, namely, tris[1,4-di(thiophen-2-yl)benzo(g]phthalazine] (Ir(dtbpa)(3), 1) and tris[1-(2,4-bis(trifluoromethyl)pheny1)-4-(thiophen-2-y1)-benzo[g]phthalazine] iridium(III) (Ir(Ftbpa)(3), 2). Actually, these two ligarids not only enable simple one-pot synthesis of homoleptic Ir(III) complexes without any catalyst under mild conditions, but also contribute to intense NIR-emission with high photoluminescence quantum yield up to 5.2% at 824 nm for 1 and 17.3% at 765 nm for 2 respectively. Single-crystal structure of 1 demonstrates desired facial form with short Ir-N and Ir-C bonds because of strong coordination and small steric hindrance of those highly conjugated C<^>N=N ligands. Importantly, the incorporation Of CF3 groups in 2 further leads to high thermal stability and a good ability to sublime, thus resulting in ultrapurity for highly efficient NIR-organic light-emitting diodes (NIR-OLEDs) with a high maximum external quantum efficiency of 4.5% at 760 run and small efficiency roll-off remaining of 3.5% at 100 mA. cm(-2), values which rank with those of the most efficient NIR-OLEDs with small roll-off and peak emission over 750 nm. Notably, the content percentages of the noble metal in these two complexes, (similar to 10% Ir) are markedly lower by about two-thirds than that of typical green-emitting tris(2-phenylpyridine)iridium (similar to 30% Ir). The findings may provide a new strategy to develop robust NIR emitters and achieve high efficiency, small roll-off, and low cost simultaneously in NIR-OLEDs for practical applications.

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Healthcare careers for chemists are once again largely based in laboratories, Product Details of 24650-42-8, although increasingly there is opportunity to work at the point of care, helping with patient investigation. 24650-42-8, Name is 2,2-Dimethoxy-2-phenylacetophenone, SMILES is COC(OC)(C(=O)C1=CC=CC=C1)C1=CC=CC=C1, belongs to phthalazine compound. In a document, author is Tayebee, R., introduce the new discover.

A new inorganic-organic hybrid material Al-SBA-15-TPI/H6P2W18O62 was prepared and fully characterized by SEM, XRD, FT-IR, TGA-DTA, and UV-Vis spectroscopic techniques. Then, the prepared nanomaterial was used as a simple, cost-effective, and reusable heterogeneous catalyst for the synthesis of 2H-indazolo[ 2,1-b] phthalazine-1,6,11(13H)-trione derivatives by a one-pot, three-component condensation reaction of phthalhydrazide, cyclic diones, and aromatic aldehydes under solvent free conditions at 100 degrees C in a short time. This methodology has proven to be efficient and environmentally benign in terms of high yields and low reaction times and offers significant improvements with regard to the scope of transformation and simplicity of operation by avoiding expensive or corrosive catalysts.

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Synthetic Route of 5509-65-9, Chemistry graduates have much scope to use their knowledge in a range of research sectors, including roles within chemical engineering, chemical and related industries, healthcare and more. 5509-65-9, Name is 2,6-Difluoroaniline, SMILES is C1=CC=C(C(=C1F)N)F, belongs to phthalazine compound. In a article, author is Sheikh, Davood, introduce new discover of the category.

This article describes a facile pathway for one-pot synthesis of 2H-indazolo[2,1-b] phthalazine-triones in the presence of tannic acid as an ecofriendly catalyst. The reactions proceed smoothly at room temperature to afford the products in high yields.

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

The prevalence of solvent effects in heterogeneous catalysis in condensed media has motivated developing quantitative kinetic, and theoretical assessments of solvent structures and their interactions with reaction intermediates and transition states. 767-00-0, Name is 4-Hydroxybenzonitrile, molecular formula is C7H5NO, belongs to phthalazine compound. In a document, author is Li, Guifei, introduce the new discover, Application of 767-00-0.

An efficient rhodium-catalyzed tandem C-H bond olefination and annulation approach was developed to afford 1,2-dihydrophthalazines in good to excellent yields from easily accessible sulfonylhydrazones and alkenes.

Application of 767-00-0, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. I hope my blog about 767-00-0 is helpful to your research.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Chemical engineers ensure the efficiency and safety of chemical processes, adapt the chemical make-up of products to meet environmental or economic needs, and apply new technologies to improve existing processes. 524-95-8, Name is 2-((Diphenylboryl)oxy)ethanamine, SMILES is NCCOB(C1=CC=CC=C1)C2=CC=CC=C2, belongs to phthalazine compound. In a document, author is Xin Jingchao, introduce the new discover, Recommanded Product: 2-((Diphenylboryl)oxy)ethanamine.

In order to find more efficient and economical antitumor drugs, a series of 1-phenyl-4-substituted phthalazine derivatives were synthesized and evaluated for antiproliferative activity in vivo. The structures of the synthesized compounds were confirmed by H-1 NMR, C-13 NMR and HRMS. The antitumor activity of the target compounds was performed against four cancer cell lines by 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tetrazolium bromide (MTT). The results showed that some compounds had a good antitumor activity, especially, N-(4-methoxyphenyl)-2-((4-phenylphthalazin-1-yl)thio)acetamide (5f) and N-(3-chloro-4-fluorophenyl)-2-(4-(4-phenylphthalazin-1-yl)piperazin-1-yl)acetamide (8c), exhibited better antitumor activities with IC50 values of 8.13 and 9.31 mu mol.L-1 against the human esophageal cancer cells, which were superior to 5-fuorouracil.

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Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Having gained chemical understanding at molecular level, chemistry graduates may choose to apply this knowledge in almost unlimited ways, as it can be used to analyze all matter and therefore our entire environment., Quality Control of H-Glu(OBzl)-OH, 1676-73-9, Name is H-Glu(OBzl)-OH, SMILES is N[C@@H](CCC(OCC1=CC=CC=C1)=O)C(O)=O, belongs to phthalazine compound. In a document, author is Xu, Xianlin, introduce the new discover.

High temperature-resistant separation membranes are widely considered in various fields. However, incompetent support layer limits the performance of high temperature-resistant membranes severely. In this work, a homogeneous composite nonwoven support (HCNS) is developed by wet-laid and hot-pressing technology using undrawn polyethylene terephthalate fibers as bonding fibers. The significance of hot-pressing parameters on the performances of the HCNS is investigated, and quadratic regression models are established. The HCNS exhibits a smooth surface (roughness of 118 nm) and a porous structure (porosity of 21.06% and pore size of 6.548 mu m) with a mechanical property (tensile index of 45.80 N m g(-1)). The ultrafiltration membranes supported by the HCNS are prepared from poly(phthalazine ether sulfone ketone), which demonstrates high permeance, high rejection rate, and long-term stability at raised operation temperature, thereby suggesting the potential application of HCNS in high-temperature filtration.

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Having gained chemical understanding at molecular level, chemistry graduates may choose to apply this knowledge in almost unlimited ways, as it can be used to analyze all matter and therefore our entire environment., Name: 2,4-Dimethoxybenzaldehyde, 613-45-6, Name is 2,4-Dimethoxybenzaldehyde, SMILES is O=CC1=CC=C(OC)C=C1OC, belongs to phthalazine compound. In a document, author is Saundane, Anand R., introduce the new discover.

A new series of novel compounds 1-tert-butyl-9-substituted-12H-indolo[2,3-c]isoquinolino[5,6-c]-1,2,4-triazoles (4a-4c), 10-substituted-2-phenyl-1,13-dihydroindolo[2,3-c]isoquinolino[5,6-c]-1,2,4-triazines (5a-5l), 2-(10-substituted-7H-indolo[2,3-c]isoquinolin-5-yl)-4-phenylphthalazin-1-ones (6a-6c), 2-[2-(10-substituted-7H-indolo[2,3-c]isoquinolinyl)hydrazinecarbonyl]benzoic acid (7a-7c), and 2-(10-substituted-7H-indolo[2,3-c]isoquinolin-5-yl)phthalazine-1,4-diones (8a-8c) were synthesized. The structures of these newly synthesized compounds were confirmed by their spectral studies and elemental analysis. These compounds have been screened for their antimicrobial, antitubercular, antioxidant, and cytotoxic activities. Compounds 4b, 5a, 5g, 5h, 6a, 6b, and 7b exhibited the maximum zone of inhibition against Staphylococcus aureus. Compounds 5d and 6c exhibited the maximum zone of inhibition against Pseudomonas aeruginosa. Compounds 7a and 8c showed maximum zone of inhibition against Aspergillus niger. Compounds 5k and 8c showed maximum zone of inhibition against Aspergillus flavus. Compounds 4a (MIC-1.6 A mu g/ml) and 5 h (MIC-0.2 A mu g/ml) exhibited promising antitubercular activity against Mycobacterium tuberculosis H37Rv strain. Compounds 4b, 4c, 5a, 5c, 5e, 5h, 6a, 6b, 6c, 8a, and 8b exhibited good radical scavenging activity compared with standards. Compounds 4b, 4c, 5a, 5c, 5g, 6a, and 8b exhibited maximum reducing ability. Compounds 4a and 5h exhibited 100 % cell lysis at concentration 10 A mu g/ml.

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem