Category: phthalazine

Having gained chemical understanding at molecular level, chemistry graduates may choose to apply this knowledge in almost unlimited ways, as it can be used to analyze all matter and therefore our entire environment., Related Products of 56-95-1, 56-95-1, Name is Chlorhexidine Diacetate, SMILES is N=C(NCCCCCCNC(NC(NC1=CC=C(Cl)C=C1)=N)=N)NC(NC2=CC=C(Cl)C=C2)=N.CC(O)=O.CC(O)=O, belongs to phthalazine compound. In a document, author is Aslam, Afeefa, introduce the new discover.

Piperazine rings are important heterocyclic targets in organic synthesis and are useful synthetic intermediates or intricate parts of biologically active molecules. In our efforts, a series of piperazine derivatives has been prepared discovering new classes of antimicrobial agents, including bis(phthalimido)piperazine, bis(3-aminopropyl) piperazine, 2,3-dihydro-phthalazine-1,4-dione, and bis(3,4-aminophenol)piperazine. The synthesized antimicrobial agents have been studied using various spectroscopic techniques. Furthermore, these compounds have been screened for their in vitro antimicrobial activity against selected bacterial and fungal strains. Three compounds exhibited mild to good antibacterial activity, but somewhat lower antifungal activity against tested microbial strains.

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Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Chemical engineers work across a number of sectors, processes differ within each of these areas, but chemistry and chemical engineering roles are found throughout, creation and manufacturing process of chemical products and materials. Safety of Boc-D-Phenylglycinol, 102089-74-7, Name is Boc-D-Phenylglycinol, SMILES is [C@@H](NC(OC(C)(C)C)=O)(C1=CC=CC=C1)CO, in an article , author is Maheswari, Cinnathambi Subramani, once mentioned of 102089-74-7.

A new protocol for the synthesis of 2H-indazolo[2,1-b]phthalazine-trione derivatives is described via a one-pot three-component condensation reaction of phthalhydrazide, dimedone or 1,3-cyclohexanedione and aromatic aldehydes catalyzed by SnO2 nanoparticles as a heterogeneous catalyst under solvent-free conditions. The SnO2 nanoparticles (NPs) were characterized by FT-IR, X-ray diffraction (XRD), field emission scanning electron microscopy (FE-SEM) and energy dispersive X-ray analyzer (EDAX). The advantages of the protocol are the shorter reaction time, simple work-up procedure and reusable catalyst. [GRAPHICS] .

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Redox catalysis has been broadly utilized in electrochemical synthesis due to its kinetic advantages over direct electrolysis. 622-95-7, Name is 1-(Bromomethyl)-4-chlorobenzene, molecular formula is , belongs to phthalazine compound. In a document, author is Wang, Shi-Ben, HPLC of Formula: https://www.ambeed.com/products/622-95-7.html.

A series of 1-alkoxy-4-(1H-1,2,4-triazol-1-yl)phthalazine derivatives were synthesized using 2,3-dihydrophthalazine-1,4-dione as starting material. The structures of the compounds were characterized by elemental analysis, IR, H-1-NMR and MS data. Anticonvulsant activities of these compounds were evaluated by maximal electroshock (MES) test following intraperitoneal injection in mice. Among the synthesized compounds 3a-3t, compound 3e was the most active compound with an ED50 of 28.9 mg/kg, TD50 of 173.6 mg/kg and protective index (PI) of 6.0.

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Chemistry involves the study of all things chemical – chemical processes, chemical compositions and chemical manipulation – in order to better understand the way in which materials are structured, how they change and how they react in certain situations. , Product Details of 775-12-2, 775-12-2, Name is Diphenylsilane, molecular formula is C12H12Si, belongs to phthalazine compound. In a document, author is Shafe-Mehrabadi, Sayed Rasul, introduce the new discover.

Nanostructured SiO2-H2SO4 as an efficient and nano catalyst for one-pot synthesis of phtahalazines via three-component condensation of an aromatic or aliphatic aldehyde, malononitrile and 5-amino-2,3-dihydro-phthalazine-1,4-dione. Nanostructured SiO2-H2SO4 was synthesized and characterized via FT-IR and SEM techniques. It is rapid and efficient catalyst for one-pot synthesis of the biologically important 3,9-diamino-5,10-dioxo-1-aryl-5,10-dihydropyrazolo[1,2-b]phthalazine-2-carbonitrile derivatives. The significant features of this methodology are nontoxic catalyst, short reaction time (10 min), recyclability, low catalyst loading, green organic solvent (ethanol), and avoiding tedious purification step.

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Computed Properties of https://www.ambeed.com/products/201611-92-9.html, Reactions catalyzed within inorganic and organic materials and at electrochemical interfaces commonly occur at high coverage and in condensed media, causing turnover rates to depend strongly on interfacial structure and composition. 201611-92-9, Name is 4-Cyano-4-((phenylcarbonothioyl)thio)pentanoic acid, SMILES is CC(SC(C1=CC=CC=C1)=S)(C#N)CCC(O)=O, belongs to phthalazine compound. In a article, author is Safaei-Ghomi, J., introduce new discover of the category.

ZrP2O7 and CuFe2O4 nanoparticles as efficient and reusable heterogeneous catalysts have been used for the preparation of 2H-indazolo[2,1-b]phthalazine-triones and 1H-pyrazolo[1,2-b]phthalazine-diones, respectively, under solvent-free conditions in good to excellent yields and short reaction times. (C) 2016 Sharif University of Technology. All rights reserved.

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Product Details of 62-23-7, Reactions catalyzed within inorganic and organic materials and at electrochemical interfaces commonly occur at high coverage and in condensed media, causing turnover rates to depend strongly on interfacial structure and composition. 62-23-7, Name is 4-Nitrobenzoic acid, SMILES is O=C(O)C1=CC=C([N+]([O-])=O)C=C1, belongs to phthalazine compound. In a article, author is Maftei, Dan, introduce new discover of the category.

The X-ray crystal structure of 8-(4-methylbenzoyl)benzo[5,6]isoindolo[1,2-a]phthalazine-9,14-dione, a derivative of fused pyrrolophtalazine heterocycle, is reported. The compound crystallfzes in the monoclinic C2/c space group (no. 15) with a = 23.968(4) angstrom, b = 7.6709(14) angstrom, c = 22.353(3) angstrom, alpha = gamma = 90.00, beta = 110.680(15)degrees, V=3845 angstrom(3) and Z = 7. Molecular and crystal packing parameters for the novel heterocyclic system were obtained from intensity data collected at room temperature. Both the benzo [5,6]isoindolo [1,2-a]phthalazine-9,14-dione and the 4-methyl-benzoyl fragments are planar and oriented at 78 degrees. Crystal packing is based on multiple (strong) pi-pi stacking interactions.

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Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Related Products of 613-45-6, Reactions catalyzed within inorganic and organic materials and at electrochemical interfaces commonly occur at high coverage and in condensed media, causing turnover rates to depend strongly on interfacial structure and composition. 613-45-6, Name is 2,4-Dimethoxybenzaldehyde, SMILES is O=CC1=CC=C(OC)C=C1OC, belongs to phthalazine compound. In a article, author is Brachet, Etienne, introduce new discover of the category.

We report the synthesis of various phthalazines via a new cascade reaction, initiated by visible light photocatalysis, involving a radical hydroamination reaction followed by a radical Smiles rearrangement. Phthalazine derivatives are obtained in high yields and from a broad scope readily accessible orthoalkynylsulfonohydrazone precursors. The mild photoredox conditions ensure an excellent functional group tolerance. Application of this strategy to a one-pot protocol starting from the corresponding carbonyl compounds, and subsequent functionalization allow the rapid synthesis of structurally diverse structures.

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

You could be based in a university, combining chemical research with teaching; in a pharmaceutical company, working on developing and trialing new drugs; helping to ensure national healthcare provision keeps pace with new discoveries. 402-50-6, Name is 1-(Trifluoromethyl)-4-vinylbenzene, SMILES is FC(F)(F)C1=CC=C(C=C)C=C1, belongs to phthalazine compound. In a document, author is Khidre, Rizk E., introduce the new discover, HPLC of Formula: https://www.ambeed.com/products/402-50-6.html.

The reaction of 3-(1,4-dioxo-3,4-dihydrophthalazin-2(1H)-yl)-3-oxopropanenitrile 1 and salicyladehyde furnished coumarin derivatives 4 and 5. Coupling reaction of 1 with aryl diazonium chlorides and benzene-1,4-bis (diazonium) chloride gave the corresponding hydrazones 6a,b and bishydrazone 9, respectively. Hydrazones 6 underwent intramolecular cyclization upon treating with hydrazine hydrate to give 3-aminopyrazoles 7. Pyranyl phthalazine 13 was prepared from the reaction of 1 with ethyl 2-cyano-3-ethoxyacrylate 10. Enaminonitrile 14 was reacted with hydrazine hydrate/phenylhydrazine and hydroxylamine to afford the corresponding pyrazoles 16 and oxime 17. The antimicrobial evaluation revealed pyrazole derivatives 7a,b and 16a,b displayed a broad spectrum activity against most strains. 3-Aminopyrazole derivative 7b showed potent antibacterial activity against all tested microorganisms.

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Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Healthcare careers for chemists are once again largely based in laboratories, Category: phthalazines, although increasingly there is opportunity to work at the point of care, helping with patient investigation. 7524-50-7, Name is H-Phe-OMe.HCl, SMILES is N[C@@H](CC1=CC=CC=C1)C(OC)=O.[H]Cl, belongs to phthalazine compound. In a document, author is Aslam, Afeefa, introduce the new discover.

Piperazine rings are important heterocyclic targets in organic synthesis and are useful synthetic intermediates or intricate parts of biologically active molecules. In our efforts, a series of piperazine derivatives has been prepared discovering new classes of antimicrobial agents, including bis(phthalimido)piperazine, bis(3-aminopropyl) piperazine, 2,3-dihydro-phthalazine-1,4-dione, and bis(3,4-aminophenol)piperazine. The synthesized antimicrobial agents have been studied using various spectroscopic techniques. Furthermore, these compounds have been screened for their in vitro antimicrobial activity against selected bacterial and fungal strains. Three compounds exhibited mild to good antibacterial activity, but somewhat lower antifungal activity against tested microbial strains.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 7524-50-7 is helpful to your research. Category: phthalazines.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Product Details of 1008-72-6, We’ll be discussing some of the latest developments in chemical about CAS: 1008-72-6, Name is Sodium 2-formylbenzenesulfonate, SMILES is O=S(C1=CC=CC=C1C=O)([O-])=O.[Na+], belongs to phthalazine compound. In a article, author is Kovalev, V. V., introduce new discover of the category.

The coordination compound [ZnCl2(Phtz)(2)] has been synthesized by the reaction of ZnCl2 with phthalazine (Phtz, L, C8H6N2) in an ethanol solution. Its crystal structure has been determined: crystals are triclinic, space group P 0000000, a = 7.346(1) , b = 8.095(1) , c = 14.275(1) , alpha = 85.63(1)A degrees, beta = 75.75(1)A degrees, gamma = 88.43(1)A degrees, V = 820.4(2) (3), rho(calc) = 1.605 g/cm(3), Z = 2. The zinc atom is tetrahedrally coordinated to two crystallographically nonequivalent chlorine atoms and two nitrogen atoms of the ligands L (Zn(1)-N(1), 2.036(4) ; Zn(1)-N(3), 2.043(4) ; Zn(1)-Cl(1), 2.225(2) ; Zn(1)-Cl(2), 2.220(2) ; angles NZnN, 106.1(2)A degrees; ClZnCl, 116.47(7)A degrees). The complexes are combined into a 1D supramolecular structure by nonclassical hydrogen bonds C-H center dot center dot center dot Cl and pi-pi-stacking interaction between centrosymmetric pairs of aromatic rings of one of the independent ligands. The compounds [CdI2(Phtz)] and [HgBr2(Phtz)] have also been synthesized, and their luminescent properties have been studied.

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem