Category: phthalazine

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. Name: Triphenylsilane, 789-25-3, Name is Triphenylsilane, SMILES is [SiH](C1=CC=CC=C1)(C2=CC=CC=C2)C3=CC=CC=C3, in an article , author is Martins, Felipe Terra, once mentioned of 789-25-3.

Phthalazine (2,3-diazanaphthalene) and phthalhydrazide (2,3-dihydro-1,4-phthalazinedione) compounds are heterocycles with several biological properties. Most recently, analogous phthalazine-triones also emerged as drug candidates. Herein, we introduced a phthalazine-trione moiety as a promising fluorophore in the blue and green spectral regions. This desired optical property was rationalized based on their crystal structure and time-dependent density functional theory (TD-DFT) calculations. Under ultraviolet (UV) excitation (ca. 360 nm), two light emission maxima at ca. 460 nm and 480 nm were observed for ten phthalazine-triones, regardless of the substitution pattern. This conservation in the light-emitting property was rationalized by our time-dependent DFT calculations for the three phthalazine-triones whose crystal geometries were also determined in this study (4-chlorophenyl, 3-methoxyphenyl and 4-nitrophenyl derivatives) and for those available in literature (4-fluorophenyl and 4-bromophenyl derivatives). Electronic transitions with the largest oscillator strengths were near 360 nm and were in excellent agreement with the experimental excitation energy (UV-visible and photoluminescence spectra). Lifetime values of selected samples could also be determined, which were between 1.59 ns and 3.21 ns. In all compounds, the Frontier molecular orbitals involved in these excitations were distributed over the phthalazine-trione moiety and were not localized on the changeable substituent.

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, such as the rate of change in the concentration of reactants or products with time. 402-49-3, Name is 1-(Bromomethyl)-4-(trifluoromethyl)benzene, formurla is C8H6BrF3. In a document, author is Mousapour, Maryam, introducing its new discovery. Category: phthalazines.

In this work, poly(vinylpyrrolidonium) perchlorate {[PVPH]ClO4}, a newly reported modified polymeric catalyst, is used as an efficient and reusable solid acid catalyst for the promotion of the synthesis of 2H-indazolo[2,1-b]phthalazine-trione derivatives. All reactions were performed under mild conditions and the products were formed over short reaction times in excellent yields. It is important to note that this solid acid catalyst can be reused several times without any appreciable loss in its activity.

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, HPLC of Formula: https://www.ambeed.com/products/608141-42-0.html608141-42-0, Name is (S)-1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethanamine, SMILES is O=S(C[C@@H](N)C1=CC=C(OC)C(OCC)=C1)(C)=O, belongs to phthalazine compound. In a article, author is Heirati, Seyedeh Zahra Dalil, introduce new discover of the category.

In this work, a series of 2H-indazolo[2,1-b]phthalazine-triones and Biginelli-like products were efficiently synthesized for the first time using O-Sulfonic acid poly(4-vinylpyrrolidonium) chloride ([PVP-SO3H]Cl) as an eco-friendly polymer-supported catalyst. At first, the catalyst preparation process was optimized based on the chlorosulfonic acid amount and the sulfonation time to obtain a catalyst with the maximum acidity content. The maximum acidity content for [PVP-SO3H]Cl was obtained to be 3.31 mmol g(-1). Then, the optimized [PVP-SO3H]Cl was used as a catalyst for the synthesis of a series of 2H-indazolo[2,1-b]phthalazine-triones and Biginelli-like products. It was observed that only 10 mg of the catalyst was enough to catalyze these reactions under mild conditions, and the corresponding products were obtained in high to excellent yields. Moreover, the catalyst could be repeatedly used for at least five times without a noticeable decrease in its catalytic activity.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 608141-42-0. HPLC of Formula: https://www.ambeed.com/products/608141-42-0.html.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Application of 89-86-1, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C–H bond functionalisation has revolutionised modern synthetic chemistry. 89-86-1, Name is 2,4-Dihydroxybenzoic acid, SMILES is O=C(O)C1=CC=C(O)C=C1O, belongs to phthalazine compound. In a article, author is Mori, Massiel, introduce new discover of the category.

The vaporization enthalpy of imidazo[1,2-a]pyrazine is evaluated by correlation gas chromatography using two sets of standards and by transpiration. Vaporization enthalpies were evaluated using heterocyclic standards with dipole moments that vary from 0 to 3.0 D and using standards with dipole moments > 3.0 D. A value of (70.7 +/- 1.0) kJ.mol-1 measured by transpiration compares to (67.9 +/- 1.4) kJ.mol1 measured by correlation gas chromatography using standards characterized by dipole moments > 3.0 D. The results suggest that imidazo[1,2-a]pyrazine is a member of this series of compounds whose vaporization enthalpies exceed those less polar heterocycles by a fairly constant amount, (6.9 +/- 0.3) kJ.mol-1, in this case by (5.9 +/- 3.0) kJ.mol(-1) using the less polar heterocycles. The crystal structures of phthalazine, another member of the polar series, and of imidazo[1,2-a]pyrazine were determined to examine whether p-p stacking, present in the solid state of two other members of the polar series, was a characteristic of this series. If present in the liquid, p-p stacking could offer a possible explanation for the vaporization enthalpy differences observed. The sublimation enthalpy of imidazo[1,2-a]pyrazine was also evaluated.

Application of 89-86-1, Consequently, the presence of a catalyst will permit a system to reach equilibrium more quickly, but it has no effect on the position of the equilibrium as reflected in the value of its equilibrium constant.I hope my blog about 89-86-1 is helpful to your research.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

In an article, author is Berber, Nurcan, once mentioned the application of 56-95-1, Formula: https://www.ambeed.com/products/56-95-1.html, Name is Chlorhexidine Diacetate, molecular formula is C26H38Cl2N10O4, molecular weight is 625.5505, MDL number is MFCD00012532, category is phthalazine. Now introduce a scientific discovery about this category.

A new series of phthalazine substituted beta-lactam derivatives were synthesized and their inhibitory effects on the activity of purified human carbonic anhydrase (hCA I and II) were evaluated. 2H-Indazolo[2,1-b]phthalazine-trione derivative was prepared with 4-nitrobenzaldehyde, dimedone, and phthalhydrazide in the presence of TFA in DMF, and the nitro group was reduced to 13-(4-aminophenyl)-3,3-dimethyl-3,4-dihydro-2H-indazolo[1,2-b]phthalazine-1,6,11(13H)-trione with SnCl2 center dot 2H(2)O. The reduced compound was reacted with different aromatic aldehydes, and phthalazine substituted imines were synthesized. The imine compounds undergo (2+2) cycloaddition reactions with ketenes to produce 2H-indazolo[2,1-b]phthalazine-trione substituted beta-lactam derivatives. The beta-lactam compounds were tested as inhibitors of the CA isoenzyme activity. The results showed that all the synthesized compounds inhibited the CA isoenzyme activity. 1-(4-(3,3-dimethyl-1,6,11-trioxo-2,3,4,6,11,13-hexahydro-1H-indazolo[1,2b]phthalazin-13-yl)phenyl)-2-oxo-4-p-tolylazetidin-3-yl acetate (IC50 = 6.97 A mu M for hCA I and 8.48 A mu M for hCA II) had the most inhibitory effect.

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 2935-35-5, Name is H-Phg-OH, SMILES is O=C(O)[C@@H](N)C1=CC=CC=C1, belongs to phthalazine compound. In a document, author is Eswararao, S., V, introduce the new discover, Quality Control of H-Phg-OH.

1H-pyrazolo[1,2-b]phthalazine-5,10-diones (5) and 2H-indazolo[2,1-b]phthalazine-1,6,11(13H)-triones (7) have been synthesized by one pot, four-component method. To synthesise them phthalic anhydride (1), hydrazine hydrate (2), benzaldehydes (3) and malononitrile (4a) /ethyl cynoacetate (4b) /dimedone (6) in refluxing water for 1-1.5 h in the presence of InCl3 as a catalyst yielding 75-85%. These reactions have an easy workup, provides excellent yields, and uses water as the solvent which is considered to be relatively environmentally benign. The structures of the products were established from their spectral properties IR, H-1-NMR, C-13-NMR & Mass spectroscopy.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 2935-35-5 is helpful to your research. Quality Control of H-Phg-OH.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Synthetic Route of 93-28-7, As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 93-28-7, Name is Eugenol Acetate, SMILES is CC(OC1=CC=C(CC=C)C=C1OC)=O, belongs to phthalazine compound. In a article, author is Karnali, Fatemeh, introduce new discover of the category.

In this work, the preparation and characterization of Fe3O4@SiO2-ZrCl2-MNPs as novel nano magnetic reagents is reported. After preparation, the promoting ability of this catalyst in the synthesis of tetrahydrobenzimidazo [2,1-b]quinazolin-1(2H)-ones and 2H-indazolo[2,1-b]phthalazine-triones is studied. The most important features of the present protocol are the easy preparation of the catalyst, mild reaction conditions, short reaction times, high yields and recyclability of the catalyst for at least four runs.

Synthetic Route of 93-28-7, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 93-28-7.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

In an article, author is Glisic, Biljana D., once mentioned the application of 886-86-2, Computed Properties of https://www.ambeed.com/products/886-86-2.html, Name is Ethyl 3-aminobenzoate methanesulfonate, molecular formula is C10H15NO5S, molecular weight is 261.29, MDL number is MFCD00013176, category is phthalazine. Now introduce a scientific discovery about this category.

Five copper(II) complexes 1-5 with aromatic nitrogen-containing heterocycles, pyrimidine (pm, 1), pyrazine (pz, 2), quinazoline (qz, 3 and 4) and phthalazine (phtz, 5) have been synthesized and structurally characterized by spectroscopic and single-crystal X-ray diffraction techniques. The crystallographic results show that, dependent on the ligand structure, complexes 1-5 are of different nuclearity. The antimicrobial efficiency of complexes 1-5 has been evaluated against three clinically relevant microorganisms and none of the complexes showed significant growth inhibiting activity, with values of minimum inhibitory concentrations (MIC) in the mM range. Since in many bacteria, pathogenicity and virulence are regulated by intercellular communication processes, quorum sensing (QS), the effect of the copper(II) complexes on bacterial QS has also been examined. The results indicate that the investigated complexes inhibit violacein production in Chromobacterium violaceum CV026, suggesting an anti-QS activity. In order to differentiate, which of the QS pathways was affected by the copper(II) complexes, three biosensor strains were used: the PAO1 Delta rhlIpKD-rhlA and the PA14-R3 Delta lasIPrsaI lux strain to directly measure the levels of C4-HSL (N-butanoyl-homoserine lactone) and 3OC12-HSL (N-3-oxo-dodecanoyl- homoserine lactone), respectively, and PAO1 Delta pqsA mini-CTX luxPpqsA for the detection of AHQs (2-alkyl-4-quinolones). Complexes 1-5 were shown to be efficient inhibitors of biofilm formation of the human opportunistic pathogen Pseudomonas aeruginosa PAO1, with the qz-containing complex 3 being the most active. Finally, the most anti-QS-active complexes 1 and 3 showed synergistic activity against a multi-drug resistant clinical isolate of P. aeruginosa, when supplied in combination with the known antibiotics piperacillin and ceftazidime.

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Related Products of 618-88-2, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 618-88-2, Name is 5-Nitroisophthalic acid, SMILES is O=C(O)C1=CC([N+]([O-])=O)=CC(C(O)=O)=C1, belongs to phthalazine compound. In a article, author is Tuerkmen, Yunus E., introduce new discover of the category.

A highly effective silver-catalyzed formal inverse electron-demand Diets Alder reaction of 1,2-diazines and siloxy alkynes has been developed. The reactions provide ready access to a wide range of siloxy naphthalenes and anthracenes, which are formed in good to high yields, under mild reaction conditions, using low catalyst loadings.

Related Products of 618-88-2, Consequently, the presence of a catalyst will permit a system to reach equilibrium more quickly, but it has no effect on the position of the equilibrium as reflected in the value of its equilibrium constant.I hope my blog about 618-88-2 is helpful to your research.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Synthetic Route of 83-53-4, Catalysts allow a reaction to proceed via a pathway that has a lower activation energy than the uncatalyzed reaction. 83-53-4, Name is 1,4-Dibromonaphthalene, SMILES is C1=CC=CC2=C(C=CC(=C12)Br)Br, belongs to phthalazine compound. In a article, author is Pavithra, Dalavai, introduce new discover of the category.

A solvent-free synthesis of 2H-indazolo[1,2-b]phthalazinetriones 4 and pyrazolo[1,2-b]phthalazines 6 scaffolds using benzyl alcohol 1 via TEMPO/CAN and TBAB mediated aerobic oxidation, sequential addition-cyclization with phthalhydrazide 2 and beta-diketones 3,5 is reported. The experimental strategy offers several advantages, such as simple workup, inexpensive chemicals without any use of solvents, and short reaction time. [GRAPHICS] .

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem