Category: phthalazine

23981-47-7, Name is 2-(6-Methoxynaphthalen-2-yl)acetic acid, molecular formula is C13H12O3, belongs to phthalazine compound, is a common compound. In a patnet, author is Reddy, Mudumala Veeranarayana, once mentioned the new application about 23981-47-7, Computed Properties of https://www.ambeed.com/products/23981-47-7.html.

A simple, efficient, and green practical approach to 1H-pyrazolo[1,2-b]phthalazine-5,10-diones from phthalhydrazide, aldehydes, and malononitrile/ethyl cyanoacetate has been developed that uses inexpensive and readily available InCl3 as a catalyst in solvent-free one-pot three-component cyclo condensation reaction. This method should provide high yields, shorter reaction time, easy work-up, purification of products by nonchromatographic method, and cleaner reaction. It is a new strategy for N-fused heterocycles synthesis, which haswider application in organic and medicinal chemistry. (c) 2013 Elsevier Ltd. All rights reserved.

We’ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, 23981-47-7. The above is the message from the blog manager. Computed Properties of https://www.ambeed.com/products/23981-47-7.html.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. 482-05-3, Name is [1,1′-Biphenyl]-2,2′-dicarboxylic acid, SMILES is O=C(C1=CC=CC=C1C2=CC=CC=C2C(O)=O)O, in an article , author is Davarpanah, Jamal, once mentioned of 482-05-3, Recommanded Product: 482-05-3.

In the present work, amorphous silica nanoparticles were synthesized from low-cost rice husk ash (RH-SiO2). The nanoparticles were later modified by an acidic ionic liquid containing double-charged diazoniabi-cyclo[2.2.2]octane chloride using sol-gel method (RH@[SiPrDABCO@BuSO3H]HSO4). The structural properties of this Bronsted solid acid were systematically investigated by Fourier transform infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), thermal gravimetric analysis-derivative thermogravimetric analysis (TGA-DTG), and Brunauer-Emmett-Teller (BET) measurements. The catalytic activity of this nanocomposite was successfully tested through the one-pot synthesis of 1H-pyrazolo[1,2-b]phthalazine-5,10-diones via three-component couplings of phthalhydrazide, aromatic aldehydes, and malononitrile. The heterogeneous catalyst could be recovered easily and reused without significant loss of its catalytic activity.

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. COA of Formula: https://www.ambeed.com/products/89-86-1.html, 89-86-1, Name is 2,4-Dihydroxybenzoic acid, SMILES is O=C(O)C1=CC=C(O)C=C1O, in an article , author is Zhou, Jiadi, once mentioned of 89-86-1.

An efficient silver-catalyzed d-regioselective C(sp(3))-H heteroarylation of free alcohols has been developed. Various alcohols reacted with quinolines, isoquinoline, pyridines, pyrimidine, phthalazine, 4-hydroxyquinazoline, acridine, quinoxaline and pyrazine to give the corresponding C(sp(2))-H alkylation products in 31-89% yields. Notably, all types (1 degrees, 2 degrees, and 3 degrees) of d-C(sp(3))-H bonds in the alcohols could be regioselectively activated. This protocol provides a platform to access divergent functionalizations of alcohols and heteroaryls by forming the challenging d-selective C(sp(3))-C(sp(2)) bond.

But sometimes, even after several years of basic chemistry education, it is not easy to form a clear picture on how they govern reactivity! 89-86-1, you can contact me at any time and look forward to more communication. COA of Formula: https://www.ambeed.com/products/89-86-1.html.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Electric Literature of 620-14-4, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 620-14-4, Name is 3-Ethyltoluene, SMILES is CC1=CC(CC)=CC=C1, belongs to phthalazine compound. In a article, author is Lashkari, Mojtaba, introduce new discover of the category.

A clean and simple synthesis of 1H-pyrazolo [1, 2-b] phthalazine-5, 10-dione derivatives via one-pot four-component condensation reaction of phthalimide, hydrazine monohydrate, aromatic aldehydes derivatives and malononitrile in the presence of neodymium (III) chloride hexahydrate (NdCl3.6H(2)O) as an efficient and eco-friendly Lewis acidic catalyst under thermal and solvent-free conditions with good yields and short reaction times is developed. This present methodology has notable benefits such as highly efficient, non-toxic catalyst, one-pot, solvent-free conditions, simplicity of operation with no necessity of chromatographic purification steps and eco-friendly. And all products have been characterized by melting points and H-1 NMR spectroscopy.

Electric Literature of 620-14-4, Because enzymes can increase reaction rates by enormous factors and tend to be very specific, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 620-14-4.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, such as the rate of change in the concentration of reactants or products with time. 24324-17-2, Name is 9-Fluorenemethanol, formurla is C14H12O. In a document, author is Shahsavani, Mohammad Bagher, introducing its new discovery. Recommanded Product: 24324-17-2.

In the current study, two binuclear Pt (II) complexes, containing cis, cis-[Me2Pt (mu-NN) (mu-dppm) PtMe2] (1), and cis,cis-[Me2Pt(mu-NN)(mu dppm,) Pt((CH2)(4))] (2) in which NN = phthalazine and dppm = bis (diphenylphosphino) methane were evaluated for their anticancer activities and DNA/purine nucleotide binding properties. These Pt (II) complexes, with the non-classical structures, demonstrated a significant anticancer activity against Jurkat and MCF-7 cancer cell lines. The results of ethidium bromide/acridine orange staining and Caspase-III activity suggest that these complexes were capable to stimulate an apoptotic mechanism of cell death in the cancer cells. Using different biophysical techniques and docking simulation analysis, we indicated that these complexes were also capable to interact efficiently with DNA via a non-intercalative mechanism. According to our results, substitution of cyclopentane (in complex 2) with two methyl groups (in complex 1) results in significant improvement of the complex ability to interact with DNA and subsequently to induce the anticancer activity. Overall, these binuclear Pt (II) complexes are promising group of the non-classical potential anticancer agents which can be considered as molecular templates in designing of highly efficient platinum anticancer drugs. (C) 2016 Elsevier B.V. All rights reserved.

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Electric Literature of 122-99-6, As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 122-99-6, Name is 2-Phenoxyethanol, SMILES is OCCOC1=CC=CC=C1, belongs to phthalazine compound. In a article, author is Soliman, Saied M., introduce new discover of the category.

A novel route for the synthesis of Cu(II)-triazolophthalazine complexes using the Cu(II)-promoted cyclization dehydrogenation reactions of hydrazonophthalazines under reflux was presented. Two hydrazonophthalazines were cyclized to the corresponding triazolophthalazine ligands, 3-pyridin-2-yl-3,10b-dihydro-[1,2,4]triazolo[3,4-a]phthalazine (TPP) and 3-(3,10b-dihydro-[1,2,4]triazolo[3,4-a]phthalazin-3-yl)-benzoic acid (TP3COOH), followed by in situ complexation with Cu(II) yielding six novel Cu(II)-triazolophthalazine complexes depending on the reaction conditions. The molecular and supramolecular structures of the Cu(II)-triazolophthalazine complexes were discussed. The metal sites have rectangular pyramidal geometry in the [Cu(TPP)Cl-2](2); 1 and [Cu(TP3COOEt)Cl-2(H2O)](2); 4 dinuclear complexes, distorted square planar in [Cu(TP3COOMe)(2)Cl-2]; 3, [Cu(TP3COOH)(2)Cl-2]; 5 and [Cu(TP3COOH)(2)Cl-2]center dot H2O; 6 and a distorted octahedral in [Cu(TPP)(H2O)(2)(NO3)(2)]; 2. Hirshfeld analysis showed that the O horizontal ellipsis H, C horizontal ellipsis H, Cl horizontal ellipsis H (except TP3COOH and 2), N horizontal ellipsis H and pi-pi stacking interactions are the most important intermolecular contacts. The pi-pi stacking interactions are the maximum for TP3COOH and complex 6 with net C horizontal ellipsis C/C horizontal ellipsis N contacts of 19.4% and 15.4%, respectively. The orbital-orbital interaction energies of the Cu-N/Cu-Cl bonds correlated inversely with the corresponding Cu-N/Cu-Cl distances, respectively. The charge transfer processes between Cu(II) and ligand groups were also discussed. The charge densities of the Cu(II) centers are reduced to 0.663-0.995 e due to the interactions with the ligand groups coordinating it.

Electric Literature of 122-99-6, Consequently, the presence of a catalyst will permit a system to reach equilibrium more quickly, but it has no effect on the position of the equilibrium as reflected in the value of its equilibrium constant.I hope my blog about 122-99-6 is helpful to your research.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Chemistry is an experimental science, Category: phthalazines, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 89797-68-2, Name is 5-(Ethylthio)-1H-tetrazole, molecular formula is C3H6N4S, belongs to phthalazine compound. In a document, author is Olmo, Francisco.

A series of new phthalazine derivatives (1-4) containing imidazole rings and functionalized with nitro groups in the benzene ring of the phthalazine moiety were prepared and identified on the basis of their MS, elemental analyses and bidimensional H-1 and C-13 NMR data, and their trypanocidal activity was tested. The 8-nitrosubstituted compound (3) was more active in vitro against Trypanosoma cruzi and less toxic against Vero cells than the reference drug benznidazole, and showed a SI value that was 47-fold better than the reference drug in amastigote forms. It also remarkably reduced the infectivity rate in Vero cells and decreased the reactivation of parasitemia in immunodeficient mice. Ultrastructural alterations found in epimastigotes treated with 3 confirmed extensive cytoplasm destruction in the parasites, whereas histopathological analysis of the hearts of mice infected and treated with 3 resulted in a decrease in cardiac damage. Biochemical markers showed that livers, hearts, and kidneys of treated mice were substantially unaffected by the administration of 3, despite the presence of the potentially toxic nitro group. It was also found that this compound selectively inhibited the antioxidant parasite enzyme Fe-superoxide dismutase (Fe-SOD) in comparison with human CuZn-SOD, and molecular modeling suggested interaction with the H-bonding system of the iron-based moiety as a feasible mechanism of action against the enzyme. (C) 2015 Elsevier Masson SAS. All rights reserved.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 89797-68-2, in my other articles. Category: phthalazines.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Chemistry can be defined as the study of matter and the changes it undergoes. You’ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology. 83-38-5, Name is 2,6-Dichlorobenzaldehyde, molecular formula is , belongs to phthalazine compound. In a document, author is Romero, Angel H., Formula: https://www.ambeed.com/products/83-38-5.html.

A series of six 3-aryl-6-(N-methylpiperazin)-1,2,4-triazolo[3,4-a]phthalazines were prepared through a facile and efficient one-pot copper-catalyzed procedure from 4-chloro-1-phthalazinyl-arylhydrazones with relatively good yields (62-83%). The one-pot copper-catalytic procedure consists of two simultaneous reactions: (i) a direct intramolecular dehydrogentaive cyclization between ylidenic carbon and adjacent pyrazine nitrogen to form 1,2,4-triazolo ring and, (ii) a direct N-amination on carbon-chlorine bond. Then, an in vitro anticancer evaluation was performed for the synthesized compounds against five selected human cancer cells (A549, MCF-7, SKBr3, PC-3 and HeLa). The nitro-derivatives were significantly more active against cancer strains than against the rest of tested compounds. Specifically, compound 8d was identified as the most promising anticancer agent with significant biological responses and low relative toxicities on human dermis fibroblast. The cytotoxic effect of compound 8d was more significant on PC3, MCF-7 and SKBr3 cancer cells with low-micromolar IC50 value ranging from 0.11 to 0.59 mu M, superior to Adriamycin drug. Mechanistic experimental and theoretical studies demonstrated that compounds 8d act as a K+ channel inhibitor in cancer models. Further molecular docking studies suggest that the EGFR Tyrosine Kinase enzyme may be a potential target for the most active 3-aryl-6-(N-methylpiperazin)-1,2,4-triazolo[3,4-a]phthalazines.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 83-38-5, in my other articles. Formula: https://www.ambeed.com/products/83-38-5.html.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. , Recommanded Product: 62-23-7, 62-23-7, Name is 4-Nitrobenzoic acid, molecular formula is C7H5NO4, belongs to phthalazine compound. In a document, author is Banerjee, Dipanwita, introduce the new discover.

The present report articulates a potential and green method for the synthesis of pyrazolo[1,2-b]phthalazine-5,10-dione by one-pot four component reaction involving phthalimide (1), hydrazine hydrate (2), aldehyde (3) and malononitrile (4). Proline has been utilized as organo-catalyst in a mixed solvent of ethanol and water in the ratio of 2:1 at 80 degrees C. The reaction reveals excellent reactivity, functional group tolerance, and quite high yields without using any extreme reaction condition like strong acid or metal catalyst. Eighteen compounds have been synthesised by this method including five new compounds.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 62-23-7. Recommanded Product: 62-23-7.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Related Products of 402-49-3, As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 402-49-3, Name is 1-(Bromomethyl)-4-(trifluoromethyl)benzene, SMILES is FC(C1=CC=C(CBr)C=C1)(F)F, belongs to phthalazine compound. In a article, author is Zhang Luye, introduce new discover of the category.

In order to find more efficient and low toxicity antitumor drugs, a series of novel 1,3-disubstituted pyridazinone derivatives were synthesized and evaluated for their antiproliferative activities against four human cancer cell lines (MCF-7, PC-3, SW-620 and HGC-27) in vitro. The results showed that most compounds had good antiproliferative activities, especially 2-(4-(4-bromophenyl)-1-oxo-tolylazine-2(1H)-yl)-N-(2-fluorophenyl)acetamide (5g) exhibited better antiproliferative activities with IC50 value of 6.01 mu mol/L. In a nutshell, this work provided clues to discover antitumor agent based on the quinazoline scaffold.

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem