Category: phthalazine

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 775-12-2, Name is Diphenylsilane, molecular formula is C12H12Si. In an article, author is Simijonovic, Dusica,once mentioned of 775-12-2, Application In Synthesis of Diphenylsilane.

A series of new phthalhydrazide-coumarin hybrids was obtained in the reaction of phthalhydrazide with corresponding bromopropoxycoumarin derivatives. These reactions were performed in the presence of Cs2CO3, in acetonitrile as solvent, and under reflux for 5 h. Obtained hybrids contain one or two coumarin scaffolds bonded to phthalhydrazide nitrogen via propoxy linker. Ten new phthalhydrazide-coumarin hybrids were obtained in moderate to good yields, and characterized with melting point, elemental analysis, IR and NMR spectroscopy, and LC-MS spectrometry. Additionally, the structures of these compounds were elucidated based on experimental and theoretical data (IR, H-1 NMR, and C-13 NMR). Excellent agreement between experimental and simulated spectra was achieved. The prediction of the potential biological activity of synthesized compounds was done using the online program PASS (Prediction of Activity Spectra for Substances). Based on the obtained results, the serotonin 2A receptor (5-HT2AR) was selected for molecular docking study. Molecular docking was also performed with commercially available drug Risperidone, and obtained results were compared with potential bioactive conformations of obtained phthalhydrazide-coumarin hybrids. (C) 2020 Elsevier B.V. All rights reserved.

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Phthalazine – Wikipedia,
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Reactions catalyzed within inorganic and organic materials and at electrochemical interfaces commonly occur at high coverage and in condensed media, causing turnover rates to depend strongly on interfacial structure and composition, 1008-72-6, Name is Sodium 2-formylbenzenesulfonate, SMILES is O=S(C1=CC=CC=C1C=O)([O-])=O.[Na+], in an article , author is Ji, Dezhong, once mentioned of 1008-72-6, SDS of cas: 1008-72-6.

A series of anthranilamide derivatives were designed and synthesized as novel smoothened (SMO) inhibitors based on the SMO inhibitor taladegib (LY2940680), which can also inhibit the SMO-D473H mutant, via a ring-opening strategy. The phthalazine core in LY2940680 was replaced with anthranilamide, which retained the inhibitory activity towards the hedgehog (Hh) signaling pathway as evidenced by a dual luciferase reporter gene assay. Compound 12a displayed the best inhibitory activity against the Hh signaling pathway with IC50 value of 34.09 nM, and exhibited better proliferation inhibitory activity towards the Daoy cell line (IC50=0.48 mu M) than LY2940680 (IC50=0.79 mu M).

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Phthalazine – Wikipedia,
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Chemistry is traditionally divided into organic and inorganic chemistry. The former is the study of compounds containing at least one carbon-hydrogen bonds. 1679-64-7, Name is 4-(Methoxycarbonyl)benzoic acid, molecular formula is C9H8O4, belongs to phthalazine compound, is a common compound. In a patnet, author is Li Jiali, once mentioned the new application about 1679-64-7, Recommanded Product: 4-(Methoxycarbonyl)benzoic acid.

In this paper, a series of 6-substituted-pyrido[3,2-e][1,2,4] triazolo[4,3-a] pyrazine derivatives have been synthesized. Their anticonvulsant activity and neurotoxicity in mice were evaluated by maximal electroshock (MES) and rotarod test, respectively. The structures were confirmed by H-1 NMR, C-13 NMR, MS and HRMS. The experimental results show that 6-phenoxypyrido[3,2-e][1,2,4] triazolo[4,3-a]pyrazine (5g) was safer than the reference drug, carbamazepine, with ED50 value of 93.9 mg.kg(-1) and protective index (PI) value of 24.3, which was a potential anti-epilepsy candidate compound.

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Phthalazine – Wikipedia,
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Reference of 31618-90-3, As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 31618-90-3, Name is (Diethoxyphosphoryl)methyl 4-methylbenzenesulfonate, SMILES is O=S(C1=CC=C(C)C=C1)(OCP(OCC)(OCC)=O)=O, belongs to phthalazine compound. In a article, author is Glisic, Biljana D., introduce new discover of the category.

Five copper(II) complexes 1-5 with aromatic nitrogen-containing heterocycles, pyrimidine (pm, 1), pyrazine (pz, 2), quinazoline (qz, 3 and 4) and phthalazine (phtz, 5) have been synthesized and structurally characterized by spectroscopic and single-crystal X-ray diffraction techniques. The crystallographic results show that, dependent on the ligand structure, complexes 1-5 are of different nuclearity. The antimicrobial efficiency of complexes 1-5 has been evaluated against three clinically relevant microorganisms and none of the complexes showed significant growth inhibiting activity, with values of minimum inhibitory concentrations (MIC) in the mM range. Since in many bacteria, pathogenicity and virulence are regulated by intercellular communication processes, quorum sensing (QS), the effect of the copper(II) complexes on bacterial QS has also been examined. The results indicate that the investigated complexes inhibit violacein production in Chromobacterium violaceum CV026, suggesting an anti-QS activity. In order to differentiate, which of the QS pathways was affected by the copper(II) complexes, three biosensor strains were used: the PAO1 Delta rhlIpKD-rhlA and the PA14-R3 Delta lasIPrsaI lux strain to directly measure the levels of C4-HSL (N-butanoyl-homoserine lactone) and 3OC12-HSL (N-3-oxo-dodecanoyl- homoserine lactone), respectively, and PAO1 Delta pqsA mini-CTX luxPpqsA for the detection of AHQs (2-alkyl-4-quinolones). Complexes 1-5 were shown to be efficient inhibitors of biofilm formation of the human opportunistic pathogen Pseudomonas aeruginosa PAO1, with the qz-containing complex 3 being the most active. Finally, the most anti-QS-active complexes 1 and 3 showed synergistic activity against a multi-drug resistant clinical isolate of P. aeruginosa, when supplied in combination with the known antibiotics piperacillin and ceftazidime.

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Phthalazine – Wikipedia,
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Chemistry can be defined as the study of matter and the changes it undergoes. You’ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology. 886-86-2, Name is Ethyl 3-aminobenzoate methanesulfonate, molecular formula is , belongs to phthalazine compound. In a document, author is Schweighauser, Luca, Name: Ethyl 3-aminobenzoate methanesulfonate.

A domino process consisting of an inverse and a normal electron-demand Diels-Alder reaction is presented for the formation of bridged tri- and tetracyclic 1,2,3,4-tetrahydronaphthalenes catalyzed by a bidentate Lewis acid. The products were synthesized in a one-pot reaction from commercially available starting materials and contain up to six stereogenic centers. The tetrahydronaphthalenes were isolated as single diastereomers and are derivatives of phenylethylamine, which is well-known as a scaffold of amphetamine or dopamine.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 886-86-2, in my other articles. Name: Ethyl 3-aminobenzoate methanesulfonate.

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Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. In an article, author is Takaoka, Naoki, once mentioned the application of 1603-79-8, Name is Ethyl benzoylformate, molecular formula is C10H10O3, molecular weight is 178.1846, MDL number is MFCD00009120, category is phthalazine. Now introduce a scientific discovery about this category, Computed Properties of https://www.ambeed.com/products/1603-79-8.html.

As aldehyde oxidase (AOX) plays an emerging role in drug metabolism, understanding its significance for drug-drug interactions (DDI) is important. Therefore, we tested 10 compounds for species-specific and substrate-dependent differences in the inhibitory effect of AOX activity using genetically engineered HEK293 cells over- expressing human AOX1, mouse AOX1 or mouse AOX3 The IC50 values of 10 potential inhibitors of the three AOX enzymes were determined using phthalazine and O-6-benzylguanine as substrates 17 beta-Estradiol, mena dione, norharmane and raloxifene exhibited marked differences in inhibitory effects between the human and mouse AOX isoforms when the phthalazine substrate was used. Some of the compounds tested exhibited substrate dependent differences m their inhibitory effects. Docking simulations with human AOX1 and mouse AOX3 were conducted for six representative inhibitors. The rank order of the minimum binding energy reflected the order of the corresponding IC50 values. We also evaluated the potential DDI between an AOX substrate (O-6-benzylguanine) and an inhibitor (hydralazine) using chimeric mice with humanized livers. Pretreatment of hydralazine increased the maximum plasma concentration (C-max) and the area under the plasma concentration- time curve (AUC(0-24)) of O-6-benzylguanine compared to single administration. Our in vitro data indicate species-specific and substrate-dependent differences in the inhibitory effects on AOX activity. Our in vivo data demon strate the existence of a DDI which may be of relevance in the clinical context.

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Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

56-95-1, Name is Chlorhexidine Diacetate, molecular formula is C26H38Cl2N10O4, belongs to phthalazine compound, is a common compound. In a patnet, author is Fallah-Ghasemi Gildeh, Sara, once mentioned the new application about 56-95-1, Application In Synthesis of Chlorhexidine Diacetate.

Benzylation of DBU followed by anion exchange of the resulting salt with trifluoroacetate gave nearly quantitatively the ionic liquid [Bn-DBU][TFA]. It is shown here to be an efficient catalyst for the synthesis of 1H-pyrazolo[1,2-b]phthalazine-5,10-dionesviathe three-component reaction of phthalhydrazide, aromatic aldehydes, and active alpha-methylene nitriles. DFT calculations at the B3LYP/SVP level and the experimental results are in agreement with a three-step mechanism for this reaction. Based on the DFT calculations, the catalytic effect largely arises from the intrinsic ionic properties of the ionic liquid rather than its action as a simple base. These calculations also predict the existence of two close-in-energy activated complexes whose rate determining roles and energies depend on their interaction with the anionic component of the ionic liquid, as [Bn-DBU][TFA] has shown a higher catalytic activity than [Bn-DBU][OAc]. This mechanistic approach opens up new and promising insights into the rational design of ionic liquid catalysts for the synthesis of 1H-pyrazolo[1,2-b]phthalazine-5,10-diones. The synthetic method presented here has several prominent advantages.

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Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

622-88-8, Name is (4-Bromophenyl)hydrazine hydrochloride, molecular formula is C6H8BrClN2, belongs to phthalazine compound, is a common compound. In a patnet, author is Wei, Cheng-Xi, once mentioned the new application about 622-88-8, SDS of cas: 622-88-8.

In a previous research, we synthesized and evaluated the anticonvulsant activity of a series of 6-substituted-oxy-[1,2,4] triazolo[3,4-a] phthalazine compounds. Reference to other studies, we deduce that the compounds may be useful for regulating inotropic activity by effecting stroke volume, so in this study, we evaluated 20 compounds (15a-t) for their changed inotropic activity by measuring the left atrium stroke volume in heart preparations isolated from Wistar rats. Among the 20 compounds, 15j was the most potent with an increased stroke volume of 27.39 +/- 3.16 % at the concentration of 50 mu M, compound 15m was identified as the most potent with an decreased stroke volume of -95.59 +/- 0.50 % at the same concentration which is much more effective than referenced drug Nifedipine (-55.22 +/- 1.87% at the concentration of 1 mu M).

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Phthalazine – Wikipedia,
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Chemistry is traditionally divided into organic and inorganic chemistry. The former is the study of compounds containing at least one carbon-hydrogen bonds. 81-48-1, Name is 1-Hydroxy-4-(p-tolylamino)anthracene-9,10-dione, molecular formula is C21H15NO3, belongs to phthalazine compound, is a common compound. In a patnet, author is Hiremath, Prashant B., once mentioned the new application about 81-48-1, Application In Synthesis of 1-Hydroxy-4-(p-tolylamino)anthracene-9,10-dione.

An efficient and rapid one-pot multicomponent synthesis of 1H-pyrazolo[1,2-b]phthalazine-5,10-diones through condensation of aldehyde, malononitrile and phthalhydrazide catalyzed by agro-waste solvent catalyst-derived water extract of mango peel ash (WEMPA) under microwave irradiation is described. Further, the catalyst is prepared from agricultural waste and characterized for elemental composition by different techniques such as SEM-EDX, XRD and flame photometry. This green synthetic approach offers various advantages such as inexpensive, abundantly available source, shorter reaction time (6-8 min), good-to-excellent yield (83%-89%), simple workup and a sustainable alternative method to the existing protocols. All the synthesized compounds (4a-l) was confirmed by FT-IR,H-1-NMR,C-13-NMR and LC-MS.

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Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 1149-26-4, Name is Z-L-Val-OH, molecular formula is C13H17NO4. In an article, author is Maheswari, Cinnathambi Subramani,once mentioned of 1149-26-4, Application In Synthesis of Z-L-Val-OH.

A new protocol for the synthesis of 2H-indazolo[2,1-b]phthalazine-trione derivatives is described via a one-pot three-component condensation reaction of phthalhydrazide, dimedone or 1,3-cyclohexanedione and aromatic aldehydes catalyzed by SnO2 nanoparticles as a heterogeneous catalyst under solvent-free conditions. The SnO2 nanoparticles (NPs) were characterized by FT-IR, X-ray diffraction (XRD), field emission scanning electron microscopy (FE-SEM) and energy dispersive X-ray analyzer (EDAX). The advantages of the protocol are the shorter reaction time, simple work-up procedure and reusable catalyst. [GRAPHICS] .

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