Category: phthalazine

SDS of cas: 62-23-7. In 2020.0 J BURN CARE RES published article about OUTCOMES in [Nizamani, Rabia; Heisler, Stephen; Chrisco, Lori; Jones, Samuel W.; Williams, Felicia N.] Univ N Carolina, Dept Surg, Sch Med, Chapel Hill, NC 27515 USA; [Nizamani, Rabia; Chrisco, Lori; Jones, Samuel W.; Williams, Felicia N.] North Carolina Jaycee Burn Ctr, Chapel Hill, NC USA; [Campbell, Harold] Mt Area Hlth Educ Ctr, Asheville, NC USA in 2020.0, Cited 14.0. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7.

In patients with diabetes mellitus (DM), amputation rates exceed 30% when lower extremity osteomyelitis is present. We sought to determine the rate of osteomyelitis and any subsequent amputation in our patients with DM and lower extremity burns. We performed a single-site, retrospective review at our burn center using the institutional burn center registry, linked to clinical and administrative data. Adults (>= 18 years old) with DM admitted from January 1, 2014 to December 31, 2018 for isolated lower extremity burns were eligible for inclusion. We evaluated demographics, burn characteristics, comorbidities, presence of radiologically confirmed osteomyelitis, length of stay (LOS), inpatient hospitalization costs, and amputation rate at 3 months and 12 months after injury. We identified 103 patients with DM and isolated lower extremity burns. Of these, 88 patients did not have osteomyelitis, while 15 patients had radiologically confirmed osteomyelitis within 3 months of the burn injury. Compared to patients without osteomyelitis, patients with osteomyelitis had significantly increased LOS (average LOS 22.7 days vs 12.1 days, P = .0042), inpatient hospitalization costs (average $135,345 vs $62,237, P = .0008), amputation rate within 3 months (66.7% vs 5.70%, P < .00001), and amputation rate within 12 months (66.7% vs 9.1%, P < .0001). The two groups were otherwise similar in demographics, burn injury characteristics, access to healthcare, and preexisting comorbidities. Patients with DM and lower extremity burns incurred increased LOS, higher inpatient hospitalization costs, and increased amputation rates if radiologically confirmed osteomyelitis was present within 3 months of the burn injury. SDS of cas: 62-23-7. About 4-Nitrobenzoic acid, If you have any questions, you can contact Nizamani, R; Heisler, S; Chrisco, L; Campbell, H; Jones, SW; Williams, FN or concate me.

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Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Ma, ZH; Jiang, L; Li, GX; Liang, DL; Li, LF; Liu, L; Jiang, C in [Ma, Zonghui; Li, Guoxin; Liang, Dailin; Jiang, Cheng] China Pharmaceut Univ, Jiang Su Key Lab Drug Design & Optimizat, Tongjiaxiang 24, Nanjing 210009, Peoples R China; [Ma, Zonghui; Li, Guoxin; Liang, Dailin; Li, Luanfeng; Jiang, Cheng] China Pharmaceut Univ, Dept Med Chem, Tongjiaxiang 24, Nanjing 210009, Peoples R China; [Jiang, Ling; Liu, Li] China Pharmaceut Univ, Key Lab Drug Metab & Pharmacokinet, Tongjiaxiang 24, Nanjing 210009, Peoples R China published Design, synthesis of 1,3-dimethylpyrimidine-2,4-diones as potent and selective aldehyde dehydrogenase 1A1 (ALDH1A1) inhibitors with glucose consumption improving activity in 2020, Cited 21. Recommanded Product: 62-23-7. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7.

LDH1A1, one of 19 NAD(P)(+)-dependent aldehyde dehydrogenases, participates in multiple metabolic pathways and has been indicated to play an important role in obesity and diabetes. In this study, a series of 1,3-di-methylpyrimidine-2,4-diones were designed, synthesized and evaluated as novel selective aldehyde dehy-drogenase 1A1 inhibitors. Among them, compounds 46, 50, 53, 56 and 57 exhibited excellent inhibitory activity against ALDH1A1 with IC50 values in the low nanomolar range and high selectivity over ALDH1A2, ALDH1A3, ALDH2 and ALDH3A1. Furthermore, in vitro study demonstrated that compound 57 effectively improved glucose consumption in HepG2 cells compared to compound 1 (CM026).

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Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Authors Naef, R in MDPI published article about STANDARD MOLAR ENTHALPY; STRUCTURE-PROPERTY RELATIONSHIPS; THERMODYNAMIC PROPERTIES; IONIC LIQUIDS; THERMOPHYSICAL PROPERTIES; TEMPERATURE-RANGE; GROUP ADDITIVITY; VAPOR-PRESSURES; THERMAL-ANALYSIS; COMPUTATIONAL THERMOCHEMISTRY in [Naef, Rudolf] Univ Basel, Dept Chem, CH-4003 Basel, Switzerland in 2019, Cited 287. Name: 4-Nitrobenzoic acid. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7

A universally applicable method for the prediction of the isobaric heat capacities of the liquid and solid phase of molecules at 298.15 K is presented, derived from their true volume. The molecules’ true volume in A(3) is calculated on the basis of their geometry-optimized structure and the Van-der-Waals radii of their constituting atoms by means of a fast numerical algorithm. Good linear correlations of the true volume of a large number of compounds encompassing all classes and sizes with their experimental liquid and solid heat capacities over a large range have been found, although noticeably distorted by intermolecular hydrogen-bond effects. To account for these effects, the total amount of 1303 compounds with known experimental liquid heat capacities has been subdivided into three subsets consisting of 1102 hydroxy-group-free compounds, 164 monoalcohols/monoacids, and 36 polyalcohols/polyacids. The standard deviations for Cp(liq,298) were 20.7 J/mol/K for the OH-free compunds, 22.91 J/mol/K for the monoalcohols/monoacids and 16.03 J/mol/K for the polyols/polyacids. Analogously, 797 compounds with known solid heat capacities have been separated into a subset of 555 OH-free compounds, 123 monoalcohols/monoacids and 119 polyols/polyacids. The standard deviations for Cp(sol,298) were calculated to 23.14 J/mol/K for the first, 21.62 J/mol/K for the second, and 19.75 J/mol/K for the last subset. A discussion of structural and intermolecular effects influencing the heat capacities as well as of some special classes, in particular hydrocarbons, ionic liquids, siloxanes and metallocenes, has been given. In addition, the present method has successfully been extended to enable the prediction of the temperature dependence of the solid and liquid heat capacities in the range between 250 and 350 K.

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Phthalazine – Wikipedia,
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Quality Control of 4-Nitrobenzoic acid. In 2019 EUR J ORG CHEM published article about IN-SITU GENERATION; DIFLUOROMETHYL DIAZOMETHANE; TRIFLUOROMETHYL DIAZOMETHANE; 3+2 CYCLOADDITION; CARBOXYLIC-ACIDS; ETHOSUXIMIDE; DERIVATIVES; FLUORINE; CF3CHN2; 2,2,2-TRIFLUORODIAZOETHANE in [Gao, Yu; Peng, Shan-Qing; Liu, De-Yong; Rui, Pei-Xin; Hu, Xiang-Guo] Jiangxi Normal Univ, Natl Engn Res Ctr Carbohydrate Synth, Nanchang 330022, Jiangxi, Peoples R China; [Gao, Yu; Peng, Shan-Qing; Liu, De-Yong; Rui, Pei-Xin; Hu, Xiang-Guo] Jiangxi Normal Univ, Key Lab Small Funct Organ Mol, Minist Educ, Nanchang 330022, Jiangxi, Peoples R China in 2019, Cited 72. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7.

A general and efficient method for the synthesis N-difluoroethyl imides has been developed. This copper-catalyzed four-component reaction proceeds via in-situ generated difluorodiazomethane, which does not require prior formation and transferring. The reaction is scalable, tolerant toward a range of functional groups, and also suitable for the late-stage functionalization of drugs and drug-like molecules.

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Phthalazine – Wikipedia,
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An article Facile synthesis of acyl sulfonamides from carboxyic acids using the Mukaiyama reagent WOS:000456353000013 published article about DISCOVERY; EFFICIENT in [Chen, Ling; Luo, Guanglin] Bristol Myers Squibb Res & Dev, POB 4000, Princeton, NJ 08543 USA in 2019, Cited 15. HPLC of Formula: C7H5NO4. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7

A fast and convenient method using the Mukaiyama reagent was developed to prepare acyl sulfonamides from carboxylic acids and sulfonamides. This methodology is effective for a range of acids and sulfonamides proceeding in moderate to good yields with the majority of reactions complete within one hour under the optimized condition. (C) 2018 Elsevier Ltd. All rights reserved.

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Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

An article Synthesis of a human long-term oxymetholone metabolite WOS:000486110300004 published article about ANABOLIC-STEROIDS; STEREOSELECTIVE REDUCTION; URINARY METABOLITES; IDENTIFICATION; CHROMATOGRAPHY in [Kratena, Nicolas; Biedermann, Nina; Enev, Valentin S.; Gaertner, Peter] Vienna Univ Technol, Inst Appl Synthet Chem, Vienna, Austria; [Weil, Matthias] Vienna Univ Technol, Inst Chem Technol & Analyt, Vienna, Austria; [Stojanovic, Biljana; Goeschl, Lorenz; Gmeiner, Guenter] Seibersdorf Lab GmbH, Doping Control Lab, Seibersdorf, Austria in 2019, Cited 26. Product Details of 62-23-7. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7

A long-term metabolite of the doping agent oxymetholone (OXM-M2, 17 beta-hydroxymethyl-2,17 alpha-methyl-18-norandrost-13-en-3-one) which has been identified by GC-MS/MS was synthesized from commercially available materials. Two efficient synthetic routes to access both C-17 epimers of tentative metabolites were developed. The identity and molecular configuration of the in vivo metabolite: 17 beta-hydroxymethyl-2 alpha,17 alpha-methyl-18-norandrost-13-en-3-one was confirmed by single crystal X-ray diffraction.

Product Details of 62-23-7. Welcome to talk about 62-23-7, If you have any questions, you can contact Kratena, N; Biedermann, N; Stojanovic, B; Goschl, L; Weil, M; Enev, VS; Gmeiner, G; Gartner, P or send Email.

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Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Authors Xu, YW; Xu, XZ; Wu, B; Gan, CL; Lin, XY; Wang, J; Ke, F in WILEY-V C H VERLAG GMBH published article about NONACTIVATED CARBOXYLIC-ACIDS; CHEMISTRY RESEARCH AREAS; DIRECT AMIDATION; ALPHA,BETA-UNSATURATED AMIDES; C-O; AMINES; SUBSTITUTION; PERSPECTIVE; GENERATION; AMINATION in [Xu, Yiwen; Xu, Xiuzhi; Wu, Bin; Gan, Chenling; Lin, Xiaoyan; Wang, Jin; Ke, Fang] Fujian Med Univ, Inst Mat Med, Sch Pharm, Fujian Prov Key Lab Nat Med Pharmacol, Fuzhou 350122, Peoples R China in 2020, Cited 77. HPLC of Formula: C7H5NO4. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7

A visible-light-catalyzed radical N-acylation of amines with carboxylic acids was achieved by means of eosin Y as the photocatalyst under aqueous medium without any transition-metal-based catalytic systems. The new method takes advantages of visible-light photocatalysis to generate the amides under mild conditions. A variety of amides have been synthesized in good to excellent yields. Moreover, the strategy was successfully applied in the preparation of paracetamol.

Welcome to talk about 62-23-7, If you have any questions, you can contact Xu, YW; Xu, XZ; Wu, B; Gan, CL; Lin, XY; Wang, J; Ke, F or send Email.. HPLC of Formula: C7H5NO4

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Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

An article Synthesis of novel of 2, 5-disubstituted 1, 3, 4-oxadiazole derivatives and their in vitro anti-inflammatory, anti-oxidant evaluation, and molecular docking study WOS:000536456300010 published article about PHARMACOLOGICAL EVALUATION; ANTIBACTERIAL ACTIVITY; ANTIMICROBIAL ACTIVITY; ACCURATE DOCKING; OXAZOLIDINONE; OXADIAZOLES; DESIGN; GLIDE in [Kashid, Bharat B.; Salunkhe, Pravin H.; Dongare, Balasaheb B.; Ghanwat, Anil A.] Solapur Univ, Sch Chem Sci, Chem Res Lab, Solapur 413255, India; [Salunkhe, Pravin H.] CSIR Natl Chem Lab, Dr Homi Bhabha Rd, Pune 411008, Maharashtra, India; [More, Kishor R.] Shandong Keyuan Pharmaceut Co Ltd, Keyuan St, Jinan, Shandong, Peoples R China; [Khedkar, Vijay M.] Vishwakarma Univ, Sch Pharm, Survey 2,3,4 Laxminagar, Pune 411048, Maharashtra, India in 2020, Cited 43. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7. Formula: C7H5NO4

A series of novel 2, 5-disubstituted 1, 3, 4-Oxadiazole derivatives as a potential anti-inflammatory, and antioxidant agent were synthesized via cyclisation. Hydrazide molecule treated with substituted acids in the presence of phosphorus oxychloride (POCl3) as an efficient reagent as well as solvent by conventional method with shorter reaction time and excellent yield. The newly synthesized 1, 3, 4-oxadiazole derivatives exhibited excellent to good anti-inflammatory and anti-oxidant activities compaired to the standard drugs. Molecular docking study on the crucial anti-inflammatory target-cyclooxygenase-2 (COX-2) revealed the ability of the scaffold to correctly recognize the active site and achieve significant bonded and non-bonded interactions with key residues therein. This study could identify potential compounds which can be pertinent starting points for structure-based drug design to obtain newer anti-inflammatory agents.

Formula: C7H5NO4. Welcome to talk about 62-23-7, If you have any questions, you can contact Kashid, BB; Salunkhe, PH; Dongare, BB; More, KR; Khedkar, VM; Ghanwat, AA or send Email.

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Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

An article Mechanism-based structure-activity relationship (SAR) analysis of aromatic amines and nitroaromatics carcinogenicity via statistical analyses based on CPDB WOS:000472589900002 published article about HETEROAROMATIC AMINES; AMES TEST; MUTAGENICITY; QSAR; RISK; HYDROCARBONS; EPIDEMIOLOGY; PERMEABILITY; METABOLISM; OXIDATION in [Wan, Wen-xin; Zhang, Jing; Shen, Fei; Deng, Shi-huai; Xiao, Yin-long; Huang, Chu-rui; Tian, Dong; He, Jin-song] Sichuan Agr Univ, Inst Ecol & Environm Sci, Chengdu 611130, Sichuan, Peoples R China; [Wan, Wen-xin; Zhang, Jing; Shen, Fei; Luo, Ling; Deng, Shi-huai; Xiao, Hong; Tian, Dong; He, Jin-song; Wang, Ying-jun] Sichuan Agr Univ, Coll Environm, Chengdu 611130, Sichuan, Peoples R China; [Chen, Yi] Environm Monitoring Ctr Chengdu, Chengdu 610041, Sichuan, Peoples R China; [Zhang, Jing] Sichuan Univ, State Key Lab Hydraul & Mt River Engn, Chengdu 610056, Sichuan, Peoples R China; [Zhou, Wei; Deng, Ou-ping] Sichuan Agr Univ, Coll Resource, Chengdu 610030, Sichuan, Peoples R China; [Yang, Hua] Sichuan Agr Univ, Coll Forestry, Chengdu 610030, Sichuan, Peoples R China in 2019, Cited 65. Product Details of 62-23-7. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7

Cancer is a leading cause of human mortality around the globe. In this study, mechanism-based SAR (Structure Activity Relationship) was employed to investigate the carcinogenicity of aromatic amines and nitroaromatics based on CPDB. Principal component analysis and cluster analysis were used to construct the SAR model. Principle component analysis generated three principal components from 12 mechanism-based descriptors. The extracted principal components were later used for cluster analysis, which divided the selected 55 chemicals into six clusters. The three principal components were proposed to describe the transport, reactivity and electrophilicity properties of the chemicals. Cluster analysis indicated that the relevant transport properties positively correlated with the carcinogenic potential and were contributing factors in determining the cardnogenicity of the studied chemicals. The mechanism-based SAR analysis suggested the electron donating groups, electron withdrawing groups and planarity are significant factors in determining the carcinogenic potency for studied aromatic compounds. The present study may provide insights into the relationship between the three proposed properties and the carcinogenesis of aromatic amines and nitroaromatics.

Welcome to talk about 62-23-7, If you have any questions, you can contact Wan, WX; Chen, Y; Zhang, J; Shen, F; Luo, L; Deng, SH; Xiao, H; Zhou, W; Deng, OP; Yang, H; Xiao, YL; Huang, CR; Tian, D; He, JS; Wang, YJ or send Email.. Product Details of 62-23-7

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Nejad, MJ; Salamatmanesh, A; Heydari, A in [Nejad, Masoumeh Jadidi; Salamatmanesh, Arefe; Heydari, Akbar] Tarbiat Modares Univ, Chem Dept, POB 14155-4838, Tehran, Iran published Copper (II) immobilized on magnetically separable L-arginine-beta-cyclodextrin ligand system as a robust and green catalyst for direct oxidation of primary alcohols and benzyl halides to acids in neat conditions in 2020, Cited 61. Recommanded Product: 62-23-7. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7.

Copper (II) immobilized on L-arginine-beta-cyclodextrin-functionalized magnetite nanoparticles (nano-Fe3O4@L-arginine-CD-Cu(II)) were successfully synthesized and fully characterized using FT-IR, XRD, SEM, EDX, ICP, TGA and VSM techniques. The catalytic activity of these magnetically retrievable nanoparticles was evaluated in the direct oxidation of primary alcohols and benzyl halides to acids in neat conditions that was observed to proceed well and products were obtained in good yields. In addition to showing good catalytic activity, the magnetic catalyst is easy to synthesize and can be recycled at least five times with little loss in activity. (C) 2020 Elsevier B.V. All rights reserved.

Recommanded Product: 62-23-7. Welcome to talk about 62-23-7, If you have any questions, you can contact Nejad, MJ; Salamatmanesh, A; Heydari, A or send Email.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem