Category: phthalazine

I found the field of Chemistry very interesting. Saw the article Rh(III)-Catalyzed Intramolecular Oxidative Annulation of Propargyl Amino Phenyl Benzamides to Access Pyrido/ Isoquinolino Quinoxalinones published in 2019. Computed Properties of C7H5NO4, Reprint Addresses Reddy, MS (corresponding author), CSIR, OSPC Div, Indian Inst Chem Technol, Hyderabad 500007, Andhra Pradesh, India.; Reddy, MS (corresponding author), Acad Sci & Innovat Res, New Delhi 110001, India.. The CAS is 62-23-7. Through research, I have a further understanding and discovery of 4-Nitrobenzoic acid

A rhodium catalyzed copper mediated double oxidative annulation of propargylamino phenyl benzamides is developed. A quick assembly of tri, tetra and penta cyclic pyrido/isoquinolo-quinoxilines are thus achieved from readily available linear substrates. The reaction is shown to be very general by accommodating a large variety of substrates in the transformation. A mechanism through an amide directed C-H bond activation followed by an intramolecular alkyne activation/annulation followed by an oxidation is postulated.

Welcome to talk about 62-23-7, If you have any questions, you can contact Kumar, GR; Kumar, R; Rajesh, M; Sridhar, B; Reddy, MS or send Email.. Computed Properties of C7H5NO4

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

In 2020.0 EUR J MED CHEM published article about MATRIX-METALLOPROTEINASE INHIBITORS; CANCER-CELL INVASION; BREAST-CANCER; MATRIX-METALLOPROTEINASE-9 ACTIVITY; CRYSTAL-STRUCTURES; TUMOR-GROWTH; DESIGN; ROLES; MULTICOMPONENT; OVEREXPRESSION in [Ayoup, Mohammed Salah; Fouad, Manar Ahmed; Abdel-Hamid, Hamida; Ramadan, El Sayed] Alexandria Univ, Fac Sci, Chem Dept, Alexandria 21321, Egypt; [Abu-Serie, Marwa M.] City Sci Res & Technol Applicat SRTA City, Genet Engn & Biotechnol Res Inst, Med Biotechnol Dept, Alexandria, Egypt; [Noby, Ahmed] Pharos Univ Alexandria, Fac Pharm, Dept Microbiol & Immunol, Alexandria 21311, Egypt; [Teleb, Mohamed] Alexandria Univ, Fac Pharm, Dept Pharmaceut Chem, Alexandria 21521, Egypt in 2020.0, Cited 84.0. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7. COA of Formula: C7H5NO4

Matrix metalloproteinases (MMPs) are major modulators of the tumor microenvironment. They participate in extracellular matrix turnover, tumor growth, angiogenesis and metastasis. Accordingly, MMPs inhibition seems to be ideal solution to control cancer. Many MMPs inhibitors have been introduced ranging from hydroxamate-based peptidomimetics to the next generation non-hydroxamate inhibitors. Among MMPs, MMP-9 is attractive druggable anticancer target. Studies showed that inhibiting AKT, the central signaling node of MMP-9 upregulation, provides additional MMP-9 blockade. Furthermore, caspase-dependent AKT cleavage leads to cell death. Herein, Ugi MCR was utilized as a rapid combinatorial approach to generate various decorated bis-amide scaffolds as dual MMP-9/AKT inhibitors endowed with caspase 3/7 activation potential. The target adducts were designed to mimic the thematic structural features of non-hydroxamate MMP inhibitors. p-Nitrophenyl isonitrile 1 was utilized as structure entry to Ugi products with some structural similarities to amide-based caspase 3/7 activators. Besides, various acids, amines and aldehydes were employed as Ugi educts to enrich the SAR data. All adducts were screened for cytotoxicity against normal fibroblasts and three cancer cell lines; MCF-7, NFS-60 and HepG-2 utilizing MTT assay. 8,11 and 28 were more active and safer than doxorubicin with single-digit nM IC50 and promising selectivity. Mechanistically, they exhibited dual MMP-9/AKT inhibition at single-digit nM IC50 with excellent selectivity over MMP-1,-2 and -13, and induced >51% caspase 3/7 activation. Consequently, they induced >49% apoptosis as detected by flow cytometric analysis, and inhibited cell migration (metastasis) up to 97% in cancer cells. Docking simulations were nearly consistent with enzymatic evaluation, also declared possible binding modes and essential structure features of active compounds. In silico physicochemical properties, ligand efficiency and drug-likeness metrics were reasonable for all adducts. Interestingly, 8 and 28 can be considered as drug-like candidates. (C) 2019 Elsevier Masson SAS. All rights reserved.

COA of Formula: C7H5NO4. Welcome to talk about 62-23-7, If you have any questions, you can contact Ayoup, MS; Fouad, MA; Abdel-Hamid, H; Ramadan, E; Abu-Serie, MM; Noby, A; Teleb, M or send Email.

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Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Recently I am researching about ORGANIC ELECTROOPTIC MATERIALS; NONLINEAR-OPTICAL-PROPERTIES; STABILITY; THIAZOLE; DESIGN; THIOPHENE; MONOMERS, Saw an article supported by the UGC, New Delhi under the CPEPA Program [8-2/2008(NS/PE)]; DST-PURSE-Phase-II Program [SR/PURSE Phase 2/12(G)]. Published in ROYAL SOC CHEMISTRY in CAMBRIDGE ,Authors: Doddamani, RV; Rachipudi, PS; Pattanashetti, NA; Kariduraganavar, MY. The CAS is 62-23-7. Through research, I have a further understanding and discovery of 4-Nitrobenzoic acid. SDS of cas: 62-23-7

This paper emphasizes the preparation of nonlinear optical (NLO) responsive chromophores and their corresponding polymers. Initially, the carboxyl acid group-based precursors of the chromophores containing strong acceptors such as nitro-substituted thiazole and thiadiazole groups were prepared and subjected to condensation reactions with a monomer to yield a series of polymers. Prior to the synthesis of the polymers, a thermally crosslinkable monomer, 2,6-di-(octy-1-nyl)-p-phenylenediamine, was synthesized by a Sonogashira coupling reaction. All the synthesized precursors, the monomer and their corresponding polymers were characterized using FTIR, H-1 NMR, and CHN analyses and UV-Vis spectrophotometry. Simultaneously, the molecular structures of the precursors were designed and optimized using the Gaussian 16 (Revision A.03) program. The dipole moments, energy band gaps between the HOMO and LUMO, polarizabilities and first order hyperpolarizabilities of the precursors were calculated theoretically using the DFT approach; the values were in the ranges of 9.4321-15.3354 D, 1.3709-1.4146 eV, 53.40-64.80 x 10(-24) esu and 3703.35-5254.90 x 10(-32) esu, respectively. The inherent viscosities (eta inh) of the polymers were measured by an Ubbelohde viscometer and were in the range of 0.2453-0.2860 dl g(-1). The thermal behavior of the polymers was investigated using DSC and TGA. The glass transition temperatures of the polymers were in the range of 190-218 degrees C. The thicknesses and refractive indices of the thin films were determined by ellipsometry, and the values were in the range of 0.100-0.127 mu m and 1.211-1.426, respectively. The molecular orientations in the thin polymer films were induced by corona poling and were ascertained using both a UV-Vis spectrophotometer and an atomic force microscope. The second harmonic generations (SHGs) of the poled polymers were determined using an Nd-YAG laser. The SHG coefficients (d(33)) ranged between 98.30 and 106.04 pm V-1 at 532 nm. Among the synthesized polymers, the polymer containing dinitro-substituted thiazole demonstrated an excellent SHG coefficient as high as 106.04 pm V-1. Furthermore, none of the polymers showed SHG decay below 100 degrees C, and they retained 95% of their SHG values even up to 600 h. Based on its enhanced NLO efficiency and long temporal stability, the polymer containing dinitro-substituted thiazole can be a particularly promising candidate for photonic devices.

SDS of cas: 62-23-7. Bye, fridends, I hope you can learn more about C7H5NO4, If you have any questions, you can browse other blog as well. See you lster.

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Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

An article One-pot and regioselective synthesis of polysubstituted 3,4-dihydroquinazolines and 4,5-dihydro-3H-1,4-benzodiazepin-3-ones by sequential Ugi/Staudinger/aza-Wittig reaction WOS:000458708500011 published article about FACILE SYNTHESIS; RECEPTOR ANTAGONIST; EFFICIENT SYNTHESIS; COUPLING REACTION; DERIVATIVES; CYCLIZATION; ACCESS; SERIES; ROUTE; CELLS in [Xiong, Jun; Wei, Xiao; Wan, Yu-Chen; Ding, Ming-Wu] Cent China Normal Univ, Key Lab Pesticide & Chem Biol, Minist Educ, Hubei Int Sci & Technol Cooperat Base Pesticide &, Wuhan, Hubei, Peoples R China; [Xiong, Jun] Hubei Univ Sci & Technol, Coll Pharm, Xianning 437100, Hubei, Peoples R China in 2019.0, Cited 59.0. HPLC of Formula: C7H5NO4. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7

An efficient one-pot and regioselective synthesis of 3,4-dihydroquinazolines and 4,5-dihydro-3H-1,4-benzodiazepin-3-ones by Ugi/Staudinger/aza-Wittig sequence has been developed. The Ugi reactions of 2-azidobenzylamines, aldehydes, acids (or alpha-keto acids) and isocyanides produced the azide intermediates, which were then treated with tributylphosphine or triphenylphosphine to give poly-substituted 3,4-dihydroquinazolines or 4,5-dihydro-3H-1,4-benzodiazepin-3-ones in moderate to good yields by tandem Standinger/aza-Wittig reactions. (C) 2019 Elsevier Ltd. All rights reserved.

HPLC of Formula: C7H5NO4. Welcome to talk about 62-23-7, If you have any questions, you can contact Xiong, J; Wei, X; Wan, YC; Ding, MW or send Email.

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Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

An article Choline Chloride/Urea as an Eco-Friendly Deep Eutectic Solvent for TCT-Mediated Amide Coupling at Room Temperature WOS:000467344100001 published article about CARBOXYLIC-ACIDS; BOND FORMATION; IONIC LIQUIDS; 2,4,6-TRICHLORO-1,3,5-TRIAZINE TCT; OXIDATIVE AMIDATION; CYANURIC CHLORIDE; ACTIVATION; ALDEHYDES; PHENOLS; REAGENT in [Salimiyan, Kimiya] Persian Gulf Univ, Fac Sci, Dept Chem, Bushehr 75169, Iran; [Saberi, Dariush] Persian Gulf Univ, Marine Chem Dept, Fac Marine Sci & Technol, Bushehr 75169, Iran; [Saberi, Dariush] Persian Gulf Univ, Fisheries & Aquaculture Dept, Fac Agr & Nat Resources, Bushehr 75169, Iran in 2019, Cited 59. Quality Control of 4-Nitrobenzoic acid. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7

A desirable alternative to organic solvents, very cheap, non-toxic and biodegradable deep eutectic solvent (DES) based on choline chloride and urea was introduced for 2,4,6-trichloro triazine mediated amide bond formation between carboxylic acids and amines at room temperature. Sub-stoichiometric amount of TCT was used as a cheap and readily available C-O activating reagent. Various derivatives of amines were coupled with carboxylic acids, via triacylated triazine intermediate, resulting the reaction of acids with TCT, and the corresponding amides were obtained in moderate to good yields.

Quality Control of 4-Nitrobenzoic acid. Welcome to talk about 62-23-7, If you have any questions, you can contact Salimiyan, K; Saberi, D or send Email.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

In 2020 MED CHEM RES published article about BIOLOGICAL EVALUATION; MOLECULAR DOCKING; ELLIPTICINE DERIVATIVES; AMIDE DERIVATIVES; POTENT; INHIBITORS; ANALOGS; DISCOVERY; BINDING; SERIES in [Kala, Pruthu; Khasim Sharif, Syed; Ramachandran, Dittakavi] Acharya Nagarjuna Univ, Dept Chem, Nagarjuna Nagar 522510, Andhra Pradesh, India; [Murali Krishna, CH.] Adikavi Nannaya Univ, Dept Chem, Rajamahendravaram 533296, Andhra Pradesh, India in 2020, Cited 57. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7. Product Details of 62-23-7

A library of 1,2,4-oxadiazole functionalized quinoline derivatives (13a-j) were synthesized and their structures were confirmed by H-1 NMR, (CNMR)-C-13 and Mass Spectral analysis. Further, these compounds were evaluated for their anticancer activity against four human cancer cell lines, namely MCF-7 (breast), A549 (lung), DU-145 (prostate) and MDA MB-231 (breast) using Etoposide as the positive control. Most of these derivatives exhibited more potent activity towards the four cancer cell lines compared to Etoposide. Amongst all the compounds tested, compounds 13b, 13c, 13h, 13i and 13j exhibited promising activity. Further of these compounds 13b, 13i and 13j exhibited excellent activity, when compared with Etoposide.

Welcome to talk about 62-23-7, If you have any questions, you can contact Kala, P; Sharif, SK; Krishna, CM; Ramachandran, D or send Email.. Product Details of 62-23-7

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Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

An article Integrated continuous flow/batch protocol for the photoreduction of ortho-methyl phenyl ketones using water as the hydrogen source WOS:000471669100004 published article about CONTINUOUS-FLOW SYNTHESIS; O-QUINODIMETHANES; ALDEHYDES; BENZYLATION; REDUCTION; CHEMISTRY; EFFICIENT; CATALYST in [Aand, Dnyaneshwar; Mahajan, Bhushan; Pabbaraja, Srihari; Singh, Ajay K.] Indian Inst Chem Technol, CSIR, Dept Organ Synth & Proc Chem, Hyderabad, India in 2019, Cited 41. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7. Computed Properties of C7H5NO4

Direct utilization of the abundant hydrogen in water for the transfer hydrogenation reaction (THR) is a very attractive and challenging research area. Herein, we report the first integrated photo-transfer hydrogenation reaction (PTHR) platform for the synthesis of benzhydrol derivatives (26 examples, 33-89% yields) with water as a green reducing agent. This transformation is time and labor-efficient, catalyst-free, and economical and utilizes readily available hydrocarbon(s) (o-methyl phenyl ketones) as starting materials.

Computed Properties of C7H5NO4. Bye, fridends, I hope you can learn more about C7H5NO4, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

HPLC of Formula: C7H5NO4. Verma, N; Tao, YW; Marcial, BL; Kraka, E in [Verma, Niraj; Kraka, Elfi] Southern Methodist Univ, Dept Chem, Computat & Theoret Grp CATCO, 3215 Daniel Ave, Dallas, TX 75275 USA; [Tao, Yunwen] NYU, Dept Chem, 100 Wash Sq East, New York, NY 10003 USA; [Marcial, Bruna Luana] Rodovia BR153,KM633 Zona Rural, BR-75650000 Morrinhos, Go, Brazil published Correlation between molecular acidity (pK(a)) and vibrational spectroscopy in 2019.0, Cited 125.0. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7.

Molecular acidity is an important physicochemical property, which is often represented by the pK(a) value as the measure of acidity strength. However, the accurate calculation and prediction of pK(a) values is still an unsolved problem for computational chemistry. In this work, we present for the first time a direct correlation between pK(a) values and local vibrational frequencies for 15 different groups of compounds with various substituents. This correlation was derived from a quadratic function of two selected local vibrational frequencies as independent variables used to characterize electronic structure features influencing the molecular acidity. In total, 180 molecules were investigated with this correlation model. For each group of molecules, we found a strong correlation with root mean squared errors and mean absolute errors of less than 0.11 and 0.09 pK(a) units, respectively. The correlation between pK(a) and local vibrational modes, established in this work, can be generally applied to all compounds whose pK(a) values are dominated by electronic substituent effects. In this regard, the new correlation model constitutes a powerful link between the well-known Hammett equation and vibrational spectroscopy. Furthermore, it allows a quick prediction of the pK(a) values for new group members with different substituents.

HPLC of Formula: C7H5NO4. Bye, fridends, I hope you can learn more about C7H5NO4, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Yavari, I; Khajeh-Khezri, A; Ghorbanzadeh, M; Halvagar, MR in [Yavari, Issa; Khajeh-Khezri, Aliyeh; Ghorbanzadeh, Meysam] Tarbiat Modares Univ, Dept Chem, POB 14115-175, Tehran, Iran; [Halvagar, Mohammad Reza] Chem & Chem Engn Res Ctr Iran, Dept Inorgan Chem, POB 14335-186, Tehran, Iran published Synthesis of novel alpha-acyloxyamides using choline chloride-based deep eutectic solvent in 2019, Cited 27. Product Details of 62-23-7. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7.

The Passerini three-component reaction between acenaphthylene-1,2-dione, alkyl isocyanides, and carboxylic acids, leading to the formation of alpha-acyloxyamides in common organic solvents (CH2Cl2, MeOH) and choline chloride-based deep eutectic solvent, is described. The reaction in the latter solvent proceeded faster compared to common organic solvents. The structure of a typical product was confirmed by X-ray crystallography. [GRAPHICS] .

Product Details of 62-23-7. Bye, fridends, I hope you can learn more about C7H5NO4, If you have any questions, you can browse other blog as well. See you lster.

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Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Allu, SR; Banne, S; Jiang, J; Qi, N; Guo, J; He, Y in [Allu, Srinivasa Rao; Banne, Sreenivas; Jiang, Jia; Qi, Na; Guo, Jian; He, Yun] Chongqing Univ, Sch Pharmaceut Sci, Chongqing Key Lab Nat Prod Synth & Drug Res, Chongqing 401331, Peoples R China; [Qi, Na] Chongqing Univ, Coll Bioengn, Biomed & Hlth Engn Lab, Chongqing 401331, Peoples R China published A Unified Synthetic Approach to Optically Pure Curvularin-Type Metabolites in 2019.0, Cited 40.0. HPLC of Formula: C7H5NO4. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7.

A unified and concise approach to the synthesis of nine curvularin-type metabolites and two analogues has been developed with few steps and high yields. Among them, sumalactones A-D were synthesized for the first time. The key steps in this approach included esterification, Friedel-Crafts acylation, and ring-closing metathesis (or cross metathesis).

HPLC of Formula: C7H5NO4. Welcome to talk about 62-23-7, If you have any questions, you can contact Allu, SR; Banne, S; Jiang, J; Qi, N; Guo, J; He, Y or send Email.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem