Category: phthalazine

Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics, Name: 1-(Trifluoromethyl)-4-vinylbenzene, 402-50-6, Name is 1-(Trifluoromethyl)-4-vinylbenzene, SMILES is FC(F)(F)C1=CC=C(C=C)C=C1, belongs to phthalazine compound. In a document, author is Goli-Jolodar, Omid, introduce the new discover.

Introduction of a Novel Nano Sized N-Sulfonated Bronsted Acidic Homogeneous Catalyst for the Promotion of the Synthesis of 2H-Indazolo[2,1-b] Phthalazine-1,6,11(13H)-Triones

In this research work, 4,4′-(butane-1,4-diyl) bis(1-sulfo-1,4-diazabicyclo[2.2.2]octane-1,4-diium) tetrachloride (NS-C4(DABCO-SO3H)(2)center dot 4Cl) as a new nano-sized N-sulfonic acid was prepared and characterized using different types of spectroscopic methods including FT-IR, H-1 NMR, C-13 NMR, XRD, TGA and SEM analysis. This new reagent was efficiently used as catalyst for the promotion of the one-pot synthesis of 2H-indazolo[2,1-b] phthalazine-1,6,11(13H)-triones derivatives, as a class of biologically active compounds with important pharmaceutical properties, under solvent-free conditions during short reaction times in high yields.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 402-50-6 is helpful to your research. Name: 1-(Trifluoromethyl)-4-vinylbenzene.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

In an article, author is Maleki, Behrooz, once mentioned the application of 5267-64-1, Safety of D-Penylalaninol, Name is D-Penylalaninol, molecular formula is C9H13NO, molecular weight is 151.2056, MDL number is MFCD00064298, category is phthalazine. Now introduce a scientific discovery about this category.

In Situ Generated HCl: A Highly Efficient Catalyst for One-Pot Synthesis of 1H-Indazolo [1,2-b]phthalazine-1,6,11-triones and 1H-pyrazolo[1,2-b]phthalazine-5,10-diones under Solvent-Free Conditions

The rapid and environmental synthetic route to produce 1H-indazolo[1,2-b] phthalazine-1,6,11-triones and 1H-pyrazolo[1,2-b]phthalazine-5,10-diones derivatives have been developed via multicomponent and one-pot reactions of various aldehydes, cyclic or acyclic 1,3-diketones with: i) phthalhydrazide or ii) phthalic anhydride-hydrazinium hydroxide using wet 2,4,6-trichlorotriazine (TCT) as catalyst under solvent-free conditions. Simple and mild reaction conditions, the use of a cheap catalyst and easy workup and isolation are notable features of this method.

If you are interested in 5267-64-1, you can contact me at any time and look forward to more communication. Safety of D-Penylalaninol.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 140-75-0, Name is (4-Fluorophenyl)methanamine, molecular formula is C7H8FN, belongs to phthalazine compound. In a document, author is Fan, Mingxuan, introduce the new discover, SDS of cas: 140-75-0.

Pyridazine-Containing Diazatwistanthracene and Tetraazatwisttetracene: Synthesis, Crystal Structures and Third Order Non-linear Optical Properties

In this paper, two pyridazine-heterocycles-containing azaacenes 9,12-diphenylphenanthro[4,5-fgh]phthalazine (DPPA) and 2,9-di-tert-butyl-4,7,11,14-tetraphenylpyridazino[4′,5′:9,10] phenanthro[4,5-fgh]phthalazine (TPPA) have been synthesized and fully characterized. The single crystal analysis of TPPA showed that TPPA molecule exhibits a twisted structure with the dihedral angel of 27 degrees between pyrene and pyridazine unit, which suppresses the pi-pi stackings in the solid state. The two-photon absorption properties of DPPA and TPPA were investigated, respectively, by using the femtosecond Z-scan technique. The results showed that both DPPA and TPPA showed moderate two-photon absorption cross-section values, and the larger one was found to be 454 GM with TPPA. Obviously, the introduction of pyridazine ring into the skeleton of acenes forming a A-D-A structure could lead to a much larger two-photon absorption coefficient and two-photon absorption cross section.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 140-75-0. SDS of cas: 140-75-0.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Reference of 1439-36-7, As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 1439-36-7, Name is 1-(Triphenylphosphoranylidene)propan-2-one, SMILES is CC(C=P(C1=CC=CC=C1)(C2=CC=CC=C2)C3=CC=CC=C3)=O, belongs to phthalazine compound. In a article, author is Shi, Xin, introduce new discover of the category.

A Green Synthesis of Highly Functionalized 3-amino-2-phenylsulfonyl-1-alkyl/aryl-1H-pyrazolo[1,2-b]phthalazine-5,10-diones and Their Reduction and Photophysical Studies

3-Amino-2-benzenesulfonyl-1-alkyl/aryl-1H-pyrazolo[1,2-b]phthalazine-5,10-dione derivatives were synthesized by the one-pot, three-component condensation of phthalhydrazide, aldehydes, and (phenylsulfonyl)acetonitrile in EtOH using 2-hydroxyethylammonium acetate as catalyst. The advantages of this method include environmental friendliness, easy work-up, and excellent yields. The reduction of some products and photophysical properties were also investigated.

Reference of 1439-36-7, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 1439-36-7.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 767-00-0, Name is 4-Hydroxybenzonitrile, SMILES is OC1=CC=C(C=C1)C#N, belongs to phthalazine compound. In a document, author is Zhu, Mingfei, introduce the new discover, Formula: C7H5NO.

L-4, a Well-Tolerated and Orally Active Inhibitor of Hedgehog Pathway, Exhibited Potent Anti-tumor Effects Against Medulloblastoma in vitro and in vivo

Inhibition of aberrant Hedgehog (Hh) pathway had been proved to be a promising therapeutic intervention in cancers like basal cell carcinoma (BCC), medulloblastoma (MB), and so on. Two drugs (Vismodegib, Sonidegib) were approved to treat BCC and more inhibitors are in clinical investigation. However, the adverse effects and drug resistance restricted the use of Hh inhibitors. In the present study, 61 synthesized compounds containing central backbone of phthalazine or dimethylpyridazine were screened as candidates of new Hh signaling inhibitors by performing dual luciferase reporter assay. Among the compounds, L-4 exhibited an IC50 value of 2.33 nM in the Shh-Light II assay. L-4 strongly inhibited the Hh pathway in vitro and blocked the Hh pathway by antagonizing the smoothened receptor (Smo). Remarkably, L-4 could significantly suppress the Hh pathway activity provoked by Smo mutant (D473H) which showed strong resistant properties to existing drugs such as Vismodegib. Orally administered L-4 exhibited prominent dose-dependent anti-tumor efficacy in vivo in Ptch+/-; p53-/- MB allograft model. Furthermore, L-4 showed good tolerance in acute toxicity test using ICR mice. These evidences indicated that L-4 was a potent, well-tolerated, orally active inhibitor of Hedgehog pathway, and might be a promising candidate in development of Hh-targeted anti-cancer drugs.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 767-00-0 is helpful to your research. Formula: C7H5NO.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Electric Literature of 1676-73-9, Catalysts allow a reaction to proceed via a pathway that has a lower activation energy than the uncatalyzed reaction. 1676-73-9, Name is H-Glu(OBzl)-OH, SMILES is N[C@@H](CCC(OCC1=CC=CC=C1)=O)C(O)=O, belongs to phthalazine compound. In a article, author is Mahmoud, Naglaa F. H., introduce new discover of the category.

Molecular docking and biological assessment of substituted phthalazin-1(2H)-one derivatives

2, 4-Disubstituted phthalazin-1(2H)-one derivatives were synthesized via nucleophilic attack of N-2 of phthalazin-1(2H)-one derivatives on different alkyl halides. In addition, reactive phthalazinone acetohydrazide derivative was utilized as a scaffold to synthesize different heterocyclic systems. The assigned structures for all the newly synthesized derivatives were confirmed on the basis of elemental analyses and spectral data. Mechanistic illustrations for some of the synthesized compounds were also discussed. The synthesized compounds were evaluated for in vitro antimicrobial and antitumor activity. Most of the tested compounds exhibited significant potency as antimicrobial and antitumor agents. Moreover, MOE 2014.09 software was utilized to carry out computational studies to support the biological activity results.

Electric Literature of 1676-73-9, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 1676-73-9.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Chemistry is traditionally divided into organic and inorganic chemistry. The former is the study of compounds containing at least one carbon-hydrogen bonds. 139-66-2, Name is Diphenylsulfane, molecular formula is C12H10S, belongs to phthalazine compound, is a common compound. In a patnet, author is Muddala, N. Prasad, once mentioned the new application about 139-66-2, Category: phthalazines.

Inhibitor design to target a unique feature in the folate pocket of Staphylococcus aureus dihydrofolate reductase

Staphylococcus aureus (Sa) is a serious concern due to increasing resistance to antibiotics. The bacterial dihydrofolate reductase enzyme is effectively inhibited by trimethoprim, a compound with antibacterial activity. Previously, we reported a trimethoprim derivative containing an acryloyl linker and a dihydophthalazine moiety demonstrating increased potency against S. aureus. We have expanded this series and assessed in vitro enzyme inhibition (K-i) and whole cell growth inhibition properties (MIC). Modifications were focused at a chiral carbon within the phthalazine heterocycle, as well as simultaneous modification at positions on the dihydrophthalazine. MIC values increased from 0.0626-0.5 mu g/mL into the 0.5-1 mu g/mL range when the edge positions were modified with either methyl or methoxy groups. Changes at the chiral carbon affected K-i measurements but with little impact on MIC values. Our structural data revealed accommodation of predominantly the S-enantiomer of the inhibitors within the folate-binding pocket. Longer modifications at the chiral carbon, such as p-methylbenzyl, protrude from the pocket into solvent and result in poorer K-i values, as do modifications with greater torsional freedom, such as 1-ethylpropyl. The most efficacious K-i was 0.7 +/- 0.3 nM, obtained with a cyclopropyl derivative containing dimethoxy modifications at the dihydrophthalazine edge. The co-crystal structure revealed an alternative placement of the phthalazine moiety into a shallow surface at the edge of the site that can accommodate either enantiomer of the inhibitor. The current design, therefore, highlights how to engineer specific placement of the inhibitor within this alternative pocket, which in turn maximizes the enzyme inhibitory properties of racemic mixtures. (C) 2020 Elsevier Masson SAS. All rights reserved.

We’ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, 139-66-2. The above is the message from the blog manager. Category: phthalazines.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Chemistry, like all the natural sciences, begins with the direct observation of nature— in this case, of matter.103-36-6, Name is Ethyl cinnamate, SMILES is O=C(OCC)/C=C/C1=CC=CC=C1, belongs to phthalazine compound. In a document, author is Kefayati, Hassan, introduce the new discover, Product Details of 103-36-6.

Electrocatalytic multicomponent assembling of phthalhydrazide, aldehydes and malononitrile: An efficient approach to 1H-pyrazolo[1,2-b]phthalazine-5,10-diones

Electrocatalytic multicomponent transformation of phthalhydrazide, aromatic aldehydes and malononitrile in n-propanol in an undivided cell in the presence of sodium bromide as an electrolyte leads to 1H-pyrazolo[1,2-b]phthalazine-5,10-diones in short reaction times (4-8 min) and high yields (85-98%) at room temperature. The developed efficient electrocatalytic approach to the corresponding 1H-pyrazolo[1,2-b]phthalazine-5,10-diones is beneficial from the viewpoint of diversity-oriented large-scale processes and represents a new example of the ecologically pure synthetic concept for electrocatalytic multicomponent reactions strategy. (C) 2013 Academie des sciences. Published by Elsevier Masson SAS. All rights reserved.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 103-36-6. Product Details of 103-36-6.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Chemistry can be defined as the study of matter and the changes it undergoes. You’ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology. 103-36-6, Name is Ethyl cinnamate, molecular formula is , belongs to phthalazine compound. In a document, author is Makarem, S., Product Details of 103-36-6.

Electro-Organic Synthesis: An Efficient Method for the Preparation of Nanosized Particles of Phthalazine Derivatives via One-Pot Multicomponent Reactions

Aza heterocyclic compounds are major interest for organic chemists because of their mainly pharmacological activities and clinical applications such as antianxiety, antitumor, anticonvulsant, cardiotonic and vasorelaxant. This contribution describes an electrochemical approach for the preparation of nanosized particles of phthalazine in high yields and very short reaction time. The method is based on the one-pot multicomponent reaction (MCRs) of phthalhydrazide, malononitrile and aldehydes in propanol employing undivided cell in the presence of NaBr as an electrolyte. The product was characterized, after purification, using IR, (HNMR)-H-1, C-13 NMR, MS and SEM. This procedure provides a method by which nanoparticles are synthesized directly from phthalhydrazide, malononitrile and aldehydes insides of a routine protocol for the synthesis of nano particles of organic compounds in which the synthesized organic compound is transformed into nanosized particles using modem high technology, for example ultrahighpressure rapid expansion of supercritical solution, and supercritical antisolvent with enhanced mass transfer. Size reduction is a fundamental unit operation having important applications in pharmacy. It helps to improve solubility and bioavailability, reduce toxicity, enhance release, and provide better formulation opportunities for drugs.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 103-36-6, in my other articles. Product Details of 103-36-6.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Chemistry is traditionally divided into organic and inorganic chemistry. The former is the study of compounds containing at least one carbon-hydrogen bonds. 35661-39-3, Name is Fmoc-Ala-OH, molecular formula is C18H17NO4, belongs to phthalazine compound, is a common compound. In a patnet, author is Shirini, Farhad, once mentioned the new application about 35661-39-3, Computed Properties of C18H17NO4.

Synthesis of 2H-indazolo[2,1-b]phthalazine-1,6,11(13H)-triones using 1,4-disulfo-1,4-diazabicyclo[2.2.2]octane-1,4-diium dihydrogen sulfate {DABCO(HSO3)(2)(HSO4)(2)} as a new ionic liquid catalyst

1,4-Disulfo-1,4-diazabicyclo[2.2.2]octane-1,4-diium dihydrogen sulfate {DABCO(HSO3)(2)(HSO4)(2)} as a new ionic liquid, is prepared and characterized by using different methods including FT-IR, NMR, Mass and SEM analysis as well as determination of the Hammett acidity function. This reagent can be used as an efficient catalyst for the promotion of the synthesis of 2H-indazolo[2,1-b]phthalazine-1,6,11(13H)-trione derivatives as important biologically active compounds with pharmaceutical properties. All reactions are performed in the absence of solvent using small amounts of the catalyst. Easy preparation of the catalyst, simple and easy work-up, mild reaction conditions, green process, excellent yields and short reaction times are the most important advantages this of method. (C) 2015 Elsevier Ltd. All rights reserved.

We’ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, 35661-39-3. The above is the message from the blog manager. Computed Properties of C18H17NO4.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem