Category: phthalazine

An article Selective TEMPO-Oxidation of Alcohols to Aldehydes in Alternative Organic Solvents WOS:000525898100001 published article about DIMETHYL-SULFOXIDE; SECONDARY ALCOHOLS; SUPPORTED TEMPO; CYANIDE-FREE; OXIDANT; SALTS; NAOCL-CENTER-DOT-5H(2)O; MECHANISM; CATALYSTS; EFFICIENT in [Hinzmann, Alessa; Stricker, Michael; Busch, Jasmin; Glinski, Sylvia; Oike, Keiko; Groeger, Harald] Bielefeld Univ, Fac Chem, Ind Organ Chem & Biotechnol, Univ Str 25, D-33615 Bielefeld, Germany in 2020.0, Cited 39.0. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7. Quality Control of 4-Nitrobenzoic acid

The TEMPO-catalyzed oxidation of alcohols to aldehydes has emerged to one of the most widely applied methodologies for such transformations. Advantages are the utilization of sodium hypochlorite, a component of household bleach, as an oxidation agent and the use of water as a co-solvent. However, a major drawback of this method is the often occurring strict limitation to use dichloromethane as an organic solvent in a biphasic reaction medium with water. Previous studies show that dichloromethane cannot easily be substituted because a decrease of selectivity or inhibition of the reaction is observed by using alternative organic solvents. Thus, up to now, only a few examples are known in which after a tedious optimization of the reaction dichloromethane could be replaced. In order to overcome the current limitations, we were interested in finding a TEMPO-oxidation method in alternative organic solvents, which is applicable for various alcohol oxidations. As a result, we found a method for N-oxyl radical-catalyzed oxidation using sodium hypochlorite as an oxidation agent in nitriles as an organic solvent component instead of dichloromethane. Besides the oxidation of aromatic primary alcohols also aliphatic primary alcohols, secondary alcohols as well as dialcohols were successfully converted when using this method, showing high selectivity towards the carbonyl compound and low amounts of the acid side-product.

Quality Control of 4-Nitrobenzoic acid. Welcome to talk about 62-23-7, If you have any questions, you can contact Hinzmann, A; Stricker, M; Busch, J; Glinski, S; Oike, K; Groger, H or send Email.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

COA of Formula: C7H5NO4. Salimiyan, K; Saberi, D in [Salimiyan, Kimiya] Persian Gulf Univ, Fac Sci, Dept Chem, Bushehr 75169, Iran; [Saberi, Dariush] Persian Gulf Univ, Marine Chem Dept, Fac Marine Sci & Technol, Bushehr 75169, Iran; [Saberi, Dariush] Persian Gulf Univ, Fisheries & Aquaculture Dept, Fac Agr & Nat Resources, Bushehr 75169, Iran published Choline Chloride/Urea as an Eco-Friendly Deep Eutectic Solvent for TCT-Mediated Amide Coupling at Room Temperature in 2019, Cited 59. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7.

A desirable alternative to organic solvents, very cheap, non-toxic and biodegradable deep eutectic solvent (DES) based on choline chloride and urea was introduced for 2,4,6-trichloro triazine mediated amide bond formation between carboxylic acids and amines at room temperature. Sub-stoichiometric amount of TCT was used as a cheap and readily available C-O activating reagent. Various derivatives of amines were coupled with carboxylic acids, via triacylated triazine intermediate, resulting the reaction of acids with TCT, and the corresponding amides were obtained in moderate to good yields.

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Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Recently I am researching about HISTONE DEACETYLASE INHIBITORS; DESIGN, Saw an article supported by the . Product Details of 62-23-7. Published in BENTHAM SCIENCE PUBL LTD in SHARJAH ,Authors: Chen, TP; Jiang, HW; Zhou, JJ; Li, ZC; Huang, WC; Luo, YF; Zhao, YL. The CAS is 62-23-7. Through research, I have a further understanding and discovery of 4-Nitrobenzoic acid

Background: Histone deacetylases inhibitors (HDACIs) with different chemical structures have been reported to play an important role in the treatment of cancer. Objective: The study aims to modify the structure of Entinostat (MS-275) to discover new compounds with improved anti-proliferative activities and perform SAR studies on this class of bioactive compounds. Methods: Fourteen N-substituted benzamide derivatives were synthesized and their antiproliferative activities were tested with four cancer cell lines (MCF-7, A549, K562 and MDA-MB-231) by MTT assay. Results: Compared with MS-275, six compounds exhibited comparable or even better anti-proliferative activities against specific/certain cancer cell lines. Conclusion: The preliminary SARs showed that (i) the 2-substituent of the phenyl ring in the R group and heteroatoms of amide which can chelate with zinc ion are critical to the anti-proliferative activity and (ii) chlorine atom or nitro-group on the same benzene ring largely decreases their anti-proliferative activity. Molecular docking study illustrated the interaction (binding affinity) between the synthesized compounds and HDAC2 was observed to be similar to that of MS-275.

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Phthalazine – Wikipedia,
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I found the field of Chemistry very interesting. Saw the article N-Amino-7-azaindole as the N,N’-Bidentate Directing Group: Ruthenium-Catalyzed Oxidative Annulation of N-(7-Azaindole)benzamides with Alkynes via C-H Bond Activation published in 2019. Quality Control of 4-Nitrobenzoic acid, Reprint Addresses Ravikumar, PC (corresponding author), Natl Inst Sci Educ & Res NISER Bhubaneswar, Sch Chem Sci, Jatani Campus, Bhubaneswar 752050, Odisha, India.. The CAS is 62-23-7. Through research, I have a further understanding and discovery of 4-Nitrobenzoic acid

We report a new application of N-amino-7-azaindole as a new bidentate-directing group for [Ru(p-cymene)Cl-2](2)-catalyzed C(sp(2))-H alkenylation/annulation of N-(1H-pyrrolo[2,3-b]pyridin-1-yl)benzamides with internal alkynes to afford N-isoquinolono-7-azaindole via the formation of C-C and C-N bonds. The reaction shows a wide range of substrate scope with different symmetrical and unsymmetrical alkynes, affording the desired product in good to excellent yields. In the case of unsymmetrical alkynes, a highly regioselective product was obtained, which was confirmed by single-crystal X-ray crystallography. A new ruthenium-4-methyl-N-(1H-pyrrolo[2,3-b]pyridin-1-yl)benzamide complex was isolated, and its structure was confirmed by single-crystal X-ray crystallography.

Quality Control of 4-Nitrobenzoic acid. Welcome to talk about 62-23-7, If you have any questions, you can contact Sagara, PS; Siril, PF; Ravikumar, PC or send Email.

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Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

COA of Formula: C7H5NO4. Recently I am researching about IN-VITRO; INHIBITION; GP; EFFLUX; CELLS; MDR; PHARMACOKINETICS; MODULATION; MECHANISM; CANCER, Saw an article supported by the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81872733, 81872734, 81803353]; Jiangsu Qing Lan Project; Foundation of Jiangsu Provincial Key Laboratory of Coastal Wetland Bioresources and Environmental Protection [JKLBS2017011]. Published in ACADEMIC PRESS INC ELSEVIER SCIENCE in SAN DIEGO ,Authors: Qiu, QQ; Zhu, JL; Chen, QT; Jiang, ZQ; Xu, JT; Jiang, XT; Huang, WL; Liu, ZQ; Ye, J; Xu, XJ. The CAS is 62-23-7. Through research, I have a further understanding and discovery of 4-Nitrobenzoic acid

P-glycoprotein (P-gp)-mediated multidrug resistance (MDR) is a major impediment for clinical cancer therapy. 19 novel aromatic amides with triazole-core as MDR reversal agents were designed and synthesized via click chemistry to reverse MDR. Among them, compound 42 was identified as the most promising candidate with high potency (EC50 = 78.1 +/- 5.4 nM), low cytotoxity (SI > 1282) and persistent duration in reversing doxorubicin (DOX) resistance in K562/A02 cells. 42 also enhanced the potency of other P-gp associated cytotoxic agents with different structures. In further study, remarkably increased intracellular accumulation of Rh123 and DOX in K562/A02 cells was achieved by compound 42, while CYP3A4 activity had no change by compound 42. These results indicate that compound 42 as a relatively safe modulator of P-gp-mediated MDR has good potential for further development.

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Recently I am researching about ASYMMETRIC EPOXIDATION; ALLYLIC ALCOHOLS; ENANTIOSELECTIVE EPOXIDATION; NUCLEOPHILIC OPENINGS; BETA-CYCLODEXTRIN; EFFICIENT; EPOXYALCOHOLS; DERIVATIVES; AMINOLYSIS; STRATEGIES, Saw an article supported by the JSPS KAKENHIMinistry of Education, Culture, Sports, Science and Technology, Japan (MEXT)Japan Society for the Promotion of ScienceGrants-in-Aid for Scientific Research (KAKENHI) [16H05072, 18K14861]; Platform Project for Supporting Drug Discovery and Life Science Research [Basis for Supporting Innovative Drug Discovery and Life Science Research (BINDS)] from AMED [JP18am0101100]. Published in ROYAL SOC CHEMISTRY in CAMBRIDGE ,Authors: Nakamura, D; Sasano, Y; Iwabuchi, Y. The CAS is 62-23-7. Through research, I have a further understanding and discovery of 4-Nitrobenzoic acid. Category: phthalazines

Regioselectivity of Ln(OTf)(3)-catalysed alcoholysis of 2,3- and 3,4-epoxy alcohols was closely investigated to expand the scope of the transformations. The synthetic use was demonstrated by application to the construction of 4-propoxy-5-hydroxy-2,3-pentanedione (C4-propoxy-HPD), which is a potent synthetic mediator in AI-2 quorum sensing.

Category: phthalazines. Welcome to talk about 62-23-7, If you have any questions, you can contact Nakamura, D; Sasano, Y; Iwabuchi, Y or send Email.

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Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

An article Visible-light-driven cyanoalkylation of quinoxalinones using cyclobutanone oxime esters as the radical precursors WOS:000480672900007 published article about C-H CYANOALKYLATION; IMINYL RADICALS; BOND FORMATION; QUINOXALIN-2(1H)-ONES; DERIVATIVES; INHIBITORS; ARYLATION; NITRILES; CLEAVAGE; STRATEGY in [Zhao, Bin; Kong, Xianqiang; Xu, Bo] Donghua Univ, Coll Chem Chem Engn & Biotechnol, Key Lab Sci & Technol Ecotext, Minist Educ, Shanghai 201620, Peoples R China in 2019.0, Cited 52.0. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7. Product Details of 62-23-7

We have developed a versatile visible-light-driven cyanoalkylation of quinoxalinones under mild conditions. First, the cyanoalkyl radicals are generated from readily available cyclobutanone oxime esters under blue light irradiation. Then the generated radicals react with heterocycles such as quinoxalinones to give the final cyanoalkylation products. The protocol tolerates a wide range of functional groups. Our cyanoalkylation protocol does not need cyanide-based reagents and also does not need external oxidants. (C) 2019 Elsevier Ltd. All rights reserved.

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Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

An article Ketoreductase catalyzed stereoselective bioreduction of alpha-nitro ketones WOS:000465615200011 published article about ASYMMETRIC REDUCTION; CARBONYL REDUCTASE; DERIVATIVES; CONVERSION; ALCOHOLS in [Wang, Zexu; Li, Zhining; Huang, Zedu; Chen, Fener] Fudan Univ, Dept Chem, Engn Ctr Catalysis & Synth Chiral Mol, 220 Handan Rd, Shanghai 200433, Peoples R China; [Wang, Zexu; Li, Zhining; Huang, Zedu; Chen, Fener] Shanghai Engn Res Ctr Ind Asymmetr Catalysis Chir, 220 Handan Rd, Shanghai 200433, Peoples R China; [Wu, Xiaofan] Fuzhou Univ, Coll Chem Engn, 2 Xueyuan Rd, Fuzhou 350100, Fujian, Peoples R China in 2019, Cited 29. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7. SDS of cas: 62-23-7

We report here the stereoselective bioreduction of -nitro ketones catalyzed by ketoreductases (KREDs) with publicly known sequences. YGL039w and RasADH/SyADH were able to reduce 23 class I substrates (1-aryl-2-nitro-1-ethanone (1)) and ten class II substrates (1-aryloxy-3-nitro-2-propanone (4)) to furnish both enantiomers of the corresponding -nitro alcohols, with good-to-excellent conversions (up to >99%) and enantioselectivities (up to >99% ee) being achieved in most cases. To the best of our knowledge, KRED-mediated reduction of class II -nitro ketones (1-aryloxy-3-nitro-2-propanone (4)) is unprecedented. Select -nitro alcohols, including the synthetic intermediates of bioactive molecules (R)-tembamide, (S)-tembamide, (S)-moprolol, (S)-toliprolol and (S)-propanolol, were stereoselectively synthesized in preparative scale with 42% to 90% isolated yields, showcasing the practical potential of our developed system in organic synthesis. Finally, the advantage of using KREDs with known sequence was demonstrated by whole-cell catalysis, in which -nitro alcohol (R)-2k, the key synthetic intermediate of hypoglycemic natural product (R)-tembamide, was produced in a space-time yield of 178 g L-1 d(-1) as well as 95% ee by employing the whole cells of a recombinant E. coli strain coexpressing RasADH and glucose dehydrogenase as the biocatalyst.

SDS of cas: 62-23-7. Welcome to talk about 62-23-7, If you have any questions, you can contact Wang, ZX; Wu, XF; Li, ZN; Huang, ZD; Chen, F or send Email.

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Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

An article Heterodinuclear zinc and magnesium catalysts for epoxide/CO2 ring opening copolymerizations WOS:000465940700006 published article about CARBON-DIOXIDE; CYCLOHEXENE OXIDE; ALTERNATING COPOLYMERIZATION; CO2/EPOXIDE COPOLYMERIZATION; ASYMMETRIC COPOLYMERIZATION; TRIBLOCK COPOLYMERS; CYCLOPENTENE OXIDE; DIZINC CATALYST; MG-ZN; CO2 in [Trott, Gemma; Williams, Charlotte K.] Univ Oxford, Chem Res Lab, Mansfield Rd, Oxford OX1 3TA, England; [Garden, Jennifer A.] Univ Edinburgh, Sch Chem, Edinburgh EH9 3FJ, Midlothian, Scotland in 2019.0, Cited 64.0. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7. Product Details of 62-23-7

The ring-opening copolymerization of carbon dioxide and epoxides is a useful means to make aliphatic polycarbonates and to add-value to CO2. Recently, the first heterodinuclear Zn(II)/Mg(II) catalyst showed greater activity than either homodinuclear analogue (J. Am. Chem. Soc. 2015, 137, 15078-15081). Building from this preliminary finding, here, eight new Zn(II)/Mg(II) heterodinuclear catalysts featuring carboxylate co-ligands are prepared and characterized. The best catalysts show very high activities for copolymerization using cyclohexene oxide (TOF 1/4 8880 h 1, 20 bar CO2, 120 C, 0.01 mol% catalyst loading) or cyclopentene oxide. All the catalysts are highly active in the low pressure regime and specifically at 1 bar pressure CO2. The polymerization kinetics are analysed using in situ spectroscopy and aliquot techniques: the rate law is overall second order with a first order dependence in both catalyst and epoxide concentrations and a zero order in carbon dioxide pressure. The pseudo first order rate coefficient values are compared for the catalyst series and differences are primarily attributed to effects on initiation rates. The data are consistent with a chain shuttling mechanistic hypothesis with heterodinuclear complexes showing particular rate enhancements by optimizing distinct roles in the catalytic cycles. The mechanistic hypothesis should underpin future heterodinuclear catalyst design for use both in other (co) polymerization and carbon dioxide utilization reactions.

Welcome to talk about 62-23-7, If you have any questions, you can contact Trott, G; Garden, JA; Williams, CK or send Email.. Product Details of 62-23-7

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Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

An article CO2 or SO2: Should It Stay, or Should It Go? WOS:000468696400023 published article about TRACELESS DIRECTING GROUPS; BERGMAN CYCLIZATION; RADICAL CASCADES; KINETIC CHARACTERISTICS; DENSITY FUNCTIONALS; AROYLOXYL RADICALS; CARBOXYLIC-ACIDS; DRIVING-FORCE; FRAGMENTATIONS; HYBRIDIZATION in [Gomes, Gabriel dos Passos; Smith, Joel M.; Alabugin, Igor V.] Florida State Univ, Dept Chem & Biochem, Tallahassee, FL 32309 USA; [Wimmer, Alexander; Koenig, Burkhard] Univ Regensburg, Inst Organ Chem, Univ Str 31, D-93040 Regensburg, Germany; [Gomes, Gabriel dos Passos] Univ Toronto, Dept Chem, Toronto, ON M5S 3H6, Canada in 2019.0, Cited 111.0. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7. SDS of cas: 62-23-7

A broad computational analysis of carbon-entered radical formation via the loss of either CO2 or SO2 from the respective RXO2 radical precursors (X = C or S reveals dramatic differences between these-two types of dissociative processes. Whereas the C-C scission with the loss of CO2 is usually exothermic, the C-S scission with the loss of SO2 is generally endothermic. However, two factors can make the C-S scissions thermodynamically favorable: increased entropy, characteristic for the dissociative processes, and stereoelectronic influences of substituents. The threshold between endergonic and exergonic C-S fragmentations depends on subtle structural effects. In particular, the degree of fluorination in a radical precursor has a notable impact on the reaction outcome. This study aims to demystify the intricacies in reactivity regarding the generation of radicals from sulfinates and carboxylates, as related to their role in radical cross-coupling.

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Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem