Category: phthalazine

Recommanded Product: 4-Nitrobenzoic acid. In 2019.0 TETRAHEDRON published article about FACILE SYNTHESIS; RECEPTOR ANTAGONIST; EFFICIENT SYNTHESIS; COUPLING REACTION; DERIVATIVES; CYCLIZATION; ACCESS; SERIES; ROUTE; CELLS in [Xiong, Jun; Wei, Xiao; Wan, Yu-Chen; Ding, Ming-Wu] Cent China Normal Univ, Key Lab Pesticide & Chem Biol, Minist Educ, Hubei Int Sci & Technol Cooperat Base Pesticide &, Wuhan, Hubei, Peoples R China; [Xiong, Jun] Hubei Univ Sci & Technol, Coll Pharm, Xianning 437100, Hubei, Peoples R China in 2019.0, Cited 59.0. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7.

An efficient one-pot and regioselective synthesis of 3,4-dihydroquinazolines and 4,5-dihydro-3H-1,4-benzodiazepin-3-ones by Ugi/Staudinger/aza-Wittig sequence has been developed. The Ugi reactions of 2-azidobenzylamines, aldehydes, acids (or alpha-keto acids) and isocyanides produced the azide intermediates, which were then treated with tributylphosphine or triphenylphosphine to give poly-substituted 3,4-dihydroquinazolines or 4,5-dihydro-3H-1,4-benzodiazepin-3-ones in moderate to good yields by tandem Standinger/aza-Wittig reactions. (C) 2019 Elsevier Ltd. All rights reserved.

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Song, ZL; Bai, FF; Zhang, BX; Fang, JG in [Song, Zi-Long; Bai, Feifei; Zhang, Baoxin; Fang, Jianguo] Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China; [Song, Zi-Long; Bai, Feifei; Zhang, Baoxin; Fang, Jianguo] Lanzhou Univ, Coll Chem & Chem Engn, Lanzhou 730000, Peoples R China published Synthesis of Dithiolethiones and Identification of Potential Neuroprotective Agents via Activation of Nrf2-Driven Antioxidant Enzymes in 2020, Cited 70. Application In Synthesis of 4-Nitrobenzoic acid. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7.

Oxidative stress is implicated in the pathogenesis of a wide variety of neurodegenerative disorders, and accordingly, dietary supplement of exogenous antioxidants or/and upregulation of the endogenous antioxidant defense system are promising for therapeutic intervention or chemoprevention of neurodegenerative diseases. Nrf2, a master regulator of the cellular antioxidant machinery, cardinally participates in the transcription of cytoprotective genes against oxidative/electrophilic stresses. Herein, we report the synthesis of 59 structurally diverse dithiolethiones and evaluation of their neuroprotection against 6-hydroxydopamine- or H2O2 -induced oxidative damages in PC12 cells, a neuron-like rat pheochromocytoma cell line. Initial screening identified compounds 10 and 11 having low cytotoxicity but conferring remarkable protection on PC12 cells from oxidative-mediated damages. Further studies demonstrated that both compounds upregulated a battery of antioxidant genes as well as corresponding genes’ products. Significantly, silence of Nrf2 expression abolishes cytoprotection of 10 and 11, indicating targeting Nrf2 activation is pivotal for their cellular functions. Taken together, the two lead compounds discovered here with potent neuroprotective functions against oxidative stress via Nrf2 activation merit further development as therapeutic or chemopreventive candidates for neurodegenerative disorders.

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

SDS of cas: 62-23-7. In 2020 MOLECULES published article about DERIVATIVES; 2-AMINO-1,3,4-THIADIAZOLE; THIOSEMICARBAZONES; REDUCTION in [Kudelko, Agnieszka; Olesiejuk, Monika; Luczynski, Marcin] Silesian Tech Univ, Dept Chem Organ Technol & Petrochem, Krzywoustego 4, PL-44100 Gliwice, Poland; [Swiatkowski, Marcin; Sieranski, Tomasz; Kruszynski, Rafal] Lodz Univ Technol, Inst Gen & Ecol Chem, Dept Xray Crystallog & Crystal Chem, Zeromskiego 116, PL-90924 Lodz, Poland in 2020, Cited 44. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7.

Three series of azo dyes derived from 2-amino-5-aryl-1,3,4-thiadiazoles and aniline,N,N-dimethylaniline and phenol were synthesized in high yields by a conventional diazotization-coupling sequence. The chemical structures of the prepared compounds were confirmed by(1)H-NMR,C-13-NMR, IR, UV-Vis spectroscopy, mass spectrometry and elemental analysis. In addition, the X-ray single crystal structure of a representative azo dye was presented. For explicit determination of the influence of a substituent on radiation absorption in UV-Vis range, time-dependent density functional theory calculations were performed.

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Product Details of 62-23-7. Arjun, HA; Elancheran, R; Manikandan, N; Lakshmithendral, K; Ramanathan, M; Bhattacharjee, A; Lokanath, NK; Kabilan, S in [Arjun, H. A.; Elancheran, Ramakrishnan; Lakshmithendral, K.; Kabilan, Senthamaraikannan] Annamalai Univ, Dept Chem, Drug Discovery Lab, Chidambaram, India; [Manikandan, N.; Ramanathan, Muthiah] PSG Coll Pharm, Dept Pharmacol, Coimbatore, Tamil Nadu, India; [Bhattacharjee, Atanu] North Eastern Hill Univ, Dept Biotechnol & Bioinformat, Computat Biol Lab, Shillong, Meghalaya, India; [Lokanath, N. K.] Univ Mysore, Dept Phys, Mysore, Karnataka, India published Design, Synthesis, and Biological Evaluation of (E)-N’-((1-Chloro-3,4-Dihydronaphthalen-2-yl)Methylene)Benzohydrazide Derivatives as Anti-prostate Cancer Agents in 2019, Cited 53. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7.

Prostate Cancer (PCa) is the most frequently diagnosed cancer in men in their late ’50s. PCa growth is mainly due to the activation of the androgen receptor by androgens. The treatment for PCa may involve surgery, hormonal therapy, and oral chemotherapeutic drugs. A structural based molecular docking approach revealed the findings of (E)-N’-((1-chloro-3,4-dihydronaphthalen-2-yl)methylene)benzohydrazide derivatives, where the possible binding modes of the compounds with protein (PDB ID: 3V49) are shown. The compounds (6a-k) were synthesized and characterized by using conventional methods. The compounds, 6g, 6j, and 6k were reconfirmed through single crystal X-ray diffraction (XRD). Further, the compounds (6a-k) and standard drug were evaluated against human prostate cancer cell lines, LNCaP and PC-3 and the non-cancerous cell line, 3T3. Among these compounds, 6g and 6j showed higher cytotoxicity, and 6g exhibited dose-dependent activity and reduced cell viability. The mechanism of action was observed through the induced apoptosis and was further confirmed by western blot and ELISA. Molecular dynamics simulation studies were carried out to calculate the interaction and the stability of the protein-ligand complex in motion. ADME properties were predicted for all the tested compounds. These findings may give vital information for further development.

Welcome to talk about 62-23-7, If you have any questions, you can contact Arjun, HA; Elancheran, R; Manikandan, N; Lakshmithendral, K; Ramanathan, M; Bhattacharjee, A; Lokanath, NK; Kabilan, S or send Email.. Product Details of 62-23-7

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

An article Cardiotoxicity of Consolida rugulosa, a poisonous weed in Western Chin WOS:000456890700018 published article about DITERPENOID ALKALOIDS; NORDITERPENOID ALKALOIDS; DELPHINIUM; TOXICITY; CYTOTOXICITY; MICE in [Lei, Liang; He, Wenjuan; Song, Hongping] Huazhong Univ Sci & Technol, Wuhan Hosp 4, Dept Pharm, Puai Hosp,Tongji Med Coll, Wuhan 430030, Hubei, Peoples R China; [Sun, Weiguang; Hu, Zhengxi; Zhang, Yonghui] Huazhong Univ Sci & Technol, Tongji Med Coll, Hubei Key Lab Nat Med Chem & Resource Evaluat, Sch Pharm, Wuhan 430030, Hubei, Peoples R China; [He, Long] Huazhong Univ Sci & Technol, Tongji Med Coll, Wuhan Hosp 4, Dept Clin Lab,Puai Hosp, Wuhan 430030, Hubei, Peoples R China; [Jiang, Hongfeng] Huazhong Univ Sci & Technol, Tongji Med Coll, Wuhan Hosp 4, Dept Geriatr, Wuhan 430030, Hubei, Peoples R China; [Zhang, Mingjin; Gu, Ye] Huazhong Univ Sci & Technol, Tongji Med Coll, Wuhan Hosp 4, Dept Cardiol, Wuhan 430030, Hubei, Peoples R China in 2019.0, Cited 33.0. Recommanded Product: 4-Nitrobenzoic acid. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7

Poisonous weeds are a global problem since they not only hinder local economic development, but also cause ecological harm. Consolida rugulosa (family Ranunculaceae) is a weed that is widespread in Northwestern China and causes severe poisoning when ingested by livestock. In the present study, we purified the toxins in this plant and investigated their mechanism of action. Five natural diterpene alkaloids (compounds 1-5)-including two new compounds (1 and 2)-were isolated, and five semi-synthetic derivatives (6-10) were synthesised based on 4 or 5 for structure-activity analysis. The toxicity of the compounds was evaluated in vitro with lactate dehydrogenase (LDH) assay. All of the compounds-especially 1-stimulated LDH release in primary cultured rat myocardial cells, an effect that was blocked by the Na+ channel blocker lidocaine. Electrocardiography revealed that rats treated with 1 had severe arrhythmia, while heart Doppler echocardiography and analysis of serum biomarkers levels revealed that administration of 1 for 15 days induced changes in cardiac structure and myocardial enzyme levels. These effects were antagonised by lidocaine treatment. Thus, diterpene alkaloids are the main compounds responsible for the cardiotoxicity of C. rugulosa, which can be mitigated by co-administration of lidocaine.

Welcome to talk about 62-23-7, If you have any questions, you can contact Lei, L; Sun, WG; He, L; Jiang, HF; Zhang, MJ; He, WJ; Hu, ZX; Gu, Y; Song, HP; Zhang, YH or send Email.. Recommanded Product: 4-Nitrobenzoic acid

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Formula: C7H5NO4. Kratena, N; Biedermann, N; Stojanovic, B; Goschl, L; Weil, M; Enev, VS; Gmeiner, G; Gartner, P in [Kratena, Nicolas; Biedermann, Nina; Enev, Valentin S.; Gaertner, Peter] Vienna Univ Technol, Inst Appl Synthet Chem, Vienna, Austria; [Weil, Matthias] Vienna Univ Technol, Inst Chem Technol & Analyt, Vienna, Austria; [Stojanovic, Biljana; Goeschl, Lorenz; Gmeiner, Guenter] Seibersdorf Lab GmbH, Doping Control Lab, Seibersdorf, Austria published Synthesis of a human long-term oxymetholone metabolite in 2019, Cited 26. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7.

A long-term metabolite of the doping agent oxymetholone (OXM-M2, 17 beta-hydroxymethyl-2,17 alpha-methyl-18-norandrost-13-en-3-one) which has been identified by GC-MS/MS was synthesized from commercially available materials. Two efficient synthetic routes to access both C-17 epimers of tentative metabolites were developed. The identity and molecular configuration of the in vivo metabolite: 17 beta-hydroxymethyl-2 alpha,17 alpha-methyl-18-norandrost-13-en-3-one was confirmed by single crystal X-ray diffraction.

Formula: C7H5NO4. Bye, fridends, I hope you can learn more about C7H5NO4, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Product Details of 62-23-7. Recently I am researching about STYRYL-LACTONES, Saw an article supported by the University Grants Commission (UGC), New DelhiUniversity Grants Commission, India; Council of Scientific and Industrial Research (CSIR), New DelhiCouncil of Scientific & Industrial Research (CSIR) – India. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Kotammagari, TK; Paul, S; Bhattacharya, AK. The CAS is 62-23-7. Through research, I have a further understanding and discovery of 4-Nitrobenzoic acid

(-)-5-Hydroxygoniothalamin, (-)-5-acetylgoniothalamin, and (+)-5-hydroxygoniothalamin, isolated from the Goniothalamus genus, are synthesized from triacetyl-O-D-glucal by employing the Ferrier reaction, Mitsunobu reaction, and Jones oxidation as key steps. The synthetic procedure also yields the epimers of (-)-5-hydroxygoniothalamin and (+)-5-hydroxygoniothalamin employing acid-mediated transition-metal-free epimerization at C-5 of styryllactones. Further studies reveal that the epimerization is facilitated by the phenyl group present on the styryllactones. Also, depending on the dihydroxylation reaction conditions, various analogues of saturated styryllactones are synthesized utilizing oxa-Michael reaction conditions.

Product Details of 62-23-7. Welcome to talk about 62-23-7, If you have any questions, you can contact Kotammagari, TK; Paul, S; Bhattacharya, AK or send Email.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

SDS of cas: 62-23-7. Recently I am researching about EFFICIENT STEREOSELECTIVE-SYNTHESIS; ENANTIOSELECTIVE SYNTHESIS; STEREODIVERGENT SYNTHESIS; BACTERIAL METABOLITES; ASYMMETRIC-SYNTHESIS; RADICAL CYCLIZATION; BULGECIN; ROUTE; (-)-BULGECININE; DERIVATIVES, Saw an article supported by the Council of Scientific and Industrial Research (CSIR), New Delhi, IndiaCouncil of Scientific & Industrial Research (CSIR) – India [02(243)/15/EMR-II]; Department of Science and Technology (DST)Department of Science & Technology (India); Indian Institute of Technology Delhi (IITD). Published in ELSEVIER SCI LTD in OXFORD ,Authors: Mishra, UK; Ramesh, NG. The CAS is 62-23-7. Through research, I have a further understanding and discovery of 4-Nitrobenzoic acid

A glycal based synthesis of ( + )-bulgecinine, 3-hydroxy-2,5-dihydroxymethylpyrrolidine and 2-oxapyrrolizidin-3-ones proceeding through a common intermediate is reported. The key step in the work presented here is a two-step conversion of 4,6 di-O-benzyl-D-glucal to 2,3-dideoxy-2-tosylamido-D-glucose. This manuscript reports the first carbohydrate based approach to the synthesis of ( + )-bulgecinine and the whole sequence has been accomplished with complete stereochemical integrity without the formation of mixture of products in any of these steps.

SDS of cas: 62-23-7. Bye, fridends, I hope you can learn more about C7H5NO4, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Taha, M; Uddin, N; Ali, M; Anouar, E; Rahim, F; Khan, G; Farooq, RK; Gollapalli, M; Iqbal, N; Farooq, M; Khan, KM in [Taha, Muhammad] Imam Abdulrahman Bin Faisal Univ, Inst Res & Med Consultat IRMC, Dept Clin Pharm, POB 1982, Dammam 31441, Saudi Arabia; [Uddin, Nizam] Univ Karachi, Dept Chem, Karachi 75270, Pakistan; [Ali, Muhammad] Univ Nizwa, Nat & Med Sci Res Ctr, POB 33, Birkat Al Mauz 616, Nizwa, Oman; [Anouar, El Hassane] Prince Sattam bin Abdulaziz Univ, Coll Sci & Humanities Al Kharj, Dept Chem, Al Kharj 11942, Saudi Arabia; [Rahim, Fazal] Hazara Univ, Dept Chem, Mansehra 21300, Khyber Pakhtunk, Pakistan; [Khan, Gulraiz] Imam Abdulrahman Bin Faisal Univ, Environm Engn Dept, Coll Engn Bldg A13,POB 1982, Dammam 31441, Saudi Arabia; [Farooq, Rai Khalid] Imam Abdulrahman Bin Faisal Univ, Inst Res & Med Consultat IRMC, Dept Neurosci Res, POB 1982, Dammam 31441, Saudi Arabia; [Gollapalli, Mohammed] Imam Abdulrahman Bin Faisal Univ, Coll Comp Sci & Informat Technol CCSIT, Dept Comp Informat Syst, POB 1982, Dammam 31441, Saudi Arabia; [Iqbal, Naveed] Univ Poonch Rawalakot AJK, Dept Chem, Rawalakot, Pakistan; [Farooq, Muhammad] Hazara Univ, Dept Phys, Mansehra 21300, Khyber Pakhtunk, Pakistan; [Khan, Khalid Mohammed] Univ Karachi, Int Ctr Chem & Biol Sci, HEJ Res Inst Chem, Karachi 75270, Pakistan published Inhibition potential of phenyl linked benzimidazole-triazolothiadiazole modular hybrids against beta-glucuronidase and their interactions thereof in 2020, Cited 54. COA of Formula: C7H5NO4. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7.

beta-Glucuronidase is responsible for the catalytic deconjugation of beta-D-glucuronides. beta-Glucuronidase has evolved to be a viable molecular target for numerous therapeutic treatments. It plays a pivotal role in the metabolism of drugs and endogenous substances. Herein, we report the inhibitory potentials of newly developed and modular benzimidazole-triazolothiadiazole hybrids spaced through a phenyl linker (1-26) and their interactions with the beta-glucuronidase. All analogues showed IC50 values in the range of 1.30 +/- 0.10 to 44.10 +/- 0.80 mu M, and hence were found to have outstanding inhibitory potential as compare to the standard D-saccharic acid 1,4-lactone (IC50 = 48.4 +/- 1.25 mu M). These modular hybrids were successfully synthesized, rigorously characterized through various spectroscopic techniques. Molecular docking studies further revealed the potential interactions between the inhibitor and active amino acid site in beta-glucuronidase. These findings helped in identifying the potential for new drug candidates. A Plausible structure activity relationship (SAR) were established which suggested that variation in the inhibitory potential was mainly based upon the substituents attached to the phenyl ring. (C) 2020 Elsevier B.V. All rights reserved.

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

I found the field of Chemistry very interesting. Saw the article Syngas-Free Highly Regioselective Rhodium-Catalyzed Transfer Hydroformylation of Alkynes to alpha,beta-Unsaturated Aldehydes published in 2019.0. Category: phthalazines, Reprint Addresses You, JS (corresponding author), Sichuan Univ, Coll Chem, Minist Educ, Key Lab Green Chem & Technol, 29 Wangjiang Rd, Chengdu 610064, Sichuan, Peoples R China.. The CAS is 62-23-7. Through research, I have a further understanding and discovery of 4-Nitrobenzoic acid

The hydroformylation of alkynes is a fundamental and important reaction in both academic research and industry. Conventional methods focus on the conversion of alkynes, CO, and H-2 into alpha,beta -unsaturated aldehydes, but they often suffer from problems associated with operation, regioselectivity, and chemoselectivity. Herein, we disclose an operationally simple, mild, and syngas-free rhodium-catalyzed reaction for the hydroformylation of alkynes via formyl and hydride transfer from an alkyl aldehyde. This synthetic method uses inexpensive and easy-to-handle n-butyraldehyde to overcome the challenge posed by the use of syngas in traditional approaches and employs a commercially available catalyst and ligand to transform a broad range of internal alkynes, especially alkynyl-containing complex molecules, into versatile stereodefined alpha,beta -unsaturated aldehydes with excellent chemo-, regio-, and stereoselectivity.

Bye, fridends, I hope you can learn more about C7H5NO4, If you have any questions, you can browse other blog as well. See you lster.. Category: phthalazines

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem