Category: phthalazine

In 2019.0 ACS CATAL published article about RING-OPENING POLYMERIZATION; PHOTOSWITCHABLE CATALYSIS; TRANSFER HYDROGENATION; LEWIS-ACID; LIGHT; COMPLEX; RUTHENIUM; CHEMISTRY; COPOLYMERIZATION; NANOPARTICLES in [Sarmah, Kasturi; Mukhopadhyay, Subhamoy; Maji, Tarun K.; Pratihar, Sanjay] Tezpur Univ, Dept Chem Sci, Napaam 784028, Assam, India in 2019.0, Cited 75.0. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7. Category: phthalazines

Herein we disclosed the utilization of copper loaded zinc oxide (ZnO-Cu) for its stimuli (O-2/light) responsive switchable performance between its reduced (S-1) and oxidized (S-2) state for two antagonistic reactions, namely oxidation of alkyl arenes/heteroarenes to aldehydes/ketones and reduction of nitro arenes/heteroarenes corresponding amines. The two states of the catalyst showed its switchable performance as highly active and poorly active catalyst for oxidation and reduction, and both reactions could be turned off and on by changing the stimuli (light and O-2/N-2). The switching efficiency between the states and their relative reactivity were found to be consistent under variety of reaction conditions and remain unaltered irrespective of oxidation-reduction (or vice versa) sequence and substrates used in the reaction. The photo catalysts (S-1 and S-2) demonstrated good catalytic activity, multiple reusability, broad substrate scope, and reasonable functional group tolerance for both the reactions and probed its quality performance in a large-scale setup. The system was used in an assisted tandem catalysis setup for the synthesis of benzyl amines utilizing both oxidation and reduction reaction by stimuli responsive switching between the states of the catalyst.

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I found the field of Chemistry very interesting. Saw the article Ni-catalyzed direct alcoholysis of N-acylpyrrole-type tertiary amides under mild conditions published in 2020.0. Category: phthalazines, Reprint Addresses Huang, PQ (corresponding author), Xiamen Univ, Coll Chem & Chem Engn, Collaborat Innovat Ctr Chem Ene Mat, Dept Chem,Fujian Prov Key Lab Chem Biol, Xiamen 361005, Peoples R China.. The CAS is 62-23-7. Through research, I have a further understanding and discovery of 4-Nitrobenzoic acid

N-Acylpyrrole-type amides are a class of versatile building blocks in asymmetric synthesis. We report that by employing Ni(COD)(2)/2,2 ‘-bipyridine (5 mol%) catalytic system, the direct, catalytic alcoholysis of N-acylpyrrole-type aromatic and aliphatic amides with both primary and secondary alcohols can be achieved efficiently under very mild conditions (rt, 1 h) even at gram scale. By increasing the catalyst loading to 10 mol%, prolonging reaction time (18 h), and/or elevating reaction temperature to 50 degrees C/80 degrees C, the reaction could be extended to both complex and hindered N-acylpyrroles as well as to N-acylpyrazoles, Nacylindoles, and to other (functionalized) primary and secondary alcohols. In all cases, only 1.5 equiv. of alcohol were used. The value of the method has been demonstrated by the racemization-free, catalytic alcoholysis of chiral amides yielded from other asymmetric methodologies.

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Mishra, UK; Ramesh, NG in [Mishra, Umesh K.; Ramesh, Namakkal G.] Indian Inst Technol Delhi, Dept Chem, New Delhi 110016, India published A glycal based approach to the synthesis of (+)-bulgecinine, 3-hydroxy-2,5-dihydroxymethylpyrrolidine and 2-oxapyrrolizidin-3-one in 2020.0, Cited 48.0. Computed Properties of C7H5NO4. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7.

A glycal based synthesis of ( + )-bulgecinine, 3-hydroxy-2,5-dihydroxymethylpyrrolidine and 2-oxapyrrolizidin-3-ones proceeding through a common intermediate is reported. The key step in the work presented here is a two-step conversion of 4,6 di-O-benzyl-D-glucal to 2,3-dideoxy-2-tosylamido-D-glucose. This manuscript reports the first carbohydrate based approach to the synthesis of ( + )-bulgecinine and the whole sequence has been accomplished with complete stereochemical integrity without the formation of mixture of products in any of these steps.

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Phthalazine – Wikipedia,
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COA of Formula: C7H5NO4. Recently I am researching about CHEMOSELECTIVE HYDROGENATION; 1 ATM; REDUCTION; CATALYST; NITROBENZENE; PERFORMANCE; ANILINE; BONDS; H-2, Saw an article supported by the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21868011]; National Key R&D Program of China [2017YFC1103800]. Published in ROYAL SOC CHEMISTRY in CAMBRIDGE ,Authors: Sun, ST; Du, MY; Zhao, RX; Jv, XC; Hu, P; Zhang, Q; Wang, B. The CAS is 62-23-7. Through research, I have a further understanding and discovery of 4-Nitrobenzoic acid

The hydrogenation of nitroarenes is one of the most important strategies for the preparation of anilines. However, it is still a great challenge to develop mild and efficient synthetic routes toward aniline synthesis, particularly those employing both non-precious metal catalysts and low-pressure H-2. Herein, we report a highly efficient protocol for the selective hydrogenation of nitroarenes in neutral H2O using H-2(1 atm) over a heterogeneous Zn(0) catalyst under mild conditions. The nitro groups of an array of nitroarenes can be converted into -NH(2)with up to 99% conversions and a selectivity of >99%, even when functionalized with easily reducible substituents, or in the presence of aromatic ketones or styrene. This study might open an avenue for the selective hydrogenation of nitroarenes over a zinc catalyst using 1 atm H-2.

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An article Iron(III)-catalyzed direct synthesis of diphenylmethyl esters from 2-diphenylmethoxypyridine WOS:000472440400001 published article about SULFUR-CONTAINING POLYPEPTIDES; PEPTIDES; ACIDS in [Van Hieu Tran; Minh Thanh La; Kim, Hee-Kwon] Chonbuk Natl Univ, Mol Imaging & Therapeut Med Res Ctr, Dept Nucl Med, Med Sch & Hosp, Jeonju 54907, South Korea; [Van Hieu Tran; Minh Thanh La; Kim, Hee-Kwon] Chonbuk Natl Univ Hosp, Natl Univ Biomed Res Inst, Res Inst Clin Med Chonbuk, Jeonju 54907, South Korea in 2019, Cited 26. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7. Quality Control of 4-Nitrobenzoic acid

A highly efficient method has been developed for the synthesis of diphenylmethyl (DPM) esters from 2-diphenylmethoxypyridine. Various carboxylic acids readily reacted with 2-diphenylmethoxypyridine in the presence of FeCl3 as a catalyst to provide the desired DPM esters with high yields. The procedure is facile and enables effective synthesis of a variety of esters for the protection of carboxylic acids. [GRAPHICS] .

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Phthalazine – Wikipedia,
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An article Tris(o-phenylenedioxy)cyclotriphosphazene as a Promoter for the Formation of Amide Bonds Between Aromatic Acids and Amines WOS:000579422600012 published article about CARBOXYLIC-ACIDS; PHOSPHONITRILIC COMPOUNDS; DEHYDRATIVE CONDENSATION; DIRECT AMIDATION; LEWIS-ACIDS; HYDROLYSIS; ACTIVATION; CATALYST; DICYCLOHEXYLCARBODIIMIDE; FORMYLATION in [Movahed, Farzaneh Soleymani; Bagal, Dattatraya B.; Saito, Susumu] Nagoya Univ, Grad Sch Sci, Chikusa Ku, Nagoya, Aichi 4648602, Japan; [Sawant, Dinesh N.; Saito, Susumu] Nagoya Univ, Res Ctr Mat Sci, Chikusa Ku, Nagoya, Aichi 4648602, Japan in 2020.0, Cited 72.0. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7. COA of Formula: C7H5NO4

The atom-efficient formation of amide bonds has emerged as a top-priority research field in organic synthesis, as amide bonds constitute the backbones of proteins and represent an important structural motif in drug molecules. Currently, the increasing demand for novel discoveries in this field has focused substantial attention on this challenging subject. Herein, the degradable 1,3,5-triazo-2,4,6-triphosphorine (TAP) motif is presented as a new condensation system for the dehydrative formation of amide bonds between diverse combinations of aromatic carboxylic acids and amines. The underlying reaction mechanism was investigated, and potential catalyst intermediates were characterized using(31)P NMR spectroscopy and ESI mass spectrometry.

COA of Formula: C7H5NO4. Bye, fridends, I hope you can learn more about C7H5NO4, If you have any questions, you can browse other blog as well. See you lster.

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Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

HPLC of Formula: C7H5NO4. In 2020 J MED CHEM published article about AUREUS STRESS TOLERANCE; STAPHYLOCOCCUS-AUREUS; PROTEASE; INSIGHTS; CLEAVAGE; REVEAL; ROLES in [Ju, Yuan; He, Lihui; Zhou, Yuanzheng; Yang, Tao; Sun, Ke; Song, Rao; Yang, Yang; Li, Chengwei; Bao, Rui; Luo, Youfu] Sichuan Univ, State Key Lab Biotherapy, Collaborat Innovat Ctr Biotherapy, West China Hosp, Chengdu 610041, Peoples R China; [Ju, Yuan; He, Lihui; Zhou, Yuanzheng; Yang, Tao; Sun, Ke; Song, Rao; Yang, Yang; Li, Chengwei; Bao, Rui; Luo, Youfu] Sichuan Univ, Canc Ctr, Collaborat Innovat Ctr Biotherapy, West China Hosp, Chengdu 610041, Peoples R China; [Sang, Zitai] Luoyang Normal Univ, Inst Life Sci, Luoyang 471934, Henan, Peoples R China in 2020, Cited 53. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7.

Caseinolytic protease P (ClpP) is considered as a promising target for the treatment of Staphylococcus aureus infections. In an unbiased screen of 2632 molecules, a peptidomimetic boronate, MLN9708, was found to be a potent suppressor of SaClpP function. A time-saving and cost-efficient strategy integrating in silico position scanning, multistep miniaturized synthesis, and bioactivity testing was deployed for optimization of this hit compound and led to fast exploration of structure-activity relationships. Five of 150 compounds from the miniaturized synthesis exhibited improved inhibitory activity. Compound 43Hf was the most active inhibitor and showed reversible covalent binding to SaClpP while did not destabilize the tetradecameric structure of SaClpP. The crystal structure of 43Hf-SaClpP complex provided mechanistic insight into the covalent binding mode of peptidomimetic boronate and SaClpP. Furthermore, 43Hf could bind endogenous ClpP in S. aureus cells and exhibited significant efficacy in attenuating S. aureus virulence in vitro and in vivo.

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Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

HPLC of Formula: C7H5NO4. In 2019.0 ARAB J CHEM published article about ONE-POT SYNTHESIS; N-DOPED CARBON; CATALYTIC-HYDROGENATION; METAL NANOPARTICLES; GOLD NANOPARTICLES; REDUCTION; OXIDE; NITROBENZENE; COMPOSITE; ALCOHOLS in [Bhardwaj, Madhvi; Paul, Satya] Univ Jammu, Dept Chem, Jammu 180006, India in 2019.0, Cited 40.0. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7.

This paper aimed to report a green and efficient approach for the Pd(0)-EDA/SCs catalyzed hydrogenation of nitroarenes and carbonyl compounds using environment friendly molecular hydrogen at room temperature under benign reaction media. Three different catalysts, Pd(0)-EDA/SC-1, Pd(0)-EDA/SC-2 and Pd(0)-EDA/SC-3 based on immobilization of palladium nanoparticles onto ethylene diamine functionalized silica-cellulose substrates were prepared. Among various catalysts tested, Pd(0)-EDA/SC-2 showed superior catalytic activity. Further, excellent yield of the products, recyclability and the facile work-up make the catalyst more versatile, eco-friendly and economical to perform the desired organic transformations. (C) 2016 The Authors. Published by Elsevier B.V. on behalf of King Saud University.

HPLC of Formula: C7H5NO4. Welcome to talk about 62-23-7, If you have any questions, you can contact Bhardwaj, M; Paul, S or send Email.

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Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

In 2020 EUR J ORG CHEM published article about ACTIVATED PROTEIN-KINASE; IMIDAZOLE; DERIVATIVES; INHIBITORS; AFFINITY; ACCESS in [Golubev, Pavel; Guranova, Natalia; Krasavin, Mikhail] St Petersburg Stare Univ, Inst Chem, 26 Univ Sky Prospect, Peterhof 198504, Russia in 2020, Cited 28. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7. Recommanded Product: 62-23-7

In the present study, a new synthetic strategy towardsN-acylated glycinamides was developed by the use of 1,3,5-triazinanes as formaldimine surrogates in the Ugi reaction. The targeted products were obtained in a combinatorial, diversity-oriented fashion in good yields. Further modifications allowed us to adapt this procedure for the one-pot two-step syntheses of a local anesthetic druglidocaine and several unsymmetrically substituted diketopiperazines.

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An article A Novel Camptothecin Derivative 3j Inhibits NSCLC Proliferation via Induction of Cell Cycle Arrest by Topo I-Mediated DNA Damage WOS:000472724700009 published article about TUMOR-CELLS; TOPOISOMERASE; BINDING; REPAIR; CARCINOMA; PROTEIN; DESIGN; TARGET in [Liu, Yang; Zhao, Tingli; Wang, Lai; Du, Hongzhi; Sun, Li] China Pharmaceut Univ, Jiangsu Key Lab Drug Screening, 24 Tongjiaxiang, Nanjing, Jiangsu, Peoples R China; [Zhang, Jingyin] Southeast Univ, Dept Gynaecol & Obstet, Affiliated Zhongda Hosp, Nanjing, Jiangsu, Peoples R China; [Feng, Shuyun; Li, Zhengzheng; Yuan, Shengtao] China Pharmaceut Univ, Jiangsu Ctr Pharmacodynam Res & Evaluat, 24,Tongjiaxiang, Nanjing, Jiangsu, Peoples R China; [Wang, Puhai] Nanjing Technol Univ, Jiangsu Prov Inst Materia Med, Nanjing, Jiangsu, Peoples R China in 2019, Cited 40. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7. Safety of 4-Nitrobenzoic acid

Objective: The aim of this study is to investigate the inhibitory effect of camptothecin derivative 3j on Non-Small Cell Lung Cancer (NSCLCs) cells and the potential anti-tumor mechanisms. Background: Camptothecin compounds are considered as the third largest natural drugs which are widely investigated in the world and they suffered restriction because of serious toxicity, such as hemorrhagic cystitis and bone marrow suppression. Methods: Using cell proliferation assay and S180 tumor mice model, a series of 20(S)-O-substituted benzoyl 7-ethylcamptothecin compounds were screened and evaluated the antitumor activities in vitro and in vivo. Camptothecin derivative 3j was selected for further study using flow cytometry in NSCLCs cells. Cell cycle related protein cyclin A2, CDK2, cyclin D and cyclin E were detected by Western Blot. Then, computer molecular docking was used to confirm the interaction between 3j and Topo L Also, DNA relaxation assay and alkaline cornet assay were used to investigate the mechanism of 3j on DNA damage. Results: Our results demonstrated that camptothecin derivative 3j showed a greater antitumor effect in eleven 20(S)-O-substituted benzoyl 7-ethylcamptothecin compounds in vitro and in vivo. The IC50 of 3j was 1.54 +/- 0.41 mu M lower than irinotecan with an IC50 of 13.86 +/- 0.80 mu M in NCI-H460 cell, which was reduced by 8 fold. In NCI-H1975 cell, the IC50 of 3j was 1.87 +/- 0.23 mu M lower than irinotecan (IC50 +/- SD, 5.35 +/- 0.38 mu M), dropped by 1.8 fold. Flow cytometry analysis revealed that 3j induced significant accumulation in a dose-dependent manner. After 24h of 3j (10 mu M)treatment, the percentage of NCI-H460 cell in S-phase significantly increased (to 93.54 +/- 4.4%) compared with control cells (31.67 +/- 3.4%). Similarly, the percentage of NCI-H1975 cell in S-phase significantly increased (to 83.99 +/- 2.4%) compared with control cells (34.45 +/- 3.9%) after treatment with 10 mu M of 3j. Moreover, increased levels of cyclin A2, CDK2, and decreased levels of cyclin D, cyclin E further confirmed that cell cycle arrest was induced by 3j. Furthermore, molecular docking studies suggested that 3j interacted with Topo I-DNA and DNA-relaxation assay simultaneously confirmed that 3j suppressed the activity of Topo I. Research on the mechanism showed that 3j exhibited anti-tumour activity via activating the DNA damage response pathway and suppressing the repair pathway in NSCLC cells. Conclusion: Novel camptothecin derivative 3j has been demonstrated as a promising antitumor agent and remains to be assessed in further studies.

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem