Category: phthalazine

Computed Properties of C7H5NO4. Feng, JT; He, HF; Zhou, Y; Guo, XL; Liu, HL; Cai, M; Wang, F; Feng, LL; He, HW in [Feng, Jiangtao; He, Haifeng; Zhou, Yuan; Guo, Xiaoliang; Liu, Honglin; Cai, Meng; Wang, Fang; Feng, Lingling; He, Hongwu] Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticide & Chem Biol CCNU, Wuhan 430079, Hubei, Peoples R China; [He, Haifeng] Jiangxi Sci & Technol Normal Univ, Sch Chem & Chem Engn, Nanchang 330013, Jiangxi, Peoples R China published Design, synthesis and biological evaluation of novel inhibitors against cyanobacterial pyruvate dehydrogenase multienzyme complex E1 in 2019.0, Cited 29.0. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7.

Cyanobacterial pyruvate dehydrogenase multienzyme complex E1 (PDHc E1) is a potential target enzyme for finding inhibitors to control harmful cyanobacterial blooms. In this study, a series of novel triazole thiamin diphosphate (ThDP) analogs were designed and synthesized by modifying the substituent group of triazole ring and optimizing triazole-benzene linker as potential cyanobacterial PDHc E1 (Cy-PDHc E1) inhibitors. Their inhibitory activities against Cy-PDHc E1 in vitro and algicide activities in vivo were further examined. Most of these compounds exhibited prominent inhibitory activities against Cy-PDHc E1 (IC50 1.48-4.48 mu M) and good algicide activities against Synechocystis PCC6803 (EC50 0.84-2.44 mu M) and Microcystis aeruginosa FACHB905 (EC50 0.74-1.77 mu M). Especially, compound 8d showed not only the highest inhibitory activity against Cy-PDHc E1 (IC50 1.48 mu M), but also the most powerful inhibitory selectivity between Cy-PDHc E1 (inhibitory rate 98.90%) and porcine PDHc E1 (inhibitory rate only 9.54%). Furthermore, the potential interaction between compound 8d and Cy-PDHc E1 was analyzed by a molecular docking method and site-directed mutagenesis and enzymatic analysis and fluorescence spectral analysis. These results indicated that compound 8d could be used as a hit compound for further optimization and might have potential to be developed as a new algicide.

Welcome to talk about 62-23-7, If you have any questions, you can contact Feng, JT; He, HF; Zhou, Y; Guo, XL; Liu, HL; Cai, M; Wang, F; Feng, LL; He, HW or send Email.. Computed Properties of C7H5NO4

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Name: 4-Nitrobenzoic acid. I found the field of Chemistry; Science & Technology – Other Topics; Materials Science; Physics very interesting. Saw the article A nano-reactor based on PtNi@metal-organic framework composites loaded with polyoxometalates for hydrogenation-esterification tandem reactions published in 2019.0, Reprint Addresses Kuang, Q (corresponding author), Xiamen Univ, State Key Lab Phys Chem Solid Surfaces, Coll Chem & Chem Engn, Xiamen 361005, Peoples R China.. The CAS is 62-23-7. Through research, I have a further understanding and discovery of 4-Nitrobenzoic acid.

Tandem catalysis (i.e., a process in which a desirable product is synthesized by a one-step process consisting of sequential reactions) has attracted intensive attention owing to its sustainable green and atom-economical characteristics. In this process, the utilization of a high-efficiency multifunctional catalyst is key. However, different functional sites integrated within the catalyst are required to be rationally designed and precisely engineered to guarantee the synergy between the catalytic reactions. Herein, a novel kind of hydrogenation-esterification tandem catalyst with metal/acid (alloy/polyoxometalates) active sites integrated within the metal-organic frameworks (MOFs) was prepared by a facile self-sacrificial template route. In this tandem catalyst, the MOF cavities served as tandem reactors, the PtNi alloy sites encapsulated within the MOF material acted as hydrogenation sites, and the solid phosphotungstic acid embedded in the MOF cavities provided esterification sites. This well-designed tandem catalyst showed outstanding activity and selectivity towards the one-step synthesis of amino-ester-type anesthetics (e.g., benzocaine) owing to the synergistic catalysis of the metal and acid sites. Clearly, this novel tandem catalyst simplifies the traditional industry process and provides a new method to rationally construct new tandem catalysts.

Name: 4-Nitrobenzoic acid. Welcome to talk about 62-23-7, If you have any questions, you can contact Chen, LN; Zhang, XB; Zhou, JH; Xie, ZX; Kuang, Q; Zheng, LS or send Email.

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Rani, D; Bhargava, M; Agarwal, J in [Rani, Dixita; Bhargava, Meha; Agarwal, Jyoti] Panjab Univ, Dept Chem, Chandigarh 160014, India; [Rani, Dixita; Bhargava, Meha; Agarwal, Jyoti] Panjab Univ, Ctr Adv Studies, Chandigarh 160014, India published Asymmetric Michael Addition of Unactivated Ketones with beta-Nitrostyrenes Mediated by Bifunctional L-Prolinamide Organocatalysts in 2020.0, Cited 102.0. Name: 4-Nitrobenzoic acid. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7.

The catalytic activity of two types of L-prolinamide organocatalysts was investigated for asymmetric Michael addition reaction of cyclic/acyclic ketones with beta-nitrostyrens. L-Prolinamides bearing amino groups on phenyl ring worked well, though their catalytic efficiency as well as selectivity was found to be dependent upon the position of amine group to the amide bond. Organocatalyst having -NH2 group ortho to amide bond provided the best results. Substrate scope was also studied by performing the reaction of various beta-nitrostyrenes with ketones to afford the corresponding Michael adducts in excellent yields with very high diastereoselectivities and enantioselectivities in almost all cases.

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Authors Huang, TH; Wu, X; Yu, YB; An, L; Yin, XX in PERGAMON-ELSEVIER SCIENCE LTD published article about 3CL PROTEASE INHIBITORS; BIOLOGICAL EVALUATION; TANDEM REACTION; SELECTIVE INHIBITORS; DESIGN; DERIVATIVES; POTENT; ARYL; OXAZOLES; KETONES in [Huang, Tonghui; Wu, Xin; Yu, Yongbo; An, Lin; Yin, Xiaoxing] Xuzhou Med Univ, Jiangsu Key Lab New Drug Res & Clin Pharm, Xuzhou 221000, Jiangsu, Peoples R China; [Huang, Tonghui] Xuzhou Med Univ, Sci Pk, Xuzhou 221006, Jiangsu, Peoples R China in 2019, Cited 43. Product Details of 62-23-7. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7

A convenient and efficient strategy for the synthesis of 2-acyl benzothiazoles/thiazoles has been developed. The treatment of benzothiazole/thiazole with allylic Grignard reagents readily generates the corresponding 2-Grignard reagents, which is followed by a reaction with N,N’-carbonyldiimidazole activated carboxylic acids to afford various 2-acyl benzothiazoles/thiazoles products. The synthetic method is applicable to a wide array of carboxylic acids and allows easy access to 2-acyl benzothiazoles/thiazoles with considerable yields under mild reaction conditions. (C) 2019 Elsevier Ltd. All rights reserved.

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An article Microwave-Enhanced Coupling of Carboxylic Acids with Liquid Ketones and Cyclic Ethers Using Tetrabutylammonium Iodide/t-Butyl Hydroperoxide WOS:000530092400027 published article about ASSISTED SYNTHESIS; METAL-FREE; BOND in [Macias-Benitez, Pablo; Moreno-Dorado, F. Javier; Guerra, Francisco M.] Univ Cadiz, Fac Ciencias, Dept Quim Organ, Cadiz 11510, Spain in 2020, Cited 29. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7. Computed Properties of C7H5NO4

The oxidative coupling of carboxylic acids with liquid ketones and cyclic ethers has been accomplished in minutes using t-butyl hydroperoxide in the presence of tetrabutylammonium iodide under microwave irradiation in the absence of a solvent. In addition to drastically shortening the reaction times, the use of microwaves resulted, in general, in yields equal to or higher than those obtained by conventional heating.

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Recommanded Product: 62-23-7. I found the field of Chemistry very interesting. Saw the article Synthesis, in vitro and in silico Anti-Proliferative Studies of Novel Piperiene-Oxadiazole and Thiadiazole Analogs published in 2019, Reprint Addresses Amperayani, KR (corresponding author), GVP Degree & PG Coll, Dept Chem, Visakhapatnam 530045, Andhra Pradesh, India.. The CAS is 62-23-7. Through research, I have a further understanding and discovery of 4-Nitrobenzoic acid.

Piperine is a component of pepper which has earlier been reported as anticancer active compound. This work is emphasized on the design and synthesis of new hybrid piperine analogs by coupling piperine with the amine group of oxadiazoles and thiadiazoles. The new series of twelve piperine analogs was been tested for in vitro anti-proliferative activity using sulforhodamine B (SRB) assay test against MCF-7, PC-3, and HeLa cell lines. Among the twelve synthesised molecules piperine derivative with oxadiazole baring hydroxyl group (3) exhibits the higher activity against MCF-7 cell line than the reference drug Adriamycin and also displays the highest binding energy in the in silico studies. The other analogs are moderately active.

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An article Access to Phenothiazine Derivatives via Iodide-Mediated Oxidative Three-Component Annulation Reaction WOS:000607535100044 published article about TRISULFUR RADICAL-ANION; CASCADE C-S; SUBSTITUTED PHENOTHIAZINES; BOND FUNCTIONALIZATION; SULFUR; AZAPHENOTHIAZINES; CONSTRUCTION; NANOCOBALT; THIOPHENE; CELLS in [Chen, Qinghua; Xie, Rong; Jia, Huanhuan; Sun, Jialu; Lu, Guangpeng; Jiang, Huanfeng; Zhang, Min] South China Univ Technol, Key Lab Funct Mol Engn Guangdong Prov, Sch Chem & Chem Engn, Guangzhou 510641, Peoples R China in 2020.0, Cited 64.0. HPLC of Formula: C7H5NO4. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7

Herein, a new iodide-mediated three-component annulation reaction of secondary anilines, cyclohexanones, and elemental sulfur is demonstrated, which allows access to various phenothiazines with the merits of formation of multiple chemical bonds in one single operation, high step and atom efficiency, readily available feedstocks and catalyst system, and good substrate and functional group compatibility. The developed chemistry capable of constructing novel phenothiazines with structural diversity offers a significant basis for further applications.

HPLC of Formula: C7H5NO4. Bye, fridends, I hope you can learn more about C7H5NO4, If you have any questions, you can browse other blog as well. See you lster.

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Ma, ZH; Jiang, L; Li, GX; Liang, DL; Li, LF; Liu, L; Jiang, C in [Ma, Zonghui; Li, Guoxin; Liang, Dailin; Jiang, Cheng] China Pharmaceut Univ, Jiang Su Key Lab Drug Design & Optimizat, Tongjiaxiang 24, Nanjing 210009, Peoples R China; [Ma, Zonghui; Li, Guoxin; Liang, Dailin; Li, Luanfeng; Jiang, Cheng] China Pharmaceut Univ, Dept Med Chem, Tongjiaxiang 24, Nanjing 210009, Peoples R China; [Jiang, Ling; Liu, Li] China Pharmaceut Univ, Key Lab Drug Metab & Pharmacokinet, Tongjiaxiang 24, Nanjing 210009, Peoples R China published Design, synthesis of 1,3-dimethylpyrimidine-2,4-diones as potent and selective aldehyde dehydrogenase 1A1 (ALDH1A1) inhibitors with glucose consumption improving activity in 2020, Cited 21. Computed Properties of C7H5NO4. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7.

LDH1A1, one of 19 NAD(P)(+)-dependent aldehyde dehydrogenases, participates in multiple metabolic pathways and has been indicated to play an important role in obesity and diabetes. In this study, a series of 1,3-di-methylpyrimidine-2,4-diones were designed, synthesized and evaluated as novel selective aldehyde dehy-drogenase 1A1 inhibitors. Among them, compounds 46, 50, 53, 56 and 57 exhibited excellent inhibitory activity against ALDH1A1 with IC50 values in the low nanomolar range and high selectivity over ALDH1A2, ALDH1A3, ALDH2 and ALDH3A1. Furthermore, in vitro study demonstrated that compound 57 effectively improved glucose consumption in HepG2 cells compared to compound 1 (CM026).

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An article Synthesis and anticancer evaluation of new lipophilic 1,2,4 and 1,3,4-oxadiazoles WOS:000459358600003 published article about BIOLOGICAL EVALUATION; DERIVATIVES SYNTHESIS; MOLECULAR DOCKING; INHIBITORS; APOPTOSIS; MOIETY; TOXICITY; ANALOGS; GROWTH; POTENT in [Caneschi, Wiliam; Enes, Karine Braga; de Mendonca, Camille Carvalho; Fernandes, Fabio de Souza; Miguel, Fabio Balbino; Le Hyaric, Mireille; Duarte, Lucas Mattos; Leal de Oliveira, Marcone Augusto; Dos Santos, Hello F.; Costa Couri, Mara Rubia] Univ Fed Juiz de Fora, Dept Quim, ICE, Campus Martelo, BR-36036330 Juiz De Fora, MG, Brazil; [Martins, Jefferson da Silva; Pinho, Roberto Rosas] Univ Fed Juiz de Fora, Dept Fis, ICE, Campus Martelo, BR-36036330 Juiz De Fora, MG, Brazil; [Paz Lopes, Miriam Teresa; Dittz, Dalton] Univ Fed Minas Gerais, ICB, Dept Farmacol, BR-31270901 Belo Horizonte, MG, Brazil; [Silva, Heveline] Univ Fed Minas Gerais, Dept Quim, BR-31270901 Belo Horizonte, MG, Brazil in 2019.0, Cited 37.0. Recommanded Product: 62-23-7. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7

A series of1,2,4- and 1,3,4-oxadiazole derivatives were synthesized and evaluated for their anticancer activity. Halogenated 1,2,4-oxadiazoles were obtained from benzonitrile and coupled either lipophilic amines or with aminoalcohols. Lipophilic 1,3,4-oxadiazole derivatives were obtained through the Mannich reactions between 5-(aryl)-1,3,4-oxadiazole-2-thiol and alkylated or acylated amines. The in vitro cytotoxic effects were evaluated against 4T1- mammary carcinoma and CT26 – colon cancer cells. The best results were obtained for the 1,3,4-oxadiazole coupled to alkylated piperazine with 10-14 carbon chain moiety, with IC50 values ranging from 1.6 to 3.55 mu M for the 4T1 cell line, and from 1.6 to 3.9 mu M for the CT26.WT cell line, and selectivity index up to 19. The most potent compounds were investigated with AnnexinV and PI staining as indicative of apoptosis induction. (C) 2019 Published by Elsevier Masson SAS.

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Authors Ma, QN; Yang, XD; Lei, XS; Lin, GQ in ROYAL SOC CHEMISTRY published article about ASYMMETRIC-SYNTHESIS; QUATERNARY CARBON; ALPHA(2C)-ADRENOCEPTOR ANTAGONIST; STEREOSELECTIVE CONSTRUCTION; REDUCTION; DELTA(3)-2-HYDROXYBAKUCHIOL; ACIDS in [Ma, Qiaoning; Lei, Xinsheng; Lin, Guo-Qiang] Fudan Univ, Inst Biomed Sci, 826 Zhangheng Rd, Shanghai 201203, Peoples R China; [Ma, Qiaoning; Lei, Xinsheng; Lin, Guo-Qiang] Fudan Univ, Sch Pharm, 826 Zhangheng Rd, Shanghai 201203, Peoples R China; [Yang, Xiaodi; Lin, Guo-Qiang] Shanghai Univ Tradit Chinese Med, Expt Ctr Sci & Technol, Shanghai 201203, Peoples R China; [Lin, Guo-Qiang] Chinese Acad Sci, Shanghai Inst Organ Chem, Ctr Excellence Mol Synth, Key Lab Synthet Chem Nat Subst, 345 Lingling Rd, Shanghai 200032, Peoples R China in 2019.0, Cited 32.0. SDS of cas: 62-23-7. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7

The preparation of ORM-10921, a selective (2C)-adrenoceptor antagonist with promising anti-psychotic properties, was successfully achieved using asymmetric -alkylation of ,-unsaturated imide and Bischler-Napieralski cyclization/asymmetric reduction as the key steps. When the tetracyclic iminium 11S was used in the reduction, the diastereo-selectivity was poor, from which four stereoisomers of ORM-10921 were obtained, respectively. However, the diastereoselectivity could be significantly improved (with dr up to >97:3) when the tricyclic imine substrate 19S was applied in this reduction, suggesting an additional chelation from the side-chain methoxy group in the transition state. According to this protocol, ORM-10921 was accomplished in a highly enantioselective manner. In addition, two analogs 26Aa and 26Ba were prepared using this novel method, and the absolute configurations were unambiguously assigned by single crystal X-ray crystallography.

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem