Category: phthalazine

An article Correlation between molecular acidity (pK(a)) and vibrational spectroscopy WOS:000457307000002 published article about GAUSSIAN-BASIS SETS; DISSOLVED ORGANIC-MATTER; CARBOXYLIC-ACIDS; QUANTITATIVE ASSESSMENT; DISSOCIATION-CONSTANTS; THERMODYNAMIC PROPERTIES; ELECTRONIC-PROPERTIES; INTRINSIC STRENGTH; FUNCTIONAL-GROUPS; ORBITAL METHODS in [Verma, Niraj; Kraka, Elfi] Southern Methodist Univ, Dept Chem, Computat & Theoret Grp CATCO, 3215 Daniel Ave, Dallas, TX 75275 USA; [Tao, Yunwen] NYU, Dept Chem, 100 Wash Sq East, New York, NY 10003 USA; [Marcial, Bruna Luana] Rodovia BR153,KM633 Zona Rural, BR-75650000 Morrinhos, Go, Brazil in 2019.0, Cited 125.0. Recommanded Product: 62-23-7. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7

Molecular acidity is an important physicochemical property, which is often represented by the pK(a) value as the measure of acidity strength. However, the accurate calculation and prediction of pK(a) values is still an unsolved problem for computational chemistry. In this work, we present for the first time a direct correlation between pK(a) values and local vibrational frequencies for 15 different groups of compounds with various substituents. This correlation was derived from a quadratic function of two selected local vibrational frequencies as independent variables used to characterize electronic structure features influencing the molecular acidity. In total, 180 molecules were investigated with this correlation model. For each group of molecules, we found a strong correlation with root mean squared errors and mean absolute errors of less than 0.11 and 0.09 pK(a) units, respectively. The correlation between pK(a) and local vibrational modes, established in this work, can be generally applied to all compounds whose pK(a) values are dominated by electronic substituent effects. In this regard, the new correlation model constitutes a powerful link between the well-known Hammett equation and vibrational spectroscopy. Furthermore, it allows a quick prediction of the pK(a) values for new group members with different substituents.

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Recently I am researching about COPPER-CATALYZED CARBOXYLATION; LATE-STAGE FUNCTIONALIZATION; BOND FUNCTIONALIZATION; 1,3-DISUBSTITUTED ARENES; ESTERS; ACTIVATION; REGIOSELECTIVITY; DIVERSIFICATION; CONSTRUCTION; HETEROARENES, Saw an article supported by the NordForsk [85378]; Tromso Research Foundation [TFS2016KHH]. Published in WILEY-V C H VERLAG GMBH in WEINHEIM ,Authors: Gevorgyan, A; Hopmann, KH; Bayer, A. The CAS is 62-23-7. Through research, I have a further understanding and discovery of 4-Nitrobenzoic acid. Computed Properties of C7H5NO4

A formal C-H carboxylation of unactivated arenes using CO2 in green solvents is described. The present strategy combines a sterically controlled Ir-catalyzed C-H borylation followed by a Cu-catalyzed carboxylation of the in situ generated organoboronates. The reaction is highly regioselective for the C-H carboxylation of 1,3-disubstituted and 1,2,3-trisubstituted benzenes, 1,2- or 1,4-symmetrically substituted benzenes, fluorinated benzenes and different heterocycles. The developed methodology was applied to the late-stage C-H carboxylation of commercial drugs and ligands.

Computed Properties of C7H5NO4. Welcome to talk about 62-23-7, If you have any questions, you can contact Gevorgyan, A; Hopmann, KH; Bayer, A or send Email.

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Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Authors Benedekovic, G; Popsavin, M; Kovacevic, I; Kojic, V; Rodic, M; Popsavin, V in ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER published article about STEREOSELECTIVE TOTAL-SYNTHESIS; GENERAL DEFINITION; EFFICIENT in [Benedekovic, Goran; Popsavin, Mirjana; Kovacevic, Ivana; Rodic, Marko; Popsavin, Velimir] Univ Novi Sad, Fac Sci, Dept Chem Biochem & Environm Protect, Trg Dositeja Obradovica 3, Novi Sad, Serbia; [Kojic, Vesna] Univ Novi Sad, Fac Med, Oncol Inst Vojvodina, Put Dr Goldmana 4, Sremska Kamenica 21204, Serbia; [Popsavin, Velimir] Serbian Acad Arts & Sci, Knez Mihajlova 35, Belgrade 11000, Serbia in 2020.0, Cited 28.0. Recommanded Product: 62-23-7. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7

A new, modified total synthesis of (-)-cleistenolide (1) and sixteen new analogues or derivatives was achieved starting from commercially available 1,2-O-isopropylidene-alpha-D-glucofuranose. The synthesis of 1 proceeds in six steps and 67% overall yield, using single-carbon atom degradation of a protected chiral precursor, (Z)-selective Wittig olefination, and acid catalyzed delta-lactonization. A new Lewis acid promoted procedure for one-pot O-debenzylation/O-acylation has been developed to complete the synthesis of natural product 1 and selected analogues. The synthesized compounds were tested in vitro to evaluate their cytotoxicity against K562, HL-60, Jurkat, Raji, MCF-7, MDA-MB 231, HeLa, A549, and MRC-5 cell lines. All (-)-cleistenolide analogues exhibited significantly higher cytotoxicity than lead 1 against the majority of cell lines tested. Most of the synthesized compounds are more active than doxorubicin on at least one malignant cell line, but were almost completely inactive against normal MRC-5 cells. The structural features of the tested compounds responsible for their antiproliferative activity have been identified by preliminary SAR analysis. (C) 2020 Elsevier Masson SAS. All rights reserved.

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Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

In 2019 EUR J MED CHEM published article about ACUTE MYELOID-LEUKEMIA; KINASE INHIBITOR; MUTATIONS; SORAFENIB; DISCOVERY; OUTCOMES; MUTANTS; POTENT in [Heng, Hao; Wang, Zhijie; Li, Hongmei; Huang, Yatian; Lan, Qingyuan; Guo, Xiaoxing; Zhang, Liang; Lu, Shuai] China Pharmaceut Univ, Sch Sci, Nanjing 211198, Jiangsu, Peoples R China; [Zhi, Yanle] Henan Univ Chinese Med, Sch Pharm, Zhengzhou 450046, Henan, Peoples R China; [Cai, Jiongheng; Qin, Tianren; Xiang, Li; Wang, Shuxian] China Pharmaceut Univ, Sch Pharm, Nanjing 210009, Jiangsu, Peoples R China; [Chen, Yadong] China Pharmaceut Univ, Lab Mol Design & Drug Discovery, Nanjing 211198, Jiangsu, Peoples R China; [Lu, Tao] China Pharmaceut Univ, State Key Lab Nat Med, Nanjing 210009, Jiangsu, Peoples R China in 2019, Cited 32. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7. Safety of 4-Nitrobenzoic acid

FLT3 mutation is among the most common genetic mutations in acute myeloid leukemia (AML), which is also related with poor overall survival and refractory in AML patients. Recently, FLT3 inhibitors have been approved for AML therapy. Herein, a series of new compounds with pyrazole amine scaffold was discovered, which showed potent inhibitory activity against FLT3-ITD and significant selectivity against both FLT3-ITD and AML cells expressing FLT3-ITD. Compound 46, possessing the most promising cellular activity, blocked the autophosphorylation of FLT3 pathway in MV4-11 cell line. Furthermore, the apoptosis and downregulation of P-STAT5 were also observed in tumor cells extracted from the MV411 cell xenografts model upon compound 46 treatment. Compound 46 was also metabolically stable in vitro and suppressed tumor growth significantly in MV4-11 xenografts model in vivo. Compound 46 showed no toxicity to the viscera of mice and caused no decrease in body weight of mice. In conclusion, the results of this study could provide valuable insights into discovery of new FLT3 inhibitors, and compound 46 was worthy of further development as potential drug candidate to treat AML (C) 2019 Elsevier Masson SAS. All rights reserved.

Safety of 4-Nitrobenzoic acid. Welcome to talk about 62-23-7, If you have any questions, you can contact Heng, H; Wang, ZJ; Li, HM; Huang, YT; Lan, QY; Guo, XX; Zhang, L; Zhi, YL; Cai, JH; Qin, TR; Xiang, L; Wang, SX; Chen, YD; Lu, T; Lu, S or send Email.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Recommanded Product: 4-Nitrobenzoic acid. I found the field of Chemistry very interesting. Saw the article POCl3 promoted metal-free synthesis of tertiary amides by coupling of carboxylic acids and N,N-disubstituted formamides published in 2019, Reprint Addresses Xiao, JH (corresponding author), State Key Lab NBC Protect Civilian, Beijing, Peoples R China.. The CAS is 62-23-7. Through research, I have a further understanding and discovery of 4-Nitrobenzoic acid.

Herein we report a robust and synthetically useful catalyst-free amination methodology by the coupling of carboxylic acids and N-substituted formamides using POCl3 as a promoter. Versatile amides with a wide array of substituent groups were prepared within only 1 h in good to excellent yields. And even multi-substituted aromatic carboxylic acids could give the desired products with satisfactory results.

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Recommanded Product: 4-Nitrobenzoic acid. In 2019.0 ORGANOMETALLICS published article about CARBOXYLIC-ACID SALTS; CP-H BONDS; PRIMARY ALCOHOLS; UNACTIVATED C(SP(3))-H; AEROBIC OXIDATION; WATER; AMINES; ESTERIFICATION; ALKYLATION; CONVERSION in [Dolui, Pritam; Hazra, Susanta; Deb, Mayukh; Elias, Anil J.] Indian Inst Technol, Dept Chem, New Delhi 110016, India in 2019.0, Cited 68.0. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7.

Picolinamide group assisted sp(3) C-H bond oxidation of methylene groups to the corresponding carbonyl compounds has been achieved by using simple bottle ferrocene as catalyst and Cu(OAc)(2) or tert-butyl peroxybenzoate (TBPB) as oxidant under mild conditions. This method is applicable for picolinamide bound organic as well as organometallic compounds with yields in the range of 46-82%. Control experiments and mechanistic studies indicate that a radical mechanism is responsible for these oxidative transformations in which ferrocene acts as a catalyst.

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Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Authors Ren, DD; Xu, LB; Wang, L; Li, SS in AMER CHEMICAL SOC published article about HIGH-PRESSURE REACTION; C(SP(3))-H BONDS; 2,5-DIMETHYLFURAN; CYCLOADDITIONS; CONSTRUCTION; CASCADE in [Ren, Didi; Xu, Lubin; Wang, Liang; Li, Shuai-Shuai] Qingdao Agr Univ, Coll Chem & Pharmaceut Sci, Qingdao 266109, Peoples R China in 2019.0, Cited 40.0. Application In Synthesis of 4-Nitrobenzoic acid. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7

The inert benzylic C-H bond of pi-electron-rich heteroaromatic 2,5-dialkylfuran derivatives was conveniently functionalized with ferrocenyl alcohols as alkylation reagents under catalytic acidic conditions at room temperature, which features chemo- and regiospecificity, mild and metallic catalyst free conditions, and environmental benignity.

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

An article Unusual Epimerization in Styryllactones: Synthesis of (-)-5-Hydroxygoniothalamin, (-)-5-Acetylgoniothalamin, and O-TBS-Goniopypyrone WOS:000505078800031 published article about STYRYL-LACTONES in [Kotammagari, Tharun K.; Paul, Sayantan; Bhattacharya, Asish K.] Natl Chem Lab, CSIR, Div Organ Chem, Dr Homi Bhabha Rd, Pune 411008, Maharashtra, India; [Kotammagari, Tharun K.; Paul, Sayantan; Bhattacharya, Asish K.] Natl Chem Lab, CSIR, Acad Sci & Innovat Res AcSIR, Dr Homi Bhabha Rd, Pune 411008, Maharashtra, India in 2019.0, Cited 26.0. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7. Application In Synthesis of 4-Nitrobenzoic acid

(-)-5-Hydroxygoniothalamin, (-)-5-acetylgoniothalamin, and (+)-5-hydroxygoniothalamin, isolated from the Goniothalamus genus, are synthesized from triacetyl-O-D-glucal by employing the Ferrier reaction, Mitsunobu reaction, and Jones oxidation as key steps. The synthetic procedure also yields the epimers of (-)-5-hydroxygoniothalamin and (+)-5-hydroxygoniothalamin employing acid-mediated transition-metal-free epimerization at C-5 of styryllactones. Further studies reveal that the epimerization is facilitated by the phenyl group present on the styryllactones. Also, depending on the dihydroxylation reaction conditions, various analogues of saturated styryllactones are synthesized utilizing oxa-Michael reaction conditions.

Welcome to talk about 62-23-7, If you have any questions, you can contact Kotammagari, TK; Paul, S; Bhattacharya, AK or send Email.. Application In Synthesis of 4-Nitrobenzoic acid

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Formula: C7H5NO4. In 2019.0 J CATAL published article about EFFICIENT CARBOCATALYST; ORGANIC POLLUTANTS; CARBON NANOTUBES; GRAPHENE OXIDE; REDUCTION; NITROGEN; NANOPARTICLES; OXIDATION; 4-NITROPHENOL; DEGRADATION in [He, Zhaolin; Liu, Jin; Zhao, Wang; Wen, Zhipan; Chen, Jun; Xi, Jiangbo; Yu, Junxia; Bai, Zhengwu] Wuhan Inst Technol, Sch Chem & Environm Engn, Wuhan 430073, Hubei, Peoples R China; [Wang, Qijun; Manoj, Devaraj; Xie, Chuyi; Wang, Shuai] Huazhong Univ Sci & Technol, Sch Chem & Chem Engn, Key Lab Mat Chem Energy Convers & Storage, Minist Educ, Wuhan 430074, Hubei, Peoples R China; [Tang, Chunyan] Guangxi Univ, Sch Comp Elect & Informat, Nanning 530004, Guangxi, Peoples R China in 2019.0, Cited 53.0. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7.

Eco-friendly carbocatalyst is extremely desirable in organic catalysis and wastewater treatment. Herein, we reported a one-pot synchronous hydrothermal process to synthesize a highly efficient N doped holey graphene (NHG) carbocatalyst, in which graphene oxide nanosheets are self-assembled, reduced, chemically etched, and simultaneously doped with nitrogen to form a graphene hydrogel in the presence of H2O2 and NH4OH. Benefiting from the good hydrophilicity, unique hierarchical porous structure, large specific surface area (322.1 m(2)g(-1)), and high N content (9.77 at. %), the resultant NHG carbocatalyst exhibits an excellent catalytic performance for the hydrogenation of N-containing unsaturated compounds. In 4-nitrophenol reduction reaction, the NHG carbocatalyst delivers a turnover frequency of 3.32 x 10(-2) min(-1). This catalytic activity is superior to that of the commercial Pd/C (5.0 wt%), other previously reported carbocatalysts, and many noble-metal-based catalysts. Furthermore, the molecular structure analysis combined with density functional theory calculations elucidate metal-free catalytic mechanism of hydrogenation reaction for unsaturated chromophore groups in N-containing organic dyes. (C) 2019 Elsevier Inc. All rights reserved.

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

An article Palladium nanoparticles onto ethylenediamine functionalized silica-cellulose substrates [Pd(0)-EDA/SCs]: An efficient and sustainable approach for hydrogenation of nitroarenes and carbonyl compounds under mild conditions WOS:000504900300235 published article about ONE-POT SYNTHESIS; N-DOPED CARBON; CATALYTIC-HYDROGENATION; METAL NANOPARTICLES; GOLD NANOPARTICLES; REDUCTION; OXIDE; NITROBENZENE; COMPOSITE; ALCOHOLS in [Bhardwaj, Madhvi; Paul, Satya] Univ Jammu, Dept Chem, Jammu 180006, India in 2019.0, Cited 40.0. Recommanded Product: 4-Nitrobenzoic acid. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7

This paper aimed to report a green and efficient approach for the Pd(0)-EDA/SCs catalyzed hydrogenation of nitroarenes and carbonyl compounds using environment friendly molecular hydrogen at room temperature under benign reaction media. Three different catalysts, Pd(0)-EDA/SC-1, Pd(0)-EDA/SC-2 and Pd(0)-EDA/SC-3 based on immobilization of palladium nanoparticles onto ethylene diamine functionalized silica-cellulose substrates were prepared. Among various catalysts tested, Pd(0)-EDA/SC-2 showed superior catalytic activity. Further, excellent yield of the products, recyclability and the facile work-up make the catalyst more versatile, eco-friendly and economical to perform the desired organic transformations. (C) 2016 The Authors. Published by Elsevier B.V. on behalf of King Saud University.

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem