Category: phthalazine

An article Semi-synthesis and anti-tumor activity of novel 25-OCH3-PPD derivatives incorporating aromatic moiety WOS:000454616600012 published article about IN-VITRO; NATURAL-PRODUCT; PANAX-GINSENG; CANCER; GINSENOSIDES; 20(S)-25-METHOXYL-DAMMARANE-3-BETA; 20-TRIOL; 12-BETA; VIVO in [Qu, Fan-Zhi; Xiao, Sheng-Nan; Wang, Xu-De; Zhang, Yan; Su, Guang-Yue; Zhao, Yu-Qing] Shenyang Pharmaceut Univ, Shenyang 110016, Liaoning, Peoples R China; [Su, Guang-Yue; Zhao, Yu-Qing] Shenyang Pharmaceut Univ, Minist Educ, Key Lab Struct Based Drug Design & Discovery, Shenyang 110016, Liaoning, Peoples R China in 2019, Cited 26. Safety of 4-Nitrobenzoic acid. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7

Previously we have reported that 25-OCH3-PPD could suppress the reproduction of cancer cells and cause apoptosis without obvious toxicity. Herein, we aimed to enhance its bioactivity by introducing aromatic groups to its dammarane-type skeleton. These synthesized derivatives were tested for their inhibitory activities against five cancer cell lines. Of them, compounds 3a, 14a and 18a had the strongest antiproliferative activities against tumor cells (IC50 < 15 mu M, 5-fold to 10-fold increases than 25-OCH3-PPD). Especially compound 14a displayed the most potent activity against DU145, MCF-7 and HepG2 cells (IC50 = 6.7 +/- 0.8, 4.3 +/- 0.8 and 5.8 +/- 0.6 mu M, respectively). Structure-activity relationships demonstrated that having aromatic ester at the C3 position could improve the bioactivity. The data provided new insights into exploring novel antiproliferative lead compounds. Bye, fridends, I hope you can learn more about C7H5NO4, If you have any questions, you can browse other blog as well. See you lster.. Safety of 4-Nitrobenzoic acid

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

In 2019.0 ORG LETT published article about PHOTOREDOX-CATALYSIS; FUNCTIONALIZATION; ALPHA; AMIDOALKYLATION; ETHERS in [Xu, Jin-hui; Wu, Wen-bin; Wu, Jie] Natl Univ Singapore, Dept Chem, 3 Sci Dr 3, Singapore 117543, Singapore in 2019.0, Cited 47.0. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7. Quality Control of 4-Nitrobenzoic acid

Ortho-alkylated and ortho-acylated pyridines have been conveniently synthesized from pyridine N-oxides and alkynes under visible-light-mediation in a metal-free manner. The alkynes served as both alkylating and acylating agents via switching between anaerobic and aerobic conditions. The overall strategy accommodates a broad scope of substituted pyridine N-oxides and alkynes, with excellent regioselectivity in a number of cases.

Welcome to talk about 62-23-7, If you have any questions, you can contact Xu, JH; Wu, WB; Wu, J or send Email.. Quality Control of 4-Nitrobenzoic acid

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Recently I am researching about BIOLOGICAL EVALUATION; MOLECULAR DOCKING; ELLIPTICINE DERIVATIVES; AMIDE DERIVATIVES; POTENT; INHIBITORS; ANALOGS; DISCOVERY; BINDING; SERIES, Saw an article supported by the . Published in SPRINGER BIRKHAUSER in NEW YORK ,Authors: Kala, P; Sharif, SK; Krishna, CM; Ramachandran, D. The CAS is 62-23-7. Through research, I have a further understanding and discovery of 4-Nitrobenzoic acid. Name: 4-Nitrobenzoic acid

A library of 1,2,4-oxadiazole functionalized quinoline derivatives (13a-j) were synthesized and their structures were confirmed by H-1 NMR, (CNMR)-C-13 and Mass Spectral analysis. Further, these compounds were evaluated for their anticancer activity against four human cancer cell lines, namely MCF-7 (breast), A549 (lung), DU-145 (prostate) and MDA MB-231 (breast) using Etoposide as the positive control. Most of these derivatives exhibited more potent activity towards the four cancer cell lines compared to Etoposide. Amongst all the compounds tested, compounds 13b, 13c, 13h, 13i and 13j exhibited promising activity. Further of these compounds 13b, 13i and 13j exhibited excellent activity, when compared with Etoposide.

Name: 4-Nitrobenzoic acid. Welcome to talk about 62-23-7, If you have any questions, you can contact Kala, P; Sharif, SK; Krishna, CM; Ramachandran, D or send Email.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Salimiyan, K; Saberi, D in [Salimiyan, Kimiya] Persian Gulf Univ, Fac Sci, Dept Chem, Bushehr 75169, Iran; [Saberi, Dariush] Persian Gulf Univ, Marine Chem Dept, Fac Marine Sci & Technol, Bushehr 75169, Iran; [Saberi, Dariush] Persian Gulf Univ, Fisheries & Aquaculture Dept, Fac Agr & Nat Resources, Bushehr 75169, Iran published Choline Chloride/Urea as an Eco-Friendly Deep Eutectic Solvent for TCT-Mediated Amide Coupling at Room Temperature in 2019, Cited 59. Computed Properties of C7H5NO4. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7.

A desirable alternative to organic solvents, very cheap, non-toxic and biodegradable deep eutectic solvent (DES) based on choline chloride and urea was introduced for 2,4,6-trichloro triazine mediated amide bond formation between carboxylic acids and amines at room temperature. Sub-stoichiometric amount of TCT was used as a cheap and readily available C-O activating reagent. Various derivatives of amines were coupled with carboxylic acids, via triacylated triazine intermediate, resulting the reaction of acids with TCT, and the corresponding amides were obtained in moderate to good yields.

Computed Properties of C7H5NO4. About 4-Nitrobenzoic acid, If you have any questions, you can contact Salimiyan, K; Saberi, D or concate me.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Recently I am researching about STEREOSELECTIVE-SYNTHESIS; ASYMMETRIC-SYNTHESIS; GLYCOSYLATION; 2-DEOXY-BETA-GLYCOSIDES; DIGITOXIN; SUGARS; ANTIBIOTICS; DONORS, Saw an article supported by the National Research Foundation of KoreaNational Research Foundation of Korea [NRF-2017R1A2B1010757]. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Seo, K; Rhee, YH. The CAS is 62-23-7. Through research, I have a further understanding and discovery of 4-Nitrobenzoic acid. Name: 4-Nitrobenzoic acid

Here, we report a de novo synthetic strategy toward beta-2,6-dideoxypyranoglycosides. The key event is the ruthenium-catalyzed regioselective olefin migration of dihydropyran allylic acetals to homoallylic acetals. In combination with other metal-catalyzed reactions, this new protocol led to the synthesis of beta-2,6-dideoxypyranoglycosides in a highly efficient manner. Using this sequential metal catalysis, various mono-, di-, and trisaccharide forms of beta-2,6-dideoxypyranoglycosides were prepared.

Name: 4-Nitrobenzoic acid. Welcome to talk about 62-23-7, If you have any questions, you can contact Seo, K; Rhee, YH or send Email.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Recently I am researching about GAUSSIAN-BASIS SETS; DISSOLVED ORGANIC-MATTER; CARBOXYLIC-ACIDS; QUANTITATIVE ASSESSMENT; DISSOCIATION-CONSTANTS; THERMODYNAMIC PROPERTIES; ELECTRONIC-PROPERTIES; INTRINSIC STRENGTH; FUNCTIONAL-GROUPS; ORBITAL METHODS, Saw an article supported by the National Science FoundationNational Science Foundation (NSF) [CHE 1464906]. Published in SPRINGER in NEW YORK ,Authors: Verma, N; Tao, YW; Marcial, BL; Kraka, E. The CAS is 62-23-7. Through research, I have a further understanding and discovery of 4-Nitrobenzoic acid. Computed Properties of C7H5NO4

Molecular acidity is an important physicochemical property, which is often represented by the pK(a) value as the measure of acidity strength. However, the accurate calculation and prediction of pK(a) values is still an unsolved problem for computational chemistry. In this work, we present for the first time a direct correlation between pK(a) values and local vibrational frequencies for 15 different groups of compounds with various substituents. This correlation was derived from a quadratic function of two selected local vibrational frequencies as independent variables used to characterize electronic structure features influencing the molecular acidity. In total, 180 molecules were investigated with this correlation model. For each group of molecules, we found a strong correlation with root mean squared errors and mean absolute errors of less than 0.11 and 0.09 pK(a) units, respectively. The correlation between pK(a) and local vibrational modes, established in this work, can be generally applied to all compounds whose pK(a) values are dominated by electronic substituent effects. In this regard, the new correlation model constitutes a powerful link between the well-known Hammett equation and vibrational spectroscopy. Furthermore, it allows a quick prediction of the pK(a) values for new group members with different substituents.

Computed Properties of C7H5NO4. Bye, fridends, I hope you can learn more about C7H5NO4, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

An article Ultrasound-Assisted Synthesis of N -Acylcyanamides and N -Acyl-Substituted Imidazolones from Carboxylic Acids by Using Trichloroisocyanuric Acid/Triphenylphosphine WOS:000526694900012 published article about CATALYZED CARBONYLATIVE SYNTHESIS; FACILE SYNTHESIS; CYANAMIDES; INHIBITORS; POTENT; TRIPHENYLPHOSPHINE; ISOTHIOCYANATES; QUINAZOLINONES; TRANSFORMATION; LEUCETTINES in [Phakhodee, Wong; Yamano, Dolnapa; Pattarawarapan, Mookda] Chiang Mai Univ, Fac Sci, Dept Chem, Chiang Mai 50200, Thailand; [Phakhodee, Wong; Yamano, Dolnapa; Pattarawarapan, Mookda] Chiang Mai Univ, Fac Sci, Ctr Excellence Innovat Chem, Chiang Mai 50200, Thailand; [Phakhodee, Wong; Pattarawarapan, Mookda] Chiang Mai Univ, Fac Sci, Res Ctr Chem Dev Hlth Promoting Prod Northern Res, Chiang Mai 50200, Thailand in 2020, Cited 46. Formula: C7H5NO4. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7

A convenient ultrasound-assisted one-pot synthesis of N -acylcyanamides starting from readily available carboxylic acids and sodium cyanamide has been developed. Upon activation in the presence of trichloroisocyanuric acid (TCCA) and triphenylphosphine, a range of carboxylic acids was converted into N -acylcyanamides in good to excellent yields within 10 minutes at room temperature without base. Remarkably, N -acyl-substituted imidazolones were readily accessible through guanylation-cyclization of the in situ generated N -acylcyanamides.

Welcome to talk about 62-23-7, If you have any questions, you can contact Phakhodee, W; Yamano, D; Pattarawarapan, M or send Email.. Formula: C7H5NO4

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Recommanded Product: 62-23-7. Song, ZL; Bai, FF; Zhang, BX; Fang, JG in [Song, Zi-Long; Bai, Feifei; Zhang, Baoxin; Fang, Jianguo] Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China; [Song, Zi-Long; Bai, Feifei; Zhang, Baoxin; Fang, Jianguo] Lanzhou Univ, Coll Chem & Chem Engn, Lanzhou 730000, Peoples R China published Synthesis of Dithiolethiones and Identification of Potential Neuroprotective Agents via Activation of Nrf2-Driven Antioxidant Enzymes in 2020, Cited 70. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7.

Oxidative stress is implicated in the pathogenesis of a wide variety of neurodegenerative disorders, and accordingly, dietary supplement of exogenous antioxidants or/and upregulation of the endogenous antioxidant defense system are promising for therapeutic intervention or chemoprevention of neurodegenerative diseases. Nrf2, a master regulator of the cellular antioxidant machinery, cardinally participates in the transcription of cytoprotective genes against oxidative/electrophilic stresses. Herein, we report the synthesis of 59 structurally diverse dithiolethiones and evaluation of their neuroprotection against 6-hydroxydopamine- or H2O2 -induced oxidative damages in PC12 cells, a neuron-like rat pheochromocytoma cell line. Initial screening identified compounds 10 and 11 having low cytotoxicity but conferring remarkable protection on PC12 cells from oxidative-mediated damages. Further studies demonstrated that both compounds upregulated a battery of antioxidant genes as well as corresponding genes’ products. Significantly, silence of Nrf2 expression abolishes cytoprotection of 10 and 11, indicating targeting Nrf2 activation is pivotal for their cellular functions. Taken together, the two lead compounds discovered here with potent neuroprotective functions against oxidative stress via Nrf2 activation merit further development as therapeutic or chemopreventive candidates for neurodegenerative disorders.

Recommanded Product: 62-23-7. Bye, fridends, I hope you can learn more about C7H5NO4, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

An article Benzyne-mediated trichloromethylation of chiral oxazolines WOS:000458417400012 published article about HIGHLY DIASTEREOSELECTIVE SYNTHESIS; ASYMMETRIC-SYNTHESIS; N-HETEROAROMATICS; ARYNES; KETONES; CYCLOADDITION; CYCLIZATION; QUINOLINES; BOND in [Huang, Xin; Zhao, Weizhao; Chen, De-Li; Zhan, Yaling; Zeng, Tingting; Jin, Huiquan; Peng, Bo] Zhejiang Normal Univ, Key Lab, Minist Educ Adv Catalysis Mat, Jinhua 321004, Peoples R China in 2019, Cited 48. Product Details of 62-23-7. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7

A three-component reaction between benzyne, oxazolines and chloroform was developed for the synthesis of trichloromethylated chiral oxazolidines. Benzyne not only serves as an electrophile towards oxazolines but also acts as a base for the deprotonation of chloroform. The dual functions of benzyne enable the trichloromethylation of chiral oxazolines and thus construct chiral N, Oquaternary stereocenters.

Product Details of 62-23-7. Bye, fridends, I hope you can learn more about C7H5NO4, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Mishra, UK; Ramesh, NG in [Mishra, Umesh K.; Ramesh, Namakkal G.] Indian Inst Technol Delhi, Dept Chem, New Delhi 110016, India published A glycal based approach to the synthesis of (+)-bulgecinine, 3-hydroxy-2,5-dihydroxymethylpyrrolidine and 2-oxapyrrolizidin-3-one in 2020.0, Cited 48.0. Category: phthalazines. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7.

A glycal based synthesis of ( + )-bulgecinine, 3-hydroxy-2,5-dihydroxymethylpyrrolidine and 2-oxapyrrolizidin-3-ones proceeding through a common intermediate is reported. The key step in the work presented here is a two-step conversion of 4,6 di-O-benzyl-D-glucal to 2,3-dideoxy-2-tosylamido-D-glucose. This manuscript reports the first carbohydrate based approach to the synthesis of ( + )-bulgecinine and the whole sequence has been accomplished with complete stereochemical integrity without the formation of mixture of products in any of these steps.

Category: phthalazines. Welcome to talk about 62-23-7, If you have any questions, you can contact Mishra, UK; Ramesh, NG or send Email.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem