Category: phthalazines

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 611-73-4, Name is 2-Oxo-2-phenylacetic acid, molecular formula is C8H6O3. In an article, author is Eswararao, S., V,once mentioned of 611-73-4, Safety of 2-Oxo-2-phenylacetic acid.

WATER MEDIATED ONE- POT- SYNTHESIS OF 1H-PYRAZOLO[1,2-B]PHTHALAZINE-5,10-DIONES AND 2H-INDAZOLO[2,1-B]PHTHALAZINE-1,6,11(13H)-TRIONES

1H-pyrazolo[1,2-b]phthalazine-5,10-diones (5) and 2H-indazolo[2,1-b]phthalazine-1,6,11(13H)-triones (7) have been synthesized by one pot, four-component method. To synthesise them phthalic anhydride (1), hydrazine hydrate (2), benzaldehydes (3) and malononitrile (4a) /ethyl cynoacetate (4b) /dimedone (6) in refluxing water for 1-1.5 h in the presence of InCl3 as a catalyst yielding 75-85%. These reactions have an easy workup, provides excellent yields, and uses water as the solvent which is considered to be relatively environmentally benign. The structures of the products were established from their spectral properties IR, H-1-NMR, C-13-NMR & Mass spectroscopy.

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Related Products of 1439-36-7, Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, 1439-36-7, Name is 1-(Triphenylphosphoranylidene)propan-2-one, SMILES is CC(C=P(C1=CC=CC=C1)(C2=CC=CC=C2)C3=CC=CC=C3)=O, belongs to phthalazines compound. In a article, author is De Abreu, Maxime, introduce new discover of the category.

Phosphoramidates as Transient Precursors of Nitrogen-Centered Radical Under Visible-Light Irradiation: Application to the Synthesis of Phthalazine Derivatives

Phosphoramidates are for the first time presented as efficient N-Centered Radical (NCR) precursors under visible-light irradiation. More precisely among this class of phosphorus-derived compounds, we studied the radical reactivity of phosphonohydrazones, under mild reaction conditions, which allowed the synthesis of a wide and diversified library of the scarcely reported phthalazine scaffold. Mechanistic investigations confirmed the formation of a NCR from these brand-new phosphonohydrazones (derivatived from phosphoramidates), which were further engaged in an intramolecular 6-exo-dig cyclization to provide phthalazines. Compared to other pre-activated moieties, the phosphoramidate group is self-immolative, thus enhancing its attractiveness for the C-N bond formation.

Related Products of 1439-36-7, Consequently, the presence of a catalyst will permit a system to reach equilibrium more quickly, but it has no effect on the position of the equilibrium as reflected in the value of its equilibrium constant.I hope my blog about 1439-36-7 is helpful to your research.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. , SDS of cas: 81-16-3, 81-16-3, Name is 2-Aminonaphthalene-1-sulfonic acid, molecular formula is C10H9NO3S, belongs to phthalazines compound. In a document, author is Shalkouhi, Somaye Nikzad, introduce the new discover.

Synthesis of novel spiro[chromeno[4 ‘,3 ‘:3,4]pyrazolo[1,2-b]phthalazine-7,3 ‘-indoline]-2 ‘,6,9,14-tetraone

Fe3O4@Cys-SO3H magnetic nanocatalyst has been used as an effective and reusable solid acid catalyst for the one pot synthesis of novel spiro[chromeno[4′,3′:3,4]pyrazolo[1,2-b]phthalazine-7,3′-indoline]-2’,6,9,14-tetraone via a three-component reaction of phthalhydrazide, 4-hydroxycoumarin and isatin derivatives. Easy separation of catalyst, good yields of reaction and synthesis of novel heterocyclic compound are some advantages of this procedure.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 81-16-3. SDS of cas: 81-16-3.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Electric Literature of 371-42-6, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C¨CH bond functionalisation has revolutionised modern synthetic chemistry. 371-42-6, Name is 4-Fluorothiophenol, SMILES is SC1=CC=C(F)C=C1, belongs to phthalazines compound. In a article, author is Lamera, Esma, introduce new discover of the category.

Synthesis, characterization, X-ray structure, optical properties and theoretical calculations of condensed phthalazines

Two condensed phthalazine compounds were synthesized and characterized by FT-IR, UV-Vis, NMR spectroscopic studies. Single crystal XRD and molecular orbital calculations. Optimized geometrical structures were computed with RB3LYP method with the 6-31G(p, d) basis set. The geometrical parameters of both compounds obtained from Single Crystal XRD were found to be in accord with the calculated (DFT) values. The electronic contribution was measured using the third harmonic generation technique on thin films at 1064 nm for both compounds. Also, the values of dipole moment , the average polarizability , and the first static hyperpolarizability were computed. The theoretical and experimental results confirm the NLO behavior of both compounds.

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics, SDS of cas: 4474-86-6, 4474-86-6, Name is N-Cbz-D-Asparagine, SMILES is O=C(N)C[C@H](C(O)=O)NC(OCC1=CC=CC=C1)=O, belongs to phthalazines compound. In a document, author is Soltanzadeh, Zahra, introduce the new discover.

Solvent-free organic salt media mono symmetrical aza-Michael: synthesis of new N-mono substituted phthalhydrazide derivatives

In this paper, C-N bond formation between 2,3-dihydrophthalazine-1(4H),4-dione (phthalhydrazide) and alpha,beta-unsaturated esters was investigated and a new series of phthalazine derivatives was synthesized using an efficient and simple method under solvent-free conditions. An aza-Michael addition of phthalhydrazide to both acrylic and fumaric esters led to N-monosubstituted phthalhydrazides (as mono-Michael adduct) in the presence of tetrabutylammonium bromide as a high polar media, and 1,4-diaza-bicyclo[2,2,2] octane as an available organic base. In this reaction, the N1,N2-bis-Michael adduct was not observed at all. Also, reactions were performed at 90 degrees C and yields of products were good to excellent.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 4474-86-6. SDS of cas: 4474-86-6.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 104-86-9, Name is (4-Chlorophenyl)methanamine, molecular formula is C7H8ClN. In an article, author is Wang Yinglei,once mentioned of 104-86-9, SDS of cas: 104-86-9.

Synthesis of Pyrazolo[1,2-b]phthalazine-5,10-diones Catalyzed by Poly(ethylene glycol) Grafted 4-Dimethylaminopyridine Functionalized Ionic Liquid

A novel poly(ethylene glycol) grafted 4-dimethylaminopyridine functionalized ionic liquid ([DMAP-PEG(1000)-DIL][BF4]) was prepared and characterized by H-1 NMR, C-13 NMR, FT-IR and ESI-MS. In the presence of [DMAP-PEG(1000)-DIL][BE4], various substituted aromatic aldehyde could react with malononitrile (or ethyl cyanoacetate) and phthalhydrazide in water to obtain a series of pyrazolo[1,2-b]phthalazine-5,10-dione derivatives with 85%similar to 96% yields. The mild reaction conditions, high stable and recyclable ionic liquids, environmental friendliness are advantages of this methodology.

Interested yet? Keep reading other articles of 104-86-9, you can contact me at any time and look forward to more communication. SDS of cas: 104-86-9.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Chemistry is an experimental science, SDS of cas: 696-63-9, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 696-63-9, Name is 4-Methoxythiophenol, molecular formula is C7H8OS, belongs to phthalazines compound. In a document, author is Ziarani, Ghodsi Mohammadi.

Efficient One-Pot Solvent-Free Synthesis of 1H-Pyrazolo[1,2-b]phthalazine-5,10-diones Catalyzed by Sulfonic Acid Functionalized Nanoporous Silica (SBA-Pr-SO3H)

A green protocol has been developed for the synthesis of 1H-pyrazolo[1,2-b]phthalazine-5,10-diones by one-pot cyclocondensation reaction of phthalhydrazide, aromatic aldehydes, and malononitrile or ethyl cyanoacetate using sulfonic acid functionalized SBA-15 (SBA-Pr-SO3H) as a heterogeneous solid acid catalyst under solvent-free conditions.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 696-63-9. SDS of cas: 696-63-9.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Reactions catalyzed within inorganic and organic materials and at electrochemical interfaces commonly occur at high coverage and in condensed media, causing turnover rates to depend strongly on interfacial structure and composition, 54381-16-7, Name is 2,2′-((4-Aminophenyl)azanediyl)diethanol sulfate, SMILES is NC1=CC=C(N(CCO)CCO)C=C1.O=S(O)(O)=O, in an article , author is Heirati, Seyedeh Zahra Dalil, once mentioned of 54381-16-7, COA of Formula: C10H18N2O6S.

Application of O-sulfonic acid poly(4-vinylpyrrolidonium) chloride as an efficient polymer-supported catalyst in the rapid synthesis of 2H-indazolo[2,1-b]phthalazine-triones and Biginelli-like products

In this work, a series of 2H-indazolo[2,1-b]phthalazine-triones and Biginelli-like products were efficiently synthesized for the first time using O-Sulfonic acid poly(4-vinylpyrrolidonium) chloride ([PVP-SO3H]Cl) as an eco-friendly polymer-supported catalyst. At first, the catalyst preparation process was optimized based on the chlorosulfonic acid amount and the sulfonation time to obtain a catalyst with the maximum acidity content. The maximum acidity content for [PVP-SO3H]Cl was obtained to be 3.31 mmol g(-1). Then, the optimized [PVP-SO3H]Cl was used as a catalyst for the synthesis of a series of 2H-indazolo[2,1-b]phthalazine-triones and Biginelli-like products. It was observed that only 10 mg of the catalyst was enough to catalyze these reactions under mild conditions, and the corresponding products were obtained in high to excellent yields. Moreover, the catalyst could be repeatedly used for at least five times without a noticeable decrease in its catalytic activity.

But sometimes, even after several years of basic chemistry education, it is not easy to form a clear picture on how they govern reactivity! 54381-16-7, you can contact me at any time and look forward to more communication. COA of Formula: C10H18N2O6S.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Application of 875-74-1, As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 875-74-1, Name is H-D-Phg-OH, SMILES is O=C(O)[C@H](N)C1=CC=CC=C1, belongs to phthalazines compound. In a article, author is Appleby, Kate M., introduce new discover of the category.

Investigating pyridazine and phthalazine exchange in a series of iridium complexes in order to define their role in the catalytic transfer of magnetisation from para-hydrogen

The reaction of [Ir(IMes)(COD)Cl], [IMes = 1,3-bis(2,4,6-trimethylphenyl)imidazol-2-ylidene, COD = 1,5-cyclooctadiene] with pyridazine (pdz) and phthalazine (phth) results in the formation of [Ir(COD)(IMes)(pdz)]Cl and [Ir(COD)(IMes)(phth)]Cl. These two complexes are shown by nuclear magnetic resonance (NMR) studies to undergo a haptotropic shift which interchanges pairs of protons within the bound ligands. When these complexes are exposed to hydrogen, they react to form [Ir(H)(2)(COD)(IMes)(pdz)]Cl and [Ir(H)(2)(COD)(IMes)(phth)]Cl, respectively, which ultimately convert to [Ir(H)(2)(IMes)(pdz)(3)]Cl and [Ir(H)(2)(IMes)(phth)(3)] Cl, as the COD is hydrogenated to form cyclooctane. These two dihydride complexes are shown, by NMR, to undergo both full N-heterocycle dissociation and a haptotropic shift, the rates of which are affected by both steric interactions and free ligand pK(a) values. The use of these complexes as catalysts in the transfer of polarisation from para-hydrogen to pyridazine and phthalazine via signal amplification by reversible exchange (SABRE) is explored. The possible future use of drugs which contain pyridazine and phthalazine motifs as in vivo or clinical magnetic resonance imaging probes is demonstrated; a range of NMR and phantom-based MRI measurements are reported.

Application of 875-74-1, The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 875-74-1 is helpful to your research.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 789-25-3, Name is Triphenylsilane, molecular formula is C18H16Si. In an article, author is Zhang, Qiu-Rong,once mentioned of 789-25-3, Safety of Triphenylsilane.

Synthesis and antimicrobial activities of novel 1,2,4-triazolo [3,4-a] phthalazine derivatives

A series of novel 1,2,4-triazolo [3,4-a] phthalazine derivatives were synthesized in five steps from a common precursor, phthalic anhydride. Most of synthesized phthalazine derivatives showed inhibitory activity against Staphylococcus aureus. One of phthalazine derivatives 5l showed inhibitory activity against all tested bacterial and fungal strains. (C) 2014 Published by Elsevier Ltd.

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem