Category: phthalazines

Electric Literature of 587-04-2, As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 587-04-2, Name is 3-Chlorobenzaldehyde, SMILES is O=CC1=CC=CC(Cl)=C1, belongs to phthalazines compound. In a article, author is Mazaahir, Kidwai, introduce new discover of the category.

Efficient CAN catalyzed synthesis of 1H-indazolo[1,2-b] phthalazine-1,6,11-triones: An eco-friendly protocol

A convenient, economical and green approach to the synthesis of 1H-indazolo[1,2-b]phthalazine-1,6,11-trione derivatives has been achieved via a one-pot protocol using phthalhydrazide, a cyclic-beta-diketone and an aldehyde in the presence of a ceric ammonium nitrate catalyst in polyethylene glycol. The simple work up, mild conditions, excellent yields, inexpensive and non-toxic catalyst and simple solvent recyclability render this protocol both attractive and economically viable.

Electric Literature of 587-04-2, Because enzymes can increase reaction rates by enormous factors and tend to be very specific, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 587-04-2.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics, HPLC of Formula: C3H6N4S, 89797-68-2, Name is 5-(Ethylthio)-1H-tetrazole, SMILES is CCSC1=NN=NN1, belongs to phthalazines compound. In a document, author is Tayebee, Reza, introduce the new discover.

A new simple method for the preparation of PbO nanoparticles and implementation of an efficient and reusable catalytic system for the synthesis of 1H-pyrazolo[1,2-b]phthalazine-5,10-diones

PbO nanoparticles were explored as a highly efficient, simple, cheap, and recyclable catalyst for the fast synthesis of 1H-pyrazolo[1,2-b]phthalazine-5,10-dione derivatives by means of a one-pot three-component reaction of phthalhydrazide, aromatic aldehyde, and malononitrile under solvent-free conditions at 80 A degrees C. Furthermore, nanosized PbO was prepared by the two conventional methods of planetary ball milling and dispersion of commercial PbO in n-octane, and their catalytic performances were compared with the commercial bulk PbO. The prepared nano-PbO via ball milling was described by SEM, TEM, XRD, EDX, and FT-IR spectroscopy. The present protocol conveyed major proficiencies such as the use of a reasonable and readily available catalyst, simple work-up and purification of products by nonchromatographic strategy, low reaction times, and enhanced yields under relatively environmental benign conditions. The heterogeneous catalyst was appropriately recyclable and could be reused for several times without loss of activity.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 89797-68-2. HPLC of Formula: C3H6N4S.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Chemistry is traditionally divided into organic and inorganic chemistry. The former is the study of compounds containing at least one carbon-hydrogen bonds. 524-95-8, Name is 2-((Diphenylboryl)oxy)ethanamine, molecular formula is C14H16BNO, belongs to phthalazines compound, is a common compound. In a patnet, author is Abida, once mentioned the new application about 524-95-8, Recommanded Product: 524-95-8.

Synthesis of some pyridazine derivatives as antioxidants and antimicrobial agents

Purpose: To prepare some pyridazine derivatives as antioxidant and antimicrobial agents. Methods: The coupling of aryl diazonium salts with diethyl 2-cyano-3-methylglutaconate afforded pyridazine-5-carbonitrile derivatives (3a-e). The methyl function in the pyridazine derivatives (3a-e) reacted with cinnamonitriles to yield phthalazine derivatives (6a-h). Imino-pyridazine derivatives (9a-h) were obtained by reacting 2-aminoprop-1-ene-1,1,3-tricarbonitrile along with aryl diazonium salts (1a-h). Structure elucidation was done by spectral analysis. The 1,1-diphenyl-2-picryl hydrazyl (DPPH) technique was employed to assess antioxidant effect, while evaluation of antimicrobial activity was carried out by serial dilution technique. Results: Compounds, 6f (IC50 = 12.68 mu g/mL; p < 0.05), 6a (IC50 = 14.23 mu g/mL; p < 0.05), and 3c (IC50 = 14.34 mu g/mL; p < 0.05) displayed good antioxidant activity compared to ascorbic acid (IC50 = 12.45 mu g/mL; p < 0.05). Based on the zone of inhibition, compound 6c (p < 0.05) displayed higher activity than ofloxacin (p < 0.05) against E. coli. Conclusion: The presence of an oxo group and carboxylate group plays an important role in the antioxidant activity of these compounds. Compounds 6a, 6f, and 3c can potentially serve as lead compounds for the development of promising antioxidants. We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, 524-95-8. The above is the message from the blog manager. Recommanded Product: 524-95-8.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

In an article, author is Asif, M., once mentioned the application of 613-45-6, Quality Control of 2,4-Dimethoxybenzaldehyde, Name is 2,4-Dimethoxybenzaldehyde, molecular formula is C9H10O3, molecular weight is 166.17, MDL number is MFCD00003311, category is phthalazines. Now introduce a scientific discovery about this category.

Some Recent Approaches of Biologically Active Substituted Pyridazine and Phthalazine Drugs

Nitrogen atom containing heterocyclic compounds, pyridazines, pyridazinones and phthalazines are important structural feature of many biologically active compounds and show diverse pharmacological properties. Pyridazines and phthalazines hold considerable interest relative to the preparation of organic intermediates and physiologically active compounds. On the basis of literature, pyridazines, pyridazinone and phthalazines further focus our attention because of their easy fictionalization at various ring positions, which makes them attractive synthetic compounds for designing and development of the novel pyridazines and phthalazines drugs in future.

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

In an article, author is Wakshe, Saubai B., once mentioned the application of 1821-12-1, Product Details of 1821-12-1, Name is 4-Phenylbutanoic acid, molecular formula is C10H12O2, molecular weight is 164.2011, MDL number is MFCD00004403, category is phthalazines. Now introduce a scientific discovery about this category.

Synthesis of phthalazine derivative based organic nanoflakes in aqueous solvent as a potential nano-anticancer agent: A new approach in medical field

A simple phthalazine derivative 13-(4-bromophenyl)-3,3-dimethyl-3,4-dihydro-1H-indazolo[1,2-b] phthalazine-1,6,11(2H,13H)-trione (IDP) was synthesized by Knoevenagel condensation with Michael addition reaction. The present articles deals with preparation of highly fluorescent nanoparticles as prepared drug (IDP) by simple reprecipitation method using single aqueous solvent. The DLS measurement predicted the 150 nm size of a synthesized IDP NPs. Furthermore UV-Visible and fluorescence spectroscopy measurement showed a distinct peak for IDP NPs from their parent molecule. Scanning Electron Microscopy (SEM) microphotograph of air dried film of nanoparticles exhibited nanoflakes type and feathery morphology. The highly fluorescent nature of IDP NPs ultimately revealed in high quantum yield than IDP parent molecule. These fluorescent organic nanoflakes then further applied as anticancer agent. Interestingly it showed better activity than IDP molecules. Thus this is the first report to use organic nanoflakes as an anticancer agent, which may open new avenues in medical field’s and related sciences. (C) 2019 Elsevier B.V. All rights reserved.

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

In an article, author is Han, Lyrialle W., once mentioned the application of 14348-75-5, Recommanded Product: 2,7-Dibromo-9H-fluoren-9-one, Name is 2,7-Dibromo-9H-fluoren-9-one, molecular formula is C13H6Br2O, molecular weight is 337.99, MDL number is MFCD00010790, category is phthalazines. Now introduce a scientific discovery about this category.

Effect of N-Acetyltransferase 2 Genotype on the Pharmacokinetics of Hydralazine During Pregnancy

Hydralazine, an antihypertensive agent used during pregnancy, undergoes N-acetylation primarily via N-acetyltransferase 2 (NAT2) to form 3-methyl-1,2,4-triazolo[3,4-a]phthalazine (MTP). To characterize the steady-state pharmacokinetics (PK) of hydralazine during pregnancy and evaluate the effects of NAT2 genotype on hydralazine and MTP PK during pregnancy, 12 pregnant subjects received oral hydralazine (5-25 mg every 6 hours) in mid- (n = 5) and/or late pregnancy (n = 8). Serial blood samples were collected over 1 dosing interval, and steady-state noncompartmental PK parameters were estimated. Subjects were classified as either (rapid acetylators, n = 6) or slow acetylators (SAs, n = 6) based on NAT2 genotype. During pregnancy, when compared with the SA group, the RA group had faster weight-adjusted hydralazine apparent oral clearance (70.0 +/- 13.6 vs 20.1 +/- 6.9 L/h, P .05), lower dose-normalized area under the concentration-time curve (AUC; 1.5 +/- 0.8 vs 5.9 +/- 3.7 ng center dot h/mL, P .05), lower dose-normalized peak concentrations (0.77 +/- 0.51 vs 4.04 +/- 3.18 ng/mL, P .05), and larger weight-adjusted apparent oral volume of distribution (302 +/- 112 vs 116 +/- 45 L/kg, P .05). Furthermore, the MTP/hydralazine AUC ratio was similar to 10-fold higher in the RA group (78 +/- 30 vs 8 +/- 3, P .05) than in the SA group. No gestational age or dose-dependent effects were observed, possibly because of the small sample size. This study describes for the first time, the PK of oral hydralazine and its metabolite, MTP, during pregnancy, and confirmed that the PK of oral hydralazine is NAT2 genotype dependent during pregnancy.

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, such as the rate of change in the concentration of reactants or products with time. 122-99-6, Name is 2-Phenoxyethanol, formurla is C8H10O2. In a document, author is De Abreu, Maxime, introducing its new discovery. Quality Control of 2-Phenoxyethanol.

Phosphoramidates as Transient Precursors of Nitrogen-Centered Radical Under Visible-Light Irradiation: Application to the Synthesis of Phthalazine Derivatives

Phosphoramidates are for the first time presented as efficient N-Centered Radical (NCR) precursors under visible-light irradiation. More precisely among this class of phosphorus-derived compounds, we studied the radical reactivity of phosphonohydrazones, under mild reaction conditions, which allowed the synthesis of a wide and diversified library of the scarcely reported phthalazine scaffold. Mechanistic investigations confirmed the formation of a NCR from these brand-new phosphonohydrazones (derivatived from phosphoramidates), which were further engaged in an intramolecular 6-exo-dig cyclization to provide phthalazines. Compared to other pre-activated moieties, the phosphoramidate group is self-immolative, thus enhancing its attractiveness for the C-N bond formation.

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Reactions catalyzed within inorganic and organic materials and at electrochemical interfaces commonly occur at high coverage and in condensed media, causing turnover rates to depend strongly on interfacial structure and composition, 5267-64-1, Name is D-Penylalaninol, SMILES is OC[C@H](N)CC1=CC=CC=C1, in an article , author is Choughule, Kanika V., once mentioned of 5267-64-1, Computed Properties of C9H13NO.

Evaluation of Rhesus Monkey and Guinea Pig Hepatic Cytosol Fractions as Models for Human Aldehyde Oxidases

Aldehyde oxidase (AOX) is a cytosolic enzyme expressed across a wide range of species, including guinea pig and rhesus monkey. These species are believed to be the best preclinical models for studying human AOX-mediated metabolism. We compared AOX activity in rhesus monkeys, guinea pigs, and humans using phthalazine and N-[2-(dimethylamino) ethyl] acridone-4-carboxamide (DACA) as substrates and raloxifene as an inhibitor. Michaelis-Menten kinetics was observed for phthalazine oxidation in rhesus monkey, guinea pig, and human liver cytosol, whereas substrate inhibition was seen with DACA oxidase activity in all three livers. Raloxifene inhibited phthalazine and DACA oxidase activity uncompetitively in guinea pig, whereas mixed-mode inhibition was seen in rhesus monkey. Our analysis of the primary sequence alignment of rhesus monkey, guinea pig, and human aldehyde oxidase isoform 1 (AOX1) along with homology modeling has led to the identification of several amino acid residue differences within the active site and substrate entrance channel of AOX1. We speculate that some of these residues might be responsible for the differences observed in activity. Overall, our data indicate that rhesus monkeys and guinea pigs would overestimate intrinsic clearance in humans and would be unsuitable to use as animal models. Our study also showed that AOX metabolism in species is substrate-dependent and no single animal model can be reliably used to predict every drug response in humans.

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, Formula: C8H7BrO2, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 7507-86-0, Name is 2-Bromo-5-methoxybenzaldehyde, molecular formula is C8H7BrO2. In an article, author is Awadallah, Fadi M.,once mentioned of 7507-86-0.

Synthesis, vasorelaxant activity, and molecular modeling study of some new phthalazine derivatives

New phthalazine-based vasodilators were synthesized through the chloroacylation of the starting compound 1-hydrazinophthalazine 4 to give the two key intermediates 5 and 7. These intermediates were used to alkylate various cyclic amines to furnish the final compounds 6a-h and 8a-h. Compounds were tested for their vasorelaxant activities against nor-adrenaline-induced spasm on thoracic rat aorta rings and compared to the reference drug, prazosin. Seven compounds showed higher activity than prazosin, especially compound 8d having an IC50 = 0.10 mM. Molecular modeling studies, including fitting of the synthesized compounds to a 3D-pharmacophore and their docking into optimized homology model as alpha(1)-AR antagonists showed high docking score and fit values. Most vasodilation activities of tested compounds are consistent with their molecular modeling results. (C) 2012 Elsevier Masson SAS. All rights reserved.

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 482-05-3, Name is [1,1′-Biphenyl]-2,2′-dicarboxylic acid, molecular formula is C14H10O4. In an article, author is Banerjee, Dipanwita,once mentioned of 482-05-3, Name: [1,1′-Biphenyl]-2,2′-dicarboxylic acid.

An efficient one-pot four-component synthesis of 1H-pyrazolo[1,2-b] phthalazine-5,10-dione derivatives catalyzed by proline

The present report articulates a potential and green method for the synthesis of pyrazolo[1,2-b]phthalazine-5,10-dione by one-pot four component reaction involving phthalimide (1), hydrazine hydrate (2), aldehyde (3) and malononitrile (4). Proline has been utilized as organo-catalyst in a mixed solvent of ethanol and water in the ratio of 2:1 at 80 degrees C. The reaction reveals excellent reactivity, functional group tolerance, and quite high yields without using any extreme reaction condition like strong acid or metal catalyst. Eighteen compounds have been synthesised by this method including five new compounds.

Interested yet? Keep reading other articles of 482-05-3, you can contact me at any time and look forward to more communication. Name: [1,1′-Biphenyl]-2,2′-dicarboxylic acid.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem