Category: phthalazines

Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. , Application In Synthesis of 2,6-Dichlorobenzaldehyde, 83-38-5, Name is 2,6-Dichlorobenzaldehyde, molecular formula is C7H4Cl2O, belongs to phthalazines compound. In a document, author is Park, Hae-Sun, introduce the new discover.

Discovery and synthesis of novel allylthioaralkylthiopyridazines: their antiproliferative activity against MCF-7 and Hep3B cells

A new series of 6-allylthio-3-aralkylthio-4,5-dimethylpyridazines 5a-5k and 1-allylthio-4-alkylthio5,6,7,8-tetrahydrophthalazine 6a-6j was synthesized from maleic anhydride derivatives for development of new anticancer agents. The process involves the formation of pyridazine and phthalazine rings, dichlorination, allylthiolation, and aralkylthiolation. These new compounds showed antiproliferative activities against breast cancer (MCF-7) and hepatocarcinoma (Hep3B) cells in CCK-8 assays, and could be promising candidates for chemotherapy of carcinomas. Among 21 synthesized compounds, five compounds (5a, 5b, 6b, 6d, and 6f) showed higher potency than 5-FU for inhibiting the growth of cell line. The results indicated that compound 6f had the highest activity towards MCF-7 and Hep3B cells. These results suggest the potential anticancer activity of compounds 5a, 5b, 6b, 6d, and 6f.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 83-38-5. Application In Synthesis of 2,6-Dichlorobenzaldehyde.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Chemistry can be defined as the study of matter and the changes it undergoes. You’ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology. 611-73-4, Name is 2-Oxo-2-phenylacetic acid, molecular formula is , belongs to phthalazines compound. In a document, author is Atar, Amol B., Safety of 2-Oxo-2-phenylacetic acid.

beta-Cyclodextrine-SO3H: the most efficient catalyst for one-pot synthesis of 2H-indazolo[2,1-b]phthalazine-triones under solvent-free conditions

An environmentally benign and efficient method has been developed for the synthesis of a series of 2H-indazolo[2,1-b]phthalazine-triones derivatives with beta-cyclodextrine-SO3H as a recyclable catalyst by simply combining of various aldehydes with cyclic 1,3-diketones and phthalhydrazide under solvent free condition. The advantageous features of this methodology are high atom-economy, operational simplicity, shorter reaction time, convergence, and facile automation. A greener, efficient, and expeditious method has been developed for the synthesis of 2H-indazolo [2,1-b] phthalazine-triones derivatives with beta-cyclodextrine-SO3H as a recyclable catalyst for the first time. [GRAPHICS] .

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 611-73-4, in my other articles. Safety of 2-Oxo-2-phenylacetic acid.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Chemistry can be defined as the study of matter and the changes it undergoes. You’ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology. 104-86-9, Name is (4-Chlorophenyl)methanamine, molecular formula is , belongs to phthalazines compound. In a document, author is Amiri, Ali Alinasab, Name: (4-Chlorophenyl)methanamine.

SO3H-functionalized mesoporous silica materials as solid acid catalyst for facile and solvent-free synthesis of 2H-indazolo[2,1-b]phthalazine-1,6,11-trione derivatives

SO3H-functionalized mesoporous silica materials (SO3H-FMSM), as an efficient, mild, recoverable and environmentally friendly heterogeneous mesoporous nanocatalyst, was used to synthesize 2H-indazolo[2,1-b]phthalazine-1,6,11-trione derivatives in a one-pot three-component condensation reaction of 2,3-dihydrophthalazine-1,4-dione, dimedone, and benzaldehyde derivatives under thermal solvent-free (SF) conditions in excellent yields and short reaction times.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 104-86-9, in my other articles. Name: (4-Chlorophenyl)methanamine.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 622-88-8, Name is (4-Bromophenyl)hydrazine hydrochloride, molecular formula is C6H8BrClN2, belongs to phthalazines compound. In a document, author is Mulik, Abhijeet, introduce the new discover, COA of Formula: C6H8BrClN2.

Polymer-Supported Sulfonic Acid-Catalyzed Candid Synthesis and Photophysical Properties of 2H-indazolo[2,1-b]phthalazinetriones

Polystyrene-supported sulfonic acid has been found to be an efficient catalyst for the one-pot, three-component synthesis of 2H-indazolo[2,1-b]phthalazinetriones in greener solvent glycerol. Use of greener solvent glycerol along with a polymer-supported, low toxic, and inexpensive catalyst renders the method eco-friendly. High yields, simple product isolation procedure, and fluorescent and electroluminescent natures of the products are the noteworthy aspects of this protocol.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 622-88-8. COA of Formula: C6H8BrClN2.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 886-86-2, Name is Ethyl 3-aminobenzoate methanesulfonate, molecular formula is , belongs to phthalazines compound. In a document, author is Wang, Haitao, Safety of Ethyl 3-aminobenzoate methanesulfonate.

Enantioselective Fluorocyclizations Mediated by Amino-Acid-Derived Phthalazine

Novel amino-acid-derived phthalazine reagents have been designed and synthesized for the enantioselective fluorocyclizations of prochiral indoles. The scope of reaction is evidenced by 28 examples of fluorinated furoindole and pyrroloindole heterocycles bearing various functionalities with up to 99% ee. The resulting enantioenriched fluorinated products are found to be potent AChE inhibitors. Advantages of the current new chiral reagents include ease in the synthesis of analogues and readily tunable steric/electronic demands.

If you are hungry for even more, make sure to check my other article about 886-86-2, Safety of Ethyl 3-aminobenzoate methanesulfonate.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, Category: phthalazines, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 737-31-5, Name is Sodium 3,5-diacetamido-2,4,6-triiodobenzoate, molecular formula is C11H8I3N2NaO4. In an article, author is Boraei, Ahmed T. A.,once mentioned of 737-31-5.

Design and synthesis of new phthalazine-based derivatives as potential EGFR inhibitors for the treatment of hepatocellular carcinoma

Searching for new leads in the battle of cancer will never ends, we herein disclose the design and synthesis of new phthalazine derivatives and their in vitro and in vivo testing for their antiproliferative activity. Phthalazine was selected as a privilege moiety that is incorporated in a big number of anticancer drugs in clinical use or that are still under clinical or preclinical studies. We utilized the drug extension strategy to tailor the designed compounds to fit the EGFR hydrophobic sub pocket and cleft region. The designed phthalazine derivatives was synthesized by linking phthalazine moiety with 1,3,4-oxadiazole-thione and 1,2,4-triazole-thione. Alkylation and glycosylation of the new heterocyclic systems were successfully performed to be used in the drug extension. Coupling of some phthalazine derivatives with different amino acids was also performed to improve the drug selectivity. The synthesized compounds were tested for their antiproliferative activity against cancer cells both in vivo and in vitro. The in vitro activity against hepatocellular carcinoma (HepG2 cell line) ranged from 5.7 mu g/mL to 43.4 mu g/mL. Compounds 31a and 16 were the most active with an IC(50)5.7 mu g/mL and 7.09 mu g/mL, respectively compared to the standard compound doxorubicin (4.0 mu g/mL). In vivo, compounds 10 and 16 showed IC50 values 7.25 mu g/mL and 7.5 mu g/mL, respectively compared to the standard compound cisplatin (IC50, 9.0 mu g/mL). In silico, testing of the phthalazine derivatives showed that they are good inhibitors for EGFR. The docking studies substantiated compounds 4, 10, 16 and 31a as new lead compounds and identified Arg841 as a key residue in the cleft region for binding stronger inhibitors.

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 5509-65-9, Name is 2,6-Difluoroaniline, molecular formula is C6H5F2N. In an article, author is Marvi, Omid,once mentioned of 5509-65-9, Computed Properties of C6H5F2N.

Solvent-free Synthesis of Phthalazine-2(1H)-carboxamide Derivatives Using K-10 Clay Under Microwave Irradiation

Montmorillonite K-10 clay catalyzes the reaction of different anhydrides with semicarbazide under microwave irradiation. The corresponding carboxamide derivatives are obtained in high yield and short reaction times.

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Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. In an article, author is Rostamnia, Sadegh, once mentioned the application of 83-53-4, Name is 1,4-Dibromonaphthalene, molecular formula is C10H6Br2, molecular weight is 285.96, MDL number is MFCD00041823, category is phthalazines. Now introduce a scientific discovery about this category, SDS of cas: 83-53-4.

A mesoporous silica/fluorinated alcohol adduct: an efficient metal-free, three-component synthesis of indazolophthalazinetrione heterocycles using a reusable nanoporous/trifluoroethanol adduct (SBA-15/TFE)

The channels of mesoporous (SBA-15) represent a straightforward reactor for the rapid synthesis of indazolophthalazinetrione skeletons via three-component coupling reactions in 2,2,2-trifluoroethanol. The solid SBA-15 and TFE could be recovered and reused. The present method carries the advantage of being performed under neutral conditions and requires no activation or modification of the substrates. (C) 2014 Elsevier Ltd. All rights reserved.

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. COA of Formula: C15H18N2, 838-88-0, Name is 4,4′-Methylenebis(2-methylaniline), SMILES is NC1=CC=C(CC2=CC=C(C(C)=C2)N)C=C1C, in an article , author is Yan, Xiaohui, once mentioned of 838-88-0.

Inhibition of water adsorption into polar solid-phase microextraction materials with ultrathin polydimethylsiloxane coating for thermal desorption-gas chromatography analysis

Solid-phase microextraction (SPME) coupled with thermal desorption-gas chromatography (TD-GC) has become a powerful analysis tool for volatile organic compounds (VOCs) and semi-volatile organic compounds (SVOCs) in water samples. However, water adsorption into polar microextraction phase is usually unavoidable during the extraction process, and the burst of large amounts of water vapour during thermal desorption will cause serious problems to GC separation and detectors. Pawliszyn’s group had demonstrated that the tens of micron-thick, defect-free polydimethylsiloxane (PDMS) coating could act as a perfect barrier for water adsorption and offer much better compatibility in complex matrices. However, the PDMS overcoat largely decreased the uptake rate of polar analytes into the inner sorbent. In order to quantify the effect of PDMS coating thickness on water adsorption amount and the extraction kinetics, ultrathin PDMS layer was used to coat the polar extraction phase with polyimide (PI) as a model in this work. It was surprising to find that the PDMS coating with the thickness less than one micron can decrease the water adsorption by 96%, while the extraction efficiency for polar analytes (phenolic compounds and nitroaromatic explosives) was decreased by less than 20% at the extraction time of 30 min. Moreover, the kinetic data showed that the thinner the PDMS coating was, the less the uptake rate of polar analytes into PI extraction phase decreased. Finally, polar poly (phthalazine ether sulfone ketone) (PPESK) extraction phase was also coated with ultrathin PDMS coating to verify the universality of the strategy. Generally, the water adsorption problem in polar SPME was overcome to a great extent, and the extraction efficiency of polar analytes was mainly preserved with this ultrathin PDMS coating, which could broaden the application of SPME in the environmental field. (C) 2018 Elsevier B.V. All rights reserved.

But sometimes, even after several years of basic chemistry education, it is not easy to form a clear picture on how they govern reactivity! 838-88-0, you can contact me at any time and look forward to more communication. COA of Formula: C15H18N2.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. In an article, author is Kiasat, Ali Reza, once mentioned the application of 369-34-6, Name is 3,4-Difluoronitrobenzene, molecular formula is C6H3F2NO2, molecular weight is 159.09, MDL number is MFCD00007198, category is phthalazines. Now introduce a scientific discovery about this category, Formula: C6H3F2NO2.

Fe3O4@silica sulfuric acid nanoparticles: An efficient reusable nanomagnetic catalyst as potent solid acid for one-pot solvent-free synthesis of indazolo[2,1-b]phthalazine-triones and pyrazolo[1,2-b]phthalazine-diones

Regarding the green chemistry’s goals, silica-coated magnetite nanoparticles (MNPs) open up new avenue to introduce an amazing and efficient system for facilitating catalyst recovery in different organic reactions. Therefore, in this paper the preparation of sulfuric acid functionalized silica-coated magnetite nanoparticles with core-shell structure (Fe3O4@silica sulfuric acid) are presented by using Fe3O4 spheres as the core and silica sulfuric acid nanoparticles as the shell. The catalyst was characterized by infrared spectroscopy (FT-IR), scanning electron microscope (SEM), transmission electron microscopy (TEM), X-ray diffraction (XRD) spectroscopy, and vibrating sample magnetometer (VSM). Ability of this nano-magnetic solid acid catalyst in the one-pot three-components condensation reaction of phthalhydrazide, aromatic aldehydes and cyclic or acyclic 1,3-diketones are also described. Utilization of easy reaction conditions, catalyst with high catalytic activity and good reusability, and simple magnetically work-up, makes this methodology as an interesting option for the economic synthesis of indazolo[2,1-b]phthalazine-triones and pyrazolo[1,2-b]phthalazine-diones. (C) 2013 Elsevier B.V. All rights reserved.

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem