Category: phthalazines

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. 117-34-0, Name is 2,2-Diphenylacetic acid, SMILES is O=C(O)C(C1=CC=CC=C1)C2=CC=CC=C2, in an article , author is Abdel-Aziz, Hatem A., once mentioned of 117-34-0, Recommanded Product: 2,2-Diphenylacetic acid.

Isatin-benzoazine molecular hybrids as potential antiproliferative agents: synthesis and in vitro pharmacological profiling

In continuation of our endeavor with respect to the development of potent and effective isatin-based anticancer agents, we adopted the molecular hybridization approach to design and synthesize four different sets of isatin-quinazoline (6a-f and 7a-e)/phthalazine (8a-f)/quinoxaline (9a-f) hybrids. The antiproliferative activity of the target hybrids was assessed towards HT-29 (colon), ZR-75 (breast) and A-549 (lung) human cancer cell lines. Hybrids 8b-d emerged as the most active antiproliferative congener in this study. Compound 8c induced apoptosis via increasing caspase 3/7 activity by about 5-fold in the A-549 human cancer cell line. In addition, it exhibited an increase in the G1 phase and a decrease in the S and G2/M phases in the cell cycle effect assay. Furthermore, it displayed an inhibitory concentration 50% value of 9.5 mu M against multidrug-resistant NCI-H69AR lung cancer cell line. The hybrid 8c was also subjected to in vitro metabolic investigations through its incubation with rat liver microsomes and analysis of the resulting metabolites with the aid of liquid chromatography-mass spectrometry.

Interested yet? Read on for other articles about 117-34-0, you can contact me at any time and look forward to more communication. Recommanded Product: 2,2-Diphenylacetic acid.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. , Recommanded Product: Eugenol Acetate, 93-28-7, Name is Eugenol Acetate, molecular formula is C12H14O3, belongs to phthalazines compound. In a document, author is Simijonovic, Dusica, introduce the new discover.

A new efficient domino approach for the synthesis of pyrazolyl-phthalazine-diones. Antiradical activity of novel phenolic products

Pyrazolyl-phthalazine-dione derivatives (PPDs) were synthetized in the ionic liquid catalyzed one-pot multicomponent reaction of acetylacetone, 2,3-dihydrophthalazine-1,4-dione, and different aldehydes in moderate to good yields. Six new PPDs were obtained, and the crystal structure of 2-acetyl-1-(4-fluorophenyl)- 3-methyl-1H-pyrazolo[1,2-b] phthalazine-5,10-dione (PPD-4) was determined. The most interesting structural features of the novel PPD-4 is the formation of a rather short intermolecular distance between the F atom of one molecule and the midpoint of the neighbouring six-membered heterocyclic ring. This interaction arranges all molecules into parallel supramolecular chains. UV-Vis spectra of all PPDs were acquired and compared to the simulated ones obtained with TD-DFT. All synthetized compounds were subjected to evaluation of their in vitro antioxidative activity using a stable DPPH radical. It was shown that PPD-7, with a catechol motive, is the most active antioxidant, while PPD-9, with two neighbouring methoxy groups to the phenolic OH, exerted a somewhat lower, but significant antioxidative potential. The results of DFT thermodynamical study are in agreement with experimental findings that PPD-7 and PPD-9 should be considered as powerful radical scavengers. In addition, the obtained theoretical results (bond dissociation and proton abstraction energies) specify SPLET as a prevailing radical scavenging mechanism in polar solvents, and HAT in solvents with lower polarity. On the other hand, the obtained reaction enthalpies for inactivation of free radicals suggest competition between HAT and SPLET mechanisms, except in the case of the (OH)-O-center dot radical in polar solvents, where HAT is labeled as prefered.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 93-28-7. Recommanded Product: Eugenol Acetate.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Related Products of 88-44-8, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C¨CH bond functionalisation has revolutionised modern synthetic chemistry. 88-44-8, Name is 4-Aminotoluene-3-sulfonic acid, SMILES is O=S(C1=CC(C)=CC=C1N)(O)=O, belongs to phthalazines compound. In a article, author is Lyu, Xue-Li, introduce new discover of the category.

Visible-Light-Induced Copper-Catalyzed Decarboxylative Coupling of Redox-Active Esters with N-Heteroarenes

Herein we report a protocol for visible-light-induced copper-catalyzed decarboxylative coupling reactions between N-heteroarenes and redox-active esters. Various N-hydroxyphthalimide esters reacted with isoquinoline, quinoline, pyridine, pyrimidine, quinazoline, phthalazine, phenanthridine, and pyridazine to give the corresponding products in modest to excellent yields. The reactions proceed under mild conditions and have a broad scope and high functional group tolerance. Mechanistic studies revealed that the catalytic behavior of Cu-I photocatalyst generated in situ was consistent with that of preformed [Cu(dmp)(xantphos)]BF4.

Related Products of 88-44-8, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 88-44-8.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Related Products of 608141-42-0, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C¨CH bond functionalisation has revolutionised modern synthetic chemistry. 608141-42-0, Name is (S)-1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethanamine, SMILES is O=S(C[C@@H](N)C1=CC=C(OC)C(OCC)=C1)(C)=O, belongs to phthalazines compound. In a article, author is Bakherad, Mohammad, introduce new discover of the category.

Synthesis of New Derivatives of 1,2,3-Triazole-Linked Phthalazine-1,4-dionein Water: Experimental Aspects and Molecular Docking Calculations

A new series of phthalazine-based 1,2,3-triazole derivatives are synthesized by the reaction of 2-methyl-3-(prop-2-yn-1-yl)-2,3dihydro- phthalazine-1,4-dione or 2,3-bis(prop-2-yn-1-yl)-2,3-dihydrophthalaz- ine-1,4-dione with aromatic azides via coppercatalyzed azide-alkyne cycloaddition reactions in the presence of metformine as a ligand. These reaction procedures have the advantages of high-to-excellent yields, short reaction times, mild experimental conditions, and operational simplicity. All the synthesized compounds are screened in vitro for their antibacterial activities against the three bacterial strains Micrococcus luteus, Pseudomonas aeruginosa, and Bacillus subtilis. Furthermore, the results of anti-bacterial activity of the synthesized compounds was investigated using molecular docking calculations.

Related Products of 608141-42-0, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 608141-42-0.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics, Name: 2,2-Diphenylacetic acid, 117-34-0, Name is 2,2-Diphenylacetic acid, SMILES is O=C(O)C(C1=CC=CC=C1)C2=CC=CC=C2, belongs to phthalazines compound. In a document, author is Glisic, Biljana D., introduce the new discover.

Copper(II) complexes with aromatic nitrogen-containing heterocycles as effective inhibitors of quorum sensing activity in Pseudomonas aeruginosa

Five copper(II) complexes 1-5 with aromatic nitrogen-containing heterocycles, pyrimidine (pm, 1), pyrazine (pz, 2), quinazoline (qz, 3 and 4) and phthalazine (phtz, 5) have been synthesized and structurally characterized by spectroscopic and single-crystal X-ray diffraction techniques. The crystallographic results show that, dependent on the ligand structure, complexes 1-5 are of different nuclearity. The antimicrobial efficiency of complexes 1-5 has been evaluated against three clinically relevant microorganisms and none of the complexes showed significant growth inhibiting activity, with values of minimum inhibitory concentrations (MIC) in the mM range. Since in many bacteria, pathogenicity and virulence are regulated by intercellular communication processes, quorum sensing (QS), the effect of the copper(II) complexes on bacterial QS has also been examined. The results indicate that the investigated complexes inhibit violacein production in Chromobacterium violaceum CV026, suggesting an anti-QS activity. In order to differentiate, which of the QS pathways was affected by the copper(II) complexes, three biosensor strains were used: the PAO1 Delta rhlIpKD-rhlA and the PA14-R3 Delta lasIPrsaI lux strain to directly measure the levels of C4-HSL (N-butanoyl-homoserine lactone) and 3OC12-HSL (N-3-oxo-dodecanoyl- homoserine lactone), respectively, and PAO1 Delta pqsA mini-CTX luxPpqsA for the detection of AHQs (2-alkyl-4-quinolones). Complexes 1-5 were shown to be efficient inhibitors of biofilm formation of the human opportunistic pathogen Pseudomonas aeruginosa PAO1, with the qz-containing complex 3 being the most active. Finally, the most anti-QS-active complexes 1 and 3 showed synergistic activity against a multi-drug resistant clinical isolate of P. aeruginosa, when supplied in combination with the known antibiotics piperacillin and ceftazidime.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 117-34-0. Name: 2,2-Diphenylacetic acid.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. 35661-39-3, Name is Fmoc-Ala-OH, SMILES is C[C@H](NC(OCC1C2=C(C3=C1C=CC=C3)C=CC=C2)=O)C(O)=O, in an article , author is Jadhav, Amol Maruti, once mentioned of 35661-39-3, Product Details of 35661-39-3.

Silica-supported tungstic acid (STA): A recyclable catalyst for the synthesis of 1H-indazolo [1,2-b]phthalazine-trione and spiro-triazolo[1,2-a]indazole-tetraone derivatives under solvent-free condition

An efficient one-pot synthesis of 1 H-indazolo[1,2-b]phthalazine-trione and spiro-triazolo[1,2-a]indazole-tetraone derivatives via three-component condensation reaction of phthalhydrazide or 4-phenylurazole, aldehydes or isatins and dimedone in the presence of a catalytic amount of silica-supported tungstic acid (STA), as a heterogeneous solid acid catalyst under solvent-free conditions is presented. This ecofriendly protocol offers several advantages such as a cost-effective procedure with excellent yields, short reaction time, simple workup, recovery and reusability of catalyst with broad scope of usable substrates. This has made the protocol sustainable and economic.

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Chemistry is an experimental science, COA of Formula: C7H8N2O2, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 619-67-0, Name is 4-Hydrazinylbenzoic acid, molecular formula is C7H8N2O2, belongs to phthalazines compound. In a document, author is Hashemzadeh, Alireza.

A magnetically-separable H3PW12O40@Fe3O4/EN-MIL-101 catalyst for the one-pot solventless synthesis of 2H-indazolo[2,1-b] phthalazine-triones

A magnetic inorganic-organic catalyst, PTA@Fe3O4/EN-MIL-101 (EN = ethylenediamine, PTA = phosphotungstic acid) was fabricated and characterized by XRD, HRTEM, FESEM, UV-vis, TGA-DTA, FT-IR, XPS and porosimetry. PTA retained the parent Keggin structure upon dispersion throughout the amine-functionalized chromium terephthalate metal-organic framework, over which magnetic Fe3O4 nanoparticles were previously introduced. The resulting composite heterogeneous solid acid was an active catalyst for the one-pot synthesis of diverse 2H-indazolo[2,1-b] phthalazine-triones in good -> excellent yields under mild, solventless condition, and offers facile separation and excellent recyclability. (C) 2017 Elsevier B.V. All rights reserved.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 619-67-0, in my other articles. COA of Formula: C7H8N2O2.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Chemistry, like all the natural sciences, HPLC of Formula: C12H12Si, begins with the direct observation of nature¡ª in this case, of matter.775-12-2, Name is Diphenylsilane, SMILES is C1([SiH2]C2=CC=CC=C2)=CC=CC=C1, belongs to phthalazines compound. In a document, author is Wang, Xue-Mei, introduce the new discover.

Synthesis, structure and DFT calculation of a facial tris-cyclometalated phosphorescent iridium(III) complex containing substituted phthalazine ligands

The facial tris-cyclometalated iridium(III) complex fac-Ir(dmpopopz)(3) (dmpopopzH = 1-(2,6-dimethylphenyloxy)-4-(4-phenyloxyphenyl)-phthalazine) was synthesized from the reaction of iridium (III) chloride hydrate and ligand dmpopopzH in refluxing ethoxyethanol. The conformation of complex fac-Ir(dmpopopz)(3) is described on the basis of the H-1 NMR, C-13 NMR, FT-IR and mass spectroscopies, the crystal structure of fac-Ir(dmpopopz)(3) was determined by X-ray crystallography, and the theoretical calculation of complex fac-Ir(dmpopopz)(3) was also investigated by the DFT method. The absorption and emission spectral results exhibit that complex fac-[Ir(dmpopopz)(3)] may be used as a red-emitting phosphorescent material. Efficient OLEDs have been achieved using the complex fac-[Ir(dmpopopz)(3)] in the red-emitting region. (C) 2017 Published by Elsevier B.V.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 775-12-2. HPLC of Formula: C12H12Si.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 2128-93-0, Name is 4-Benzoylbiphenyl, molecular formula is , belongs to phthalazines compound. In a document, author is Lashkari, Mojtaba, Product Details of 2128-93-0.

Clean and facile synthesis of 1H-pyrazolo [1, 2-b] phthalazine-5, 10-dione derivatives catalyzed by Neodymium (III) chloride hexahydrate as an efficient Lewis acidic catalyst under solvent-free conditions

A clean and simple synthesis of 1H-pyrazolo [1, 2-b] phthalazine-5, 10-dione derivatives via one-pot four-component condensation reaction of phthalimide, hydrazine monohydrate, aromatic aldehydes derivatives and malononitrile in the presence of neodymium (III) chloride hexahydrate (NdCl3.6H(2)O) as an efficient and eco-friendly Lewis acidic catalyst under thermal and solvent-free conditions with good yields and short reaction times is developed. This present methodology has notable benefits such as highly efficient, non-toxic catalyst, one-pot, solvent-free conditions, simplicity of operation with no necessity of chromatographic purification steps and eco-friendly. And all products have been characterized by melting points and H-1 NMR spectroscopy.

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Related Products of 369-34-6, Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, 369-34-6, Name is 3,4-Difluoronitrobenzene, SMILES is C1=C(C=CC(=C1F)F)[N+](=O)[O-], belongs to phthalazines compound. In a article, author is Cui, Zhi-Ming, introduce new discover of the category.

Simple Analogues of Quaternary Benzo[c]phenanthridine Alkaloids: Discovery of a Novel Antifungal 2-Phenylphthalazin-2-ium Scaffold with Excellent Potency against Phytopathogenic Fungi

Inspired by sanguinarine and chelerythrine, a novel antifungal 2-phenylphthalazin-2-ium scaffold as a simple analogue was designed. Most of the 30 compounds showed excellent inhibition activity against almost all eight phytopathogenic fungi, far superior to sanguinarine and chelerythrine. A third of the compounds were more active than azoxystrobin in most cases. Compounds 26 and 27 showed the highest total activity against all the fungi with EC50 means of ca. 4.6 mu g/mL. Fusarium solani showed the highest susceptibility with an EC50 mean of 3.62 mu g/mL to 19 compounds. A concentration of 25.0 mu g/mL 27 can fully control the Colletotrichum gloeosporioides infection in apples over 9 days. Electron microscopic observations showed that 27 was able to damage the structures of the hypha and cell membrane. The structure-activity relationship showed that the presence of electron-withdrawing groups on the C-ring increases the activity against most of the fungi. Thus, 2-phenylphthalazin-2-ium compounds represent promising leads for the development of novel fungicides.

Related Products of 369-34-6, Consequently, the presence of a catalyst will permit a system to reach equilibrium more quickly, but it has no effect on the position of the equilibrium as reflected in the value of its equilibrium constant.I hope my blog about 369-34-6 is helpful to your research.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem