Category: phthalazines

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. Category: phthalazines, 7524-50-7, Name is H-Phe-OMe.HCl, SMILES is N[C@@H](CC1=CC=CC=C1)C(OC)=O.[H]Cl, in an article , author is Kashanna, Jajula, once mentioned of 7524-50-7.

2,3-Dihydrofurans as Potential Cytotoxic and Antibacterial Agents: Tandem Knoevenagel-Michael Cyclization for the Synthesis of 2,3-Dihydrofurans by Using alpha-Tosyloxy Ketone Precursors

Novel 2,3-dihydrofuran derivatives were synthesized through a tandem Knoevenagel-Michael cyclization in good yield by reacting alpha-tosyloxy ketone, 5,5-dimethyl-1,3-cyclohexanedione, and various aldehydes in the presence of phthalazine in acetonitrile. These compounds were subjected to in vitro antibacterial screening against eight micro-organisms by using diffusion method and also in vitro cytotoxicity screening against four human cancerous cell lines by applying MTT assay. Some of the compounds showed impressive activities.

But sometimes, even after several years of basic chemistry education, it is not easy to form a clear picture on how they govern reactivity! 7524-50-7, you can contact me at any time and look forward to more communication. Category: phthalazines.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Synthetic Route of 92-92-2, Redox catalysis has been broadly utilized in electrochemical synthesis due to its kinetic advantages over direct electrolysis. The appropriate choice of redox mediator can avoid electrode passivation and overpotential. 92-92-2, Name is [1,1′-Biphenyl]-4-carboxylic acid, SMILES is O=C(C1=CC=C(C2=CC=CC=C2)C=C1)O, belongs to phthalazines compound. In a article, author is Liu, Hai-Jie, introduce new discover of the category.

Mononuclear ruthenium compounds bearing N-donor and N-heterocyclic carbene ligands: structure and oxidative catalysis

A new CNNC carbene-phthalazine tetradentate ligand has been synthesised, which in the reaction with [Ru(T)Cl-3] (T = trpy, tpm, bpea; trpy = 2,2′; 6′, 2”’-terpyridine; tpm = tris(pyrazol-1-yl)methane; bpea = N, N-bis(pyridin-2-ylmethyl) ethanamine) in MeOH or iPrOH undergoes a C-N bond scission due to the nucleophilic attack of a solvent molecule, with the subsequent formation of the mononuclear complexes cis-[Ru(PhthaPz-OR)(trpy) X](n+), [Ru(PhthaPz-OMe)(tpm) X](n+) and trans, fac-[Ru(PhthaPz-OMe) (bpea) X] n+ (X = Cl, n = 1; X = H2O, n = 2; PhthaPz-OR = 1-(4-alkoxyphthalazin-1-yl)-3-methyl-1H-imidazol- 3-ium), named 1a(+)/2a(2+) (R = Me), 1b(+)/2b(2+) (R = iPr), 3(+)/4(2+) and 5(+)/6(2+), respectively. Interestingly, regulation of the stability regions of different Ru oxidation states is obtained by different ligand combinations, going from 6(2+), where Ru(III) is clearly stable and mono-electronic transfers are favoured, to 2a(2+)/2b(2+), where Ru(III) is almost unstable with regard to its disproportionation. The catalytic performance of the Ru-OH2 complexes in chemical water oxidation at pH 1.0 points to poor stability (ligand oxidation), with subsequent evolution of CO2 together with O-2, especially for 4(2+) and 6(2+). In electrochemically driven water oxidation, the highest TOF values are obtained for 2a(2+) at pH 1.0. In alkene epoxidation, complexes favouring bi-electronic transfer processes show better performances and selectivities than those favouring mono-electronic transfers, while alkenes containing electron-donor groups show better performances than those bearing electron-withdrawing groups. Finally, when cis-beta-methylstyrene is employed as the substrate, no cis/trans isomerization takes place, thus indicating the existence of a stereospecific process.

Synthetic Route of 92-92-2, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. I hope my blog about 92-92-2 is helpful to your research.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Synthetic Route of 89797-68-2, As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 89797-68-2, Name is 5-(Ethylthio)-1H-tetrazole, SMILES is CCSC1=NN=NN1, belongs to phthalazines compound. In a article, author is Khazaei, Ardeshir, introduce new discover of the category.

N,2-Dibromo-6-chloro-3,4-dihydro-2H-benzo[e]-[1,2,4]thiadiazine-7-sulfonamide 1,1-dioxide: an efficient and homogeneous catalyst for one-pot synthesis of 4H-pyran, pyranopyrazole and pyrazolo[1,2-b]phthalazine derivatives under aqueous media

N,2-Dibromo-6-chloro-3,4-dihydro-2H-benzo[e][1,2,4]thiadiazine-7-sulfonamide 1,1-dioxide (DCDBTSD) as a highly efficient and homogeneous catalyst was successfully applied for the synthesis of 4H-pyran, pyranopyrazole and pyrazolo[1,2-b] phthalazine derivatives by a one-pot multi-component reaction (MCR) in water. The described method has some advantages such as mild and neutral reaction media, high yields, short reaction times, cleaner and easier reaction profiles and compliance with green chemistry protocols.

Synthetic Route of 89797-68-2, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. I hope my blog about 89797-68-2 is helpful to your research.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

In an article, author is Shekouhy, Mohsen, once mentioned the application of 2128-93-0, HPLC of Formula: C19H14O, Name is 4-Benzoylbiphenyl, molecular formula is C19H14O, molecular weight is 258.31, MDL number is MFCD00003079, category is phthalazines. Now introduce a scientific discovery about this category.

Ultrasound-promoted catalyst-free one-pot four component synthesis of 2H-indazolo[2,1-b]phthalazine-triones in neutral ionic liquid 1-butyl-3-methylimidazolium bromide

A catalyst-free one-pot four component methodology for the synthesis of 2H-indazolo[2,1-b]phthalazine-triones under ultrasonic irradiation at room temperature using 1-butyl-3-methylimidazolium bromide, [Bmim]Br, as a neutral reaction medium is described. A broad range of structurally diverse aldehydes (aromatic aldehydes bearing electron withdrawing and/or electron releasing groups as well as heteroaromatic aldehydes) were applied successfully, and corresponding products were obtained in good to excellent yields without any byproduct. (C) 2011 Elsevier B.V. All rights reserved.

If you are interested in 2128-93-0, you can contact me at any time and look forward to more communication. HPLC of Formula: C19H14O.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Electric Literature of 775-12-2, Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. 775-12-2, Name is Diphenylsilane, SMILES is C1([SiH2]C2=CC=CC=C2)=CC=CC=C1, belongs to phthalazines compound. In a article, author is El-Hashash, Maher A., introduce new discover of the category.

Synthesis and Antimicrobial Activity of Some Condensed [4-(2,4,6-Trimethylphenyl)-1(2H)-oxo-phthalazin-2-yl]acetic Acid Hydrazide

Some new 1,2,4-triazolo-, 1,3,4-oxadiazolo-, 1,3,4-thiadiazol-, and pyrazolo-2,4,6-trimethylphenyl-1(2H)-oxo-phthalazine derivatives were synthesized and identified by IR, 1H NMR, 13C NMR, MS and elemental analysis. The new compounds were synthesized with the objective of studying their antimicrobial activity.

Electric Literature of 775-12-2, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 775-12-2.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

In an article, author is Mosaddegh, Elaheh, once mentioned the application of 789-25-3, Application In Synthesis of Triphenylsilane, Name is Triphenylsilane, molecular formula is C18H16Si, molecular weight is 260.4052, MDL number is MFCD00003003, category is phthalazines. Now introduce a scientific discovery about this category.

Preparation, characterization, and catalytic activity of Ca2CuO3/CaCu2O3/CaO nanocomposite as a novel and bio-derived mixed metal oxide catalyst in the green synthesis of 2H-indazolo[2,1-b]phthalazine-triones

As a novel and heterogeneous catalyst, the Ca2CuO3/CaCu2O3/CaO nanocomposite was synthesized via coprecipitation and thermal decomposition methods using CuSO4 and eggshell wastes as inexpensive starting materials. The catalytic activity of the mesoporous mixed metal oxide in the synthesis of 2H-indazolo[2,1-b]phthalazine-triones was investigated. The reaction proceeds to completion within 5-20 min with yields of 80-94%. The suggested strategy for synthesizing 2H-indazolo[2,1-b]phthalazine-triones is of great interest because a novel, green, and low-cost mixed metal oxide is used as a heterogeneous catalyst, on account of its convenient preparation, short reaction time, and high reusability without any loss of catalytic activity. (C) 2015 Elsevier B.V. All rights reserved.

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Synthetic Route of 89-86-1, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 89-86-1, Name is 2,4-Dihydroxybenzoic acid, SMILES is O=C(O)C1=CC=C(O)C=C1O, belongs to phthalazines compound. In a article, author is Zhu, Guanxing, introduce new discover of the category.

Access to a Phthalazine Derivative Through an Angular cis-Quinacridone

Intramolecular electrophilic cyclization of a bisanthranilate afforded an angular cis-quinacridone compound, which condensed with hydrazine to give a phthalazine derivative. A [2+2+2] cyclization reaction occurred at the C-N double bond position of phthalazine when reacted with dimethyl acetylenedicarboxylate. The structures of these novel compounds were confirmed by crystallographic analysis. The phthalazine derivative decomposes back to quinacridone at ambient condition in the dark and as a solid with a half lifetime of about 22 months.

Synthetic Route of 89-86-1, The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 89-86-1 is helpful to your research.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

In an article, author is Shalkouhi, Somaye Nikzad, once mentioned the application of 80382-23-6, HPLC of Formula: C15H17NaO3, Name is Sodium 2-(4-((2-oxocyclopentyl)methyl)phenyl)propanoate, molecular formula is C15H17NaO3, molecular weight is 268.2835, MDL number is MFCD00941425, category is phthalazines. Now introduce a scientific discovery about this category.

Synthesis, characterization and catalytic application of Fe3O4@Cys-SO3H for preparation of 2H-indazolo[1,2-b]phthalazine-triones

The surface of Fe3O4 magnetic nanoparticles (MNPs) was modified by L-cysteine through condensation of COOH groups of L-cysteine and OH groups on the surface of Fe3O4. The -SH group of prepared Fe3O4@Cys MNPs oxidized to -SO3H group and Fe3O4@Cys-SO3H as an environmentally friendly magnetic nanoparticle was prepared. The MNPs were characterized by FT-IR, XRD, SEM and TEM studies. Then, the catalytic activity of the MNPs was evaluated as an effective and reusable catalyst for one-pot synthesis of 2H-indazolo [1,2-b] phthalazine-triones derivatives. The results show that the catalytic activity of Fe3O4@Cys-SO3H was comparable to that of other reported heterogeneous and homogeneous catalysts.

If you are interested in 80382-23-6, you can contact me at any time and look forward to more communication. HPLC of Formula: C15H17NaO3.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics, Computed Properties of C12H19NO4S, 608141-42-0, Name is (S)-1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethanamine, SMILES is O=S(C[C@@H](N)C1=CC=C(OC)C(OCC)=C1)(C)=O, belongs to phthalazines compound. In a document, author is Wang, Yuxiang, introduce the new discover.

Cascade Oxidation/Halogenoaminocyclization Reaction of Trifluoromethylated Homoallylic N-Acylhydrazines: Metal-free Synthesis of CF3-Substituted Pyrazolines

An efficient and practical cascade oxidation/halogenoaminocyclization of trifluoromethylated homoallylic N-acylhydrazines is developed. The protocol enables an efficient access to various biologically interesting CF3-containing pyrazoline compounds from readily accessible trifluoromethylated homoallylic N-acylhydrazines in good to excellent yields under mild conditions without any other additives or catalysts. The produced pyrazoline compounds can be further manipulated to other more complicated derivatives through transformation of residual halogen atom.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 608141-42-0. Computed Properties of C12H19NO4S.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 14348-75-5, Name is 2,7-Dibromo-9H-fluoren-9-one, SMILES is C3=C2C1=C(C=C(Br)C=C1)C(C2=CC(=C3)Br)=O, belongs to phthalazines compound. In a document, author is Bourne, Christina R., introduce the new discover, Product Details of 14348-75-5.

Structure-activity relationship for enantiomers of potent inhibitors of B. anthracis dihydrofolate reductase

Background: Bacterial resistance to antibiotic therapies is increasing and new treatment options are badly needed. There is an overlap between these resistant bacteria and organisms classified as likely bioterror weapons. For example, Bacillus anthracis is innately resistant to the anti-folate trimethoprim due to sequence changes found in the dihydrofolate reductase enzyme. Development of new inhibitors provides an opportunity to enhance the current arsenal of anti-folate antibiotics while also expanding the coverage of the anti-folate class. Methods: We have characterized inhibitors of B. anthracis dihydrofolate reductase by measuring the K-i and MIC values and calculating the energetics of binding. This series contains a core diaminopyrimidine ring, a central dimethoxybenzyl ring, and a dihydrophthalazine moiety. We have altered the chemical groups extended from a chiral center on the dihydropyridazine ring of the phthalazine moiety. The interactions for the most potent compounds were visualized by X-ray structure determination. Results: We find that the potency of individual enantiomers is divergent with clear preference for the S-enantiomer, while maintaining a high conservation of contacts within the binding site. The preference for enantiomers seems to be predicated largely by differential interactions with protein residues Leu29, Gln30 and Arg53. Conclusions: These studies have clarified the activity of modifications and of individual enantiomers, and highlighted the role of the less-active R-enantiomer in effectively diluting the more active S-enantiomer in racemic solutions. This directly contributes to the development of new antimicrobials, combating trimethoprim resistance, and treatment options for potential bioterrorism agents. Published by Elsevier B.V.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 14348-75-5 is helpful to your research. Product Details of 14348-75-5.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem