Category: phthalazines

Chemistry, like all the natural sciences, begins with the direct observation of nature¡ª in this case, of matter.1878-68-8, Name is 4-Bromophenylacetic acid, SMILES is OC(=O)CC1=CC=C(Br)C=C1, belongs to phthalazines compound. In a document, author is Safaei-Ghomi, J., introduce the new discover, Formula: C8H7BrO2.

CuFe2O4 and ZrP2O7 nanoparticles as highly efficient catalysts for the one-pot synthesis of phthalazine derivatives under solvent-free conditions

ZrP2O7 and CuFe2O4 nanoparticles as efficient and reusable heterogeneous catalysts have been used for the preparation of 2H-indazolo[2,1-b]phthalazine-triones and 1H-pyrazolo[1,2-b]phthalazine-diones, respectively, under solvent-free conditions in good to excellent yields and short reaction times. (C) 2016 Sharif University of Technology. All rights reserved.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 1878-68-8. Formula: C8H7BrO2.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Synthetic Route of 62965-37-1, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 62965-37-1, Name is Dicyclohexylamine (S)-2-(((benzyloxy)carbonyl)amino)-3,3-dimethylbutanoate, SMILES is C1CCC(CC1)NC1CCCCC1.[H][C@@](NC(=O)OCC1=CC=CC=C1)(C(O)=O)C(C)(C)C, belongs to phthalazines compound. In a article, author is Ebrahimiasl, Hakimeh, introduce new discover of the category.

Synthesis of Fe3O4-supported Schiff base Cu (II) complex: a novel efficient and recyclable magnetic nanocatalyst for one-pot three-component synthesis of quinolin-5-one, chromene-3-carbonitrile and phthalazine-5,10-dione derivatives

In this research, synthesis and characterization of a novel Schiff base Cu (II) complex immobilized on Fe3O4@SiO(2)nanoparticles are reported. Then, the catalytic activity of these nanoparticles as magnetic recyclable nanocatalyst was explored for the one-pot three-component synthesis of quinolin-5-one, chromene-3-carbonitrile and phthalazine-5,10-dione derivatives. The reactions proceeded smoothly to provide the respective products in excellent yields under green conditions. Facile preparation of the catalyst, high yields of the products, low reaction times, and use of water as green solvent are the main advantages of the present protocol. Moreover, the catalyst can be easily separated from the reaction mixture in a magnetic field, recycled and reused for six consecutive fresh runs without considerable loss of catalytic activity. Graphic abstract

Synthetic Route of 62965-37-1, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 62965-37-1.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics, 886-86-2, Name is Ethyl 3-aminobenzoate methanesulfonate, SMILES is O=C(OCC)C1=CC=CC(N)=C1.CS(=O)(O)=O, belongs to phthalazines compound. In a document, author is Han, Yi, introduce the new discover, Product Details of 886-86-2.

Ag NPs on chitosan-alginate coated magnetite for synthesis of indazolo [2,1-b]phthalazines and human lung protective effects

Biocomposite nanomaterials have been evolved as the new generation catalysts and therapeutic supplement in these days. Magnetically isolation has added new features to this category. This has encouraged us to synthesize a novel Ag NP adorned chitosan-alginate dual bio-polysaccharide (two of the more versatile polysaccharides) modified core-shell magnetic nanocomposite (Fe3O4/CS-Alg/Ag NPs). The material was meticulously characterized following different physicochemical techniques, such as, FT-IR, ICP-OES, FESEM, EDX, atomic mapping, TEM, VSM, XRD and XPS studies. The as synthesized material was catalytically explored in the one-pot multicomponent synthesis of biologically potent 2H-indazolo[2,1-b]phthalazine-trione derivatives involving a wide range of substrates. The reactions were ended up with excellent yields under solvent-free heating conditions. The catalyst recyclability, heterogeneity and leaching tests were performed to ensure its high stability and robustness. It could be reused as much as 10 times in succession with almost unchanged catalytic performances. In the lung protective part of the present research, the human lung toxicity was induced by alpha-Guttiferin. The cell viability of lung MRC-5, CCD-19Lu, WI-38, and BEAS-2B cell lines was measured by trypan blue assay. Caspase-3 activity was assessed by the caspase activity colorimetric assay kit and mitochondrial membrane potential of lung cells was studied by Rhodamine123 fluorescence dye. Terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) test was used to show DNA fragmentation and apoptosis of lung cells. Also, the Rat inflammatory cytokine assay kit was used to measure the concentrations of inflammatory cytokines. The catalyst-treated cell cutlers significantly (p <= 0.01) reduced the DNA fragmentation, caspase-3 activity, and inflammatory cytokines concentrations, and raised the mitochondrial membrane potential and cell viability in the high concentration of alpha-Guttiferin-treated lung MRC-5, CCD-19Lu, WI-38, and BEAS-2B cells. The best result of lung protective properties of catalyst against alpha-Guttiferin was seen in the high dose of catalyst i.e., 4 mu g. DPPH test revealed similar antioxidant potentials for catalyst and butylated hydroxytoluene. The catalyst inhibited half of the DPPH molecules in the concentration of 171 mu g/mL. According to the above results, catalyst can be administrated as a lung protective drug for the treatment of lung diseases after approving in the clinical trial studies in humans. (C) 2020 Elsevier B.V. All rights reserved. The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 886-86-2 is helpful to your research. Product Details of 886-86-2.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Electric Literature of 81-16-3, Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, 81-16-3, Name is 2-Aminonaphthalene-1-sulfonic acid, SMILES is O=S(C1=C2C=CC=CC2=CC=C1N)(O)=O, belongs to phthalazines compound. In a article, author is Berber, Nurcan, introduce new discover of the category.

Synthesis and evaluation of new phthalazine substituted beta-lactam derivatives as carbonic anhydrase inhibitors

A new series of phthalazine substituted beta-lactam derivatives were synthesized and their inhibitory effects on the activity of purified human carbonic anhydrase (hCA I and II) were evaluated. 2H-Indazolo[2,1-b]phthalazine-trione derivative was prepared with 4-nitrobenzaldehyde, dimedone, and phthalhydrazide in the presence of TFA in DMF, and the nitro group was reduced to 13-(4-aminophenyl)-3,3-dimethyl-3,4-dihydro-2H-indazolo[1,2-b]phthalazine-1,6,11(13H)-trione with SnCl2 center dot 2H(2)O. The reduced compound was reacted with different aromatic aldehydes, and phthalazine substituted imines were synthesized. The imine compounds undergo (2+2) cycloaddition reactions with ketenes to produce 2H-indazolo[2,1-b]phthalazine-trione substituted beta-lactam derivatives. The beta-lactam compounds were tested as inhibitors of the CA isoenzyme activity. The results showed that all the synthesized compounds inhibited the CA isoenzyme activity. 1-(4-(3,3-dimethyl-1,6,11-trioxo-2,3,4,6,11,13-hexahydro-1H-indazolo[1,2b]phthalazin-13-yl)phenyl)-2-oxo-4-p-tolylazetidin-3-yl acetate (IC50 = 6.97 A mu M for hCA I and 8.48 A mu M for hCA II) had the most inhibitory effect.

Electric Literature of 81-16-3, Consequently, the presence of a catalyst will permit a system to reach equilibrium more quickly, but it has no effect on the position of the equilibrium as reflected in the value of its equilibrium constant.I hope my blog about 81-16-3 is helpful to your research.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 54381-16-7, Name is 2,2′-((4-Aminophenyl)azanediyl)diethanol sulfate, molecular formula is C10H18N2O6S, belongs to phthalazines compound. In a document, author is Bakherad, Mohammad, introduce the new discover, Quality Control of 2,2′-((4-Aminophenyl)azanediyl)diethanol sulfate.

Synthesis of New Derivatives of 1,2,3-Triazole-Linked Phthalazine-1,4-dionein Water: Experimental Aspects and Molecular Docking Calculations

A new series of phthalazine-based 1,2,3-triazole derivatives are synthesized by the reaction of 2-methyl-3-(prop-2-yn-1-yl)-2,3dihydro- phthalazine-1,4-dione or 2,3-bis(prop-2-yn-1-yl)-2,3-dihydrophthalaz- ine-1,4-dione with aromatic azides via coppercatalyzed azide-alkyne cycloaddition reactions in the presence of metformine as a ligand. These reaction procedures have the advantages of high-to-excellent yields, short reaction times, mild experimental conditions, and operational simplicity. All the synthesized compounds are screened in vitro for their antibacterial activities against the three bacterial strains Micrococcus luteus, Pseudomonas aeruginosa, and Bacillus subtilis. Furthermore, the results of anti-bacterial activity of the synthesized compounds was investigated using molecular docking calculations.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 54381-16-7. Quality Control of 2,2′-((4-Aminophenyl)azanediyl)diethanol sulfate.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Reference of 371-42-6, Redox catalysis has been broadly utilized in electrochemical synthesis due to its kinetic advantages over direct electrolysis. The appropriate choice of redox mediator can avoid electrode passivation and overpotential. 371-42-6, Name is 4-Fluorothiophenol, SMILES is SC1=CC=C(F)C=C1, belongs to phthalazines compound. In a article, author is Hirakawa, Shota, introduce new discover of the category.

Synthesis and Dynamic Behavior of an Anthyridine-Ligated Ruthenium Complex

A ruthenium complex containing a 1,9,10-anthyridine derivative, [Ru(L)(bpy)(2)](PF6)(2) ( [1] (PF6)(2); L = 1,13,14-triazadibenz[a,j]anthracene, bpy = 2,2′-bipyridyl), was synthesized. X-ray crystal structural analysis of [1](PF6)2 showed that L is coordinated to the Ru center as a bidentate ligand. When [1](PF6)(2) was dissolved in acetonitrile, a new complex incorporating one acetonitrile molecule, [Ru(L)(CH3CN)(bpy)(2)](PF6)(2) ([2] (PF6)(2)), was formed. X-ray crystallographic data revealed that, in [2](PF6)(2), L is coordinated to the Ru center in a monodentate fashion. The coordinated L in [2](PF6)(2) shows a unique haptotropic rearrangement in an acetonitrile solution.

Reference of 371-42-6, Consequently, the presence of a catalyst will permit a system to reach equilibrium more quickly, but it has no effect on the position of the equilibrium as reflected in the value of its equilibrium constant.I hope my blog about 371-42-6 is helpful to your research.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Chemistry can be defined as the study of matter and the changes it undergoes. You¡¯ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology. 36809-26-4, Name is (4-Bromophenyl)diphenylamine, molecular formula is , belongs to phthalazines compound. In a document, author is Shaterian, Hamid Reza, Product Details of 36809-26-4.

One-pot, four-component synthesis of 2H-indazolo[2,1-b]phthalazine-triones catalyzed by cellulose-SO3H as a reusable heterogeneous and efficient catalyst

A practical and green method for the synthesis of 2H-indazolo[2,1-b]phthalazine-1,6,11(13H)-trione derivatives using cellulose-SO3H as a solid acidic catalyst for the four-component condensation reaction of hydrazinium hydroxide, phthalic anhydride, dimedone, and aromatic aldehydes under thermal solvent-free conditions is described. Cellulose-SO3H as a recyclable green chemical compound has been demonstrated as a new catalyst for the synthesis of this class of compounds.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 36809-26-4, in my other articles. Product Details of 36809-26-4.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

In an article, author is Boulebd, Houssem, once mentioned the application of 41263-74-5, Product Details of 41263-74-5, Name is 4-(Methylamino)-3-nitrobenzoic acid, molecular formula is C8H8N2O4, molecular weight is 196.16, MDL number is MFCD00464322, category is phthalazines. Now introduce a scientific discovery about this category.

Thermodynamic and Kinetic Studies of the Radical Scavenging Behavior of Hydralazine and Dihydralazine: Theoretical Insights

Hydralazine (HZ) and dihydralazine (DHZ) are phthalazine derivatives substituted at position 1 (HZ) or positions 1 and 4 (DHZ) by a hydrazinyl substituent. These compounds are widely used for treating hypertension and heart failure, essentially acting as vasodilators on the arteries and arterioles. In this study, the antioxidant activity of HZ and DHZ in the gas phase and in physiological environments was investigated by thermodynamic and kinetic calculations. It was found that the HOO center dot radical scavenging activity of these compounds follows the formal hydrogen transfer (FHT) mechanism. The H abstraction of the N9-H bond plays a deciding role in the HOO center dot radical scavenging of HZ-1 and DHZ-I, whereas the HOO center dot radical scavenging activities of HZ-2 and DHZ-2 are defined by the dissociation of the N10-H and Nil-H bonds, respectively. The rate constants for the HOO center dot radical scavenging of the HZ and DHZ in the gas phase are in the range of 9.64 x 10(6) to 4.52 x 10(8) M-1 s(-1), whereas in aqueous solutions and the lipid medium they are in the range of 2.62 X 10(4) to 5.13 x 10(7) M-1 s(-1) and 5.75 x 10(4) to 6.66 x 10(6) M-1 s(-1), respectively. The HOO center dot radical scavenging of DHZ-1 and DHZ-2 is thus faster than that of the reference antioxidant compound Trolox in all the studied environments. Consistently, DHZs are not only vasodilators but also potent antioxidants.

If you are interested in 41263-74-5, you can contact me at any time and look forward to more communication. Product Details of 41263-74-5.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Related Products of 502496-34-6, As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 502496-34-6, Name is 4-Bromo-2-fluoro-6-nitrotoluene, SMILES is CC1=C([N+]([O-])=O)C=C(Br)C=C1F, belongs to phthalazines compound. In a article, author is Wang Wang, introduce new discover of the category.

An improved procedure for the three-component synthesis of 1H-pyrazolo[1,2-b]phthalazine-5,10-dione derivatives using basic ionic liquid

An efficient and green method for the synthesis of 1H-pyrazolo[1,2-b]phthalazine-5,10-dione derivatives has been achieved through the one-pot, three-component condensation of aromatic aldehydes, malononitrile or ethyl cyanoacetate, and phthalhydrazide in the presence of 1-butyl-3-methyl imidazolium hydroxide ([bmim]OH) as catalyst in EtOH. This reaction does not involve any hazardous organic solvent and toxic catalyst. The ionic liquid can be recovered and recycled for subsequent reactions. Moreover, this protocol has the advantages of easy work-up, short reaction time, mild reaction conditions and environmentally benign procedures compared with the reported methods.

Related Products of 502496-34-6, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. I hope my blog about 502496-34-6 is helpful to your research.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 875-74-1, Name is H-D-Phg-OH, SMILES is O=C(O)[C@H](N)C1=CC=CC=C1, belongs to phthalazines compound. In a document, author is Atar, Amol B., introduce the new discover, Application In Synthesis of H-D-Phg-OH.

beta-Cyclodextrine-SO3H: the most efficient catalyst for one-pot synthesis of 2H-indazolo[2,1-b]phthalazine-triones under solvent-free conditions

An environmentally benign and efficient method has been developed for the synthesis of a series of 2H-indazolo[2,1-b]phthalazine-triones derivatives with beta-cyclodextrine-SO3H as a recyclable catalyst by simply combining of various aldehydes with cyclic 1,3-diketones and phthalhydrazide under solvent free condition. The advantageous features of this methodology are high atom-economy, operational simplicity, shorter reaction time, convergence, and facile automation. A greener, efficient, and expeditious method has been developed for the synthesis of 2H-indazolo [2,1-b] phthalazine-triones derivatives with beta-cyclodextrine-SO3H as a recyclable catalyst for the first time. [GRAPHICS] .

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 875-74-1 is helpful to your research. Application In Synthesis of H-D-Phg-OH.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem