Category: phthalazines

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 502496-34-6, Name is 4-Bromo-2-fluoro-6-nitrotoluene, molecular formula is C7H5BrFNO2. In an article, author is Kefayati, H.,once mentioned of 502496-34-6, COA of Formula: C7H5BrFNO2.

Ultrasound-assisted synthesis of pyrazolo[1,2-b]phthalazines and dihydrospiro[indoline-3,1′-pyrazolo[1,2-b]phthalazines] using TBAF as an efficient phase-transfer catalyst

Tetrabutylammonim fluoride has been used as an efficient catalyst for synthesis of pyrazolo[1,2-b]-phthalazine-5,10-diones and dihydrospiro[indoline-3,1′-pyrazolo[1,2-b]phthalazines] by one-pot three-component reaction of phthalhydrazide, aromatic aldehydes or isatin derivatives, with malononitrile in water under ultrasond irradiation. This rapid method gave the products in high yield.

Interested yet? Keep reading other articles of 502496-34-6, you can contact me at any time and look forward to more communication. COA of Formula: C7H5BrFNO2.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Reactions catalyzed within inorganic and organic materials and at electrochemical interfaces commonly occur at high coverage and in condensed media, causing turnover rates to depend strongly on interfacial structure and composition, 93-28-7, Name is Eugenol Acetate, SMILES is CC(OC1=CC=C(CC=C)C=C1OC)=O, in an article , author is Hasaninejed, Alireza, once mentioned of 93-28-7, SDS of cas: 93-28-7.

Solvent-free, one-pot, four-component synthesis of 2H-indazolo[2,1-b]phthalazine-triones using sulfuric acid-modified PEG-6000 as a green recyclable and biodegradable polymeric catalyst

A green practical method for the efficient synthesis of 2H-indazolo[2,1-b]phthalazine-1,6,11(13H)-triones using sulfuric acid-modified polyethylene glycol-6000 (PEG-OSO3H) as an eco-friendly polymeric catalyst from the four-component condensation reaction of phthalic anhydride, hydrazinium hydroxide, 1,3-cyclohexanedione or 5,5-dimethyl 1,3-cyclohexanedione (dimedone) and aromatic aldehydes under solvent-free conditions at 80 degrees C is described. This approach allowed the environmental impact factor (E-factor) to be minimized. (C) 2012 Elsevier B. V. All rights reserved.

But sometimes, even after several years of basic chemistry education, it is not easy to form a clear picture on how they govern reactivity! 93-28-7, you can contact me at any time and look forward to more communication. SDS of cas: 93-28-7.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 622-95-7, Name is 1-(Bromomethyl)-4-chlorobenzene, molecular formula is C7H6BrCl. In an article, author is Raghuvanshi, Dushyant Singh,once mentioned of 622-95-7, Application In Synthesis of 1-(Bromomethyl)-4-chlorobenzene.

A convenient and green approach for the synthesis of 2H-indazolo[2,1-b]phthalazinetriones

A high yielding and environmentally benign synthesis of 2H-indazolo[2,1-b]phthalazine-1,6,11(13H)-trione derivatives has been achieved using silica-supported KHSO4 catalyst under solvent-free conditions. The methodology adopted is simple, versatile and requires no column chromatography.

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

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Magnetic nanoparticles Fe3O4-supported guanidine as an efficient nanocatalyst for the synthesis of 2H-indazolo[2,1-b]phthalazine-triones under solvent-free conditions

Here, the application of guanidine supported on magnetic nanoparticles Fe3O4 (MNPs-guanidine) as a novel magnetically separable base nanocatalyst is described. We have investigated the application of this new catalyst for the synthesis of 2H-indazolo[2,1-b]phthalazine-trione derivatives from the three-component, one-pot condensation reaction of phthalhydrazide, cyclic 1,3-dicarbonyl, and aromatic aldehydes under solvent-free conditions. The products were obtained in short reaction times with good to high yields. The supported catalyst could be simply separated and recovered from the reaction mixture with the assistance of an external magnet and reused 18 times with little loss of activity.

If you are hungry for even more, make sure to check my other article about 5509-65-9, HPLC of Formula: C6H5F2N.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Related Products of 88-99-3, Catalysts allow a reaction to proceed via a pathway that has a lower activation energy than the uncatalyzed reaction. 88-99-3, Name is Pathalic acid, SMILES is O=C(O)C1=CC=CC=C1C(O)=O, belongs to phthalazines compound. In a article, author is Eldehna, Wagdy M., introduce new discover of the category.

Increasing the binding affinity of VEGFR-2 inhibitors by extending their hydrophobic interaction with the active site: Design, synthesis and biological evaluation of 1-substituted-4-(4-methoxybenzyl) phthalazine derivatives

A series of anilinophthalazine derivatives 4a-j was initially synthesized and tested for its VEGFR-2 inhibitory activity where it showed promising activity (IC50 = 0.636-5.76 mu M). Molecular docking studies guidance was used to improve the binding affinity for series 4a-j towards VEGFR-2 active site. This improvement was achieved by increasing the hydrophobic interaction with the hydrophobic back pocket of the VEGFR-2 active site lined with the hydrophobic side chains of Ile888, Leu889, Ile892, Val898, Val899, Leu1019 and Ile1044. Increasing the hydrophobic interaction was accomplished by extending the anilinophthalazine scaffold with a substituted phenyl moiety through an uriedo linker which should give this extension the flexibility required to accommodate itself deeply into the hydrophobic back pocket. As planned, the designed uriedo-anilinophthalazines 7a-i showed superior binding affinity than their anilinophthalazine parents (IC50 = 0.083-0.473 mu M). In particular, compounds 7g-i showed IC50 of 0.086, 0.083 and 0.086 mu M, respectively, which are better than that of the reference drug sorafenib (IC50 = 0.09 mu M). (C) 2016 Elsevier Masson SAS. All rights reserved.

Related Products of 88-99-3, The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 88-99-3 is helpful to your research.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. In an article, author is Kiasat, Ali Reza, once mentioned the application of 24324-17-2, Name is 9-Fluorenemethanol, molecular formula is C14H12O, molecular weight is 196.2445, MDL number is MFCD00001139, category is phthalazines. Now introduce a scientific discovery about this category, Application In Synthesis of 9-Fluorenemethanol.

Experimental and theoretical study on one-pot, three-component route to 2H-indazolo[2,1-b]phthalazine-triones catalyzed by nano-alumina sulforic acid

A simple, efficient, and high yielding one-pot protocol for the synthesis of 2H-indazolo[2,1-b]phthalazine-trione derivatives has been developed by three-component coupling of phthalhydrazide, dimedone and some aromatic aldehydes in ecofriendly neat conditions promoted by nano-gamma-alumina sulforic acid. This protocol avoids the use of expensive catalysts, toxic solvents and chromatographic separation. Also the proposed protocol was extended to the linear beta-diketone (acetylaceton) instead of cyclic diketone (dimedone). The generality and functional tolerance of this convergent and environmentally benign method is demonstrated. The nature of each step of the suggested mechanism for this condensation reaction is also identified through Density Functional Theory (DFT) calculations using B3LYP/6-31G** level of theory. It is shown that the first step is charge controlled; whereas the second one is controlled by frontier molecular orbitals. The H-1 and C-13 chemical shift values together with the structural parameters of the title compound have been also computed and the scaled values have been compared with the corresponding experimental NMR and X-ray spectra. As a result, the calculated spectroscopic data and optimized geometry show a good agreement with the experimental results. (C) 2012 Elsevier B.V. All rights reserved.

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 886-86-2, Name is Ethyl 3-aminobenzoate methanesulfonate, molecular formula is C10H15NO5S. In an article, author is Chate, Asha V.,once mentioned of 886-86-2, SDS of cas: 886-86-2.

beta-Cyclodextrin as a supramolecular catalyst for the synthesis of 2H-indazolo[2,1-b]phthalazine-trione derivatives in water and their antimicrobial activities

An efficient and green method has been developed for the synthesis of 2H-indazolo[2,1-b]phthalazinetriones derivatives by employing 15 mol% beta-cyclodextrinvia a one-pot multicomponent reaction of aldehyde, dimedone, hydrazine hydrate with succinic anhydrideiphthalic anhydride in water at 80 degrees C for first time. The catalyst could be recovered and reused for four consecutive cycles without appreciable loss in catalytic activity and evaluated for in vitro antimicrobial activity against different Gram-positive and Gram-negative bacterial strains. The outcome of the screening study showed that compound 6d, 6f and 7n exhibited excellent activity against E. coil. Whereas, compound 6f and 6 h exhibited excellent activity against P. aeurginosa, and compound 6c, and 6e displayed again excellent activity against Staphylococcus aureus whereas compound 7o shows excellent activity against S. aureus and B. subtilis when compared with Ampicillin (standard control). The results indicated that maximum compounds are moderately effective against bacterial growth and their effectiveness is highest against standard drugs. (C) 2017 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Electric Literature of 618-88-2, Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. 618-88-2, Name is 5-Nitroisophthalic acid, SMILES is O=C(O)C1=CC([N+]([O-])=O)=CC(C(O)=O)=C1, belongs to phthalazines compound. In a article, author is Zhu, Guanxing, introduce new discover of the category.

Access to a Phthalazine Derivative Through an Angular cis-Quinacridone

Intramolecular electrophilic cyclization of a bisanthranilate afforded an angular cis-quinacridone compound, which condensed with hydrazine to give a phthalazine derivative. A [2+2+2] cyclization reaction occurred at the C-N double bond position of phthalazine when reacted with dimethyl acetylenedicarboxylate. The structures of these novel compounds were confirmed by crystallographic analysis. The phthalazine derivative decomposes back to quinacridone at ambient condition in the dark and as a solid with a half lifetime of about 22 months.

Electric Literature of 618-88-2, Because enzymes can increase reaction rates by enormous factors and tend to be very specific, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 618-88-2.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Let¡¯s face it, organic chemistry can seem difficult to learn. Especially from a beginner¡¯s point of view. Like 89-86-1, Name is 2,4-Dihydroxybenzoic acid. In a document, author is Kiasat, Ali Reza, introducing its new discovery. Name: 2,4-Dihydroxybenzoic acid.

Fe3O4@silica sulfuric acid nanoparticles: An efficient reusable nanomagnetic catalyst as potent solid acid for one-pot solvent-free synthesis of indazolo[2,1-b]phthalazine-triones and pyrazolo[1,2-b]phthalazine-diones

Regarding the green chemistry’s goals, silica-coated magnetite nanoparticles (MNPs) open up new avenue to introduce an amazing and efficient system for facilitating catalyst recovery in different organic reactions. Therefore, in this paper the preparation of sulfuric acid functionalized silica-coated magnetite nanoparticles with core-shell structure (Fe3O4@silica sulfuric acid) are presented by using Fe3O4 spheres as the core and silica sulfuric acid nanoparticles as the shell. The catalyst was characterized by infrared spectroscopy (FT-IR), scanning electron microscope (SEM), transmission electron microscopy (TEM), X-ray diffraction (XRD) spectroscopy, and vibrating sample magnetometer (VSM). Ability of this nano-magnetic solid acid catalyst in the one-pot three-components condensation reaction of phthalhydrazide, aromatic aldehydes and cyclic or acyclic 1,3-diketones are also described. Utilization of easy reaction conditions, catalyst with high catalytic activity and good reusability, and simple magnetically work-up, makes this methodology as an interesting option for the economic synthesis of indazolo[2,1-b]phthalazine-triones and pyrazolo[1,2-b]phthalazine-diones. (C) 2013 Elsevier B.V. All rights reserved.

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 89-86-1 help many people in the next few years. Name: 2,4-Dihydroxybenzoic acid.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Application of 2128-93-0, Catalysts allow a reaction to proceed via a pathway that has a lower activation energy than the uncatalyzed reaction. 2128-93-0, Name is 4-Benzoylbiphenyl, SMILES is C1=CC(=CC=C1)C2=CC=C(C=C2)C(C3=CC=CC=C3)=O, belongs to phthalazines compound. In a article, author is Lamera, Esma, introduce new discover of the category.

Sequential MCR/Fisher indolization strategy for the construction of polycyclic carbazole derivatives

A one-pot method for the synthesis of novel polycyclic carbazole derivatives from readily available starting materials using a sequential multicomponent reaction/Fisher indolization strategy is described. (C) 2017 Elsevier Ltd. All rights reserved.

Application of 2128-93-0, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. I hope my blog about 2128-93-0 is helpful to your research.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem