Category: phthalazines

Reference of 620-14-4, As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 620-14-4, Name is 3-Ethyltoluene, SMILES is CC1=CC(CC)=CC=C1, belongs to phthalazines compound. In a article, author is Taslimi, Parham, introduce new discover of the category.

2H-Indazolo[2,1-b]phthalazine-trione derivatives: Inhibition on some metabolic enzymes and molecular docking studies

In this study, substituted 2H-indazolo[2,1-b]phthalazine-1,6,11-trione compounds (4a-d) obtained via one-pot three-component condensation reaction of aromatic aldehydes, cyclic 1,3-dione, and phthalhydrazide in ethanol catalyzed by Y(OTf)(3) showed satisfactory inhibitory effects against some important enzymes. Also, these molecules had K-i values in the row of 185.92 +/- 36.03-294.82 +/- 50.76 nM vs carbonic anhydrase I (CA I), 204.93 +/- 46.90-374.10 +/- 83.63 nM against human CA II, 937.16 +/- 205.82-1021.83 +/- 193.66 nM against alpha-glycosidase (alpha-Gly), respectively. For cholinesterase enzymes, the K-i values were found in the range of 47.26 +/- 9.62-72.05 +/- 19.47 nM against acetylcholinesterase (AChE) and 65.03 +/- 9.88-102.83 +/- 25.04 nM against butyrylcholinesterase (BChE), respectively. The inhibition effects of these compounds against enzymes whose name are AChE, BChE, alpha-Gly, hCA I, and hCA II, were compared with control molecules like tacrine, acarbose, and acetazolamide.

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics, Application In Synthesis of Phenethyl acetate, 103-45-7, Name is Phenethyl acetate, SMILES is CC(OCCC1=CC=CC=C1)=O, belongs to phthalazines compound. In a document, author is Bodman, Samantha E., introduce the new discover.

Structural control: can [2 x 2] silver grids be formed from 4,5-disubstituted 3,6-di(2-pyridyl) pyridazines?

The reaction of ligands based on 3,6-di(2-pyridyl)pyridazine with symmetrical carbocyclic rings fused to the pyridazine ring; 7,10-di(2-pyridyl)-8,9-diazafluoranthene (L-1), 1,4-di(2-pyridyl)-6,7,8,9-tetrahydro-5H-cyclo-hepta[d]pyridazine (L-2), 1,4-di(2-pyridyl)-5,6,7,8-tetrahydro-phthalazine (L-3), 1,4-di(2-pyridyl)-6,7-dihydro-5H-cyclo-penta[d]pyridazine (L-4) with silver salts gave a series of complexes (1-7). Characterisation of these using single crystal X-ray structure determination clearly showed that the steric bulk of the carbocycle affects the degree to which pyridine groups remain co-planar with pyridizine, and hence their ability to chelate. The more hindered ligands L-1-L-3 form a mixture of bischelating and tetrabridging, while the least hindered (L-4) was able to chelate exclusively. In the case of L-4, the nature of the anion and solvent were also able to affect the outcome of the reaction, with tetrafluoroborate giving the first example of a 4,5-substituted 3,6-di(2-pyridyl) pyridazine ring forming a [2 x 2]-grid.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 103-45-7. Application In Synthesis of Phenethyl acetate.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Related Products of 139-66-2, As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 139-66-2, Name is Diphenylsulfane, SMILES is C1(SC2=CC=CC=C2)=CC=CC=C1, belongs to phthalazines compound. In a article, author is Pouramiri, Behjat, introduce new discover of the category.

Acidic ionic liquids: highly efficient catalysts for one-pot four-component synthesis of pyrazolo [1,2-b] phthalazines under solvent-free conditions

A series of novel pyrazolo[1,2-b]phthalazine-2-carboxylate derivatives has been synthesized via one-pot four-component reaction of aromatic aldehyde, ethyl or methyl acetoacetate, hydrazine hydrate, and phthalic anhydride in the presence of acidic ionic liquids such as 3-methyl-1-sulfo-1H-imidazol-3-ium chloride, 1,3-disulfo-1H-imidazol-3-ium chloride, and triethyl(sulfo)ammonium chloride as the catalyst. This method involves particular advantages such as environmentally benign catalysts, high yields of product, reusability of ionic liquids with high activity, short reaction times, no hazardous solvent, and easy workup.

Related Products of 139-66-2, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 139-66-2.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, such as the rate of change in the concentration of reactants or products with time. 24650-42-8, Name is 2,2-Dimethoxy-2-phenylacetophenone, formurla is C16H16O3. In a document, author is Liu, Baiquan, introducing its new discovery. Category: phthalazines.

Highly efficient red phosphorescent organic light-emitting diodes based on solution processed emissive layer

Highly efficient red phosphorescent organic polymer light-emitting diodes (PhOLEDs) were fabricated based on a solution-processed small-molecule host 4,4′-bis(N-carbazolyl)-1,1′-biphenyl (CBP) by doping an iridium complex, tris(1-(2,6-dimethylphenoxy)-4-(4-chlorophenyl)phthalazine)iridium (III) (Ir(MPCPPZ)(3)). A hole blocking layer 1,3,5-tri(1-phenyl-1H-benzo[d]imidazol-2-yl)phenyl (TPBI) with a function of electron transport was thermally deposited onto the top of CBP layer. The diode with the structure of ITO/PEDOT:PSS (50 nm)/CBP:Ir(MPCPPZ)(3) (55 nm)/TPBI (30 nm)/Ba (4 nm)/Al (120 nm) showed an external quantum efficiency (QE(ext)) of 19.3% and luminous efficiency (LE) of 18.3 cd/A at a current density of 0.16 mA/cm(2), and Commission International de l’Eclairage (CIE) coordinates of (0.607, 0.375). It was suggested that the diodes using TPBI layer exhibited nearly 100% internal quantum efficiency and one order magnitude enhanced LE or QE(ext) efficiencies. (c) 2013 Elsevier B.V. All rights reserved.

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Application of 90-64-2, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C¨CH bond functionalisation has revolutionised modern synthetic chemistry. 90-64-2, Name is 2-Hydroxy-2-phenylacetic acid, SMILES is C1=CC=CC=C1C(C(O)=O)O, belongs to phthalazines compound. In a article, author is Sadimenko, Alexander P., introduce new discover of the category.

Organometallic complexes of functionalized chelating azines

Organometallic compounds of the chelating azines containing carbonyl, hydroxyl, thiol, selenol, amino, imino, phosphino, thienyl, indolyl, carbazolyl, pyrazolyl, imidazolyl, 1,2,3-triazolyl, and N-heterocyclic carbene functionalities are reviewed. Synthesis and coordination modes, the role of the discussed compounds in catalysis, materials chemistry, photochemistry, and microbiology are highlighted.

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Related Products of 88-44-8, As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 88-44-8, Name is 4-Aminotoluene-3-sulfonic acid, SMILES is O=S(C1=CC(C)=CC=C1N)(O)=O, belongs to phthalazines compound. In a article, author is Paragas, Erickson M., introduce new discover of the category.

The two faces of aldehyde oxidase: Oxidative and reductive transformations of 5-nitroquinoline

Aldehyde oxidase (AOX) is a cytosolic enzyme responsible for the metabolism of some drugs and drug candidates. AOX catalyzes the oxidative hydroxylation of substrates including several aliphatic and aromatic aldehydes, and nitrogen-containing heterocyclic compounds. AOX is also reported to catalyze the reductive metabolism of nitro-compounds, N-oxides, sulfoxides, isoxazoles, isothiazoles, nitrite and hydroxamic acids. These reductive transformations are not well understood and are generally believed to only occur at low oxygen concentrations. In this study, we used 5-nitroquinoline (5NQ) as a substrate to further understand both the oxidative and the reductive transformations catalyzed by AOX. In vitro reaction of 5NQ with AOX under aerobic conditions generated the oxidized (2-oxo-5-nitroquinoline, 2-oxo-5NQ), the reduced (5-aminoquinoline, 5AQ) and the oxidized/reduced (2-oxo-5-aminoquinoline, 2-oxo-5AQ) metabolites. Interestingly, in human liver cytosol, co-incubation of 5NQ and known AOX oxidative substrates DACA and phthalazine significantly increased the yield of the reduced metabolite, while oxidized metabolites production decreased. These data indicate that 5NQ can be reduced at atmospheric oxygen concentrations and that the reductive transformation occurs at a second site that is kinetically distinct from the oxidative site. (C) 2017 Published by Elsevier Inc.

Related Products of 88-44-8, The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 88-44-8 is helpful to your research.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

In an article, author is Safaei-Ghomi, J., once mentioned the application of 201611-92-9, Name is 4-Cyano-4-((phenylcarbonothioyl)thio)pentanoic acid, molecular formula is C13H13NO2S2, molecular weight is 279.38, MDL number is MFCD10698690, category is phthalazines. Now introduce a scientific discovery about this category, Recommanded Product: 201611-92-9.

CuFe2O4 and ZrP2O7 nanoparticles as highly efficient catalysts for the one-pot synthesis of phthalazine derivatives under solvent-free conditions

ZrP2O7 and CuFe2O4 nanoparticles as efficient and reusable heterogeneous catalysts have been used for the preparation of 2H-indazolo[2,1-b]phthalazine-triones and 1H-pyrazolo[1,2-b]phthalazine-diones, respectively, under solvent-free conditions in good to excellent yields and short reaction times. (C) 2016 Sharif University of Technology. All rights reserved.

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Chemistry is traditionally divided into organic and inorganic chemistry. The former is the study of compounds containing at least one carbon-hydrogen bonds. 524-95-8, Name is 2-((Diphenylboryl)oxy)ethanamine, molecular formula is C14H16BNO, belongs to phthalazines compound, is a common compound. In a patnet, author is Xin Jingchao, once mentioned the new application about 524-95-8, Recommanded Product: 2-((Diphenylboryl)oxy)ethanamine.

Synthesis and Antitumor Activity of 1-Phenyl-4-substituted Phthalazine Derivatives

In order to find more efficient and economical antitumor drugs, a series of 1-phenyl-4-substituted phthalazine derivatives were synthesized and evaluated for antiproliferative activity in vivo. The structures of the synthesized compounds were confirmed by H-1 NMR, C-13 NMR and HRMS. The antitumor activity of the target compounds was performed against four cancer cell lines by 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tetrazolium bromide (MTT). The results showed that some compounds had a good antitumor activity, especially, N-(4-methoxyphenyl)-2-((4-phenylphthalazin-1-yl)thio)acetamide (5f) and N-(3-chloro-4-fluorophenyl)-2-(4-(4-phenylphthalazin-1-yl)piperazin-1-yl)acetamide (8c), exhibited better antitumor activities with IC50 values of 8.13 and 9.31 mu mol.L-1 against the human esophageal cancer cells, which were superior to 5-fuorouracil.

We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, 524-95-8. The above is the message from the blog manager. Recommanded Product: 2-((Diphenylboryl)oxy)ethanamine.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Reactions catalyzed within inorganic and organic materials and at electrochemical interfaces commonly occur at high coverage and in condensed media, causing turnover rates to depend strongly on interfacial structure and composition, 482-05-3, Name is [1,1′-Biphenyl]-2,2′-dicarboxylic acid, SMILES is O=C(C1=CC=CC=C1C2=CC=CC=C2C(O)=O)O, in an article , author is Behera, Dayanidhi, once mentioned of 482-05-3, Recommanded Product: [1,1′-Biphenyl]-2,2′-dicarboxylic acid.

Effect of commonly used organic solvents on Aldehyde oxidase-mediated Vanillin, Phthalazine and Methotrexate oxidation in human, rat and mouse liver subcellular fractions

1. Aldehyde oxidase (AOX) is a cytosolic molybdoflavoprotein enzyme widely distributed across many tissues. In this study, we report the effect of commonly used organic solvents such as dimethyl sulfoxide (DMSO), acetonitrile (ACN), methanol and ethanol on AOX activity in human, rat and mouse liver S9 fractions using vanillin, phthalazine and methotrexate as probe substrates. 2. Methanol was found to be the most potent solvent in inhibiting vanillic acid and 1-phthalazinone formation in comparison to DMSO, ACN and ethanol across the species tested, except 7-hydroxy methotrexate. 3. Treatment with these solvents at approximate IC50 (% v/v) concentrations showed significant reduction in Cl-int and V-max of the probe substrates and also resulted in different effects on K-m across the species. 4. Marked differences in the activity and affinity towards AOX were observed with different probe substrates with methotrexate showing least activity and affinity as compared to vanillin and phthalazine. 5. Overall, AOX activity seemed to be more resilient to the presence of organic solvents at higher concentrations in human and rodent species. These results suggest that low concentrations of organic solvents are acceptable for in vitro incubations involving AOX-mediated metabolism.

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

90-64-2, Name is 2-Hydroxy-2-phenylacetic acid, molecular formula is C8H8O3, Computed Properties of C8H8O3, belongs to phthalazines compound, is a common compound. In a patnet, author is Hashemzadeh, Alireza, once mentioned the new application about 90-64-2.

A magnetically-separable H3PW12O40@Fe3O4/EN-MIL-101 catalyst for the one-pot solventless synthesis of 2H-indazolo[2,1-b] phthalazine-triones

A magnetic inorganic-organic catalyst, PTA@Fe3O4/EN-MIL-101 (EN = ethylenediamine, PTA = phosphotungstic acid) was fabricated and characterized by XRD, HRTEM, FESEM, UV-vis, TGA-DTA, FT-IR, XPS and porosimetry. PTA retained the parent Keggin structure upon dispersion throughout the amine-functionalized chromium terephthalate metal-organic framework, over which magnetic Fe3O4 nanoparticles were previously introduced. The resulting composite heterogeneous solid acid was an active catalyst for the one-pot synthesis of diverse 2H-indazolo[2,1-b] phthalazine-triones in good -> excellent yields under mild, solventless condition, and offers facile separation and excellent recyclability. (C) 2017 Elsevier B.V. All rights reserved.

We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, 90-64-2. The above is the message from the blog manager. Computed Properties of C8H8O3.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem