Category: phthalazines

Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 369-34-6, Name is 3,4-Difluoronitrobenzene, molecular formula is C6H3F2NO2, belongs to phthalazines compound. In a document, author is Yunta, Maria J. R., introduce the new discover, Application In Synthesis of 3,4-Difluoronitrobenzene.

Tropical and Subtropical Parasitic Diseases: Targets for a New Approach to Virtual Screening

Computational techniques are widely used to reduce costs associated with new drug development with the ability to bind a specific molecular target. These studies need a Brookhaven protein data bank structure sample of the enzyme interaction with an inhibitor of adequate size. In this context, a new computational methodology is postulated to be used when there are no published samples fulfilling this requirements. In this study, 7 compounds, which showed anti-T. cruzi, L. donovani and L. infantum properties, and proved to be inhibitors of their Fe-SOD enzymes, have been theoretically evaluated against related parasites Fe-SOD enzymes, which have been proposed as targets for antiparasitic drugs. This methodology may be applied to similar cases and also to generate starting structures to be used with different CADD methods

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 369-34-6. Application In Synthesis of 3,4-Difluoronitrobenzene.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. 83-53-4, Name is 1,4-Dibromonaphthalene, SMILES is C1=CC=CC2=C(C=CC(=C12)Br)Br, in an article , author is Kour, Manmeet, once mentioned of 83-53-4, Recommanded Product: 83-53-4.

Ionic liquid coated sulfonated carbon@titania composites for the one-pot synthesis of indeno[1,2-b]indole-9,10-diones and 1H-pyrazolo[1,2-b]phthalazine-5,10-diones in aqueous media

A highly active and stable ionic liquid based novel solid Bronsted acid catalyst (C@TiO2-SO3H-ILs) was prepared by coating a long chain ionic liquid onto sulfonated carbon@titania composites. The ionic liquid coating resulted in efficient stability and activity of C@TiO2-SO3H-ILs under aqueous conditions by creating a hydrophobic environment on the catalyst surface. The catalytic activity of the newly designed catalyst was tested in the one-pot multicomponent synthesis of indeno[1,2-b]indole-9,10-diones and 1H-pyrazolo[1,2-b]phthalazine-5,10-diones in aqueous media. The structure of the most active catalyst, C@TiO2-SO3H-IL1, before and after the coating with the ionic liquid was investigated by FTIR, TGA, XRD, CHNS, EDX, SEM and HRTEM. The catalyst allows easy recovery and excellent reusability for up to five catalytic runs without considerable loss of activity.

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics, 81-48-1, Name is 1-Hydroxy-4-(p-tolylamino)anthracene-9,10-dione, SMILES is O=C(C1=C2C=CC=C1)C3=C(NC4=CC=C(C)C=C4)C=CC(O)=C3C2=O, belongs to phthalazines compound. In a document, author is Xin Jingchao, introduce the new discover, Name: 1-Hydroxy-4-(p-tolylamino)anthracene-9,10-dione.

Synthesis and Antitumor Activity of 1-Phenyl-4-substituted Phthalazine Derivatives

In order to find more efficient and economical antitumor drugs, a series of 1-phenyl-4-substituted phthalazine derivatives were synthesized and evaluated for antiproliferative activity in vivo. The structures of the synthesized compounds were confirmed by H-1 NMR, C-13 NMR and HRMS. The antitumor activity of the target compounds was performed against four cancer cell lines by 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tetrazolium bromide (MTT). The results showed that some compounds had a good antitumor activity, especially, N-(4-methoxyphenyl)-2-((4-phenylphthalazin-1-yl)thio)acetamide (5f) and N-(3-chloro-4-fluorophenyl)-2-(4-(4-phenylphthalazin-1-yl)piperazin-1-yl)acetamide (8c), exhibited better antitumor activities with IC50 values of 8.13 and 9.31 mu mol.L-1 against the human esophageal cancer cells, which were superior to 5-fuorouracil.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 81-48-1 is helpful to your research. Name: 1-Hydroxy-4-(p-tolylamino)anthracene-9,10-dione.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

In an article, author is Bolteau, Raphael, once mentioned the application of 608141-42-0, Application In Synthesis of (S)-1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethanamine, Name is (S)-1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethanamine, molecular formula is C12H19NO4S, molecular weight is 273.3486, MDL number is MFCD22677268, category is phthalazines. Now introduce a scientific discovery about this category.

Quinazoline and phthalazine derivatives as novel melatonin receptor ligands analogues of agomelatine

For further development of successors of Agomelatine through modulation of its pharmacokinetic properties, we report herein the design, synthesis and pharmacological results of a new family of melatonin receptor ligands. Issued from the introduction of quinazoline and phthalazine scaffolds carrying an ethyl amide lateral chain and a methoxy group as bioisosteric ligands analogues of previously developed Agomelatine. The biological activity of the prepared analogues was compared with that of Agomelatine. Quinazoline and phthalazine rings proved to be a versatile scaffold for easy feasible MT1 and MT2 ligands. Potent agonists with sub-micromolar binding affinity were obtained. However, the presence of two nitrogen atoms resulted in compounds with lower affinity for both MT1 and MT2, in comparison with the parent compound, balanced by the exhibition of good pharmacokinetic properties. (C) 2020 Elsevier Masson SAS. All rights reserved.

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Application of 5509-65-9, Redox catalysis has been broadly utilized in electrochemical synthesis due to its kinetic advantages over direct electrolysis. The appropriate choice of redox mediator can avoid electrode passivation and overpotential. 5509-65-9, Name is 2,6-Difluoroaniline, SMILES is C1=CC=C(C(=C1F)N)F, belongs to phthalazines compound. In a article, author is Zhao, Shanshan, introduce new discover of the category.

Recycling of high temperature steam condensed water from petroleum refinery by thermostable PPESK ultrafiltration membrane

The purification and reclaiming of synthetic and industrial high temperature condensed water containing excess oil and iron is investigated in this study using thermostable poly(phthalazine ether sulfone ketone) (PPESK) ultrafiltration membranes. The results show operation parameters such as transmembrane pressure, temperature and pH of feed solution, initial oil and iron concentration each play important roles in the permeate flux and oil/iron removal efficiencies. Membrane performance is almost recovered after washing with a combination of NaOH and ethanol. High temperature condensed water from Daqing petroleum refinery can be consecutively purified using a PPESK ultrafiltration membrane. The turbidity of the solutions is almost removed. Oil and iron concentrations in the permeate solutions are below 1 mg/L and 50 mu g/L, respectively, which satisfy the Quality Criterion of Water and Steam for Steam Power Equipment in China. UF process shows a promising alternative to existing technology in the Daqing petroleum refinery in terms of cost and environmental protection as well as energy recovery. For future possible combination of UF and NF process application, both economic cost and saving are evaluated, and the breakeven time is about 11 months. (C) 2013 Elsevier B.V. All rights reserved.

Application of 5509-65-9, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. I hope my blog about 5509-65-9 is helpful to your research.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Electric Literature of 2215-77-2, Catalysts allow a reaction to proceed via a pathway that has a lower activation energy than the uncatalyzed reaction. 2215-77-2, Name is 4-Phenoxybenzoic acid, SMILES is OC(=O)C1=CC=C(OC2=CC=CC=C2)C=C1, belongs to phthalazines compound. In a article, author is Atashkar, Bahareh, introduce new discover of the category.

Magnetic nanoparticles Fe3O4-supported guanidine as an efficient nanocatalyst for the synthesis of 2H-indazolo[2,1-b]phthalazine-triones under solvent-free conditions

Here, the application of guanidine supported on magnetic nanoparticles Fe3O4 (MNPs-guanidine) as a novel magnetically separable base nanocatalyst is described. We have investigated the application of this new catalyst for the synthesis of 2H-indazolo[2,1-b]phthalazine-trione derivatives from the three-component, one-pot condensation reaction of phthalhydrazide, cyclic 1,3-dicarbonyl, and aromatic aldehydes under solvent-free conditions. The products were obtained in short reaction times with good to high yields. The supported catalyst could be simply separated and recovered from the reaction mixture with the assistance of an external magnet and reused 18 times with little loss of activity.

Electric Literature of 2215-77-2, Because enzymes can increase reaction rates by enormous factors and tend to be very specific, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 2215-77-2.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Application of 789-25-3, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C¨CH bond functionalisation has revolutionised modern synthetic chemistry. 789-25-3, Name is Triphenylsilane, SMILES is [SiH](C1=CC=CC=C1)(C2=CC=CC=C2)C3=CC=CC=C3, belongs to phthalazines compound. In a article, author is Khalili, Akram, introduce new discover of the category.

Synthesis and characterization of 4-methyl-1-(3-sulfopropyl)pyridinium hydrogen sulfate as a new ionic liquid immobilized on silica nanoparticles: A recyclable nanocomposite ionic liquid for the production of various substituted phthalazine-ones

4-Methyl-1-(3-sulfopropyl)pyridinium hydrogen sulfate ([MSPP][HSO4]) as a new acidic ionic liquid was prepared in a quick and easy process, and characterized by some techniques such as H-1 NMR, C-13 NMR and FT-IR analysis. Then, [MSPP][HSO4] was immobilized on silica nanoparticles by impregnation method to afforded heterogeneous acidic ionic liquid ([MSPP]HSO4@nSiO(2)) and characterized by elemental analysis (CHNS), FT-IR, and SEM. The worthiness of [MSPP]HSO4@nSiO(2) has been investigated for the synthesis of various substituted phthalazine-ones as well as selective synthesis of mono- and bis-phthalazine-ones as imperative biologically active compounds. The reaction has been carried out under solvent-free conditions, simple work-up procedure and the products were obtained in excellent to good yields. Moreover, the catalyst was reused five times without decay in catalytic activity performance. (C) 2018 Elsevier B.V. All rights reserved.

Application of 789-25-3, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 789-25-3.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

In an article, author is Esmaeilpour, Mohsen, once mentioned the application of 402-50-6, Computed Properties of C9H7F3, Name is 1-(Trifluoromethyl)-4-vinylbenzene, molecular formula is C9H7F3, molecular weight is 172.1471, MDL number is MFCD00075539, category is phthalazines. Now introduce a scientific discovery about this category.

Preparation, characterization and catalytic activity of dendrimer-encapsulated phosphotungstic acid nanoparticles immobilized on nanosilica for the synthesis of 2H-indazolo[2,1-b]phthalazine-triones under solvent-free or sonochemical conditions

In this paper, we adopt a facile method to prepare a type of porous silica nanoparticles (n-SiO2) from tetraethyl orthosilicate as the source of silica. Then, dendritic polymer supported on nanosilica with surface amino groups was fabricated. Finally, H3PW12O40 nanoparticles (PWA(n)) were synthesized by the treatment of H3PW12O40 powder with n-Octane as solvent by a solvothermal method and then immobilized onto the dendrimer polymer functionalized nanosilica. The synthesized nanostructures were characterized by fourier transform infrared (FT-IR), X-ray diffraction (XRD), thermogravimetric analysis (TGA), dynamic light scattering (DLS), N-2 adsorption-desorption isotherm analysis, UV-Vis and elemental analysis. The morphology of the catalyst was characterized using transmission electron microscopes (TEM). The acidity of the catalyst was determined by FTIR pyridine adsorption spectroscopy. Then, this catalytic system was used as an efficient catalyst for the synthesis of 2H-indazolo[2,1-b]phthalazine-triones via multi-component and one-pot reactions of various aldehydes, phthalic anhydride, hydrazinium hydroxide, and dimedone under thermal solvent-free conditions or ultrasound irradiation at room temperature. Also, the catalyst can be easily recovered and reused for six consecutive reaction cycles without significant loss of activity.

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics, Computed Properties of C9H9NO3, 495-69-2, Name is 2-Benzamidoacetic acid, SMILES is O=C(O)CNC(C1=CC=CC=C1)=O, belongs to phthalazines compound. In a document, author is Gol’dberg, A. E., introduce the new discover.

Crystal structure of a trinuclear complex of zinc(II) with 2,6-Di-tert-butyl-p-quinone 1′-phthalazinylhydrazone

2,6-Di-tert-butyl-p-quinone 1′-phthalazynylhydrazone (HL) is synthesized; the total energies and geometry of the possible hydrazone tautomeric forms are calculated by quantum chemical methods. The hydrazone phthalazone tautomer is shown to be the most stable, which is well consistent with the H-1 NMR spectroscopic data for hydrazone. An X-ray crystallographic analysis is performed of the hydrazone-based Zn(II) trinuclear complex, in which zinc atoms are linked by the diazine bridge of the phthalazine cycle and two pivalate bridges. The geometric properties of the monodeprotonated hydrazone residue in the complex are similar to the calculated data for the phthalazone hydrazone tautomeric form.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 495-69-2. Computed Properties of C9H9NO3.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 104-86-9, Name is (4-Chlorophenyl)methanamine, molecular formula is C7H8ClN, belongs to phthalazines compound. In a document, author is Khazaei, Ardeshir, introduce the new discover, Category: phthalazines.

N,2-Dibromo-6-chloro-3,4-dihydro-2H-benzo[e]-[1,2,4]thiadiazine-7-sulfonamide 1,1-dioxide: an efficient and homogeneous catalyst for one-pot synthesis of 4H-pyran, pyranopyrazole and pyrazolo[1,2-b]phthalazine derivatives under aqueous media

N,2-Dibromo-6-chloro-3,4-dihydro-2H-benzo[e][1,2,4]thiadiazine-7-sulfonamide 1,1-dioxide (DCDBTSD) as a highly efficient and homogeneous catalyst was successfully applied for the synthesis of 4H-pyran, pyranopyrazole and pyrazolo[1,2-b] phthalazine derivatives by a one-pot multi-component reaction (MCR) in water. The described method has some advantages such as mild and neutral reaction media, high yields, short reaction times, cleaner and easier reaction profiles and compliance with green chemistry protocols.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 104-86-9. Category: phthalazines.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem