Heterocyclic Building Blocks-phthalazine

COA of Formula: C7H5NO4. Beddoe, RH; Edwards, DC; Goodman, L; Sneddon, HF; Denton, RM in [Beddoe, Rhydian H.; Edwards, Daniel C.; Goodman, Louis; Denton, Ross M.] Univ Nottingham, Sch Chem, GlaxoSmithKline, Carbon Neutral Labs Sustainable Chem, 6 Triumph Rd, Nottingham NG7 2GA, England; [Sneddon, Helen F.] GlaxoSmithKline, Green Chem, Med Res Ctr, Stevenage SG1 2NY, Herts, England published Synthesis of O-18-labelled alcohols from unlabelled alcohols in 2020.0, Cited 37.0. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7.

The synthesis of primary, secondary and tertiary O-18-enriched alcohols from readily available O-16-alcohols via a Mitsunobu esterification and hydrolysis is described. The method is further exemplified in the labelling of the active pharmaceutical ingredient, dropropizine and is shown to be tolerant of modern, separation friendly Mitsunobu reagents.

COA of Formula: C7H5NO4. Welcome to talk about 62-23-7, If you have any questions, you can contact Beddoe, RH; Edwards, DC; Goodman, L; Sneddon, HF; Denton, RM or send Email.

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Phthalazine – Wikipedia,
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Recommanded Product: 4-Nitrobenzoic acid. Recently I am researching about MARKOVNIKOV-SELECTIVE HYDROFUNCTIONALIZATION; HETEROATOM BOND FORMATION; UNACTIVATED OLEFINS; ELECTRON-TRANSFER; CARBOXYLIC-ACIDS; OXIDATION; HYDROAMINATION; COMPLEXES; FE; ORGANOCOBALT(IV), Saw an article supported by the College of Chemistry and Molecular Engineering, Peking University; BNLMS. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Zhou, XL; Yang, F; Sun, HL; Yin, YN; Ye, WT; Zhu, R. The CAS is 62-23-7. Through research, I have a further understanding and discovery of 4-Nitrobenzoic acid

A functional group tolerant cobalt-catalyzed method for the intermolecular hydrofunctionalization of alkenes with oxygen- and nitrogen-based nucleophiles is reported. This protocol features a strategic use of hypervalent iodine(III) reagents that enables a mechanistic shift from conventional cobalt-hydride catalysis. Key evidence was found supporting a unique bimetallic-mediated rate-limiting step involving two distinct cobalt(III) species, from which a new carbon-heteroatom bond is formed.

Recommanded Product: 4-Nitrobenzoic acid. Welcome to talk about 62-23-7, If you have any questions, you can contact Zhou, XL; Yang, F; Sun, HL; Yin, YN; Ye, WT; Zhu, R or send Email.

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Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Category: phthalazines. I found the field of Chemistry very interesting. Saw the article Ni-catalyzed direct alcoholysis of N-acylpyrrole-type tertiary amides under mild conditions published in 2020.0, Reprint Addresses Huang, PQ (corresponding author), Xiamen Univ, Coll Chem & Chem Engn, Collaborat Innovat Ctr Chem Ene Mat, Dept Chem,Fujian Prov Key Lab Chem Biol, Xiamen 361005, Peoples R China.. The CAS is 62-23-7. Through research, I have a further understanding and discovery of 4-Nitrobenzoic acid.

N-Acylpyrrole-type amides are a class of versatile building blocks in asymmetric synthesis. We report that by employing Ni(COD)(2)/2,2 ‘-bipyridine (5 mol%) catalytic system, the direct, catalytic alcoholysis of N-acylpyrrole-type aromatic and aliphatic amides with both primary and secondary alcohols can be achieved efficiently under very mild conditions (rt, 1 h) even at gram scale. By increasing the catalyst loading to 10 mol%, prolonging reaction time (18 h), and/or elevating reaction temperature to 50 degrees C/80 degrees C, the reaction could be extended to both complex and hindered N-acylpyrroles as well as to N-acylpyrazoles, Nacylindoles, and to other (functionalized) primary and secondary alcohols. In all cases, only 1.5 equiv. of alcohol were used. The value of the method has been demonstrated by the racemization-free, catalytic alcoholysis of chiral amides yielded from other asymmetric methodologies.

Category: phthalazines. Welcome to talk about 62-23-7, If you have any questions, you can contact Chen, H; Chen, DH; Huang, PQ or send Email.

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Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Yavari, I; Khajeh-Khezri, A; Ghorbanzadeh, M; Halvagar, MR in [Yavari, Issa; Khajeh-Khezri, Aliyeh; Ghorbanzadeh, Meysam] Tarbiat Modares Univ, Dept Chem, POB 14115-175, Tehran, Iran; [Halvagar, Mohammad Reza] Chem & Chem Engn Res Ctr Iran, Dept Inorgan Chem, POB 14335-186, Tehran, Iran published Synthesis of novel alpha-acyloxyamides using choline chloride-based deep eutectic solvent in 2019, Cited 27. Computed Properties of C7H5NO4. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7.

The Passerini three-component reaction between acenaphthylene-1,2-dione, alkyl isocyanides, and carboxylic acids, leading to the formation of alpha-acyloxyamides in common organic solvents (CH2Cl2, MeOH) and choline chloride-based deep eutectic solvent, is described. The reaction in the latter solvent proceeded faster compared to common organic solvents. The structure of a typical product was confirmed by X-ray crystallography. [GRAPHICS] .

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Phthalazine – Wikipedia,
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An article Synthesis and Antiplatelet Potential Evaluation of 1,3,4-Oxadiazoles Derivatives WOS:000501340900004 published article about CHARGE-TRANSPORT PROPERTIES; PLATELET-AGGREGATION; MOLECULAR DOCKING; CROSS-TALK; ANTIOXIDANTS; RESONANCE; ASPIRIN; DRUGS in [Ramzan, Ayesha; Nazeer, Areesha; Munawar, Munawar A.; Khan, Misbahul A.; Basra, Muhammad Asim Raza] Univ Punjab, Inst Chem, Quaid E Azam New Campus, Lahore 54590, Pakistan; [Khan, Misbahul A.] Islamia Univ Bahawalpur, Dept Chem, Bahawalpur 63100, Pakistan; [Irfan, Ahmad] King Khalid Univ, Fac Sci, Dept Chem, POB 9004, Abha 61413, Saudi Arabia; [Al-Sehemi, Abdullah G.] King Khalid Univ, RCAMS, POB 9004, Abha 61413, Saudi Arabia; [Verpoort, Francis; Khatak, Zafar A.] Wuhan Univ Technol, State Key Lab Adv Technol Mat Synth & Proc, Lab Organometall Catalysis & Ordered Mat, Wuhan 430070, Hubei, Peoples R China; [Ahmad, Aftab] Univ Punjab, Ctr Excellence Mol Biol, Lahore, Pakistan in 2019, Cited 51. Recommanded Product: 4-Nitrobenzoic acid. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7

A novel series of 2-(3-methyl-1,6-diphenyl-1H-pyrazolo[3,4-b]pyridin4-yl)-5-aryl-1,3,4-oxadiazoles (4a-4h) has been synthesized from corresponding hydrazones (3a-3h) and evaluated their antiplatelet aggregation effect induced by arachidonic acid and collagen. Spectral data and elemental evaluation were used to confirm the structure of the compounds while molecular docking against cyclooxygenase 1 and 2 (COX1 & COX2) and quantitative structure-activity relationship (QSAR) were performed in describing their antiplatelet potential. All synthesized compound exhibited more than 50% platelet aggregation inhibition against both arachidonic acid and collagen. Antiplatelet activities results showed that 4b and 4f compounds have highest % inhibition against arachidonic acid. High Egap and ionization potential values showed that the compound 4d, 4e and 4f were supposed to be more active and good electron donor while 4b, 4c, 4d, 4e, 4g and 4h might be more active due to more electrophilic sites. Interaction with more than one residues in the binding pocket of COX-1 in comparison with aspirin and ligand efficacy (LE) consequences showed that compounds have excellent action potential for COX-1. Computational evaluations are in good agreement with antiplatelet activities of the compounds. All compounds might be promising antiplatelet agents especially 4b, 4f and helpful in the synthesis of new drugs for the treatment of cardiovascular diseases (CVDs).

Welcome to talk about 62-23-7, If you have any questions, you can contact Ramzan, A; Nazeer, A; Irfan, A; Al-Sehemi, AG; Verpoort, F; Khatak, ZA; Ahmad, A; Munawar, MA; Khan, MA; Basra, MAR or send Email.. Recommanded Product: 4-Nitrobenzoic acid

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Liu, QB; Cheng, YY; Li, W; Huang, L; Asada, Y; Hsieh, MT; Morris-Natschke, SL; Chen, CH; Koike, K; Lee, KH in [Liu, Qingbo; Li, Wei; Asada, Yoshihisa; Koike, Kazuo] Toho Univ, Fac Pharmaceut Sci, Miyama 2-2-1, Funabashi, Chiba 2748510, Japan; [Liu, Qingbo] Shenyang Pharmaceut Univ, Minist Educ, Key Lab Struct Based Drug Design & Discovery, Shenyang 110016, Liaoning, Peoples R China; [Cheng, Yung-Yi; Hsieh, Min-Tsang; Morris-Natschke, Susan L.; Lee, Kuo-Hsiung] Univ N Carolina, UNC Eshelman Sch Pharm, Nat Prod Res Labs, Chapel Hill, NC 27599 USA; [Cheng, Yung-Yi; Hsieh, Min-Tsang; Lee, Kuo-Hsiung] China Med Univ & Hosp, Chinese Med Res & Dev Ctr, Taichung 40402, Taiwan; [Huang, Li; Chen, Chin-Ho] Duke Univ, Med Ctr, Dept Surg, Surg Sci, Durham, NC 27710 USA published Synthesis and Structure-Activity Relationship Correlations of Gnidimacrin Derivatives as Potent HIV-1 Inhibitors and HIV Latency Reversing Agents in 2019, Cited 21. Category: phthalazines. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7.

Currently, due to the HIV latency mechanism, the search continues for effective drugs to combat this issue and provide a cure for AIDS. Gnidimacrin activates latent HIV-1 replication and inhibits HIV-1 infection at picomolar concentrations. This natural diterpene was able to markedly reduce the latent HIV-1 DNA level and the frequency of latently infected cells. Therefore, gnidimacrin is an excellent lead compound, and its anti-HIV potential merits further investigation. Twenty-nine modified gnidimacrin derivatives were synthesized and evaluated in assays for HIV replication and latency activation to establish which molecular structures must be maintained and which can tolerate changes that may be needed for better pharmacological properties. The results indicated that hydroxyl substituents at C-5 and C-20 are essential, while derivatives modified at 3-OH with aromatic esters retain anti-HIV replication and latent activation activities. The half-lives of the potent GM derivatives are over 20 h, which implies that they are stable in the plasm even though they contain ester linkages. The established structure activity relationship should be useful in the development of gnidimacrin or structurally related compounds as clinical trial candidates.

Category: phthalazines. Welcome to talk about 62-23-7, If you have any questions, you can contact Liu, QB; Cheng, YY; Li, W; Huang, L; Asada, Y; Hsieh, MT; Morris-Natschke, SL; Chen, CH; Koike, K; Lee, KH or send Email.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Recommanded Product: 62-23-7. In 2019.0 TETRAHEDRON published article about POLYMERIZATION in [Sekerova, Lada; Vyskocilova, Eliska; Cerveny, Libor] Univ Chem & Technol Prague, Dept Organ Technol, Prague 16628 6, Czech Republic; [Sedlacek, Jan] Charles Univ Prague, Fac Sci, Dept Phys & Macromol Chem, Prague 12840 2, Czech Republic in 2019.0, Cited 24.0. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7.

The theoretical study focused on the possible use of low-molecular-weight mono-as well as multifunctional terminal alkynes as catalysts for two reactions, which are known to be typically acid catalyzed – acetalization and esterification, is presented in this study. Multifunctional terminal alkynes [(diethynylbenzenes, triethynylbenzene, and tetrakis(4-ethynylphenyl)methane] were significantly more active than the monofunctional ones (cyclopropylacetylene, phenylacetylene, 3-cyclohexylprop-1-yne, 1-ethynyl-2-fluorobenzene, 1-ethynyl-4-fluorobenzene, 4-ethynyltoluene, 4-tert-butylphenylacetylene, and 2-ethynyl-alpha,alpha,alpha-trifluorotoluene), this fact can be partly explained by the higher amount of ethynyl groups per alkyne molecule. We confirmed that terminal ethynyl groups in low-molecular-weight alkynes can successfully act as acid catalytic centers for acetalization as well as for esterification. (C) 2019 Elsevier Ltd. All rights reserved.

Recommanded Product: 62-23-7. Welcome to talk about 62-23-7, If you have any questions, you can contact Sekerova, L; Vyskocilova, E; Cerveny, L; Sedlacek, J or send Email.

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Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Nejad, MJ; Salamatmanesh, A; Heydari, A in [Nejad, Masoumeh Jadidi; Salamatmanesh, Arefe; Heydari, Akbar] Tarbiat Modares Univ, Chem Dept, POB 14155-4838, Tehran, Iran published Copper (II) immobilized on magnetically separable L-arginine-beta-cyclodextrin ligand system as a robust and green catalyst for direct oxidation of primary alcohols and benzyl halides to acids in neat conditions in 2020, Cited 61. Recommanded Product: 62-23-7. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7.

Copper (II) immobilized on L-arginine-beta-cyclodextrin-functionalized magnetite nanoparticles (nano-Fe3O4@L-arginine-CD-Cu(II)) were successfully synthesized and fully characterized using FT-IR, XRD, SEM, EDX, ICP, TGA and VSM techniques. The catalytic activity of these magnetically retrievable nanoparticles was evaluated in the direct oxidation of primary alcohols and benzyl halides to acids in neat conditions that was observed to proceed well and products were obtained in good yields. In addition to showing good catalytic activity, the magnetic catalyst is easy to synthesize and can be recycled at least five times with little loss in activity. (C) 2020 Elsevier B.V. All rights reserved.

Recommanded Product: 62-23-7. Welcome to talk about 62-23-7, If you have any questions, you can contact Nejad, MJ; Salamatmanesh, A; Heydari, A or send Email.

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Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

An article Mechanism-based structure-activity relationship (SAR) analysis of aromatic amines and nitroaromatics carcinogenicity via statistical analyses based on CPDB WOS:000472589900002 published article about HETEROAROMATIC AMINES; AMES TEST; MUTAGENICITY; QSAR; RISK; HYDROCARBONS; EPIDEMIOLOGY; PERMEABILITY; METABOLISM; OXIDATION in [Wan, Wen-xin; Zhang, Jing; Shen, Fei; Deng, Shi-huai; Xiao, Yin-long; Huang, Chu-rui; Tian, Dong; He, Jin-song] Sichuan Agr Univ, Inst Ecol & Environm Sci, Chengdu 611130, Sichuan, Peoples R China; [Wan, Wen-xin; Zhang, Jing; Shen, Fei; Luo, Ling; Deng, Shi-huai; Xiao, Hong; Tian, Dong; He, Jin-song; Wang, Ying-jun] Sichuan Agr Univ, Coll Environm, Chengdu 611130, Sichuan, Peoples R China; [Chen, Yi] Environm Monitoring Ctr Chengdu, Chengdu 610041, Sichuan, Peoples R China; [Zhang, Jing] Sichuan Univ, State Key Lab Hydraul & Mt River Engn, Chengdu 610056, Sichuan, Peoples R China; [Zhou, Wei; Deng, Ou-ping] Sichuan Agr Univ, Coll Resource, Chengdu 610030, Sichuan, Peoples R China; [Yang, Hua] Sichuan Agr Univ, Coll Forestry, Chengdu 610030, Sichuan, Peoples R China in 2019, Cited 65. Product Details of 62-23-7. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7

Cancer is a leading cause of human mortality around the globe. In this study, mechanism-based SAR (Structure Activity Relationship) was employed to investigate the carcinogenicity of aromatic amines and nitroaromatics based on CPDB. Principal component analysis and cluster analysis were used to construct the SAR model. Principle component analysis generated three principal components from 12 mechanism-based descriptors. The extracted principal components were later used for cluster analysis, which divided the selected 55 chemicals into six clusters. The three principal components were proposed to describe the transport, reactivity and electrophilicity properties of the chemicals. Cluster analysis indicated that the relevant transport properties positively correlated with the carcinogenic potential and were contributing factors in determining the cardnogenicity of the studied chemicals. The mechanism-based SAR analysis suggested the electron donating groups, electron withdrawing groups and planarity are significant factors in determining the carcinogenic potency for studied aromatic compounds. The present study may provide insights into the relationship between the three proposed properties and the carcinogenesis of aromatic amines and nitroaromatics.

Welcome to talk about 62-23-7, If you have any questions, you can contact Wan, WX; Chen, Y; Zhang, J; Shen, F; Luo, L; Deng, SH; Xiao, H; Zhou, W; Deng, OP; Yang, H; Xiao, YL; Huang, CR; Tian, D; He, JS; Wang, YJ or send Email.. Product Details of 62-23-7

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

An article Synthesis of novel of 2, 5-disubstituted 1, 3, 4-oxadiazole derivatives and their in vitro anti-inflammatory, anti-oxidant evaluation, and molecular docking study WOS:000536456300010 published article about PHARMACOLOGICAL EVALUATION; ANTIBACTERIAL ACTIVITY; ANTIMICROBIAL ACTIVITY; ACCURATE DOCKING; OXAZOLIDINONE; OXADIAZOLES; DESIGN; GLIDE in [Kashid, Bharat B.; Salunkhe, Pravin H.; Dongare, Balasaheb B.; Ghanwat, Anil A.] Solapur Univ, Sch Chem Sci, Chem Res Lab, Solapur 413255, India; [Salunkhe, Pravin H.] CSIR Natl Chem Lab, Dr Homi Bhabha Rd, Pune 411008, Maharashtra, India; [More, Kishor R.] Shandong Keyuan Pharmaceut Co Ltd, Keyuan St, Jinan, Shandong, Peoples R China; [Khedkar, Vijay M.] Vishwakarma Univ, Sch Pharm, Survey 2,3,4 Laxminagar, Pune 411048, Maharashtra, India in 2020, Cited 43. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7. Formula: C7H5NO4

A series of novel 2, 5-disubstituted 1, 3, 4-Oxadiazole derivatives as a potential anti-inflammatory, and antioxidant agent were synthesized via cyclisation. Hydrazide molecule treated with substituted acids in the presence of phosphorus oxychloride (POCl3) as an efficient reagent as well as solvent by conventional method with shorter reaction time and excellent yield. The newly synthesized 1, 3, 4-oxadiazole derivatives exhibited excellent to good anti-inflammatory and anti-oxidant activities compaired to the standard drugs. Molecular docking study on the crucial anti-inflammatory target-cyclooxygenase-2 (COX-2) revealed the ability of the scaffold to correctly recognize the active site and achieve significant bonded and non-bonded interactions with key residues therein. This study could identify potential compounds which can be pertinent starting points for structure-based drug design to obtain newer anti-inflammatory agents.

Formula: C7H5NO4. Welcome to talk about 62-23-7, If you have any questions, you can contact Kashid, BB; Salunkhe, PH; Dongare, BB; More, KR; Khedkar, VM; Ghanwat, AA or send Email.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem