Heterocyclic Building Blocks-phthalazine

Authors Lu, WC; Wang, J; Li, Y; Tao, HR; Xiong, H; Lian, FL; Gao, J; Ma, HN; Lu, T; Zhang, D; Ye, XQ; Ding, H; Yue, LY; Zhang, YY; Tang, HY; Zhang, NX; Yang, YX; Jiang, HL; Chen, KX; Zhou, B; Luo, C in ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER published article about PROTEIN S-PALMITOYLATION; HIPPO PATHWAY; YAP; LIGAND; CANCER; MAP in [Lu, Wenchao; Wang, Jun; Tao, Hongru; Ma, Hongna; Lu, Tian; Zhang, Dan; Ye, Xiaoqing; Ding, Hong; Yue, Liyan; Zhang, Yuanyuan; Jiang, Hualiang; Chen, Kaixian; Luo, Cheng] Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China; [Lu, Wenchao; Li, Yong; Tang, Huanyu; Yang, Yaxi; Jiang, Hualiang; Chen, Kaixian; Zhou, Bing; Luo, Cheng] Univ Chinese Acad Sci, 19 Yuquan Rd, Beijing 100049, Peoples R China; [Li, Yong; Xiong, Huan; Tang, Huanyu; Yang, Yaxi; Zhou, Bing] Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Dept Med Chem, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China; [Wang, Jun; Lu, Tian] Nanjing Univ Chinese Med, Jiangsu Key Lab High Technol Res TCM Formulae, 138 Xianlin Rd, Nanjing 210023, Jiangsu, Peoples R China; [Tao, Hongru] Shanghai Univ, Coll Sci, Dept Chem, 99 Shangda Rd, Shanghai 200444, Peoples R China; [Lian, Fulin; Gao, Jing; Zhang, Naixia] Chinese Acad Sci, Shanghai Inst Mat Med, Dept Analyt Chem, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China; [Gao, Jing] Chinese Acad Sci, Shanghai Inst Mat Med, CAS Key Lab Receptor Res, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China; [Ma, Hongna] Guiyang Univ Tradit Chinese Med, Dept Pharm, South Dong Qing Rd, Guiyang 550025, Guizhou, Peoples R China; [Zhang, Dan] Guizhou Univ, Sch Pharmaceut Sci, Key Lab Guizhou Fermentat Engn & Biomed, Guiyang 550025, Guizhou, Peoples R China; [Ye, Xiaoqing] Zhejiang Sci Tech Univ, Coll Life Sci, 928 2 St, Hangzhou 310018, Zhejiang, Peoples R China; [Chen, Kaixian; Luo, Cheng] Pilot Natl Lab Marine Sci & Technol Qingdao, Open Studio Druggabil Res Marine Nat Prod, 1 Wenhai Rd, Qingdao 266237, Shandong, Peoples R China; [Lu, Wenchao] Dana Farber Canc Inst, Dept Canc Biol, Boston, MA 02215 USA in 2019.0, Cited 48.0. Product Details of 62-23-7. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7

Transcriptional enhancer associated domain family members (TEADs) are the most important downstream effectors that play the pivotal role in the development, regeneration and tissue homeostasis. Recent biochemical studies have demonstrated that TEAD5 could undergo autopalmitoylation that is indispensable for its function making the lipid-binding pocket an attractive target for chemical intervention. Herein, through structure-based virtual screen and rational medicinal chemistry optimization, we identified DC-TEADin02 as the most potent, selective, covalent TEAD autopalmitoylation inhibitor with the IC50 value of 197 +/- 19 nM while it showed minimal effect on TEAD-YAP interaction. Further biochemical counter-screens demonstrate the specific thiol reactivity and selectivity of DC-TEADin02 over the kinase family, lipid-binding proteins and epigenetic targets. Notably, DC-TEADin02 inhibited TEADs transcription activity leading to downregulation of YAP-related downstream gene expression. Taken together, our findings proved the validity of modulating transcriptional output in the Hippo signaling pathway through irreversible chemical interventions of TEAD5 autopalmitoylation activity, which may serve as a qualified chemical tool for TEADs palmitoylation-related studies in the future. (C) 2019 Elsevier Masson SAS. All rights reserved.

Welcome to talk about 62-23-7, If you have any questions, you can contact Lu, WC; Wang, J; Li, Y; Tao, HR; Xiong, H; Lian, FL; Gao, J; Ma, HN; Lu, T; Zhang, D; Ye, XQ; Ding, H; Yue, LY; Zhang, YY; Tang, HY; Zhang, NX; Yang, YX; Jiang, HL; Chen, KX; Zhou, B; Luo, C or send Email.. Product Details of 62-23-7

Reference:
Phthalazine – Wikipedia,
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Product Details of 62-23-7. I found the field of Pharmacology & Pharmacy very interesting. Saw the article Synthesis and anticancer evaluation of new lipophilic 1,2,4 and 1,3,4-oxadiazoles published in 2019.0, Reprint Addresses Couri, MRC (corresponding author), Univ Fed Juiz de Fora, Dept Quim, ICE, Campus Martelo, BR-36036330 Juiz De Fora, MG, Brazil.. The CAS is 62-23-7. Through research, I have a further understanding and discovery of 4-Nitrobenzoic acid.

A series of1,2,4- and 1,3,4-oxadiazole derivatives were synthesized and evaluated for their anticancer activity. Halogenated 1,2,4-oxadiazoles were obtained from benzonitrile and coupled either lipophilic amines or with aminoalcohols. Lipophilic 1,3,4-oxadiazole derivatives were obtained through the Mannich reactions between 5-(aryl)-1,3,4-oxadiazole-2-thiol and alkylated or acylated amines. The in vitro cytotoxic effects were evaluated against 4T1- mammary carcinoma and CT26 – colon cancer cells. The best results were obtained for the 1,3,4-oxadiazole coupled to alkylated piperazine with 10-14 carbon chain moiety, with IC50 values ranging from 1.6 to 3.55 mu M for the 4T1 cell line, and from 1.6 to 3.9 mu M for the CT26.WT cell line, and selectivity index up to 19. The most potent compounds were investigated with AnnexinV and PI staining as indicative of apoptosis induction. (C) 2019 Published by Elsevier Masson SAS.

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Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Authors Wen, JC; Chennamadhavuni, D; Morel, SR; Hadden, MK in AMER CHEMICAL SOC published article about SMOOTHENED MUTATIONS; ACQUIRED-RESISTANCE; PATHWAY INHIBITOR; ANTIFUNGAL; VISMODEGIB in [Wen, Jiachen; Chennamadhavuni, Divya; Morel, Shana R.; Hadden, M. Kyle] Univ Connecticut, Dept Pharmaceut Sci, 69 North Eagleville Rd,Unit 3092, Storrs, CT 06029 USA in 2019, Cited 25. Computed Properties of C7H5NO4. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7

We conducted a structure-activity relationship study to explore simplified analogues of the itraconazole (ITZ) scaffold for their ability to inhibit the hedgehog (Hh) signaling pathway. These analogues were based on exploring the effects of chemical modifications to the linker and triazolone/side chain region of ITZ. Analogue 11 was identified as the most potent compound in our first generation, with an IC50 value of 81 nM in a murine Hh-dependent basal cell carcinoma. Metabolic identification studies led us to identify truncated piperazine (26) as the major metabolite in human liver microsomes (HLMs) and an improved Hh pathway inhibitor (IC50 = 22 nM). This work verifies that continued truncation of the ITZ scaffold is a practical method to maintain potent anti-Hh activity while also reducing the molecular weight for the ITZ scaffold and achieving improved pharmacokinetic properties.

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Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

COA of Formula: C7H5NO4. In 2020.0 ORG BIOMOL CHEM published article about C BOND-CLEAVAGE; OXIDATIVE CYANATION; MEDIATED CYANATION; ARYLBORONIC ACIDS; H ACTIVATION; CARBON; HETEROARENES; DERIVATIVES; ISOCYANIDE; NITRILES in [Liu, Bifu; Liu, Min; Li, Yuanhua; Feng, Kejun] Huizhou Univ, Sch Chem & Mat Engn, Huizhou 516007, Guangdong, Peoples R China; [Liu, Min] Nanchang Hangkong Univ, Key Lab Jiangxi Prov Persistent Pollutants Cont, Nanchang 330063, Jiangxi, Peoples R China; [Li, Qiang] Liaocheng Univ, Coll Chem & Chem Engn, Liaocheng 252059, Shandong, Peoples R China; [Li, Qiang; Zhou, Yongbo] Hunan Univ, Coll Chem & Chem Engn, Changsha 410082, Hunan, Peoples R China in 2020.0, Cited 60.0. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7.

The ligand-free palladium-catalyzed C3-cyanation of indolesviadirect C-H functionalization was achieved. This protocol, utilizing CH3CN as a green and readily available cyanide source, produced the desired products in moderate to good yields through transition-metal-catalyzed C-CN bond cleavage.

Welcome to talk about 62-23-7, If you have any questions, you can contact Liu, BF; Liu, M; Li, Q; Li, YH; Feng, KJ; Zhou, YB or send Email.. COA of Formula: C7H5NO4

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Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

I found the field of Chemistry very interesting. Saw the article Oxidative C-H/N-H Annulation of Aromatic Amides with Dialkyl Malonates: Access to Isoindolinones and Dihydrobenzoindoles published in 2020.0. Category: phthalazines, Reprint Addresses Punniyamurthy, T (corresponding author), Indian Inst Technol Guwahati, Dept Chem, Gauhati 781039, India.. The CAS is 62-23-7. Through research, I have a further understanding and discovery of 4-Nitrobenzoic acid

A copper-mediated oxidative C-H/N-H annulation of aromatic amides with dialkyl malonates has been presented to afford synthetically valuable dihydrobenzoindoles and isoindolinones. The reaction proceeds through direct oxidative C(sp(2))H/C(sp(3))-H coupling followed by an intramolecular N-H/C(sp(3))-H dehydrogenative coupling to deliver the target motifs with broad scope and functional group tolerance.

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Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

An article Fe3O4 MNPs as a green catalyst for syntheses of functionalized [1,3]-oxazole and 1H-pyrrolo-[1,3]-oxazole derivatives and evaluation of their antioxidant activity WOS:000496329900005 published article about ENANTIOSELECTIVE CONSTRUCTION; 1,3-DIPOLAR CYCLOADDITIONS; NANOPARTICLES; EFFICIENT; OXAZOLE; ANTIBACTERIAL; HETEROCYCLES; CHEMISTRY; FRAMEWORK in [Abdolmohammadi, Shahrzad] Islamic Azad Univ, Dept Chem, East Tehran Branch, POB 18735-138, Tehran, Iran; [Hossaini, Zinatossadat] Islamic Azad Univ, Dept Chem, Qaemshahr Branch, Qaemshahr, Iran in 2019.0, Cited 41.0. Formula: C7H5NO4. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7

In the present study, iron oxide magnetic nanoparticles (Fe3O4 MNPs) were synthesized in a green biosynthetic manner using aqueous extract of clover leaves. Fe3O4 MNPs were applied as a magnetically separable nanocatalyst for the green syntheses of functionalized [1,3]-oxazoles 1(a-e) and 1H-pyrrolo-[1,3]-oxazoles 4(a-i) as promising antioxidant compounds in excellent yields at 50 degrees C and room temperature, respectively. The antioxidant activities of the most stable compounds (1a, 1b, 4a, and 4b) were evaluated by both 2,2-diphenyl-1-picrylhydrazyl radical scavenging and ferric reduction activity potential assays. Compound 1b was shown a remarkable radical scavenging activity, and 4a was shown very good reducing activity relative to standards (BHT and TBHQ). [GRAPHICS] .

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Phthalazine – Wikipedia,
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Recently I am researching about ASYMMETRIC-SYNTHESIS; QUATERNARY CARBON; ALPHA(2C)-ADRENOCEPTOR ANTAGONIST; STEREOSELECTIVE CONSTRUCTION; REDUCTION; DELTA(3)-2-HYDROXYBAKUCHIOL; ACIDS, Saw an article supported by the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21472024, 21242008]. Published in ROYAL SOC CHEMISTRY in CAMBRIDGE ,Authors: Ma, QN; Yang, XD; Lei, XS; Lin, GQ. The CAS is 62-23-7. Through research, I have a further understanding and discovery of 4-Nitrobenzoic acid. Quality Control of 4-Nitrobenzoic acid

The preparation of ORM-10921, a selective (2C)-adrenoceptor antagonist with promising anti-psychotic properties, was successfully achieved using asymmetric -alkylation of ,-unsaturated imide and Bischler-Napieralski cyclization/asymmetric reduction as the key steps. When the tetracyclic iminium 11S was used in the reduction, the diastereo-selectivity was poor, from which four stereoisomers of ORM-10921 were obtained, respectively. However, the diastereoselectivity could be significantly improved (with dr up to >97:3) when the tricyclic imine substrate 19S was applied in this reduction, suggesting an additional chelation from the side-chain methoxy group in the transition state. According to this protocol, ORM-10921 was accomplished in a highly enantioselective manner. In addition, two analogs 26Aa and 26Ba were prepared using this novel method, and the absolute configurations were unambiguously assigned by single crystal X-ray crystallography.

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Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

An article Iron(III)-catalyzed direct synthesis of diphenylmethyl esters from 2-diphenylmethoxypyridine WOS:000472440400001 published article about SULFUR-CONTAINING POLYPEPTIDES; PEPTIDES; ACIDS in [Van Hieu Tran; Minh Thanh La; Kim, Hee-Kwon] Chonbuk Natl Univ, Mol Imaging & Therapeut Med Res Ctr, Dept Nucl Med, Med Sch & Hosp, Jeonju 54907, South Korea; [Van Hieu Tran; Minh Thanh La; Kim, Hee-Kwon] Chonbuk Natl Univ Hosp, Natl Univ Biomed Res Inst, Res Inst Clin Med Chonbuk, Jeonju 54907, South Korea in 2019, Cited 26. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7. HPLC of Formula: C7H5NO4

A highly efficient method has been developed for the synthesis of diphenylmethyl (DPM) esters from 2-diphenylmethoxypyridine. Various carboxylic acids readily reacted with 2-diphenylmethoxypyridine in the presence of FeCl3 as a catalyst to provide the desired DPM esters with high yields. The procedure is facile and enables effective synthesis of a variety of esters for the protection of carboxylic acids. [GRAPHICS] .

HPLC of Formula: C7H5NO4. Bye, fridends, I hope you can learn more about C7H5NO4, If you have any questions, you can browse other blog as well. See you lster.

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Phthalazine – Wikipedia,
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In 2019.0 ORGANOMETALLICS published article about CARBOXYLIC-ACID SALTS; CP-H BONDS; PRIMARY ALCOHOLS; UNACTIVATED C(SP(3))-H; AEROBIC OXIDATION; WATER; AMINES; ESTERIFICATION; ALKYLATION; CONVERSION in [Dolui, Pritam; Hazra, Susanta; Deb, Mayukh; Elias, Anil J.] Indian Inst Technol, Dept Chem, New Delhi 110016, India in 2019.0, Cited 68.0. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7. Application In Synthesis of 4-Nitrobenzoic acid

Picolinamide group assisted sp(3) C-H bond oxidation of methylene groups to the corresponding carbonyl compounds has been achieved by using simple bottle ferrocene as catalyst and Cu(OAc)(2) or tert-butyl peroxybenzoate (TBPB) as oxidant under mild conditions. This method is applicable for picolinamide bound organic as well as organometallic compounds with yields in the range of 46-82%. Control experiments and mechanistic studies indicate that a radical mechanism is responsible for these oxidative transformations in which ferrocene acts as a catalyst.

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Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Beddoe, RH; Edwards, DC; Goodman, L; Sneddon, HF; Denton, RM in [Beddoe, Rhydian H.; Edwards, Daniel C.; Goodman, Louis; Denton, Ross M.] Univ Nottingham, Sch Chem, GlaxoSmithKline, Carbon Neutral Labs Sustainable Chem, 6 Triumph Rd, Nottingham NG7 2GA, England; [Sneddon, Helen F.] GlaxoSmithKline, Green Chem, Med Res Ctr, Stevenage SG1 2NY, Herts, England published Synthesis of O-18-labelled alcohols from unlabelled alcohols in 2020.0, Cited 37.0. HPLC of Formula: C7H5NO4. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7.

The synthesis of primary, secondary and tertiary O-18-enriched alcohols from readily available O-16-alcohols via a Mitsunobu esterification and hydrolysis is described. The method is further exemplified in the labelling of the active pharmaceutical ingredient, dropropizine and is shown to be tolerant of modern, separation friendly Mitsunobu reagents.

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Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem