Tag: 176.172

Cleavage of phthaloylglycine by substituted hydrazines was written by Rosenthal, Arthur F.. And the article was included in Journal of Organic Chemistry in 1957.COA of Formula: C9H8N2O2 This article mentions the following:

Refluxing 1.8 g. 2,5-dichlorophenylhydrazine, 1.03 g. phthaloylglycine (I), and 0.93 g. Bu₃N in 5 cc. 95% EtOH 12 hrs. on a steam bath, adding 15 cc. Me₂CO, refluxing the mixture another 15 min., evaporating the filtered solution in vacuo, taking up the residue in 15 cc. Et₂O, treating the Et₂O solution 1 min. with HCl, and evaporating the Et₂O give 40% N-(2,5-dichlorophenyl)phthalhydrazide, faintly yellow crystals, m. 204-5°. Refluxing 1.03 g. I, 1.85 g. Bu₃N, and MeNHNH₂ from 1.44 g. sulfate 20 hrs. in 30 cc. 95% EtOH, evaporating the mixture to 1/3 its volume, adding 40 cc. EtCOMe, refluxing the mixture 15 min., filtering off 346 mg. glycine, evaporating the filtrate, and adding 40 cc. Et₂O and 100 cc. C₅H₁₂ give 88% N-methylphthalhydrazide, m. 238.5-9.5° (N-acetyl-N’-methylphthalhydrazide, m. 139.5-40.5°). In the experiment, the researchers used many compounds, for example, 2-Methyl-2,3-dihydrophthalazine-1,4-dione (cas: 18393-54-9COA of Formula: C9H8N2O2).

2-Methyl-2,3-dihydrophthalazine-1,4-dione (cas: 18393-54-9) belongs to phthalazine derivatives.Like many other isomeric benzodiazines, phthalazine derivatives reveal numerous pharmacological and biological activities such as analgesic, anticonvulsant, antitumor, antiproliferative. In addition, phthalazines are known as serotonin reuptake inhibitors and are considered as anti-depression agents.COA of Formula: C9H8N2O2

Referemce:
Phthalazine – Wikipedia,
Phthalazine | C8H6N2 – PubChem

Spectra and structure of derivatives of p-dihydroxypyridazine and phthalazine was written by Cheinker, Yu. N.;Gortinskaya, T. V.;Sycheva, T. P.. And the article was included in Journal de Chimie Physique et de Physico-Chimie Biologique in 1958.Reference of 18393-54-9 This article mentions the following:

IR and UV spectra of the dihydroxy derivatives of pyridazine and phthalazine, as well as their Me and Cl derivatives, were studied with a view to establishing the structure of the dihydroxy derivatives It was concluded that the compounds have mixed hydroxyoxo structures, both in the crystalline state and in solution Mols. of 3-hydroxy-6-pyridazine (I), as well as the 1-Me derivative, form chains in the crystalline state, in which each mol. is linked to 2 others by very stable H bonds. The H-bonds in 1-hydroxy-4-phthalazinone (II) do not lead to such chain formation in the crystalline state. The heats of fusion, solubility, and acidity of I, II, and derivatives are consistent with the proposed structures. IR spectra of the following compounds are given between 20 and 14 μ: 1,2-dimethyl-3,6-pyridazinedione, I, 3,6-dimethoxypyridazine, 1-methyl-3-methoxy-6-pyridazinone, 3-methoxy-6-pyridazinone, 1-methyl-3-hydroxy-6-pyridazinone, 2,3-dimethyl-1,4-phthalazinedione II, 1-methoxy-4-phthalazinone, 1-methoxy-4-chlorophthalazine, 3-chloro-6-pyridazinone, 3,6-dichloropyridazine, 3,6-bis(methylthio)pyridazine, 3-mercapto-6-thiopyridazinone, all in the crystalline state; also UV spectra in alc. In the experiment, the researchers used many compounds, for example, 2-Methyl-2,3-dihydrophthalazine-1,4-dione (cas: 18393-54-9Reference of 18393-54-9).

2-Methyl-2,3-dihydrophthalazine-1,4-dione (cas: 18393-54-9) belongs to phthalazine derivatives. Phthalazine is isomeric with other naphthyridines including quinoxaline, cinnoline and quinazoline. New methods for the functionalization of pyridazine, phthalazine, and cinnoline rings emerged in 2016. Buchwald and his group devised an asymmetric hydroarylation of vinylarenes.Reference of 18393-54-9

Referemce:
Phthalazine – Wikipedia,
Phthalazine | C8H6N2 – PubChem

Biological active acylhydrazide I. The O-acyl derivatives nature of monoacylation products of cyclic maleic- and phthalic-hydrazide was written by Panea, I.;Bodochi, Lucia;Panea, Teodora;Zinveliu, Daniela;Pascalau, Violeta. And the article was included in Southern Brazilian Journal of Chemistry in 1999.Reference of 18393-54-9 This article mentions the following:

It was confirmed, on the basis of chem. and physico-chem. (m.ps., IR and ¹H-NMR spectra) data, that the products formed by monoacylation of cyclic maleic and phthalic acid hydrazides are the O-acyl derivatives, although owing to tautomerism, these hydrazides may form N- or/and O-acyl derivatives in such reactions. Simultaneously, it was shown that claims of formation of N-acyl derivatives of cyclic maleic and phthalic acid hydrazides were not valid. Also by reacting the cyclic maleic and phthalic acid hydrazide with 4-chlorobenzoyl chloride two new O-monoacyl derivatives [3-(4-chlorobenzoyloxy)-1-H-pyridazin-6-one and 1-(4-chlorobenzoyloxy)-3-H-phthalazin-1-one] were obtained. In the experiment, the researchers used many compounds, for example, 2-Methyl-2,3-dihydrophthalazine-1,4-dione (cas: 18393-54-9Reference of 18393-54-9).

2-Methyl-2,3-dihydrophthalazine-1,4-dione (cas: 18393-54-9) belongs to phthalazine derivatives. Phthalazines, as an important class of bicyclic N-heterocycles, have attracted sizable attention due to their valuable biological and pharmacological activities. New methods for the functionalization of pyridazine, phthalazine, and cinnoline rings emerged in 2016. Buchwald and his group devised an asymmetric hydroarylation of vinylarenes.Reference of 18393-54-9

Referemce:
Phthalazine – Wikipedia,
Phthalazine | C8H6N2 – PubChem