Tag: M.W:100-200

Chemistry, like all the natural sciences, begins with the direct observation of nature— in this case, of matter.83-38-5, Name is 2,6-Dichlorobenzaldehyde, SMILES is C1=CC=C(C(=C1Cl)C=O)Cl, belongs to phthalazine compound. In a document, author is Savic, Nada D., introduce the new discover, Category: phthalazines.

Silver(I) complexes with quinazoline and phthalazine: synthesis, structural characterization and evaluation of biological activities

New silver.I) complexes with quinazoline (qz) and phthalazine (phtz), [Ag(NO3)(qz)](n) (1) and {[Ag(CH3CN)](2)(mu-phtz)(2)}[BF4](2) (2), have been synthesized and structurally characterized by using different spectroscopic and single-crystal X-ray diffraction techniques. The obtained results revealed that the reaction of AgNO3 with qz at room temperature in a 2 : 1 molar ratio led to the formation of the polynuclear complex 1. However, the reaction of AgBF4 with phtz under the same experimental conditions resulted in the formation of the dinuclear complex 2. The solution behaviour and air/light stability of these silver.I) complexes have been investigated. The complexes 1 and 2, along with the silver.I) salts used for their synthesis, were evaluated by in vitro antimicrobial studies against a panel of microbial strains that lead to many skin and soft tissue, respiratory, wound, and nosocomial infections. The obtained results indicate that all tested silver(I) compounds have good antibacterial activity with MIC values in the range from 1.5 to 15.6 mu g mL(-1) against the investigated strains. On the other hand, their antifungal activity against Candida albicans was moderate. In order to determine the therapeutic potential of 1 and 2, their antiproliferative effect on the normal human lung fibroblast cell line MRC5, hemolytic effect on red blood cells and embryotoxicity on zebrafish (Danio rerio) have also been evaluated.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 83-38-5 is helpful to your research. Category: phthalazines.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 66-99-9, Name is 2-Naphthaldehyde, molecular formula is C11H8O. In an article, author is Mogilaiah, K.,once mentioned of 66-99-9, HPLC of Formula: https://www.ambeed.com/products/66-99-9.html.

Green synthesis and antibacterial activity of 3-(3-aryl[1,8]naphthyridin-2-yl)-7-[1-[1,4-dioxo-1,2,3,4-tetrahydro-6-phthalazinyl]-2,2,2-trifluoro-1-(trifluoromethyl)ethyl]-2-(3-aryl [1,8]naphthyridin-2-yl)-1,2,3,4-tetrahydro-1,4-phthalazinediones

A simple and highly efficient procedure has been described for the synthesis of 3-(3-aryl[1,8]naphthyridin-2-yl)-7-[1-[1,4-dioxo-1, 2, 3, 4-tetrahydro-6-phthalazinyl]-2, 2, 2-trifluoro-1-(trifluoromethyl)ethyl]-2-(3-aryl[1,8]naphthyridin-2-yl)-1,2,3,4-tetrahydro-1,4-phthalazinediones 3 by the condensation of 3-aryl-2-hydrazino-1,8-naphthyridines 1 with 4,4 ‘-(hexafluoroisopropylidene)diphthalic anhydride 2 in 2:1 molar ratio in the presence of catalytic amount of DMF under microwave irradiation/ in presence of catalytic amount of PTSA in the solid state at RT under grinding conditions. The products have been obtained in very good yields and in a state of high purity. The structures of the compounds 3 have been established on the basis of their spectral (IR and H-1 NMR) and analytical data. The compounds 3 have been screened for their antibacterial activity.

Interested yet? Keep reading other articles of 66-99-9, you can contact me at any time and look forward to more communication. HPLC of Formula: https://www.ambeed.com/products/66-99-9.html.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 89-86-1, Name is 2,4-Dihydroxybenzoic acid, molecular formula is , belongs to phthalazine compound. In a document, author is Reddy, Y. Dathu, COA of Formula: https://www.ambeed.com/products/89-86-1.html.

One-Pot Syntheses of 1H-Pyrazolo[1,2-B]Phthalazine-5,10-Diones and 2-H-Indazolo[2,1-B]Phthalazine-1,6,11(13-H)-Triones in Water by Auto Catalysis

One-pot, four component syntheses for the preparation of 1-H Pyrazolo[1,2-b]phthalazine-5,10-diones (5a-5h) and 2H-indazolo[2,1-b]phthalazine-1,6,11(13-H)-triones (7a-7f) have been described from phthaloyl dichloride (1), hydrazine hydrate (2), benzaldehydes (3) and malononitrile (4a), ethyl cynoacetate (4b) or dimedone (6) in refluxing water for 1-1.5 h by in-situ generation of HCl as a catalyst. These reactions have easy workup, provide excellent yields, and use water as the solvent.

If you are hungry for even more, make sure to check my other article about 89-86-1, COA of Formula: https://www.ambeed.com/products/89-86-1.html.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

369-34-6, Name is 3,4-Difluoronitrobenzene, molecular formula is C6H3F2NO2, belongs to phthalazine compound, is a common compound. In a patnet, author is Tayebee, Reza, once mentioned the new application about 369-34-6, HPLC of Formula: https://www.ambeed.com/products/369-34-6.html.

A new natural based ionic liquid 3-sulfonic acid 1-imidazolopyridinium hydrogen sulfate as an efficient catalyst for the preparation of 2H-indazolo[2,1-b]phthalazine-1,6,11(13H)-triones

A novel Bronsted acidic ionic liquid 3-sulfonic acid 1-imidazolopyridinium hydrogen sulfate [Simp]HSO4 was synthesized via the reaction of caffeine with chlorosulfonic acid and was characterized by studying FT-IR, H-1 NMR, C-13 NMR, UV-Vis, and fluorescence spectra. Then, the prepared ionic liquid was utilized as an efficient catalyst for the preparation of 2H-indazolo[2,1-b]phthalazine-1,6,11(13H)-trione derivatives through one-pot, multi-component condensation of aldehydes, phthalhydrazide, and dimedone under solvent free conditions. The high Bronsted acidic function of this catalyst originates principally from the dual hydrogen bonding abilities of the SO3H group. (C) 2015 Elsevier B.V. All rights reserved.

We’ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, 369-34-6. The above is the message from the blog manager. HPLC of Formula: https://www.ambeed.com/products/369-34-6.html.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Synthetic Route of 66-99-9, Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. 66-99-9, Name is 2-Naphthaldehyde, SMILES is O=CC1=CC=C2C=CC=CC2=C1, belongs to phthalazine compound. In a article, author is Nikoorazm, Mohsen, introduce new discover of the category.

Synthesis and characterization of Cu(II)-Adenine-MCM-41 as stable and efficient mesoporous catalyst for the synthesis of 5-substituted 1H-tetrazoles and 1H-indazolo [1,2-b]phthalazine-triones

A simple and efficient protocol has been developed for the synthesis and characterization of new Cu(II) complex supported into MCM-41 channels modified with adenine (Cu(II)-Adenine-MCM-41) as a reusable and heterogeneous catalyst for the synthesis of 5-substituted 1H-tetrazoles and 1H-indazolo [1,2-b]phthalazine-triones. The key advantages of this method are easy work-up, short reaction times, pure product formation with good to excellent yields and reusability of the catalyst. This catalyst was characterized by TEM, SEM, XRD, TGA, EDS, AAS, BET method and FT-IR spectroscopy.

Synthetic Route of 66-99-9, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 66-99-9.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Related Products of 1571-08-0, Catalysts allow a reaction to proceed via a pathway that has a lower activation energy than the uncatalyzed reaction. 1571-08-0, Name is Methyl 4-formylbenzoate, SMILES is C1=C(C(OC)=O)C=CC(=C1)C=O, belongs to phthalazine compound. In a article, author is Abdesheikhi, Mitra, introduce new discover of the category.

Four-component synthesis of 3-amino-1-aryl-5,10-dioxo-1H-pyrazolo[1,2-b] phthalazine-2-carbonitrile derivatives promoted by potassium carbonate

The one-pot, four-component reaction of phthalic anhydride, hydrazine hydrate, aromatic aldehydes and malononitrile afford 3-amino-1aryl-5,10-dioxo-1H-pyrazolo[1,2-b]phthalazine-2-carbonitrile derivatives in the presence of potassium carbonate in ethanol under reflux conditions. These conditions offer simplified operation, easy purification, excellent yields and environmentally benign reaction conditions. Also, this method avoids the use of expensive catalysts, toxic solvents and chromatographic separation.

Related Products of 1571-08-0, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 1571-08-0.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Application of 1078-61-1, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 1078-61-1, Name is 3-(3,4-Dihydroxyphenyl)propionic acid, SMILES is O=C(O)CCC1=CC=C(O)C(O)=C1, belongs to phthalazine compound. In a article, author is Abouzid, Khaled A. M., introduce new discover of the category.

Synthesis and evaluation of anti-proliferative activity of 1,4-disubstituted phthalazines

A series of new phthalazine derivatives 3a-i and 4a-c were synthesized via the reaction of 1-chlorophthalazine derivative 2 with either N-substituted-piperazines, primary or their secondary amines. The structure of the synthesized, new compounds were characterized by spectral data. The anti-proliferative activity on human breast cancer cell line MCF-7 of the synthesized compounds was determined. The results showed that six of the test compounds (3a, 3g, 3i, and 4a-c) displayed potent cytotoxic activity ranging from 1.4 to 2.3 mu mol.

Application of 1078-61-1, Because enzymes can increase reaction rates by enormous factors and tend to be very specific, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 1078-61-1.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Chemistry, like all the natural sciences, Recommanded Product: 41263-74-5, begins with the direct observation of nature— in this case, of matter.41263-74-5, Name is 4-(Methylamino)-3-nitrobenzoic acid, SMILES is O=C(O)C1=CC=C(NC)C([N+]([O-])=O)=C1, belongs to phthalazine compound. In a document, author is Ghozlan, Said A. S., introduce the new discover.

Discrepancies in the reactivity pattern of azaenamines towards cinnamonitriles: synthesis of novel aza-steroid analogues

Azaenamine incorporating pyrazole-4-carboxylate is prepared and allowed to react with alpha,beta-substituted nitriles. A new reactivity pattern was observed leading to the formation of substituted pyrazolo[4′,3′-5,61 pyrimido[2,1-a]phthalazine-9-carbonitriles, which can be considered as aromatic aza-steroid analogues. (C) 2015 Elsevier Ltd. All rights reserved.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 41263-74-5. Recommanded Product: 41263-74-5.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics, Quality Control of 5-(Ethylthio)-1H-tetrazole, 89797-68-2, Name is 5-(Ethylthio)-1H-tetrazole, SMILES is CCSC1=NN=NN1, belongs to phthalazine compound. In a document, author is Abed, Hassen Bel, introduce the new discover.

Organophosphorus-catalyzed diaza-Wittig reaction: application to the synthesis of pyridazines

The elaboration of the first organophosphorus-catalyzed diaza-Wittig reaction is reported. This catalytic reaction is applied to the synthesis of substituted pyridazine and phthalazine derivatives bearing electron-withdrawing groups with good to excellent yields from substrates containing a diazo functionality as the starting material and a phospholene oxide as the catalyst.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 89797-68-2. Quality Control of 5-(Ethylthio)-1H-tetrazole.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Chemistry is an experimental science, Formula: https://www.ambeed.com/products/371-42-6.html, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 371-42-6, Name is 4-Fluorothiophenol, molecular formula is C6H5FS, belongs to phthalazine compound. In a document, author is Chegeni, Mahnaz Mahmoodi Fard.

A Versatile Protocol for Synthesis of 2H-Indazolo[2,1-b]Phthalazine Triones Using gamma-Al2O3/BFn/Fe3O4 as an Efficient Magnetic Nano-Catalyst

A four-component reaction of aromatic aldehydes, phthalic anhydride, hydrazine monohydrate and dimedone has been achieved in the presence of nano-gamma-Al2O3/BFn/Fe3O4 as a highly effective heterogeneous catalyst to produce 2H-indazolo[2,1-b]phthalazine triones. Atom economy, low catalyst loading, reusable catalyst, applicability to a wide range of substrates and high yields of products are some important features of this protocol.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 371-42-6, in my other articles. Formula: https://www.ambeed.com/products/371-42-6.html.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem