Tag: M.W:100-200

Application of 402-50-6, As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 402-50-6, Name is 1-(Trifluoromethyl)-4-vinylbenzene, SMILES is FC(F)(F)C1=CC=C(C=C)C=C1, belongs to phthalazine compound. In a article, author is Gol’dberg, A. E., introduce new discover of the category.

Crystal structure of a trinuclear complex of zinc(II) with 2,6-Di-tert-butyl-p-quinone 1′-phthalazinylhydrazone

2,6-Di-tert-butyl-p-quinone 1′-phthalazynylhydrazone (HL) is synthesized; the total energies and geometry of the possible hydrazone tautomeric forms are calculated by quantum chemical methods. The hydrazone phthalazone tautomer is shown to be the most stable, which is well consistent with the H-1 NMR spectroscopic data for hydrazone. An X-ray crystallographic analysis is performed of the hydrazone-based Zn(II) trinuclear complex, in which zinc atoms are linked by the diazine bridge of the phthalazine cycle and two pivalate bridges. The geometric properties of the monodeprotonated hydrazone residue in the complex are similar to the calculated data for the phthalazone hydrazone tautomeric form.

Application of 402-50-6, One of the oldest and most widely used commercial enzyme inhibitors is aspirin, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 402-50-6.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 5267-64-1, Name is D-Penylalaninol, molecular formula is C9H13NO. In an article, author is Tayebee, Reza,once mentioned of 5267-64-1, Name: D-Penylalaninol.

Heteropolyacid-based ionic liquid [Simp](3)PW12O40 nanoparticle as a productive catalyst for the one-pot synthesis of 2H-indazolo[2,1-b]phthalazine-triones under solvent-free conditions

A novel Keggin-type heteropolyacid-based ionic liquid [Simp](3)PW12O40 was developed via the reaction of the as synthesized ionic liquid 3-sulfonic acid 1-imidazolopyridinium hydrogen sulfate [Simp]HSO4 with an aqueous solution of H3PW12O40. Then, the formulated [Simp](3)PW12O40 was changed to the nano-form via solvothermal processing in tetralin at 220 degrees C. After that, the provided powdered solid nanomaterial was characterized by FTIR, H-1 NMR, XRD, SEM, EDX and TGA analyses. Then, the focused nanomaterial was handled as a productive and encouraging nanocatalyst for the establishment of 2H-indazolo[2,1-b]phthalazine-1,6,11(13H)-trione attendants through one-pot, multi-component contraction of aldehydes, phthalhydrazide, and dimedone under solventless status and the generality and practical tolerance of this useful and environmentally benign method are illustrated. The simple work-up, smooth reaction conditions, good to excellent yields, and reasonably short reaction times are the particular benefits of this protocol. Besides, the new nano-powdered ionic liquid was a successful and modest catalyst that could definitely be recycled and reused several times without apparent decrease in its catalytic activity. (C) 2017 Elsevier B.V. All rights reserved.

If you’re interested in learning more about 5267-64-1. The above is the message from the blog manager. Name: D-Penylalaninol.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 122-99-6, Name is 2-Phenoxyethanol, molecular formula is C8H10O2. In an article, author is Abouzid, Khaled A. M.,once mentioned of 122-99-6, Quality Control of 2-Phenoxyethanol.

Synthesis and evaluation of anti-proliferative activity of 1,4-disubstituted phthalazines

A series of new phthalazine derivatives 3a-i and 4a-c were synthesized via the reaction of 1-chlorophthalazine derivative 2 with either N-substituted-piperazines, primary or their secondary amines. The structure of the synthesized, new compounds were characterized by spectral data. The anti-proliferative activity on human breast cancer cell line MCF-7 of the synthesized compounds was determined. The results showed that six of the test compounds (3a, 3g, 3i, and 4a-c) displayed potent cytotoxic activity ranging from 1.4 to 2.3 mu mol.

If you’re interested in learning more about 122-99-6. The above is the message from the blog manager. Quality Control of 2-Phenoxyethanol.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Reactions catalyzed within inorganic and organic materials and at electrochemical interfaces commonly occur at high coverage and in condensed media, causing turnover rates to depend strongly on interfacial structure and composition, 41263-74-5, Name is 4-(Methylamino)-3-nitrobenzoic acid, SMILES is O=C(O)C1=CC=C(NC)C([N+]([O-])=O)=C1, in an article , author is Uckun, Fatih M., once mentioned of 41263-74-5, Recommanded Product: 4-(Methylamino)-3-nitrobenzoic acid.

Nanoscale liposomal formulation of a SYK P-site inhibitor against B-precursor leukemia

We report preclinical proof of principle for effective treatment of B-precursor acute lymphoblastic leukemia (ALL) by targeting the spleen tyrosine kinase (SYK)-dependent antiapoptotic blast cell survival machinery with a unique nanoscale pharmaceutical composition. This nanoscale liposomal formulation (NLF) contains the pentapeptide mimic 1,4-Bis (9-O dihydroquinidinyl) phthalazine/hydroquinidine 1,4-phathalazinediyl diether (C61) as the first and only selective inhibitor of the substrate binding P-site of SYK. The C61 NLF exhibited a very favorable pharmacokinetic and safety profile in mice, induced apoptosis in primary B-precursor ALL blast cells taken directly from patients as well as in vivo clonogenic ALL xenograft cells, destroyed the in vivo clonogenic fraction of ALL blast cells, and, at nontoxic dose levels, exhibited potent in vivo antileukemic activity against patient-derived ALL cells in xenograft models of aggressive B-precursor ALL. Our findings establish SYK as an attractive molecular target for therapy of B-precursor ALL. Further development of the C61 NLF may provide the foundation for therapeutic innovation against therapy-refractory B-precursor ALL.

Interested yet? Read on for other articles about 41263-74-5, you can contact me at any time and look forward to more communication. Recommanded Product: 4-(Methylamino)-3-nitrobenzoic acid.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics, Recommanded Product: 495-69-2, 495-69-2, Name is 2-Benzamidoacetic acid, SMILES is O=C(O)CNC(C1=CC=CC=C1)=O, belongs to phthalazine compound. In a document, author is Tayebee, R., introduce the new discover.

A new inorganic-organic hybrid material Al-SBA-15-TPI/H6P2W18O62 catalyzed one-pot, three-component synthesis of 2H-indazolo[2,1-b]phthalazine-triones

A new inorganic-organic hybrid material Al-SBA-15-TPI/H6P2W18O62 was prepared and fully characterized by SEM, XRD, FT-IR, TGA-DTA, and UV-Vis spectroscopic techniques. Then, the prepared nanomaterial was used as a simple, cost-effective, and reusable heterogeneous catalyst for the synthesis of 2H-indazolo[ 2,1-b] phthalazine-1,6,11(13H)-trione derivatives by a one-pot, three-component condensation reaction of phthalhydrazide, cyclic diones, and aromatic aldehydes under solvent free conditions at 100 degrees C in a short time. This methodology has proven to be efficient and environmentally benign in terms of high yields and low reaction times and offers significant improvements with regard to the scope of transformation and simplicity of operation by avoiding expensive or corrosive catalysts.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 495-69-2. Recommanded Product: 495-69-2.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Chemistry is an experimental science, Category: phthalazines, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 1078-61-1, Name is 3-(3,4-Dihydroxyphenyl)propionic acid, molecular formula is C9H10O4, belongs to phthalazine compound. In a document, author is Jimenez, Iosu.

Thermal stability of selenium, sulfur and nitrogen analogous phthalazine derivatives

Differential scanning calorimetry (DSC) and thermogravimetry (TG) are analytical and quantitative methods capable of providing reliable, fast and reproducible results. These data allow establishing the thermal stability, purity degree and the polymorphic behavior of organic compounds. Thermal analysis of fusion and degradation processes was carried out on organonitrogen, organosulfur and organoselenium phthalazine derivatives to establish thermal stability criteria. Decomposition and fusion temperatures of 27 biological active compounds, synthesized by our research group were determined using TG and DSC. Analysis of the thermal data indicated that: (a) in general, nitrogen compounds are more stable than sulfur and selenium compounds; (b) thioderivatives possess degradation temperatures higher than selenium compounds; (c) the presence of selenium atoms in molecular structure has associated a minor thermal stability; (d) sulfide derivatives decomposition process have higher T-onset values than disulfide compounds; (e) there are differences in the stability due to groups selenol, methylseleno, and cyanoseleno; (f) the nature of the substituent located on the benzyl ring has no effects on selenophthalazines thermal stability.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 1078-61-1. Category: phthalazines.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics, Recommanded Product: Ethyl cinnamate, 103-36-6, Name is Ethyl cinnamate, SMILES is O=C(OCC)/C=C/C1=CC=CC=C1, belongs to phthalazine compound. In a document, author is Wang, Chenglin, introduce the new discover.

Synthesis and evaluation of novel dimethylpyridazine derivatives as hedgehog signaling pathway inhibitors

We report herein the design and synthesis of a series of structural modified dimethylpyridazine compounds as novel hedgehog signaling pathway inhibitors. The bicyclic phthalazine core and 4-methylamino- piperidine moiety of Taladegib were replaced with dimethylpyridazine and different azacycle building blocks, respectively. The in vitro Gli-luciferase assay results demonstrate that the new scaffold still retained potent inhibitory potency. Piperidin-4-amine moiety was found to be the best linker between pharmacophores dimethylpyridazine and fluorine substituted benzoyl group. Furthermore, the optimization of 1-methyl-1H-pyrazol and 4-fluoro-2-(trifluoromethyl) benzamide by different aliphatic or aromatic rings were also investigated and the SAR were described. Several new derivatives were found to show potent Hh signaling inhibitory activity with nanomolar IC50 values. Among these compounds, compound 11c showed the highest inhibitory potency with an IC50 value of 2.33 nM, which was comparable to the lead compound Taladegib. In vivo efficacy of 11c in a ptch(+/)-p53(-/-) mouse medulloblastoma allograft model also indicated encouraging results. (C) 2018 Elsevier Ltd. All rights reserved.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 103-36-6. Recommanded Product: Ethyl cinnamate.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Chemistry, like all the natural sciences, begins with the direct observation of nature— in this case, of matter.1679-64-7, Name is 4-(Methoxycarbonyl)benzoic acid, SMILES is C1=CC(=CC=C1C(O)=O)C(OC)=O, belongs to phthalazine compound. In a document, author is Eswararao, S., V, introduce the new discover, Computed Properties of C9H8O4.

WATER MEDIATED ONE- POT- SYNTHESIS OF 1H-PYRAZOLO[1,2-B]PHTHALAZINE-5,10-DIONES AND 2H-INDAZOLO[2,1-B]PHTHALAZINE-1,6,11(13H)-TRIONES

1H-pyrazolo[1,2-b]phthalazine-5,10-diones (5) and 2H-indazolo[2,1-b]phthalazine-1,6,11(13H)-triones (7) have been synthesized by one pot, four-component method. To synthesise them phthalic anhydride (1), hydrazine hydrate (2), benzaldehydes (3) and malononitrile (4a) /ethyl cynoacetate (4b) /dimedone (6) in refluxing water for 1-1.5 h in the presence of InCl3 as a catalyst yielding 75-85%. These reactions have an easy workup, provides excellent yields, and uses water as the solvent which is considered to be relatively environmentally benign. The structures of the products were established from their spectral properties IR, H-1-NMR, C-13-NMR & Mass spectroscopy.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 1679-64-7 is helpful to your research. Computed Properties of C9H8O4.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, Recommanded Product: 3-Chlorobenzaldehyde587-04-2, Name is 3-Chlorobenzaldehyde, SMILES is O=CC1=CC=CC(Cl)=C1, belongs to phthalazine compound. In a article, author is Zhu, Jie, introduce new discover of the category.

Enantioselective Dihydroxylation of Alkenes Catalyzed by 1,4-Bis(9-O-dihydroquinidinyl)phthalazine-Modified Binaphthyl-Osmium Nanoparticles

A series of unprecedented binaphthyl-osmium nanoparticles (OsNPs) with chiral modifiers were applied in the heterogeneous asymmetric dihydroxylation of alkenes. A remarkable size effect of the OsNPs, depending on the density of the covalent organic shells, on the reactivity and enantioselectivity of the dihydroxylation reaction was revealed. Successful recycling of the OsNPs was also demonstrated and high reaction efficiency and enantioselectivity were maintained.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 587-04-2. Recommanded Product: 3-Chlorobenzaldehyde.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Application of 89797-68-2, Redox catalysis has been broadly utilized in electrochemical synthesis due to its kinetic advantages over direct electrolysis. The appropriate choice of redox mediator can avoid electrode passivation and overpotential. 89797-68-2, Name is 5-(Ethylthio)-1H-tetrazole, SMILES is CCSC1=NN=NN1, belongs to phthalazine compound. In a article, author is Yun, Yanbin, introduce new discover of the category.

Formation kinetics and characterization of polyphthalazinone ether ketone hollow fiber ultrafiltration membranes

This paper reports an evaluation of the effect of both organic and inorganic additives on the gelation kinetics, morphology and separation properties of asymmetric poly(phthalazine ether ketone) (PPEK) hollow fiber ultrafiltration membranes. Using an online optical microscope-CCD camera for observation of precipitation front movement (X), a good linear relationship between X-2 and time was observed for the whole gelation process with the correlation coefficient (R-2) higher than 0.98. It was found that the pure water flux of membranes with additives were lower than neat PPEK membranes. This observation might be attributed to the decrease in the face gelation velocity caused by the extra organic additives. The water flux of PEG600 was higher than that of Tween80 at the same additive concentration. When OA concentration increased from 3.5 to 5.0 wt.%, the pure water flux increased from 332 to 367 L/m(2) hand the rejection decreased from 98.6 to 96.8%. The PPEK hollow fiber membranes exhibited finger-like macrovoids structure and a skin layer at the outer-most region of the hollow fiber. Evaluation of the membrane chemical resistance with various chemical solutions indicated that PPEK membranes had good chemical resistance against HCI, H2SO4, HNO3, CH3COOH, OA, NaOH and H2O2, while the NaClO solution can greatly damage the membrane mechanical strength. Static sorption tests of PPEK membrane revealed that PPEK membrane adsorbed more bacitracin than BSA due to the smaller size of bacitracin. (C) 2011 Elsevier B.V. All rights reserved.

Application of 89797-68-2, Because enzymes can increase reaction rates by enormous factors and tend to be very specific, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 89797-68-2.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem