Tag: M.W:100-200

Chemistry is traditionally divided into organic and inorganic chemistry. The former is the study of compounds containing at least one carbon-hydrogen bonds. 1821-12-1, Name is 4-Phenylbutanoic acid, molecular formula is C10H12O2, belongs to phthalazine compound, is a common compound. In a patnet, author is Abida, once mentioned the new application about 1821-12-1, COA of Formula: C10H12O2.

Synthesis of some pyridazine derivatives as antioxidants and antimicrobial agents

Purpose: To prepare some pyridazine derivatives as antioxidant and antimicrobial agents. Methods: The coupling of aryl diazonium salts with diethyl 2-cyano-3-methylglutaconate afforded pyridazine-5-carbonitrile derivatives (3a-e). The methyl function in the pyridazine derivatives (3a-e) reacted with cinnamonitriles to yield phthalazine derivatives (6a-h). Imino-pyridazine derivatives (9a-h) were obtained by reacting 2-aminoprop-1-ene-1,1,3-tricarbonitrile along with aryl diazonium salts (1a-h). Structure elucidation was done by spectral analysis. The 1,1-diphenyl-2-picryl hydrazyl (DPPH) technique was employed to assess antioxidant effect, while evaluation of antimicrobial activity was carried out by serial dilution technique. Results: Compounds, 6f (IC50 = 12.68 mu g/mL; p < 0.05), 6a (IC50 = 14.23 mu g/mL; p < 0.05), and 3c (IC50 = 14.34 mu g/mL; p < 0.05) displayed good antioxidant activity compared to ascorbic acid (IC50 = 12.45 mu g/mL; p < 0.05). Based on the zone of inhibition, compound 6c (p < 0.05) displayed higher activity than ofloxacin (p < 0.05) against E. coli. Conclusion: The presence of an oxo group and carboxylate group plays an important role in the antioxidant activity of these compounds. Compounds 6a, 6f, and 3c can potentially serve as lead compounds for the development of promising antioxidants. We’ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, 1821-12-1. The above is the message from the blog manager. COA of Formula: C10H12O2.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Let’s face it, organic chemistry can seem difficult to learn. Especially from a beginner’s point of view. Like 643-79-8, Name is Benzene-1,2-dicarboxaldehyde. In a document, author is Piryaei, Forozan, introducing its new discovery. Category: phthalazines.

Efficient ZrO(NO3)(2.)2H(2)O Catalyzed Synthesis of 1H-Indazolo[1,2-b] phthalazine-1,6,11(13H)-triones and Electronic Properties Analyses, Vibrational Frequencies, NMR Chemical Shift Analysis, MEP: A DFT Study

The synthesis of 1H-indazolo[1,2-b]phthalazine-1,6,11(13H)-trione derivatives, using one-pot three-component condensation reaction of 3-nitrophthalic anhydride, hydrazine monohydrate, dimedone, and aromatic aldehydes in the presence of ZrO(NO3)(2).2H(2)O as the novel catalyst and in reflux conditions in EtOH was reported. Quantum theoretical calculations for three structures of compounds (5a, 5b, and 5c) were performed using the Hartree-Fock (HF) and density functional theory (DFT). From the optimized structure, geometric parameters were obtained and experimental measurements were compared with the calculated data. The structures of the products were confirmed by IR, H-1 NMR, C-13 NMR, mass spectra, and elemental analyses. The IR spectra data and H-1 NMR and C-13 NMR chemical shift computations of the 1H-indazolo[1,2-b]phthalazine-1,6,11(13H)-trione derivatives in the ground state were calculated. Frontier molecular orbitals (FMOs), total density of states (DOS), thermodynamic parameters, and molecular electrostatic potential (MEP) of the title compounds were investigated by theoretical calculations. Molecular properties such as the ionization potential (I), electron affinity (A), chemical hardness (eta), electronic chemical potential (mu), and electrophilicity (omega) were investigated for the structures. Thus, there was an excellent agreement between experimental and theoretical results.

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 643-79-8 help many people in the next few years. Category: phthalazines.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

1078-61-1, Name is 3-(3,4-Dihydroxyphenyl)propionic acid, molecular formula is C9H10O4, belongs to phthalazine compound, is a common compound. In a patnet, author is Mirahmadpour, Pari, once mentioned the new application about 1078-61-1, Recommanded Product: 3-(3,4-Dihydroxyphenyl)propionic acid.

Electrochemical Oxidation of 2,3-dihydrophthalazine-1,4-dione in the Presence of Indole Derivatives

The electrochemical oxidation of 2,3-dihydrophthalazine-1,4-dione (1) has been studied in the presence of indole derivatives as nucleophiles in a water/acetonitrile mixture by means of cyclic voltammetry and controlled-potential coulometry. Results indicate that electrogenerated phthalazine-1,4-dione (1ox) participates in a Michael type addition reaction with indole derivatives (2 and 3) via an EC mechanism. In this work, we propose a mechanism for the electrode process. The electrochemical synthesis of indoylphthalazines (4 and 5) has been successfully performed at a carbon rod electrode and in an undivided cell. (C) 2013 The Electrochemical Society. All rights reserved.

We’ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, 1078-61-1. The above is the message from the blog manager. Recommanded Product: 3-(3,4-Dihydroxyphenyl)propionic acid.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Application of 88-99-3, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C–H bond functionalisation has revolutionised modern synthetic chemistry. 88-99-3, Name is Pathalic acid, SMILES is O=C(O)C1=CC=CC=C1C(O)=O, belongs to phthalazine compound. In a article, author is Roy, Harendra Nath, introduce new discover of the category.

Efficient and convenient synthesis of 1H-pyrazolo[1,2-b]phthalazine-5,10-dione derivatives mediated by L-proline

An efficient, four-component, one-pot condensation reaction of phthalimide or phthalic anhydride, aromatic aldehydes, and ethyl cyanoacetate for the synthesis of 1H-pyrazolo[1,2-b]phthalazine-5,10-dione derivatives mediated by L-proline in excellent yields is reported. [GRAPHICS] .

Application of 88-99-3, One of the oldest and most widely used commercial enzyme inhibitors is aspirin, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 88-99-3.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. , COA of Formula: C8H6O3, 611-73-4, Name is 2-Oxo-2-phenylacetic acid, molecular formula is C8H6O3, belongs to phthalazine compound. In a document, author is Shaterian, Hamid Reza, introduce the new discover.

Mild basic ionic liquids catalyzed new four-component synthesis of 1H-pyrazolo[1,2-b]phthalazine-5,10-diones

A new four-component synthesis of 1H-pyrazolo[1,2-b]phthalazine-5,10-dione derivatives using three weak basic ionic liquids such as 1,8-diazabicyclo[5.4.0]-undec-7-en-8-ium acetate, pyrrolidinium formate, and pyrrolidinium acetate as efficient catalysts for condensation reaction of hydrazine monohydrate, phthalic anhydride, malononitrile or ethyl cyanoacetate, and aromatic aldehydes under ambient and solvent-free conditions in excellent yields is described. (C) 2012 Elsevier B.V. All rights reserved.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 611-73-4. COA of Formula: C8H6O3.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

In an article, author is Mouradzadegun, Arash, once mentioned the application of 371-42-6, Application In Synthesis of 4-Fluorothiophenol, Name is 4-Fluorothiophenol, molecular formula is C6H5FS, molecular weight is 128.17, MDL number is MFCD00004846, category is phthalazine. Now introduce a scientific discovery about this category.

A novel sulfamic acid functionalized nano-catalyst on the basis of calix[4]resorcinarene for the green one-pot synthesis of 2H-indazolo[2,1-b]phthalazine-triones under thermal solvent-free conditions

N-propyl sulfamic acid supported nano-catalyst on the basis of calix[4]resorcinarene was prepared via the efficient and facile reaction of amine functionalized polycalix[4]resorcinarene with chlorosulfonic acid. The achieved catalytic system was characterized using some spectroscopic techniques such as Fourier transform Infrared (FT-IR) spectroscopy, field emission scanning electron microscopy (FE-SEM), transmission electron microscopy (TEM), and CHNS elemental analysis. This newly developed acidic catalyst was employed efficiently in a one-pot three-component condensation reaction of aromatic aldehydes, dimedone and phthalhydrazide for the synthesis of 2H-indazolo[2,1-b]phthalazine-trione derivatives through an easy and eco-friendly methodology. The catalyst was easily separated from the reaction mixture by simple filtration and the desired products were achieved in good to excellent yields in short reaction times.

If you are interested in 371-42-6, you can contact me at any time and look forward to more communication. Application In Synthesis of 4-Fluorothiophenol.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

In an article, author is El-Shamy, Ibrahim E., once mentioned the application of 767-00-0, Name: 4-Hydroxybenzonitrile, Name is 4-Hydroxybenzonitrile, molecular formula is C7H5NO, molecular weight is 119.12, MDL number is MFCD00002312, category is phthalazine. Now introduce a scientific discovery about this category.

Synthesis, biological, anti-inflammatory activities and quantum chemical calculation of some [4-(2, 4, 6-trimethylphenyl)-1(2H)-oxo-phthalazin-2yl] acetic acid hydrazide derivatives

The phthalazine carbohydrazide 2 was prepared and incorporated into the corresponding 1,2,4-triazole and carbamate derivatives. Phthalazine carboxylic acid hydrazide 2 was treated with isatine and cyclohexanone to give the corresponding hydrazone derivatives 16,19 in good yields. Furthermore, cc-amino acid derivative conjugated with 1-oxophthalazine moiety 35 was synthesized by the reaction of the corresponding aizde 28, via the azide-coupling method, with glycine methyl ester. The peptide ester 35 was converted into their corresponding amide 36 by treating with methanolic ammonia. Moreover, 35 was boiled with hydrazine hydrate to afford the corresponding hydrazide 37. Finally, the dipeptide 38 was prepared by coupling of 35 with L-alanine methyl ester. Some of these compounds were screened in vitro for their antimicrobial activity. The energy gap between the highest occupied molecular orbital and lowest unoccupied molecular orbital has been calculated using the theoretical computations to reflect the chemical reactivity and kinetic stability of compounds. (C) 2014 Elsevier Ltd. All rights reserved.

If you are interested in 767-00-0, you can contact me at any time and look forward to more communication. Name: 4-Hydroxybenzonitrile.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

In an article, author is Etinski, Mihajlo, once mentioned the application of 1571-08-0, Name: Methyl 4-formylbenzoate, Name is Methyl 4-formylbenzoate, molecular formula is C9H8O3, molecular weight is 164.16, MDL number is MFCD00006950, category is phthalazine. Now introduce a scientific discovery about this category.

A theoretical study of low-lying singlet and triplet excited states of quinazoline, quinoxaline and phthalazine: insight into triplet formation

Quinazoline, quinoxaline and phthalazine are nitrogen containing heterocyclic aromatic molecules which belong to the class diazanaphthalenes. These isomers have low-lying n pi(star) and naphthalene-like pi pi(star) states that interact via spin-orbit coupling. In this contribution, we study their structure and electronic states by means of a coupled-cluster method. The computed properties are compared to those of cinnoline which were obtained in our previous study [Etinski et al., Phys. Chem. Chem. Phys., 2014, 16, 4740]. The excited state features of these isomers are dependent on the position of the nitrogen atoms. We find that quinazoline and quinoxaline exhibit similarities in the ordering and character of the excited states. In contrast, a marked difference in the electronic and geometric structures of the lowest excited triplet states of cinnoline and phthalazine is noticed, although both are orthodiazanaphthalenes. Our findings suggest that the S-1 (sic) T-1 channel is responsible for the rapid intersystem crossing in quinazoline and quinoxaline, whereas the S-1 (sic) T-2 pathway is active in phthalazine.

If you are interested in 1571-08-0, you can contact me at any time and look forward to more communication. Name: Methyl 4-formylbenzoate.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

24324-17-2, Name is 9-Fluorenemethanol, molecular formula is C14H12O, belongs to phthalazine compound, is a common compound. In a patnet, author is Orue, Analia Ivanna Chamorro, once mentioned the new application about 24324-17-2, SDS of cas: 24324-17-2.

An Experimental and Theoretical Approach to Control Salt vs Cocrystal vs Hybrid Formation-Crystal Engineering of an E/Z-Butenedioic Acid/Phthalazine System

The understanding and control of proton transfer reactions between acid-base pairs in the solid state are two of the main challenges for the crystal engineering community. The ability to control proton transfer reactions in the solid state enables a more selective preparation of cocrystals and salts, which facilitates the design of solid materials with specific physicochemical properties. In this study, an approach to control proton transfer reactions of an E-butenedioic acid/phthalazine cocrystal-salt (hybrid) system is presented, which allows the selective formation of its cocrystal and salt. In this approach the dominant intermolecular interactions between acid-base pairs are identified. Such interactions appear to be crucial for the inhibition or promotion of proton transfers in the solid state. For this, the relationship between these interactions and the so-called ApKa rule has been investigated.

If you’re interested in learning more about 24324-17-2. The above is the message from the blog manager. SDS of cas: 24324-17-2.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics, 104-53-0, Name is 3-Phenylpropanal, SMILES is O=CCCC1=CC=CC=C1, belongs to phthalazine compound. In a document, author is He, Zeng-Yang, introduce the new discover, Computed Properties of C9H10O.

Highly Regioselective Carbamoylation of Electron-Deficient Nitrogen Heteroarenes with Hydrazinecarboxamides

The use of hydrazinecarboxamides as a new class of carbamoylating agents has been established through the dehydrazinative Minisci reaction of electron-deficient nitrogen heteroarenes. A wide range of electron-deficient nitrogen heteroarenes, including isoquinoline, quinoline, pyridine, phenanthridine, quinoxaline, and phthalazine, underwent copper/acid-catalyzed oxidative carbamoylation with hydrazinecarboxamide hydrochlorides to afford structurally diverse nitrogen-heteroaryl carboxamides as single regioisomers in moderate to excellent yields. The functional group tolerance was substantially demonstrated in the direct carbamoylation of quinine obviating multistep sequences involving protecting groups and prefunctionalization of the heterocycle.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 104-53-0 is helpful to your research. Computed Properties of C9H10O.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem