Tag: M.W:100-200

Chemistry, like all the natural sciences, begins with the direct observation of nature— in this case, of matter.103-36-6, Name is Ethyl cinnamate, SMILES is O=C(OCC)/C=C/C1=CC=CC=C1, belongs to phthalazine compound. In a document, author is Kefayati, Hassan, introduce the new discover, Product Details of 103-36-6.

Electrocatalytic multicomponent assembling of phthalhydrazide, aldehydes and malononitrile: An efficient approach to 1H-pyrazolo[1,2-b]phthalazine-5,10-diones

Electrocatalytic multicomponent transformation of phthalhydrazide, aromatic aldehydes and malononitrile in n-propanol in an undivided cell in the presence of sodium bromide as an electrolyte leads to 1H-pyrazolo[1,2-b]phthalazine-5,10-diones in short reaction times (4-8 min) and high yields (85-98%) at room temperature. The developed efficient electrocatalytic approach to the corresponding 1H-pyrazolo[1,2-b]phthalazine-5,10-diones is beneficial from the viewpoint of diversity-oriented large-scale processes and represents a new example of the ecologically pure synthetic concept for electrocatalytic multicomponent reactions strategy. (C) 2013 Academie des sciences. Published by Elsevier Masson SAS. All rights reserved.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 103-36-6. Product Details of 103-36-6.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Chemistry can be defined as the study of matter and the changes it undergoes. You’ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology. 103-36-6, Name is Ethyl cinnamate, molecular formula is , belongs to phthalazine compound. In a document, author is Makarem, S., Product Details of 103-36-6.

Electro-Organic Synthesis: An Efficient Method for the Preparation of Nanosized Particles of Phthalazine Derivatives via One-Pot Multicomponent Reactions

Aza heterocyclic compounds are major interest for organic chemists because of their mainly pharmacological activities and clinical applications such as antianxiety, antitumor, anticonvulsant, cardiotonic and vasorelaxant. This contribution describes an electrochemical approach for the preparation of nanosized particles of phthalazine in high yields and very short reaction time. The method is based on the one-pot multicomponent reaction (MCRs) of phthalhydrazide, malononitrile and aldehydes in propanol employing undivided cell in the presence of NaBr as an electrolyte. The product was characterized, after purification, using IR, (HNMR)-H-1, C-13 NMR, MS and SEM. This procedure provides a method by which nanoparticles are synthesized directly from phthalhydrazide, malononitrile and aldehydes insides of a routine protocol for the synthesis of nano particles of organic compounds in which the synthesized organic compound is transformed into nanosized particles using modem high technology, for example ultrahighpressure rapid expansion of supercritical solution, and supercritical antisolvent with enhanced mass transfer. Size reduction is a fundamental unit operation having important applications in pharmacy. It helps to improve solubility and bioavailability, reduce toxicity, enhance release, and provide better formulation opportunities for drugs.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 103-36-6, in my other articles. Product Details of 103-36-6.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Chemistry can be defined as the study of matter and the changes it undergoes. You’ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology. 620-14-4, Name is 3-Ethyltoluene, molecular formula is , belongs to phthalazine compound. In a document, author is Bashti, Aigin, Recommanded Product: 620-14-4.

Synthesis and characterization of dicationic 4,4 ‘-bipyridinium dichloride ordered mesoporous silica nanocomposite and its application in the preparation of 1H-pyrazolo[1,2-b]phthalazine-5,10-dione derivatives

The sol-gel method was used for the synthesis of a dicationic 4,4′-bipyridine silica hybrid nanocomposite. In order to introduce 4,4′-bipyridine into the skeleton framework of an ordered mesoporous silica (SBA-15), first, the N, N’-bis(triethoxysilylpropyl)-4,4′-bipyridinium dichloride precursor was synthesized by the reaction of 3-chloropropyltriethoxysilane with 4,4′-bipyridine to give (TEOS)(2)BiPy2+ 2Cl(-). The organic-inorganic hybrid nanocomposite, SBA@BiPy2+ 2Cl(-), was then synthesized by the hydrolysis and polycondensation of the precursor and tetraethyl orthosilicate under mild acidic conditions. The nanocomposite was characterized by FT-IR spectroscopy, scanning electron microscopy (SEM), transmission electron microscopy (TEM), thermogravimetric analysis (TGA) and Brunauer-Emmett-Teller (BET). The characteristic results of FT-IR, XRD and TGA confirmed the coexistence of silica and 4,4′-bipyridinium dichloride networks. The catalytic ability of SBA@BiPy2+ 2Cl(-) as a novel environmentally safe heterogeneous nanoreactor for the preparation of 1H-pyrazolo[1,2-b]phthalazine-5,10-dione derivatives via a one-pot multicomponent method under solvent-free conditions has been described. The catalyst can be reused without an obvious loss of catalytic activity.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 620-14-4, in my other articles. Recommanded Product: 620-14-4.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Chemistry, like all the natural sciences, Recommanded Product: 4-Hydroxybenzonitrile, begins with the direct observation of nature— in this case, of matter.767-00-0, Name is 4-Hydroxybenzonitrile, SMILES is OC1=CC=C(C=C1)C#N, belongs to phthalazine compound. In a document, author is Ghorbani-Vaghei, Ramin, introduce the new discover.

One-pot synthesis of 1H-pyrazolo[1,2-b] phthalazine-5,10-dione derivatives under solvent-free conditions

A series of 1H-pyrazolo[1,2-b]phthalazine-5,10-diones were obtained from aldehydes, phthalhydrazide and malononitrile in good to excellent yields at 80-100 degrees C under solvent-free conditions by proceeding through a simple, mild and efficient procedure utilizing N, N, N’, N’-tetrabromobenzene-1,3-disulfonamide [TBBDA] and poly(N-bromo-N-ethylbenzene-1,3-disulfonamide) [PBBS] as catalysts.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 767-00-0. Recommanded Product: 4-Hydroxybenzonitrile.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 122-03-2, Name is p-Isopropylbenzenecarboxaldehyde, molecular formula is C10H12O. In an article, author is El-Helby, Abdel-Ghany A.,once mentioned of 122-03-2, Safety of p-Isopropylbenzenecarboxaldehyde.

Phthalazine-1,4-dione derivatives as non-competitive AMPA receptor antagonists: design, synthesis, anticonvulsant evaluation, ADMET profile and molecular docking

In view of the anticonvulsant activity reported for phthalazine derivatives as non-competitive AMPA receptor antagonists, a new series of phthalazine-1,4-diones (2-12) were designed and synthesized. The neurotoxicity was assessed using rotarod test. The molecular docking was performed for the synthesized compounds to assess their binding affinities toward AMPA receptor as non-competitive antagonists. The molecular modeling data were strongly interrelated to biological screening data. Compounds 8, 7(b), 7(a), 10 and 3(a) exhibited the highest binding affinities as non-competitive AMPA receptor antagonists and also showed the highest relative potencies of 1.78, 1.66, 1.60, 1.59 and 1.29, respectively, as anticonvulsants in comparison with diazepam. The most active compounds 8, 7(b), 7(a), 10 and 3(a) were further tested against maximal electroshock seizure (MES). Compounds 8 and 7(b) and 3(a) showed 100% protection at a dose level of 125 mu gm/kg, while compounds 7(a) and 10 exhibited 83.33% protection at the same dose level. These agents exerted low neurotoxicity and high safety margin in comparison with valproate as a reference drug. Most of our designed compounds exhibited good ADMET profile.

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Related Products of 139-66-2, As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 139-66-2, Name is Diphenylsulfane, SMILES is C1(SC2=CC=CC=C2)=CC=CC=C1, belongs to phthalazine compound. In a article, author is Kefayati, Hassan, introduce new discover of the category.

Electrocatalytic multicomponent assembling of phthalhydrazide, aldehydes and malononitrile: An efficient approach to 1H-pyrazolo[1,2-b]phthalazine-5,10-diones

Electrocatalytic multicomponent transformation of phthalhydrazide, aromatic aldehydes and malononitrile in n-propanol in an undivided cell in the presence of sodium bromide as an electrolyte leads to 1H-pyrazolo[1,2-b]phthalazine-5,10-diones in short reaction times (4-8 min) and high yields (85-98%) at room temperature. The developed efficient electrocatalytic approach to the corresponding 1H-pyrazolo[1,2-b]phthalazine-5,10-diones is beneficial from the viewpoint of diversity-oriented large-scale processes and represents a new example of the ecologically pure synthetic concept for electrocatalytic multicomponent reactions strategy. (C) 2013 Academie des sciences. Published by Elsevier Masson SAS. All rights reserved.

Related Products of 139-66-2, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. I hope my blog about 139-66-2 is helpful to your research.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 122-03-2, Name is p-Isopropylbenzenecarboxaldehyde, molecular formula is C10H12O. In an article, author is Mohamadpour, Farzaneh,once mentioned of 122-03-2, Computed Properties of C10H12O.

Caffeine: A green, natural and biodegradable catalyst for convenient and expedient eco-safe synthesis of 1H-pyrazolo [1,2-b] phthalazine-5,10-dione derivatives under solvent-free conditions

A green, convenient, highly versatile and solvent-free synthetic route for caffeine catalyzed one-pot multi-component synthesis of biologically active 1H-pyrazolo [1,2-b] phthalazine-5,10-dione derivatives via one-pot four-component condensation reaction of phthalimide, hydrazine monohydrate, aryl aldehydes and malononitrile has been studied. The green, natural, biodegradable and inexpensive catalyst, eco-safe reaction, solvent-free conditions, avoidance of hazardous or toxic catalysts, simplicity of operation and work-up procedures with no necessity of chromatographic purification steps, the availability and ease of handling of this solid catalyst and good to high yields are the notable benefits for the highly efficient synthesis of these products.

Interested yet? Keep reading other articles of 122-03-2, you can contact me at any time and look forward to more communication. Computed Properties of C10H12O.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Related Products of 1603-79-8, Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, 1603-79-8, Name is Ethyl benzoylformate, SMILES is CCOC(=O)C(=O)C1=CC=CC=C1, belongs to phthalazine compound. In a article, author is Martins, Felipe Terra, introduce new discover of the category.

Phthalazine-trione as a blue-green light-emitting moiety: crystal structures, photoluminescence and theoretical calculations

Phthalazine (2,3-diazanaphthalene) and phthalhydrazide (2,3-dihydro-1,4-phthalazinedione) compounds are heterocycles with several biological properties. Most recently, analogous phthalazine-triones also emerged as drug candidates. Herein, we introduced a phthalazine-trione moiety as a promising fluorophore in the blue and green spectral regions. This desired optical property was rationalized based on their crystal structure and time-dependent density functional theory (TD-DFT) calculations. Under ultraviolet (UV) excitation (ca. 360 nm), two light emission maxima at ca. 460 nm and 480 nm were observed for ten phthalazine-triones, regardless of the substitution pattern. This conservation in the light-emitting property was rationalized by our time-dependent DFT calculations for the three phthalazine-triones whose crystal geometries were also determined in this study (4-chlorophenyl, 3-methoxyphenyl and 4-nitrophenyl derivatives) and for those available in literature (4-fluorophenyl and 4-bromophenyl derivatives). Electronic transitions with the largest oscillator strengths were near 360 nm and were in excellent agreement with the experimental excitation energy (UV-visible and photoluminescence spectra). Lifetime values of selected samples could also be determined, which were between 1.59 ns and 3.21 ns. In all compounds, the Frontier molecular orbitals involved in these excitations were distributed over the phthalazine-trione moiety and were not localized on the changeable substituent.

Related Products of 1603-79-8, The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 1603-79-8 is helpful to your research.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Chemistry is traditionally divided into organic and inorganic chemistry. The former is the study of compounds containing at least one carbon-hydrogen bonds. 1679-64-7, Name is 4-(Methoxycarbonyl)benzoic acid, molecular formula is C9H8O4, belongs to phthalazine compound, is a common compound. In a patnet, author is Reddy, M. Veeranaryana, once mentioned the new application about 1679-64-7, Safety of 4-(Methoxycarbonyl)benzoic acid.

Silica gel-supported tungstic acid (STA): A new, highly efficient and recyclable catalyst for the synthesis of 1H-pyrazolo[1,2-b]phthalazine-5,10-dione carbonitriles and carboxylates under neat conditions

1H-Pyrazolo[1,2-6]phthalazine-5,10-dione carbonitriles and carboxylates possess a broad range of applications as active compounds in the pharmacological and biological fields. We developed an efficient and ecofriendly silica gel-supported tungstic acid (STA)-catalyzed one-pot synthesis of 1H-pyrazolo[1,2-b]phthalazine-5,10-dione carbonitriles and carboxylates by a three-component reaction of an aldehyde, a malononitrile/ethyl cyanoacetate and a phthalhydrazide under solvent-free conditions. The major advantages of the present method are experimental simplicity, use of an inexpensive and ecofriendly reusable catalyst, good yields, and short reaction times. (C) 2014 Academie des sciences. Published by Elsevier Masson SAS. All rights reserved.

We’ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, 1679-64-7. The above is the message from the blog manager. Safety of 4-(Methoxycarbonyl)benzoic acid.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. In an article, author is Saundane, Anand R., once mentioned the application of 613-45-6, Name is 2,4-Dimethoxybenzaldehyde, molecular formula is C9H10O3, molecular weight is 166.17, MDL number is MFCD00003311, category is phthalazine. Now introduce a scientific discovery about this category, Safety of 2,4-Dimethoxybenzaldehyde.

Synthesis and biological evaluation of novel indolo[2,3-c]isoquinoline derivatives

A new series of novel compounds 1-tert-butyl-9-substituted-12H-indolo[2,3-c]isoquinolino[5,6-c]-1,2,4-triazoles (4a-4c), 10-substituted-2-phenyl-1,13-dihydroindolo[2,3-c]isoquinolino[5,6-c]-1,2,4-triazines (5a-5l), 2-(10-substituted-7H-indolo[2,3-c]isoquinolin-5-yl)-4-phenylphthalazin-1-ones (6a-6c), 2-[2-(10-substituted-7H-indolo[2,3-c]isoquinolinyl)hydrazinecarbonyl]benzoic acid (7a-7c), and 2-(10-substituted-7H-indolo[2,3-c]isoquinolin-5-yl)phthalazine-1,4-diones (8a-8c) were synthesized. The structures of these newly synthesized compounds were confirmed by their spectral studies and elemental analysis. These compounds have been screened for their antimicrobial, antitubercular, antioxidant, and cytotoxic activities. Compounds 4b, 5a, 5g, 5h, 6a, 6b, and 7b exhibited the maximum zone of inhibition against Staphylococcus aureus. Compounds 5d and 6c exhibited the maximum zone of inhibition against Pseudomonas aeruginosa. Compounds 7a and 8c showed maximum zone of inhibition against Aspergillus niger. Compounds 5k and 8c showed maximum zone of inhibition against Aspergillus flavus. Compounds 4a (MIC-1.6 A mu g/ml) and 5 h (MIC-0.2 A mu g/ml) exhibited promising antitubercular activity against Mycobacterium tuberculosis H37Rv strain. Compounds 4b, 4c, 5a, 5c, 5e, 5h, 6a, 6b, 6c, 8a, and 8b exhibited good radical scavenging activity compared with standards. Compounds 4b, 4c, 5a, 5c, 5g, 6a, and 8b exhibited maximum reducing ability. Compounds 4a and 5h exhibited 100 % cell lysis at concentration 10 A mu g/ml.

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem