Tag: M.W:100-200

Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 369-34-6, Name is 3,4-Difluoronitrobenzene, molecular formula is C6H3F2NO2, belongs to phthalazines compound. In a document, author is Yunta, Maria J. R., introduce the new discover, Application In Synthesis of 3,4-Difluoronitrobenzene.

Tropical and Subtropical Parasitic Diseases: Targets for a New Approach to Virtual Screening

Computational techniques are widely used to reduce costs associated with new drug development with the ability to bind a specific molecular target. These studies need a Brookhaven protein data bank structure sample of the enzyme interaction with an inhibitor of adequate size. In this context, a new computational methodology is postulated to be used when there are no published samples fulfilling this requirements. In this study, 7 compounds, which showed anti-T. cruzi, L. donovani and L. infantum properties, and proved to be inhibitors of their Fe-SOD enzymes, have been theoretically evaluated against related parasites Fe-SOD enzymes, which have been proposed as targets for antiparasitic drugs. This methodology may be applied to similar cases and also to generate starting structures to be used with different CADD methods

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 369-34-6. Application In Synthesis of 3,4-Difluoronitrobenzene.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Application of 5509-65-9, Redox catalysis has been broadly utilized in electrochemical synthesis due to its kinetic advantages over direct electrolysis. The appropriate choice of redox mediator can avoid electrode passivation and overpotential. 5509-65-9, Name is 2,6-Difluoroaniline, SMILES is C1=CC=C(C(=C1F)N)F, belongs to phthalazines compound. In a article, author is Zhao, Shanshan, introduce new discover of the category.

Recycling of high temperature steam condensed water from petroleum refinery by thermostable PPESK ultrafiltration membrane

The purification and reclaiming of synthetic and industrial high temperature condensed water containing excess oil and iron is investigated in this study using thermostable poly(phthalazine ether sulfone ketone) (PPESK) ultrafiltration membranes. The results show operation parameters such as transmembrane pressure, temperature and pH of feed solution, initial oil and iron concentration each play important roles in the permeate flux and oil/iron removal efficiencies. Membrane performance is almost recovered after washing with a combination of NaOH and ethanol. High temperature condensed water from Daqing petroleum refinery can be consecutively purified using a PPESK ultrafiltration membrane. The turbidity of the solutions is almost removed. Oil and iron concentrations in the permeate solutions are below 1 mg/L and 50 mu g/L, respectively, which satisfy the Quality Criterion of Water and Steam for Steam Power Equipment in China. UF process shows a promising alternative to existing technology in the Daqing petroleum refinery in terms of cost and environmental protection as well as energy recovery. For future possible combination of UF and NF process application, both economic cost and saving are evaluated, and the breakeven time is about 11 months. (C) 2013 Elsevier B.V. All rights reserved.

Application of 5509-65-9, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. I hope my blog about 5509-65-9 is helpful to your research.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

In an article, author is Esmaeilpour, Mohsen, once mentioned the application of 402-50-6, Computed Properties of C9H7F3, Name is 1-(Trifluoromethyl)-4-vinylbenzene, molecular formula is C9H7F3, molecular weight is 172.1471, MDL number is MFCD00075539, category is phthalazines. Now introduce a scientific discovery about this category.

Preparation, characterization and catalytic activity of dendrimer-encapsulated phosphotungstic acid nanoparticles immobilized on nanosilica for the synthesis of 2H-indazolo[2,1-b]phthalazine-triones under solvent-free or sonochemical conditions

In this paper, we adopt a facile method to prepare a type of porous silica nanoparticles (n-SiO2) from tetraethyl orthosilicate as the source of silica. Then, dendritic polymer supported on nanosilica with surface amino groups was fabricated. Finally, H3PW12O40 nanoparticles (PWA(n)) were synthesized by the treatment of H3PW12O40 powder with n-Octane as solvent by a solvothermal method and then immobilized onto the dendrimer polymer functionalized nanosilica. The synthesized nanostructures were characterized by fourier transform infrared (FT-IR), X-ray diffraction (XRD), thermogravimetric analysis (TGA), dynamic light scattering (DLS), N-2 adsorption-desorption isotherm analysis, UV-Vis and elemental analysis. The morphology of the catalyst was characterized using transmission electron microscopes (TEM). The acidity of the catalyst was determined by FTIR pyridine adsorption spectroscopy. Then, this catalytic system was used as an efficient catalyst for the synthesis of 2H-indazolo[2,1-b]phthalazine-triones via multi-component and one-pot reactions of various aldehydes, phthalic anhydride, hydrazinium hydroxide, and dimedone under thermal solvent-free conditions or ultrasound irradiation at room temperature. Also, the catalyst can be easily recovered and reused for six consecutive reaction cycles without significant loss of activity.

If you are interested in 402-50-6, you can contact me at any time and look forward to more communication. Computed Properties of C9H7F3.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics, Computed Properties of C9H9NO3, 495-69-2, Name is 2-Benzamidoacetic acid, SMILES is O=C(O)CNC(C1=CC=CC=C1)=O, belongs to phthalazines compound. In a document, author is Gol’dberg, A. E., introduce the new discover.

Crystal structure of a trinuclear complex of zinc(II) with 2,6-Di-tert-butyl-p-quinone 1′-phthalazinylhydrazone

2,6-Di-tert-butyl-p-quinone 1′-phthalazynylhydrazone (HL) is synthesized; the total energies and geometry of the possible hydrazone tautomeric forms are calculated by quantum chemical methods. The hydrazone phthalazone tautomer is shown to be the most stable, which is well consistent with the H-1 NMR spectroscopic data for hydrazone. An X-ray crystallographic analysis is performed of the hydrazone-based Zn(II) trinuclear complex, in which zinc atoms are linked by the diazine bridge of the phthalazine cycle and two pivalate bridges. The geometric properties of the monodeprotonated hydrazone residue in the complex are similar to the calculated data for the phthalazone hydrazone tautomeric form.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 495-69-2. Computed Properties of C9H9NO3.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 104-86-9, Name is (4-Chlorophenyl)methanamine, molecular formula is C7H8ClN, belongs to phthalazines compound. In a document, author is Khazaei, Ardeshir, introduce the new discover, Category: phthalazines.

N,2-Dibromo-6-chloro-3,4-dihydro-2H-benzo[e]-[1,2,4]thiadiazine-7-sulfonamide 1,1-dioxide: an efficient and homogeneous catalyst for one-pot synthesis of 4H-pyran, pyranopyrazole and pyrazolo[1,2-b]phthalazine derivatives under aqueous media

N,2-Dibromo-6-chloro-3,4-dihydro-2H-benzo[e][1,2,4]thiadiazine-7-sulfonamide 1,1-dioxide (DCDBTSD) as a highly efficient and homogeneous catalyst was successfully applied for the synthesis of 4H-pyran, pyranopyrazole and pyrazolo[1,2-b] phthalazine derivatives by a one-pot multi-component reaction (MCR) in water. The described method has some advantages such as mild and neutral reaction media, high yields, short reaction times, cleaner and easier reaction profiles and compliance with green chemistry protocols.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 104-86-9. Category: phthalazines.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 611-73-4, Name is 2-Oxo-2-phenylacetic acid, molecular formula is C8H6O3. In an article, author is Eswararao, S., V,once mentioned of 611-73-4, Safety of 2-Oxo-2-phenylacetic acid.

WATER MEDIATED ONE- POT- SYNTHESIS OF 1H-PYRAZOLO[1,2-B]PHTHALAZINE-5,10-DIONES AND 2H-INDAZOLO[2,1-B]PHTHALAZINE-1,6,11(13H)-TRIONES

1H-pyrazolo[1,2-b]phthalazine-5,10-diones (5) and 2H-indazolo[2,1-b]phthalazine-1,6,11(13H)-triones (7) have been synthesized by one pot, four-component method. To synthesise them phthalic anhydride (1), hydrazine hydrate (2), benzaldehydes (3) and malononitrile (4a) /ethyl cynoacetate (4b) /dimedone (6) in refluxing water for 1-1.5 h in the presence of InCl3 as a catalyst yielding 75-85%. These reactions have an easy workup, provides excellent yields, and uses water as the solvent which is considered to be relatively environmentally benign. The structures of the products were established from their spectral properties IR, H-1-NMR, C-13-NMR & Mass spectroscopy.

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Electric Literature of 371-42-6, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C¨CH bond functionalisation has revolutionised modern synthetic chemistry. 371-42-6, Name is 4-Fluorothiophenol, SMILES is SC1=CC=C(F)C=C1, belongs to phthalazines compound. In a article, author is Lamera, Esma, introduce new discover of the category.

Synthesis, characterization, X-ray structure, optical properties and theoretical calculations of condensed phthalazines

Two condensed phthalazine compounds were synthesized and characterized by FT-IR, UV-Vis, NMR spectroscopic studies. Single crystal XRD and molecular orbital calculations. Optimized geometrical structures were computed with RB3LYP method with the 6-31G(p, d) basis set. The geometrical parameters of both compounds obtained from Single Crystal XRD were found to be in accord with the calculated (DFT) values. The electronic contribution was measured using the third harmonic generation technique on thin films at 1064 nm for both compounds. Also, the values of dipole moment , the average polarizability , and the first static hyperpolarizability were computed. The theoretical and experimental results confirm the NLO behavior of both compounds.

Electric Literature of 371-42-6, One of the oldest and most widely used commercial enzyme inhibitors is aspirin, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 371-42-6.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 104-86-9, Name is (4-Chlorophenyl)methanamine, molecular formula is C7H8ClN. In an article, author is Wang Yinglei,once mentioned of 104-86-9, SDS of cas: 104-86-9.

Synthesis of Pyrazolo[1,2-b]phthalazine-5,10-diones Catalyzed by Poly(ethylene glycol) Grafted 4-Dimethylaminopyridine Functionalized Ionic Liquid

A novel poly(ethylene glycol) grafted 4-dimethylaminopyridine functionalized ionic liquid ([DMAP-PEG(1000)-DIL][BF4]) was prepared and characterized by H-1 NMR, C-13 NMR, FT-IR and ESI-MS. In the presence of [DMAP-PEG(1000)-DIL][BE4], various substituted aromatic aldehyde could react with malononitrile (or ethyl cyanoacetate) and phthalhydrazide in water to obtain a series of pyrazolo[1,2-b]phthalazine-5,10-dione derivatives with 85%similar to 96% yields. The mild reaction conditions, high stable and recyclable ionic liquids, environmental friendliness are advantages of this methodology.

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Chemistry is an experimental science, SDS of cas: 696-63-9, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 696-63-9, Name is 4-Methoxythiophenol, molecular formula is C7H8OS, belongs to phthalazines compound. In a document, author is Ziarani, Ghodsi Mohammadi.

Efficient One-Pot Solvent-Free Synthesis of 1H-Pyrazolo[1,2-b]phthalazine-5,10-diones Catalyzed by Sulfonic Acid Functionalized Nanoporous Silica (SBA-Pr-SO3H)

A green protocol has been developed for the synthesis of 1H-pyrazolo[1,2-b]phthalazine-5,10-diones by one-pot cyclocondensation reaction of phthalhydrazide, aromatic aldehydes, and malononitrile or ethyl cyanoacetate using sulfonic acid functionalized SBA-15 (SBA-Pr-SO3H) as a heterogeneous solid acid catalyst under solvent-free conditions.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 696-63-9. SDS of cas: 696-63-9.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Application of 875-74-1, As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 875-74-1, Name is H-D-Phg-OH, SMILES is O=C(O)[C@H](N)C1=CC=CC=C1, belongs to phthalazines compound. In a article, author is Appleby, Kate M., introduce new discover of the category.

Investigating pyridazine and phthalazine exchange in a series of iridium complexes in order to define their role in the catalytic transfer of magnetisation from para-hydrogen

The reaction of [Ir(IMes)(COD)Cl], [IMes = 1,3-bis(2,4,6-trimethylphenyl)imidazol-2-ylidene, COD = 1,5-cyclooctadiene] with pyridazine (pdz) and phthalazine (phth) results in the formation of [Ir(COD)(IMes)(pdz)]Cl and [Ir(COD)(IMes)(phth)]Cl. These two complexes are shown by nuclear magnetic resonance (NMR) studies to undergo a haptotropic shift which interchanges pairs of protons within the bound ligands. When these complexes are exposed to hydrogen, they react to form [Ir(H)(2)(COD)(IMes)(pdz)]Cl and [Ir(H)(2)(COD)(IMes)(phth)]Cl, respectively, which ultimately convert to [Ir(H)(2)(IMes)(pdz)(3)]Cl and [Ir(H)(2)(IMes)(phth)(3)] Cl, as the COD is hydrogenated to form cyclooctane. These two dihydride complexes are shown, by NMR, to undergo both full N-heterocycle dissociation and a haptotropic shift, the rates of which are affected by both steric interactions and free ligand pK(a) values. The use of these complexes as catalysts in the transfer of polarisation from para-hydrogen to pyridazine and phthalazine via signal amplification by reversible exchange (SABRE) is explored. The possible future use of drugs which contain pyridazine and phthalazine motifs as in vivo or clinical magnetic resonance imaging probes is demonstrated; a range of NMR and phantom-based MRI measurements are reported.

Application of 875-74-1, The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 875-74-1 is helpful to your research.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem