Tag: M.W:100-200

Reactions catalyzed within inorganic and organic materials and at electrochemical interfaces commonly occur at high coverage and in condensed media, causing turnover rates to depend strongly on interfacial structure and composition, 5267-64-1, Name is D-Penylalaninol, SMILES is OC[C@H](N)CC1=CC=CC=C1, in an article , author is Choughule, Kanika V., once mentioned of 5267-64-1, Computed Properties of C9H13NO.

Evaluation of Rhesus Monkey and Guinea Pig Hepatic Cytosol Fractions as Models for Human Aldehyde Oxidases

Aldehyde oxidase (AOX) is a cytosolic enzyme expressed across a wide range of species, including guinea pig and rhesus monkey. These species are believed to be the best preclinical models for studying human AOX-mediated metabolism. We compared AOX activity in rhesus monkeys, guinea pigs, and humans using phthalazine and N-[2-(dimethylamino) ethyl] acridone-4-carboxamide (DACA) as substrates and raloxifene as an inhibitor. Michaelis-Menten kinetics was observed for phthalazine oxidation in rhesus monkey, guinea pig, and human liver cytosol, whereas substrate inhibition was seen with DACA oxidase activity in all three livers. Raloxifene inhibited phthalazine and DACA oxidase activity uncompetitively in guinea pig, whereas mixed-mode inhibition was seen in rhesus monkey. Our analysis of the primary sequence alignment of rhesus monkey, guinea pig, and human aldehyde oxidase isoform 1 (AOX1) along with homology modeling has led to the identification of several amino acid residue differences within the active site and substrate entrance channel of AOX1. We speculate that some of these residues might be responsible for the differences observed in activity. Overall, our data indicate that rhesus monkeys and guinea pigs would overestimate intrinsic clearance in humans and would be unsuitable to use as animal models. Our study also showed that AOX metabolism in species is substrate-dependent and no single animal model can be reliably used to predict every drug response in humans.

Interested yet? Read on for other articles about 5267-64-1, you can contact me at any time and look forward to more communication. Computed Properties of C9H13NO.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. 5509-65-9, Name is 2,6-Difluoroaniline, SMILES is C1=CC=C(C(=C1F)N)F, in an article , author is Zbancioc, Ana Maria, once mentioned of 5509-65-9, Name: 2,6-Difluoroaniline.

Synthesis and In vitro Analysis of Novel Dihydroxyacetophenone Derivatives with Antimicrobial and Antitumor Activities

Herein we report a feasible study concerning the design, syntheses and in vitro antimicrobial and antitumoral activities of some novel compounds with dihydroxyacetophenone (DA) moiety. An efficient and general method for the preparation of diazine with dihydroxyacetophenone (DDA) skeleton under conventional thermal heating (TH), microwave (MW) and ultrasounds (US) irradiation is presented. Antimicrobial and antitumoral tests prove that some dihydroxyacetophenone compounds (the brominated derivatives BrDA 3) have a significant biological activity. It is also to be pointed out that, basically all the dihydroxyacetophenone derivatives proved to have a powerful antibacterial activity against drug resistant Gram-negative strain Pseudomonas aeruginosa ATCC 27853. Of particular interest could be the excellent antibacterial activity of our dihydroxyacetophenone compounds against drug resistant Gram-negative strain Pseudomonas aeruginosa.

Interested yet? Read on for other articles about 5509-65-9, you can contact me at any time and look forward to more communication. Name: 2,6-Difluoroaniline.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, such as the rate of change in the concentration of reactants or products with time. 556-08-1, Name is 4-Acetamidobenzoic acid, formurla is C9H9NO3. In a document, author is Bouraiou, Abdelmalek, introducing its new discovery. Name: 4-Acetamidobenzoic acid.

Crystal structure of 13-(2-methoxyphenyl)-3,4-dihydro-2H-indazolo[1,2-b]phthalazine- 1,6,11(13H)-trione

In the title compound, C22H18N2O4, the three fused rings of the pyrazolophthalazine moiety are coplanar (r.m.s. deviation = 0.027 angstrom). The cyclohexene ring fused to the pyrazolidine ring, so forming the indazolophthalazine unit, has a half-chair conformation. The benzene ring is almost normal to the mean plane of the pyrazolophthalazine moiety, with a dihedral angle of 87.21 (6)degrees between their planes. In the crystal, molecules are linked by pairs of C-H center dot center dot center dot O hydrogen bonds forming inversion dimers. The dimers are linked via C-H center dot center dot center dot pi interactions, forming slabs parallel to (100). Between the slabs there are weak pi-pi interactions [ shortest inter-centroid distance = 3.6664 (9) angstrom], leading to the formation of a three-dimensional structure.

If you are hungry for even more, make sure to check my other article about 556-08-1, Name: 4-Acetamidobenzoic acid.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Let¡¯s face it, organic chemistry can seem difficult to learn. Especially from a beginner¡¯s point of view. Like 623-25-6, Name is ¦Á,¦Á’-Dichloro-p-xylene. In a document, author is Albota, Florin, introducing its new discovery. Category: phthalazines.

1,3-Dipolar cycloaddition between acetylenic dipolarophiles and sydnone-N-ylides as bis(1,3-dipoles)

1,3-Dipolar cycloaddition reaction of sydnone-N-ylides, as model bis(1,3-dipoles), with acetylenic dipolarophiles in 1,2-epoxybutane under reflux gave exclusively pyrroloazines containing a sydnone moiety that resulted by preferred reaction of the N-ylide 1,3-dipole with the acetylenic dipolarophiles. The assembled sydnone-ylide hybrid structures were generated in situ from N-heteroaromatic bromides. The structure of the new compounds was assigned by IR and NMR spectroscopy and confirmed by X-ray analysis for a representative compound. (C) 2015 Elsevier Ltd. All rights reserved.

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 623-25-6 help many people in the next few years. Category: phthalazines.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Reactions catalyzed within inorganic and organic materials and at electrochemical interfaces commonly occur at high coverage and in condensed media, causing turnover rates to depend strongly on interfacial structure and composition, 92-92-2, Name is [1,1′-Biphenyl]-4-carboxylic acid, SMILES is O=C(C1=CC=C(C2=CC=CC=C2)C=C1)O, in an article , author is Reddy, M. Veeranaryana, once mentioned of 92-92-2, Computed Properties of C13H10O2.

Silica gel-supported tungstic acid (STA): A new, highly efficient and recyclable catalyst for the synthesis of 1H-pyrazolo[1,2-b]phthalazine-5,10-dione carbonitriles and carboxylates under neat conditions

1H-Pyrazolo[1,2-6]phthalazine-5,10-dione carbonitriles and carboxylates possess a broad range of applications as active compounds in the pharmacological and biological fields. We developed an efficient and ecofriendly silica gel-supported tungstic acid (STA)-catalyzed one-pot synthesis of 1H-pyrazolo[1,2-b]phthalazine-5,10-dione carbonitriles and carboxylates by a three-component reaction of an aldehyde, a malononitrile/ethyl cyanoacetate and a phthalhydrazide under solvent-free conditions. The major advantages of the present method are experimental simplicity, use of an inexpensive and ecofriendly reusable catalyst, good yields, and short reaction times. (C) 2014 Academie des sciences. Published by Elsevier Masson SAS. All rights reserved.

But sometimes, even after several years of basic chemistry education, it is not easy to form a clear picture on how they govern reactivity! 92-92-2, you can contact me at any time and look forward to more communication. Computed Properties of C13H10O2.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics, 767-00-0, Name is 4-Hydroxybenzonitrile, SMILES is OC1=CC=C(C=C1)C#N, belongs to phthalazines compound. In a document, author is Wang, Shi-Ben, introduce the new discover, HPLC of Formula: C7H5NO.

Synthesis and Anticonvulsant Activity Evaluation of Some 1-alkoxy-4-(1H-1,2,4-triazol-1-yl)phthalazines

A series of 1-alkoxy-4-(1H-1,2,4-triazol-1-yl)phthalazine derivatives were synthesized using 2,3-dihydrophthalazine-1,4-dione as starting material. The structures of the compounds were characterized by elemental analysis, IR, H-1-NMR and MS data. Anticonvulsant activities of these compounds were evaluated by maximal electroshock (MES) test following intraperitoneal injection in mice. Among the synthesized compounds 3a-3t, compound 3e was the most active compound with an ED50 of 28.9 mg/kg, TD50 of 173.6 mg/kg and protective index (PI) of 6.0.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 767-00-0 is helpful to your research. HPLC of Formula: C7H5NO.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

In an article, author is Maftei, Dan, once mentioned the application of 62-23-7, Product Details of 62-23-7, Name is 4-Nitrobenzoic acid, molecular formula is C7H5NO4, molecular weight is 167.12, MDL number is MFCD00007352, category is phthalazines. Now introduce a scientific discovery about this category.

Crystal Structure of 8-(4-Methylbenzoyl)benzo [5,6]isoindolo[1,2-a]phthalazine-9,14-dione

The X-ray crystal structure of 8-(4-methylbenzoyl)benzo[5,6]isoindolo[1,2-a]phthalazine-9,14-dione, a derivative of fused pyrrolophtalazine heterocycle, is reported. The compound crystallfzes in the monoclinic C2/c space group (no. 15) with a = 23.968(4) angstrom, b = 7.6709(14) angstrom, c = 22.353(3) angstrom, alpha = gamma = 90.00, beta = 110.680(15)degrees, V=3845 angstrom(3) and Z = 7. Molecular and crystal packing parameters for the novel heterocyclic system were obtained from intensity data collected at room temperature. Both the benzo [5,6]isoindolo [1,2-a]phthalazine-9,14-dione and the 4-methyl-benzoyl fragments are planar and oriented at 78 degrees. Crystal packing is based on multiple (strong) pi-pi stacking interactions.

If you are interested in 62-23-7, you can contact me at any time and look forward to more communication. Product Details of 62-23-7.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Synthetic Route of 66-99-9, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C¨CH bond functionalisation has revolutionised modern synthetic chemistry. 66-99-9, Name is 2-Naphthaldehyde, SMILES is O=CC1=CC=C2C=CC=CC2=C1, belongs to phthalazines compound. In a article, author is Wang, Haitao, introduce new discover of the category.

Enantioselective Fluorocyclizations Mediated by Amino-Acid-Derived Phthalazine

Novel amino-acid-derived phthalazine reagents have been designed and synthesized for the enantioselective fluorocyclizations of prochiral indoles. The scope of reaction is evidenced by 28 examples of fluorinated furoindole and pyrroloindole heterocycles bearing various functionalities with up to 99% ee. The resulting enantioenriched fluorinated products are found to be potent AChE inhibitors. Advantages of the current new chiral reagents include ease in the synthesis of analogues and readily tunable steric/electronic demands.

Synthetic Route of 66-99-9, One of the oldest and most widely used commercial enzyme inhibitors is aspirin, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 66-99-9.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Chemistry can be defined as the study of matter and the changes it undergoes. You¡¯ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology. 89-86-1, Name is 2,4-Dihydroxybenzoic acid, molecular formula is , belongs to phthalazines compound. In a document, author is Yunta, Maria J. R., Application In Synthesis of 2,4-Dihydroxybenzoic acid.

Tropical and Subtropical Parasitic Diseases: Targets for a New Approach to Virtual Screening

Computational techniques are widely used to reduce costs associated with new drug development with the ability to bind a specific molecular target. These studies need a Brookhaven protein data bank structure sample of the enzyme interaction with an inhibitor of adequate size. In this context, a new computational methodology is postulated to be used when there are no published samples fulfilling this requirements. In this study, 7 compounds, which showed anti-T. cruzi, L. donovani and L. infantum properties, and proved to be inhibitors of their Fe-SOD enzymes, have been theoretically evaluated against related parasites Fe-SOD enzymes, which have been proposed as targets for antiparasitic drugs. This methodology may be applied to similar cases and also to generate starting structures to be used with different CADD methods

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 89-86-1, in my other articles. Application In Synthesis of 2,4-Dihydroxybenzoic acid.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Synthetic Route of 696-63-9, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 696-63-9, Name is 4-Methoxythiophenol, SMILES is SC1=CC=C(OC)C=C1, belongs to phthalazines compound. In a article, author is Albota, Florin, introduce new discover of the category.

1,3-Dipolar cycloaddition between acetylenic dipolarophiles and sydnone-N-ylides as bis(1,3-dipoles)

1,3-Dipolar cycloaddition reaction of sydnone-N-ylides, as model bis(1,3-dipoles), with acetylenic dipolarophiles in 1,2-epoxybutane under reflux gave exclusively pyrroloazines containing a sydnone moiety that resulted by preferred reaction of the N-ylide 1,3-dipole with the acetylenic dipolarophiles. The assembled sydnone-ylide hybrid structures were generated in situ from N-heteroaromatic bromides. The structure of the new compounds was assigned by IR and NMR spectroscopy and confirmed by X-ray analysis for a representative compound. (C) 2015 Elsevier Ltd. All rights reserved.

Synthetic Route of 696-63-9, Consequently, the presence of a catalyst will permit a system to reach equilibrium more quickly, but it has no effect on the position of the equilibrium as reflected in the value of its equilibrium constant.I hope my blog about 696-63-9 is helpful to your research.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem