Tag: M.W:100-200

Chemistry is traditionally divided into organic and inorganic chemistry. The former is the study of compounds containing at least one carbon-hydrogen bonds. 90-64-2, Name is 2-Hydroxy-2-phenylacetic acid, molecular formula is C8H8O3, belongs to phthalazines compound, is a common compound. In a patnet, author is Zhao, Shanshan, once mentioned the new application about 90-64-2, HPLC of Formula: C8H8O3.

Recycling of high temperature steam condensed water from petroleum refinery by thermostable PPESK ultrafiltration membrane

The purification and reclaiming of synthetic and industrial high temperature condensed water containing excess oil and iron is investigated in this study using thermostable poly(phthalazine ether sulfone ketone) (PPESK) ultrafiltration membranes. The results show operation parameters such as transmembrane pressure, temperature and pH of feed solution, initial oil and iron concentration each play important roles in the permeate flux and oil/iron removal efficiencies. Membrane performance is almost recovered after washing with a combination of NaOH and ethanol. High temperature condensed water from Daqing petroleum refinery can be consecutively purified using a PPESK ultrafiltration membrane. The turbidity of the solutions is almost removed. Oil and iron concentrations in the permeate solutions are below 1 mg/L and 50 mu g/L, respectively, which satisfy the Quality Criterion of Water and Steam for Steam Power Equipment in China. UF process shows a promising alternative to existing technology in the Daqing petroleum refinery in terms of cost and environmental protection as well as energy recovery. For future possible combination of UF and NF process application, both economic cost and saving are evaluated, and the breakeven time is about 11 months. (C) 2013 Elsevier B.V. All rights reserved.

We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, 90-64-2. The above is the message from the blog manager. HPLC of Formula: C8H8O3.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Electric Literature of 1679-64-7, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 1679-64-7, Name is 4-(Methoxycarbonyl)benzoic acid, SMILES is C1=CC(=CC=C1C(O)=O)C(OC)=O, belongs to phthalazines compound. In a article, author is Lyu, Xue-Li, introduce new discover of the category.

Visible-Light-Induced Copper-Catalyzed Decarboxylative Coupling of Redox-Active Esters with N-Heteroarenes

Herein we report a protocol for visible-light-induced copper-catalyzed decarboxylative coupling reactions between N-heteroarenes and redox-active esters. Various N-hydroxyphthalimide esters reacted with isoquinoline, quinoline, pyridine, pyrimidine, quinazoline, phthalazine, phenanthridine, and pyridazine to give the corresponding products in modest to excellent yields. The reactions proceed under mild conditions and have a broad scope and high functional group tolerance. Mechanistic studies revealed that the catalytic behavior of Cu-I photocatalyst generated in situ was consistent with that of preformed [Cu(dmp)(xantphos)]BF4.

Electric Literature of 1679-64-7, The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 1679-64-7 is helpful to your research.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. Category: phthalazines, 103-36-6, Name is Ethyl cinnamate, SMILES is O=C(OCC)/C=C/C1=CC=CC=C1, in an article , author is Boulebd, Houssem, once mentioned of 103-36-6.

Thermodynamic and Kinetic Studies of the Radical Scavenging Behavior of Hydralazine and Dihydralazine: Theoretical Insights

Hydralazine (HZ) and dihydralazine (DHZ) are phthalazine derivatives substituted at position 1 (HZ) or positions 1 and 4 (DHZ) by a hydrazinyl substituent. These compounds are widely used for treating hypertension and heart failure, essentially acting as vasodilators on the arteries and arterioles. In this study, the antioxidant activity of HZ and DHZ in the gas phase and in physiological environments was investigated by thermodynamic and kinetic calculations. It was found that the HOO center dot radical scavenging activity of these compounds follows the formal hydrogen transfer (FHT) mechanism. The H abstraction of the N9-H bond plays a deciding role in the HOO center dot radical scavenging of HZ-1 and DHZ-I, whereas the HOO center dot radical scavenging activities of HZ-2 and DHZ-2 are defined by the dissociation of the N10-H and Nil-H bonds, respectively. The rate constants for the HOO center dot radical scavenging of the HZ and DHZ in the gas phase are in the range of 9.64 x 10(6) to 4.52 x 10(8) M-1 s(-1), whereas in aqueous solutions and the lipid medium they are in the range of 2.62 X 10(4) to 5.13 x 10(7) M-1 s(-1) and 5.75 x 10(4) to 6.66 x 10(6) M-1 s(-1), respectively. The HOO center dot radical scavenging of DHZ-1 and DHZ-2 is thus faster than that of the reference antioxidant compound Trolox in all the studied environments. Consistently, DHZs are not only vasodilators but also potent antioxidants.

But sometimes, even after several years of basic chemistry education, it is not easy to form a clear picture on how they govern reactivity! 103-36-6, you can contact me at any time and look forward to more communication. Category: phthalazines.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Chemistry, like all the natural sciences, Recommanded Product: 103-36-6, begins with the direct observation of nature¡ª in this case, of matter.103-36-6, Name is Ethyl cinnamate, SMILES is O=C(OCC)/C=C/C1=CC=CC=C1, belongs to phthalazines compound. In a document, author is Chang, Sue-Ming, introduce the new discover.

Design and Synthesis of 1,2-Bis(hydroxymethyl)pyrrolo[2,1-a]phthalazine Hybrids as Potent Anticancer Agents that Inhibit Angiogenesis and Induce DNA Interstrand Cross-links

Hybrid molecules are composed of two pharmacophores with different biological activities. Here, we conjugated phthalazine moieties (antiangiogenetic pharmacophore) and bis(hydroxymethyl)pyrrole moieties (DNA cross-linking agent) to form a series of bis(hydroxymethyl)pyrrolo[2,1-a]phthalazine hybrids. These conjugates were cytotoxic to a variety of cancer cell lines by inducing DNA damage, arresting cell cycle progression at the G2/M phase, triggering apoptosis, and inhibiting vascular endothelial growth factor receptor 2 (VEGFR-2) in endothelial cells. Among them, compound 29d encapsulated in a liposomal formulation (e.g., 29dL) significantly suppressed the growth of small-cell lung cancer cell (H526) xenografts in mice. Based on immunohistochemical staining, the tumor xenografts in mice treated with 29dL showed time-dependent decreases in the intensity of CD31, a marker of blood vessels, whereas the intensity of gamma-H2AX, a marker of DNA damage, increased. The present data revealed that the conjugation of antiangiogenic and DNA-damaging agents can generate potential hybrid agents for cancer treatment.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 103-36-6. Recommanded Product: 103-36-6.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 620-14-4, Name is 3-Ethyltoluene, molecular formula is C9H12, belongs to phthalazines compound. In a document, author is Boulebd, Houssem, introduce the new discover, Category: phthalazines.

Thermodynamic and Kinetic Studies of the Radical Scavenging Behavior of Hydralazine and Dihydralazine: Theoretical Insights

Hydralazine (HZ) and dihydralazine (DHZ) are phthalazine derivatives substituted at position 1 (HZ) or positions 1 and 4 (DHZ) by a hydrazinyl substituent. These compounds are widely used for treating hypertension and heart failure, essentially acting as vasodilators on the arteries and arterioles. In this study, the antioxidant activity of HZ and DHZ in the gas phase and in physiological environments was investigated by thermodynamic and kinetic calculations. It was found that the HOO center dot radical scavenging activity of these compounds follows the formal hydrogen transfer (FHT) mechanism. The H abstraction of the N9-H bond plays a deciding role in the HOO center dot radical scavenging of HZ-1 and DHZ-I, whereas the HOO center dot radical scavenging activities of HZ-2 and DHZ-2 are defined by the dissociation of the N10-H and Nil-H bonds, respectively. The rate constants for the HOO center dot radical scavenging of the HZ and DHZ in the gas phase are in the range of 9.64 x 10(6) to 4.52 x 10(8) M-1 s(-1), whereas in aqueous solutions and the lipid medium they are in the range of 2.62 X 10(4) to 5.13 x 10(7) M-1 s(-1) and 5.75 x 10(4) to 6.66 x 10(6) M-1 s(-1), respectively. The HOO center dot radical scavenging of DHZ-1 and DHZ-2 is thus faster than that of the reference antioxidant compound Trolox in all the studied environments. Consistently, DHZs are not only vasodilators but also potent antioxidants.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 620-14-4. Category: phthalazines.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 619-67-0, Name is 4-Hydrazinylbenzoic acid, molecular formula is C7H8N2O2. In an article, author is Szavuly, Miklos,once mentioned of 619-67-0, SDS of cas: 619-67-0.

Catalytic oxidation of alcohols and sulfides with hydrogen peroxide using isoindoline and phthalazine-based diiron complexes

A series of diiron(III) complexes of 1,3-bis(2′-arylimino)isoindoline, [(Fe(L)Cl)(2)O] and 1,4-di-(2′-aryl)aminophthalazine, [Fe-2(mu-OMe)(2)(H2L)Cl-4], including new structurally characterized ligands, 1,4-di-(4′-methyl-2′-thiazolyl)aminophthalazine and 1,4-di-(2′-benzthiazolyl)-aminophthalazine, have been characterized, and used as catalysts for the oxidation of para-substituted phenyl methyl sulfides and benzyl alcohols. Hammett correlations and kinetic isotope effect experiments support the involvement of electrophilic metal-based oxidants. In case of [(Fe(L-1,L-2)Cl)(2)O] catalysts, direct correlation has been found between the oxidative and catalase-like activity. (C) 2014 Elsevier B.V. All rights reserved.

If you are hungry for even more, make sure to check my other article about 619-67-0, SDS of cas: 619-67-0.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. 90-64-2, Name is 2-Hydroxy-2-phenylacetic acid, SMILES is C1=CC=CC=C1C(C(O)=O)O, in an article , author is Marvi, Omid, once mentioned of 90-64-2, Recommanded Product: 2-Hydroxy-2-phenylacetic acid.

Solvent-free Synthesis of Phthalazine-2(1H)-carboxamide Derivatives Using K-10 Clay Under Microwave Irradiation

Montmorillonite K-10 clay catalyzes the reaction of different anhydrides with semicarbazide under microwave irradiation. The corresponding carboxamide derivatives are obtained in high yield and short reaction times.

Interested yet? Read on for other articles about 90-64-2, you can contact me at any time and look forward to more communication. Recommanded Product: 2-Hydroxy-2-phenylacetic acid.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

83-38-5, Name is 2,6-Dichlorobenzaldehyde, molecular formula is C7H4Cl2O, belongs to phthalazines compound, is a common compound. In a patnet, author is Uckun, Fatih M., once mentioned the new application about 83-38-5, SDS of cas: 83-38-5.

Nanoscale liposomal formulation of a SYK P-site inhibitor against B-precursor leukemia

We report preclinical proof of principle for effective treatment of B-precursor acute lymphoblastic leukemia (ALL) by targeting the spleen tyrosine kinase (SYK)-dependent antiapoptotic blast cell survival machinery with a unique nanoscale pharmaceutical composition. This nanoscale liposomal formulation (NLF) contains the pentapeptide mimic 1,4-Bis (9-O dihydroquinidinyl) phthalazine/hydroquinidine 1,4-phathalazinediyl diether (C61) as the first and only selective inhibitor of the substrate binding P-site of SYK. The C61 NLF exhibited a very favorable pharmacokinetic and safety profile in mice, induced apoptosis in primary B-precursor ALL blast cells taken directly from patients as well as in vivo clonogenic ALL xenograft cells, destroyed the in vivo clonogenic fraction of ALL blast cells, and, at nontoxic dose levels, exhibited potent in vivo antileukemic activity against patient-derived ALL cells in xenograft models of aggressive B-precursor ALL. Our findings establish SYK as an attractive molecular target for therapy of B-precursor ALL. Further development of the C61 NLF may provide the foundation for therapeutic innovation against therapy-refractory B-precursor ALL.

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

In an article, author is Munin, Javier, once mentioned the application of 88-99-3, Name is Pathalic acid, molecular formula is C8H6O4, molecular weight is 166.1308, MDL number is MFCD00002467, category is phthalazines. Now introduce a scientific discovery about this category, Computed Properties of C8H6O4.

A comparative synthesis of 6-benzyl-2,3-dihydroimidazo[2,1-a]phthalazine and 2H-7-benzyl-3,4-dihydropyrimido[2,1-a]phthalazine

Two new synthetic strategies have been developed for the synthesis of a new class of cyclophthalazine derivatives. 6-BenzyL-2,3-dihydroimidazo[2,1-a]phthalazine and 2H-7-benzyl-3,4-dihydropyrimido[2,1-a]phthalazine were obtained (i) by intramolecular cyclization of the 2-(aminoalkyl)-4-benzyl-2H-phthalazin-1-one or (ii) by intramolecular cyclization of the corresponding 2-(4-benzylphthalazin-1(2H)-ylide-neamino)alcohols previously prepared. The second of the described routes afforded the desired derivatives in high yields. (C) 2015 Elsevier Ltd. All rights reserved.

Do you like my blog? If you like, you can also browse other articles about this kind. Thanks for taking the time to read the blog about 88-99-3, Computed Properties of C8H6O4.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

90-64-2, Name is 2-Hydroxy-2-phenylacetic acid, molecular formula is C8H8O3, belongs to phthalazines compound, is a common compound. In a patnet, author is Shirini, Farhad, once mentioned the new application about 90-64-2, HPLC of Formula: C8H8O3.

1,4-Disulfopiperazine-1,4-diium chloride ([Piper-(SO3H2)center dot 2Cl) as an efficient ionic catalyst for synthesis of phthalazine derivatives

This article describe the applicability of 1,4-disulfopiperazine-1,4-diium chloride ([Piper-(SO3H)(2)].2Cl) as a green, versatile and Bronsted acidic ionic catalyst in the promotion of the synthesis of phthalazine derivatives via one-pot three component reaction between aromatic aldehydes, 1,3-diketone derivatives and phthalhydrazide under solvent-free reaction conditions. The main advantages of this method are: (1) simplicity of the procedure, (2) solvent-free conditions, (3) availability of the starting materials, (4) high reaction rates and excellent yields, (5) reusability of the catalyst and (6) no column chromatographic of the products.

If you¡¯re interested in learning more about 90-64-2. The above is the message from the blog manager. HPLC of Formula: C8H8O3.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem