Tag: M.W:100-200

Electric Literature of 767-00-0, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C¨CH bond functionalisation has revolutionised modern synthetic chemistry. 767-00-0, Name is 4-Hydroxybenzonitrile, SMILES is OC1=CC=C(C=C1)C#N, belongs to phthalazines compound. In a article, author is Cui, Zhi-Ming, introduce new discover of the category.

Simple Analogues of Quaternary Benzo[c]phenanthridine Alkaloids: Discovery of a Novel Antifungal 2-Phenylphthalazin-2-ium Scaffold with Excellent Potency against Phytopathogenic Fungi

Inspired by sanguinarine and chelerythrine, a novel antifungal 2-phenylphthalazin-2-ium scaffold as a simple analogue was designed. Most of the 30 compounds showed excellent inhibition activity against almost all eight phytopathogenic fungi, far superior to sanguinarine and chelerythrine. A third of the compounds were more active than azoxystrobin in most cases. Compounds 26 and 27 showed the highest total activity against all the fungi with EC50 means of ca. 4.6 mu g/mL. Fusarium solani showed the highest susceptibility with an EC50 mean of 3.62 mu g/mL to 19 compounds. A concentration of 25.0 mu g/mL 27 can fully control the Colletotrichum gloeosporioides infection in apples over 9 days. Electron microscopic observations showed that 27 was able to damage the structures of the hypha and cell membrane. The structure-activity relationship showed that the presence of electron-withdrawing groups on the C-ring increases the activity against most of the fungi. Thus, 2-phenylphthalazin-2-ium compounds represent promising leads for the development of novel fungicides.

Electric Literature of 767-00-0, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 767-00-0.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

122-99-6, Name is 2-Phenoxyethanol, molecular formula is C8H10O2, Product Details of 122-99-6, belongs to phthalazines compound, is a common compound. In a patnet, author is Im, Jeong Kyun, once mentioned the new application about 122-99-6.

N-Chlorinative Ring Contraction of 1,4-Dimethoxyphthalazines via a Bicyclization/Ring-Opening Mechanism

An unprecedented N-chlorinative ring contraction of 1,2-diazines was discovered and investigated with an electrophilic chlorinating reagent, trichloroisocyanuric acid (TCICA). Through optimization and mechanistic analysis, the assisting role of n-Bu4NCl as an exogenous nucleophile was identified, and the optimized reaction conditions were applied to a range of 1,4-dimethoxyphthalazine derivatives. Also, an improvement of overall efficiency was demonstrated by the use of a labile O-silyl group. A bicyclization/ring-opening mechanism, inspired by the Favorskii rearrangement, was proposed and supported by the DFT calculations. Furthermore, the efforts on scope expansion as well as the evaluation of other electrophilic promoters revealed that the newly developed ring contraction reactivity is a unique characteristic of 1,4-dimethoxyphthalazine scaffold and TCICA.

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 104-86-9, Name is (4-Chlorophenyl)methanamine, molecular formula is C7H8ClN. In an article, author is Abed, Hassen Bel,once mentioned of 104-86-9, Recommanded Product: 104-86-9.

Organophosphorus-catalyzed diaza-Wittig reaction: application to the synthesis of pyridazines

The elaboration of the first organophosphorus-catalyzed diaza-Wittig reaction is reported. This catalytic reaction is applied to the synthesis of substituted pyridazine and phthalazine derivatives bearing electron-withdrawing groups with good to excellent yields from substrates containing a diazo functionality as the starting material and a phospholene oxide as the catalyst.

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 103-36-6, Name is Ethyl cinnamate, molecular formula is C11H12O2, belongs to phthalazines compound. In a document, author is Mourad, Asmaa Kamal, introduce the new discover, Recommanded Product: Ethyl cinnamate.

Phthalazines and phthalazine hybrids as antimicrobial agents: Synthesis and biological evaluation

Phthalazine and phthalazinone derivatives are important owing to their significant biological activities and pharmacological properties. Herein, a benzoic acid derivative (2), a benzoxazin-1-one derivative (3), and an oxophthalazin-2(1H)-yl)acetohydrazide (13) are utilized as precursors to construct a novel series of phthalazinones bearing various valuable functional groups in excellent yields via several simple and promising approaches. Finally, the antimicrobial activity of the newly synthesized phthalazines is screened against different microbial strains; namely, Gram-negative and Gram-positive bacteria utilizing Amoxicillin as a standard drug.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 103-36-6. Recommanded Product: Ethyl cinnamate.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

In an article, author is Lashkari, Mojtaba, once mentioned the application of 1821-12-1, Name is 4-Phenylbutanoic acid, molecular formula is C10H12O2, molecular weight is 164.2011, MDL number is MFCD00004403, category is phthalazines. Now introduce a scientific discovery about this category, Safety of 4-Phenylbutanoic acid.

A Facile Approach for One-Pot Synthesis of 1H-pyrazolo [1,2-b]phthalazine-5,10-dione Derivatives Catalyzed by ZrCl4 as an Efficient Catalyst Under Solvent-Free Conditions

A simple synthesis of 1H-pyrazolo[1,2-b]phthalazine-5,10-dione derivatives via one-pot four-component condensation reaction of phthalimide, hydrazine monohydrate, aromatic aldehyde derivatives and malononitrile in the presence of a catalytic amount of zirconium tetrachloride (ZrCl4) as a mild and efficient Lewis acidic catalyst under thermal and solvent-free conditions with good yields and short reaction times is developed. This present methodology has notable benefits such as high efficiency, inexpensive and non-toxic catalyst, environmentally benign nature, solvent-free conditions and simplicity of operation.

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

In an article, author is Taslimi, Parham, once mentioned the application of 41263-74-5, Quality Control of 4-(Methylamino)-3-nitrobenzoic acid, Name is 4-(Methylamino)-3-nitrobenzoic acid, molecular formula is C8H8N2O4, molecular weight is 196.16, MDL number is MFCD00464322, category is phthalazines. Now introduce a scientific discovery about this category.

2H-Indazolo[2,1-b]phthalazine-trione derivatives: Inhibition on some metabolic enzymes and molecular docking studies

In this study, substituted 2H-indazolo[2,1-b]phthalazine-1,6,11-trione compounds (4a-d) obtained via one-pot three-component condensation reaction of aromatic aldehydes, cyclic 1,3-dione, and phthalhydrazide in ethanol catalyzed by Y(OTf)(3) showed satisfactory inhibitory effects against some important enzymes. Also, these molecules had K-i values in the row of 185.92 +/- 36.03-294.82 +/- 50.76 nM vs carbonic anhydrase I (CA I), 204.93 +/- 46.90-374.10 +/- 83.63 nM against human CA II, 937.16 +/- 205.82-1021.83 +/- 193.66 nM against alpha-glycosidase (alpha-Gly), respectively. For cholinesterase enzymes, the K-i values were found in the range of 47.26 +/- 9.62-72.05 +/- 19.47 nM against acetylcholinesterase (AChE) and 65.03 +/- 9.88-102.83 +/- 25.04 nM against butyrylcholinesterase (BChE), respectively. The inhibition effects of these compounds against enzymes whose name are AChE, BChE, alpha-Gly, hCA I, and hCA II, were compared with control molecules like tacrine, acarbose, and acetazolamide.

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, such as the rate of change in the concentration of reactants or products with time. 875-74-1, Name is H-D-Phg-OH, formurla is C8H9NO2. In a document, author is Nfor, Emmanuel N., introducing its new discovery. Category: phthalazines.

Synthesis, crystal structure and antifungal activity of a Ni(II) complex of a new hydrazone derived from antihypertensive drug hydralazine hydrochloride

A new complex of nickel(II) with 1-(2-[(5-methylfuran-2yl)methylene)] hydrazono) phthalazine HL (1) has been synthesized and characterized by elemental analysis, IR, electronic spectra, TGA, H-1 and C-13 NMR spectroscopy. The crystal structures of the free ligand and its complex have been determined by single crystal X-ray diffraction techniques. In the complex the hydrazone ligand chelates to the nickel(II) through nitrogen atoms in a bidentate manner. The antifungal activity of the ligand and its nickel(II) complex 3 was studied against Aspergillus niger, Aspergillus flavus and Candida albicans. The results revealed modest activity of the complex (3) against the tested organisms with inhibition zones of 14, 14 and 13 mm, compared to the free ligand 1 with inhibition zones of 11 mm each for A. niger, A. flavus and C. albicans respectively. (C) 2013 Elsevier Ltd. All rights reserved.

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Chemistry, like all the natural sciences, begins with the direct observation of nature¡ª in this case, of matter.495-69-2, Name is 2-Benzamidoacetic acid, SMILES is O=C(O)CNC(C1=CC=CC=C1)=O, belongs to phthalazines compound. In a document, author is Farahmand, Shohreh, introduce the new discover, Quality Control of 2-Benzamidoacetic acid.

Pentaerythritol as efficient H-bonding organocatalyst for synthesis of indazolo[2,1-b]phthalazine-trione derivatives

Pentaerythritol was applied as an effective, biodegradable, nontoxic, mild, and commercially available H-bonding organocatalyst for synthesis of indazolo[2,1-b]phthalazine-trione derivatives via one-pot three-component condensation of aromatic aldehydes, phthalhydrazide, and dimedone under thermal solvent-free conditions in high to excellent yield.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 495-69-2 is helpful to your research. Quality Control of 2-Benzamidoacetic acid.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem