Tag: M.W:100-200

89898-86-2, Rate laws may be derived directly from the chemical equations for elementary reactions. This is not the case, however, for ordinary chemical reactions.5-Nitrophthalazine, cas is 89898-86-2,the phthalazine compound, below Introduce a new synthetic route.

B. A solution of 5-nitro-phthalazine (0.175 g, 1 mmol) and SnCl2 (0.57 g, 3 mmol) in concentrated HCl (10 mL) is stirred at room temperature for 2 h. Ice is added to the solution. A solution of 25% NaOH is added to pH 14 (litmus). The solution is cooled for 18 h. The solution is filtered. Aqueous filtrate is extracted twice with EtOAc. EtOAc layers are combined, washed with water, brine, dried over Na2SO4, filtered and concentrated to give phthalazin-5-ylamine (0.050 g).

89898-86-2, There are, however, a few established termolecular elementary reactions. The reaction of nitric oxide with oxygen appears to involve termolecular steps. you can also browse my other articles about 89898-86-2

Reference£º
Patent; Calvo, Raul R.; Cheung, Wing S.; Player, Mark R.; US2006/116368; (2006); A1;,
Phthalazine – Wikipedia
Phthalazine | C8H6N2 – PubChem

119-39-1, An elementary termolecular reaction involves the simultaneous collision of three atoms, molecules, or ions.Phthalazin-1(2H)-one, cas is 119-39-1,the phthalazine compound. Here is a downstream synthesis route of the compound 119-39-1

General procedure: To a solution of sodium methoxide (0.0165 mol) in dry MeOH (70 ml) was added 2H-phthalazin-1-one 1 (0.0153 mol). The mixture was heated to boiling for 30 minutes. Afterwards, toluene-4-sulfonic acid 2-[methyl-(toluene-4-sulfonyl)-amino]-ethyl ester (6) (0.0230 mol) was added and heating was continued for next 7 hrs. After this time, the mixture was cooled to ambient temperature. The separated product was filtrated off, washed with dry methanol and purified by crystallization or column chromatography.

119-39-1, There are, however, a few established termolecular elementary reactions. The reaction of nitric oxide with oxygen appears to involve termolecular steps. you can also browse my other articles about 119-39-1

Reference£º
Article; Malinowski, Zbigniew; Szczes?niak, Aleksandra K.; Pakulska, Wanda; Sroczy?ski, Dariusz; Czarnecka, Elzbieta; Epsztajn, Jan; Synthetic Communications; vol. 44; 24; (2014); p. 3572 – 3581;,
Phthalazine – Wikipedia
Phthalazine | C8H6N2 – PubChem

A heterogeneous catalyst is a catalyst that is present in a different phase than the reactants. Such catalysts generally function by furnishing an active surface upon which a reaction can occur. 119-39-1, name is Phthalazin-1(2H)-one, introduce a new downstream synthesis route as follows. 119-39-1

A mixture of ethyl 3-[1-[4-(2-bromoethoxy)benzyl]-3-phenyl-1H-pyrazol-4-yl]propionate (1050 mg), 1(2H)-phthalazinone (530 mg), potassium carbonate (1000 mg) and N,N-dimethylformamide (15 ml) was stirred at 90C for 5 hours. The reaction mixture was poured into water, and extracted with ethyl acetate. The ethyl acetate layer was washed successively with dilute hydrochloric acid and saturated aqueous sodium chloride solution, dried (MgSO4) and concentrated. The residue was subjected to silica gel column chromatography to obtain a colorless oily substance from the fraction eluted with ethyl acetate-hexane (1:1, volume ratio). After a mixture of the resulting colorless oily substance, 1N aqueous sodium hydroxide solution (5 ml), tetrahydrofuran (5 ml) and ethanol (5 ml) was stirred at room temperature for 3 hours, 1N hydrochloric acid (5 ml) was added to the mixture, and then the mixture was extracted with ethyl acetate. The ethyl acetate layer was washed with a saturated aqueous sodium chloride solution, dried (MgSO4), and concentrated. The resulting colorless crystals were collected by filtration to obtain 3-[1-[4-[2-[1-oxophthalazin-2(1H)-yl]ethoxy]benzyl]-3-phenyl-1H-pyrazol-4-yl]propionic acid (1460 mg, yield : 90%). This was recrystallized from acetone-hexane. Melting point: 155-156C.

Other significant industrial processes that involve the use of heterogeneous catalysts include the preparation of sulfuric acid, the preparation of ammonia, the oxidation of ammonia to nitric acid, and the synthesis of methanol.119-39-1, if you are interested, you can browse my other articles.

Reference£º
Patent; Takeda Chemical Industries, Ltd.; EP1228067; (2004); B1;,
Phthalazine – Wikipedia
Phthalazine | C8H6N2 – PubChem

One of the major reasons is to use measurements of the macroscopic properties of a system, such as the rate of change in the concentration of reactants or products with time, to discover the sequence of events that occur at the molecular level.6-Amino-2,3-dihydrophthalazine-1,4-dione, cas is 3682-14-2,the phthalazine compound, introduce a new downstream synthesis route. 3682-14-2

A solution of 400 mg (1.44 mM) of 4-chloro-6,7-diethoxy-quinoline-3-carbonitrile and 273 mg (1.54 mM) of 4-Aminophthalhydrazide Hydrate in 15 ml of 2-methoxyethanol was refluxed for 3 hours. To the warm solution was added 1 ml of 1M sodium carbonate and the sample was heated for 5 minutes at 100C, then poured into 300 ml of ice water. The solution was made acetic by addition of concentrated HCl and the solid was collected, washed with water followed by ether and dried under vacuum at 80C. The solid was taken up into 200 ml of methanol and 500l of 5 N sodium hydroxide and boiled for 20 minutes. To this heterogeneous mixture was added 100 ml of glacial acetic acid and the volume was reduced to a total of 100 ml by boiling. To the room temperature mixture, 500 ml of ice cold water was added and the solid was collected, washed with water followed by ether and dried under vacuum at 80C. The solid was digested in 400 ml of ethanol until the volume had been reduced to 150 ml. The hot solution was filtered and the solid was washed with ethanol and to dried under vacuum at 80C yield 121 mg of the title compound as a white solid: mass spectrum (electrospray, m/e): M+H 418.0, mp = >270C.

The chemical industry reduces the impact on the environment during synthesis,3682-14-2,6-Amino-2,3-dihydrophthalazine-1,4-dione,I believe this compound will play a more active role in future production and life.

Reference£º
Patent; Wyeth Holdings Corporation; EP1117659; (2003); B1;,
Phthalazine – Wikipedia
Phthalazine | C8H6N2 – PubChem

89898-86-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 5-Nitrophthalazine, cas is 89898-86-2,the phthalazine compound, it is a common compound, a new synthetic route is introduced below.

To 0.88g (5.0mmol) of 5-nitrophthalazine in 30mL of tetrahydrofuran at 50C was added 4.37g (25.1mmol) of sodium hydrogen sulfite in 15mL of water. The reaction mixture was stirred at 50C for 15min. The organic solution was extracted with ethyl acetate (3¡Á100mL), washed with brine (50mL), and dried over magnesium sulfate. Filtration and removal of the solvent under reduced pressure gave the product as a bright yellow precipitate. The precipitate was recrystallized in a hot methanol solution to afford 0.49g (67%) of 5-aminophthalazine. 1H NMR (400MHz, DMSO-d6) delta: 9.80 (s, 1H), 9.60 (s, 1H), 7.60 (dd, J=4. 6, 7.6Hz, 1H), 7.20 (dd, J=1.9, 4.6Hz, 1H), 7.02 (d, J=7.6Hz, 1H), 6.50 (s, 2H). 13C NMR (100.17MHz, DMSO-d6) delta: 150.1, 146.5, 145.1, 133.2, 126.1, 114.7, 114.1, 112.2.

Other significant industrial processes that involve the use of heterogeneous catalysts include the preparation of sulfuric acid, the preparation of ammonia, the oxidation of ammonia to nitric acid, and the synthesis of methanol.89898-86-2, if you are interested, you can browse my other articles.

Reference£º
Article; Paige, Mikell; Kosturko, George; Bulut, Guellay; Miessau, Matthew; Rahim, Said; Toretsky, Jeffrey A.; Brown, Milton L.; Ueren, Aykut; Bioorganic and Medicinal Chemistry; vol. 22; 1; (2014); p. 478 – 487;,
Phthalazine – Wikipedia
Phthalazine | C8H6N2 – PubChem

253-52-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. Phthalazine, cas is 253-52-1,the phthalazine compound, it is a common compound, a new synthetic route is introduced below.

Example 1A1,2-phenylenedimethanamine[0168]Phthalazine (21.5 g, 0.165 mol), 10percent palladium on carbon (2 g), and methanol (125 mL) were combined in a pressure bottle and shaken at room temperature under 60 psi of hydrogen for 5 days. Raney-nickel? slurry (6.42 g) and 10percent palladium on carbon (0.50 g) were added, and the mixture was shaken at 50¡ã C. under 60 psi of hydrogen for 16 hours. The mixture was filtered through a nylon membrane and concentrated to give the titled compound: 1H NMR (300 MHz, DMSO-d6) delta ppm 7.32 (dd, J=5.4, 3.5 Hz, 2H), 7.17 (dd, J=5.6, 3.4 Hz, 2H), 3.74 (s, 4H); MS (DCI/NH3) m/z 137 (M+H)+.

253-52-1. Other significant industrial processes that involve the use of heterogeneous catalysts include the preparation of sulfuric acid, the preparation of ammonia, the oxidation of ammonia to nitric acid, and the synthesis of methanol.253-52-1, if you are interested, you can browse my other articles.

Reference£º
Patent; AbbVie Inc.; Cowart, Marlon D.; Liu, Huaqing; Altenbach, Robert; US2013/40940; (2013); A1;,
Phthalazine – Wikipedia
Phthalazine | C8H6N2 – PubChem

The molecularity of an elementary reaction is the number of molecules that collide during that step in the mechanism. 253-52-1, If there is only a single reactant molecule in an elementary reaction, that step is designated as unimolecular.Phthalazine, cas is 253-52-1,the phthalazine compound. A new synthetic method of this compound is introduced below.

Example 29 Preparation of (RS)-1-(4-fluoro-phenyl)-1,2-dihydro-phthalazine 5.53 ml of a 1.6 M solution of butyllithium in hexane are added dropwise at -78¡ã C. within 20 min. to a solution of 1.48 g of 1-bromo-4-fluoro-benzene in 5 ml of tetrahydrofuran. The resulting white suspension is stirred for a further hour. A solution of 1 g of phthalazine in 5 ml of tetrahydrofuran is added dropwise at -78¡ã C. within 10 min. The reaction mixture is left to warm to room temperature, treated with 50 ml of water and extracted 3 times with 50 ml of dichloromethane each time. The organic phases are combined washed with 50 ml of water and 50 ml of a saturated sodium chloride solution, dried over magnesium sulphate, filtered, the filtrate is concentrated and the residue is chromatographed on 100 g of silica gel with the eluent hexane/ethyl acetate 1:1. 1.49 g (86percent) of (RS)-1-(4-fluoro-phenyl)-1,2-dihydro-phthalazine are obtained as a yellow oil. MS: 227 (M+H)+.

253-52-1, In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles.,253-52-1 ,Phthalazine, other downstream synthetic routes, hurry up and to see

Reference£º
Patent; Hoffmann-La Roche Inc.; US6114330; (2000); A;,
Phthalazine – Wikipedia
Phthalazine | C8H6N2 – PubChem

The molecularity of an elementary reaction is the number of molecules that collide during that step in the mechanism. 253-52-1, If there is only a single reactant molecule in an elementary reaction, that step is designated as unimolecular.Phthalazine, cas is 253-52-1,the phthalazine compound. A new synthetic method of this compound is introduced below.

General procedure: Phthalazine (1) (91 mg, 0.70 mmol), 1,1-dicyanoalkene 2(0.70 mmol), and isocyanide 3 (0.70 mmol) were dissolvedin acetonitrile (1 ml). After that, distilled water(0.05?0.1 ml) was added to the reaction mixture up tovisible turbidity and stirred at 25?30¡ãC for 12?18 h. Thereaction mixture was evaporated to dryness and product 4was purified by crystallization from ethanol.

253-52-1, In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles.,253-52-1 ,Phthalazine, other downstream synthetic routes, hurry up and to see

Reference£º
Article; Mironov, Maxim A.; Shulepov, Iliya D.; Kozhikhova, Ksenia V.; Ivantsova, Maria N.; Tokareva, Maria I.; Chemistry of Heterocyclic Compounds; vol. 53; 4; (2017); p. 430 – 433; Khim. Geterotsikl. Soedin.; vol. 53; 4; (2017); p. 430 – 433,4;,
Phthalazine – Wikipedia
Phthalazine | C8H6N2 – PubChem

The molecularity of an elementary reaction is the number of molecules that collide during that step in the mechanism. If there is only a single reactant molecule in an elementary reaction, that step is designated as unimolecular.Phthalazin-1(2H)-one, cas is 119-39-1,the phthalazine compound. A new synthetic method of this compound is introduced below. 119-39-1

To a solution of sodium methoxide (1.52¡Á10-2 mol) in dry MeOH (40 cm3) was added 2H-phthalazin-1-one 2 (0.0137 mol). The mixture was heated under reflux for 30 minutes. Afterwards, N-tosylaziridine (1.64¡Á10-2 mol) was added and heating was continued for next 10 h. Then the mixture was cooled to ambient temperature and neutralized by solution of hydrochloric acid (1:1). The separated product was filtrated, washed with dry MeOH and purified by recrystallization from AcOEt.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of Phthalazin-1(2H)-one, 119-39-1

Reference£º
Article; Malinowski, Zbigniew; Sroczy?ski, Dariusz; Szczes?niak, Aleksandra K.; Synthetic Communications; vol. 45; 15; (2015); p. 1743 – 1750;,
Phthalazine – Wikipedia
Phthalazine | C8H6N2 – PubChem

253-52-1, An elementary termolecular reaction involves the simultaneous collision of three atoms, molecules, or ions.Phthalazine, cas is 253-52-1,the phthalazine compound. Here is a downstream synthesis route of the compound 253-52-1

General procedure: A solution of sodium azide (0.085 g, 1.3 mmol) in water (10 ml) was slowly added to the methanolic solution (15 ml) of Cd(NO3)24H2O (0.2 g, 0.65 mmol) and quinazoline (0.17 g, 1.30 mmol) and stirred at room temperature for 12 h. Light yellow crystalline precipitate of [Cd(Qnz)2(N3)2]n was collected in 70percent yield. The crystals suitable for X-ray structure determination were obtained by slow recrystallization from methanol

253-52-1, There are, however, a few established termolecular elementary reactions. The reaction of nitric oxide with oxygen appears to involve termolecular steps. you can also browse my other articles about 253-52-1

Reference£º
Article; Machura; Nawrot; Kruszynski; Dulski; Polyhedron; vol. 54; (2013); p. 272 – 284;,
Phthalazine – Wikipedia
Phthalazine | C8H6N2 – PubChem