Tag: M.W:100-200

Having gained chemical understanding at molecular level, chemistry graduates may choose to apply this knowledge in almost unlimited ways, as it can be used to analyze all matter and therefore our entire environment., Name: 2,4-Dimethoxybenzaldehyde, 613-45-6, Name is 2,4-Dimethoxybenzaldehyde, SMILES is O=CC1=CC=C(OC)C=C1OC, belongs to phthalazine compound. In a document, author is Saundane, Anand R., introduce the new discover.

A new series of novel compounds 1-tert-butyl-9-substituted-12H-indolo[2,3-c]isoquinolino[5,6-c]-1,2,4-triazoles (4a-4c), 10-substituted-2-phenyl-1,13-dihydroindolo[2,3-c]isoquinolino[5,6-c]-1,2,4-triazines (5a-5l), 2-(10-substituted-7H-indolo[2,3-c]isoquinolin-5-yl)-4-phenylphthalazin-1-ones (6a-6c), 2-[2-(10-substituted-7H-indolo[2,3-c]isoquinolinyl)hydrazinecarbonyl]benzoic acid (7a-7c), and 2-(10-substituted-7H-indolo[2,3-c]isoquinolin-5-yl)phthalazine-1,4-diones (8a-8c) were synthesized. The structures of these newly synthesized compounds were confirmed by their spectral studies and elemental analysis. These compounds have been screened for their antimicrobial, antitubercular, antioxidant, and cytotoxic activities. Compounds 4b, 5a, 5g, 5h, 6a, 6b, and 7b exhibited the maximum zone of inhibition against Staphylococcus aureus. Compounds 5d and 6c exhibited the maximum zone of inhibition against Pseudomonas aeruginosa. Compounds 7a and 8c showed maximum zone of inhibition against Aspergillus niger. Compounds 5k and 8c showed maximum zone of inhibition against Aspergillus flavus. Compounds 4a (MIC-1.6 A mu g/ml) and 5 h (MIC-0.2 A mu g/ml) exhibited promising antitubercular activity against Mycobacterium tuberculosis H37Rv strain. Compounds 4b, 4c, 5a, 5c, 5e, 5h, 6a, 6b, 6c, 8a, and 8b exhibited good radical scavenging activity compared with standards. Compounds 4b, 4c, 5a, 5c, 5g, 6a, and 8b exhibited maximum reducing ability. Compounds 4a and 5h exhibited 100 % cell lysis at concentration 10 A mu g/ml.

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

The dynamic chemical diversity of the numerous elements, ions and molecules that constitute the basis of life provides wide challenges and opportunities for research. In an article, author is Engle, James T., once mentioned the application of 402-50-6, Name is 1-(Trifluoromethyl)-4-vinylbenzene, molecular formula is C9H7F3, molecular weight is 172.1471, MDL number is MFCD00075539, category is phthalazine. Now introduce a scientific discovery about this category, Related Products of 402-50-6.

This report presents the single crystal X-ray structures of several substituted isoindolines that have been frequently used as starting materials for phthalocyanines, phthalocyanine analogs and related chelates. The structures of 1,3-diiminoisoindoline (1), 1,3-bis(hydroxyimino) isoindoline (2), 1,4-diaminophthalazine (3), 1,1,3-trichloroisoindoline (4) and 3-imino-1-oxoisoindoline (5) are reported; compounds 2 and 3 are synthesized from diiminoisoindoline (1) and 4 and 5 are produced from phthalimide. All five compounds are planar macrocycles, and localization of double bonds can be readily determined. We elucidated one of the known structures of 1 at low temperature, and observed two additional new structures of 1. For the crystal forms of 1 and compounds 2, 3, and 5, hydrogen bonding in the solid state was observed. Compounds 1, 2 and 3 form extended hydrogen bonded arrays in the solid state, whereas 5 forms discrete hydrogen bonded dimers.

Related Products of 402-50-6, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. I hope my blog about 402-50-6 is helpful to your research.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Chemistry involves the study of all things chemical – chemical processes, chemical compositions and chemical manipulation – in order to better understand the way in which materials are structured, how they change and how they react in certain situations. , Computed Properties of https://www.ambeed.com/products/623-25-6.html, 623-25-6, Name is α,α’-Dichloro-p-xylene, molecular formula is C8H8Cl2, belongs to phthalazine compound. In a document, author is Sherif, Yousery E., introduce the new discover.

1,4-Dioxo-3, 4, 4e, 5, 10, 10a-hexahydro-1H-5,10-benzenobenzo [g] phthalazin-2-yl-thioamide [6a]; 1,4-dioxo-3, 4, 4e, 5, 10, 10a-hexahydro-1H-5, 10-benzenobenzo [g] phthalazin-2-yl-N-pyridylthioamide [6b] and 1,4-dioxo-3, 4, 4e, 5, 10, 10a-hexahydro-1H-5, 10-benzenobenzo[g]phthalazin-2-yl-N-ethylthioamide [6c] and their [Cu(6a-H)(OAc)], [Zn(6a-H)(OAc)], [Cu(6b-H)(H2O)(2)(OAc)]center dot 3H(2)O and [Zn(6b-H)(OAc)], [Cu-2(6c-H)](OAc)(3)]center dot 2H(2)O and [Zn(6c-H)(OAc)] complexes have been synthesized via a reaction between phthalazinedione 6a-c derivatives and the acetate salt of Cu(II) or Zn(II). These compounds were characterized by elemental analysis, spectra (UV-Vis, IR, H-1 NMR, C-13 NMR, ESR), conductance, thermal analysis and magnetic moments.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 623-25-6. Computed Properties of https://www.ambeed.com/products/623-25-6.html.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Some examples of the diverse research done by chemistry experts include discovery of new medicines and vaccines, improving understanding of environmental issues, and development of new chemical products and materials. 643-79-8, Name is Benzene-1,2-dicarboxaldehyde, molecular formula is C8H6O2, SDS of cas: 643-79-8, belongs to phthalazine compound, is a common compound. In a patnet, author is Piryaei, Forozan, once mentioned the new application about 643-79-8.

The synthesis of 1H-indazolo[1,2-b]phthalazine-1,6,11(13H)-trione derivatives, using one-pot three-component condensation reaction of 3-nitrophthalic anhydride, hydrazine monohydrate, dimedone, and aromatic aldehydes in the presence of ZrO(NO3)(2).2H(2)O as the novel catalyst and in reflux conditions in EtOH was reported. Quantum theoretical calculations for three structures of compounds (5a, 5b, and 5c) were performed using the Hartree-Fock (HF) and density functional theory (DFT). From the optimized structure, geometric parameters were obtained and experimental measurements were compared with the calculated data. The structures of the products were confirmed by IR, H-1 NMR, C-13 NMR, mass spectra, and elemental analyses. The IR spectra data and H-1 NMR and C-13 NMR chemical shift computations of the 1H-indazolo[1,2-b]phthalazine-1,6,11(13H)-trione derivatives in the ground state were calculated. Frontier molecular orbitals (FMOs), total density of states (DOS), thermodynamic parameters, and molecular electrostatic potential (MEP) of the title compounds were investigated by theoretical calculations. Molecular properties such as the ionization potential (I), electron affinity (A), chemical hardness (eta), electronic chemical potential (mu), and electrophilicity (omega) were investigated for the structures. Thus, there was an excellent agreement between experimental and theoretical results.

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 643-79-8 help many people in the next few years. SDS of cas: 643-79-8.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

You could be based in a university, combining chemical research with teaching; in a pharmaceutical company, working on developing and trialing new drugs; helping to ensure national healthcare provision keeps pace with new discoveries. 775-12-2, Name is Diphenylsilane, SMILES is C1([SiH2]C2=CC=CC=C2)=CC=CC=C1, belongs to phthalazine compound. In a document, author is Jalili-Baleh, Leili, introduce the new discover, Computed Properties of https://www.ambeed.com/products/775-12-2.html.

A novel series of tacrine-like compounds 7a-u possessing a fused pyrazolo[1,2-b]phthalazine structure were designed and synthesized as potent and selective inhibitors of AChE. The in-vitro biological assessments demonstrated that several compounds had high anti-AChE activity at nano-molar level. The more promising compound 71 with IC50 of 49 nM was 7-fold more potent than tacrine and unlike tacrine, it was highly selective against AChE over BuChE. The cell-based assays against hepatocytes (HepG2) and neuronal cell line (PC12) revealed that 71 had significantly lower hepatotoxicity compared to tacrine, with additional neuroprotective activity against H2O2-induced damage in PC12 cells. This compound could also inhibit AChE-induced and self-induced A beta peptide aggregation. The advantages including synthetic accessibility, high potency and selectivity, low toxicity, adjunctive neuroprotective and A beta aggregation inhibitory activity, make this compound as a new multifunctional lead for Alzheimer’s disease drug discovery. (C) 2017 Elsevier Masson SAS. All rights reserved.

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Researchers are common within chemical engineering and are often tasked with creating and developing new chemical techniques, frequently combining other advanced and emerging scientific areas. Synthetic Route of 88-99-3, 88-99-3, Name is Pathalic acid, SMILES is O=C(O)C1=CC=CC=C1C(O)=O, in an article , author is Abdel-Rahman, Reda M., once mentioned of 88-99-3.

The present review summarizes the synthetic strategies to functionalized bridgehead nitrogen heteroannulated 1,2,4-triazine systems as well as their regiospecific and pharmacological properties.

Synthetic Route of 88-99-3, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 88-99-3.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Recommanded Product: 66-99-9, While the job of a research scientist varies, most chemistry careers in research are based in laboratories, where research is conducted by teams following scientific methods and standards. 66-99-9, Name is 2-Naphthaldehyde, SMILES is O=CC1=CC=C2C=CC=CC2=C1, belongs to phthalazine compound. In a article, author is Turkes, Cuneyt, introduce new discover of the category.

The synthesis, characterization and biological evaluation of a series of novel N-substituted phthalazine sulfonamide (5a-1) are disclosed. Phthalazines which are nitrogen-containing heterocyclic compounds are biologically preferential scaffolds, endowed with versatile pharmacological activity, such as anti-inflammatory, cardiotonic vasorelaxant, anticonvulsant, antihypertensive, antibacterial, anti-cancer action. The compounds were investigated for the inhibition against the cytosolic hCA I, II and AChE. Most screened sulfonamides showed high potency in inhibiting hCA II, widely involved in glaucoma, epilepsy, edema, and other pathologies (K(i)s in the ranging from 6.32 +/- 0.06 to 128.93 +/- 23.11 nM). hCA I was inhibited with K(i)s in the range of 6.80 +/- 0.10-85.91 +/- 7.57 nM, whereas AChE in the range of 60.79 +/- 3.51-249.55 +/- 7.89 nM. ADME prediction study of the designed N-substituted phthalazine sulfonamides showed that they are not only with carbonic anhydrase and acetylcholinesterase inhibitory activities but also with appropriate pharmacokinetic, physicochemical parameters and drug-likeness properties. Also, in silico docking studies were investigated the binding modes of selected compounds, to hCA I, II, and AChE.

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Chemical engineers work across a number of sectors, processes differ within each of these areas, but chemistry and chemical engineering roles are found throughout, creation and manufacturing process of chemical products and materials. Formula: https://www.ambeed.com/products/104-53-0.html, 104-53-0, Name is 3-Phenylpropanal, SMILES is O=CCCC1=CC=CC=C1, in an article , author is Hiiuk, Volodymyr M., once mentioned of 104-53-0.

Two new 2D spin-crossover (SCO) analogues of Hofmann clathrates of composition [Fe(phth)(2)M-II(CN)(4)] (where phth = phthalazine; M-II = Pd, Pt) have been synthesized and their structures and switchable behaviour have been characterized. Single-crystal X-ray analysis reveals that the Pt and Pd derivatives contain Fe-II centres equatorially surrounded by four equivalent mu(4)-[M-II(CN)(4)](2-) groups. Two crystallographically equivalent phthalazine (phth) ligands occupy the axial positions of each Fe-II site, completing its octahedral coordination environment. The stabilization of these structures is realized via supramolecular C-HM interactions and pi-pi stacking. Temperature-dependent magnetic susceptibility measurements showed that Pt (T-1/2 down arrow = 211 K and T-1/2 up arrow = 218 K) and Pd (T-1/2 down arrow = 202 K and T-1/2 up arrow = 207 K) derivatives display cooperative spin crossover with narrow thermal hysteresis loops. In addition, spin crossover in these complexes was characterized by optical measurements, differential scanning calorimetry, and IR and Raman spectroscopy. This research shows that the use of phthalazine leads to the production of new SCO systems with attractive transition characteristics and opens up new perspectives for the design of switchable complexes based on fused bicyclic azine ligands.

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Chemistry involves the study of all things chemical – chemical processes, chemical compositions and chemical manipulation – in order to better understand the way in which materials are structured, how they change and how they react in certain situations. , Recommanded Product: 4-Acetamidobenzoic acid, 556-08-1, Name is 4-Acetamidobenzoic acid, molecular formula is C9H9NO3, belongs to phthalazine compound. In a document, author is Zivkovic, Marija D., introduce the new discover.

H-1 NMR spectroscopy was applied to study the catalytic activity of dinuclear Pd(II)-aqua complexes with different benzodiazine bridging ligands, [{Pd(en)(H2O)}(2)(mu-qx)](4+)(Pd1), [{Pd(en)(H2O)}(2)(mu-qz)](4+)(Pd2) and [{Pd(en)(H2O)}(2)(mu-phtz)](4+)(Pd3) (qx, qz and phtz denote quinoxaline, quinazoline and phthalazine, respectively), in the hydrolytic cleavage of the amide bond inN-acetylated L-methionylglycine (Ac-L-Met-Gly) and L-histidylglycine (Ac-L-His-Gly) dipeptides. All reactions were investigated with an equimolar amount of the reactants at pH = 2.0-2.5 in D2O and at 37 degrees C. The obtained data for the catalytic activity ofPd1-Pd3complexes are compared with those previously reported for [{Pt(en)(H2O)}(2)(mu-L)](4+)(L denotes benzodiazine: qx, qz and phtz), [{Pd(en)(H2O)}(2)(mu-L)](4+)and [{Pt(en)(H2O)}(2)(mu-L)](4+)(L denotes diazine: pyrazine and pyridazine) complexes. It was found that catalytic activity of these complexes in peptide cleavage is strongly related to the position of the nitrogen atoms in the benzodiazine or diazine bridging ligand. The investigated dinuclear Pd(II) and Pt(II) complexes show catalytic activity in the selective hydrolysis of the Met-Gly amide bond of Ac-L-Met-Gly dipeptide. Moreover, all the above mentioned Pd(II) complexes were also able to catalyze the regioselective hydrolysis of the His-Gly amide bond of Ac-L-His-Gly dipeptide. However, in the reaction with Ac-L-His-Gly, only Pt(II) aqua complexes containing bridging ligands with two nitrogen atoms in thepara-position (quinoxaline and pyrazine) were able to cleave this dipeptide.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 556-08-1, in my other articles. Recommanded Product: 4-Acetamidobenzoic acid.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Researchers are common within chemical engineering and are often tasked with creating and developing new chemical techniques, frequently combining other advanced and emerging scientific areas. Safety of (4-Chlorophenyl)methanamine, 104-86-9, Name is (4-Chlorophenyl)methanamine, SMILES is NCC1=CC=C(Cl)C=C1, in an article , author is Karthikeyan, G., once mentioned of 104-86-9.

Alumination of Si-KIT-6 materials with ordered three-dimensional (3D) structure were prepared by post-synthesis method with various Si/Al ratios. The catalysts were characterized by X-ray diffraction analysis (XRD), N-2 porosimetry and FT-IR spectra. The presence of framework and extra framework aluminium was predicted by Aluminium MAS NMR. The strength of the acid sites of the catalysts was studied by NH3-TPD acidity measurements. The morphology of mesoporous materials was studied by SEM and TEM observation. The metal content of the samples was investigated by ICP-OES. The prepared solid acid catalysts were applied for the multi-component synthesis of 1H-pyrazolo[1,2-]phthalazine-5,10-diones from the reaction of phthalhydrazide, malononitrile/ethylcyano acetate and aromatic aldehyde in ethanol under liquid phase conditions. Activities of the catalysts follow the order: Al-KIT-6 (33) > Al-KIT-6 (56) > Al-KIT-6 (81) > Al-KIT-6 (110) > Nafion-H > Amberlyst-15 >> HM (12) > H beta (8) > HY (4). The effects of reaction conditions and different catalysts have been studied. Various advantages associated with these protocols include effective catalysis, simple work-up procedure, short reaction times, high product yields, easy recovery and reusability of the catalysts. (c) 2012 Elsevier B.V. All rights reserved.

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem