Tag: M.W:100-200

253-52-1, In an article, published in an article,authors is Bule, Mohammed Hussen, once mentioned the application of 253-52-1, Name is Phthalazine,molecular formula is C8H6N2, is a conventional compound. this article was the specific content is as follows.

Quinazolinone derivatives as a potential class of compounds in malaria drug discovery

Malaria causes over a million deaths each year (2 percent of the global total of deaths), with hundreds of millions of clinical episodes per annum. The greatest challenge to malaria control and eradication is the emergence of malaria parasites that are resistant to antimalarial drugs. The development of resistance to conventionally used anti-malarial drugs, such as chloroquine (CQ) and Sulfadoxine-Pyrimethamine (SP) has been documented. To counter this WHO recommended that artemisinin-based combination therapy (ACT) should be used for treating uncomplicated Plasmodium falciparum malaria to ensure efficacy and reduce the emergence of drug-resistant parasites. Currently available antimalarial drugs are ineffective and their number is declining because of the widespread resistance. Thus, the new antimalarial agent is in urgent demand; however, the development of new antimalarial drug presents challenges due to resistance, toxicity, minimal efficacy of those on the pipeline and high cost of drug research. Identification of novel drug targets and design of new chemical compounds acting on new targets is important to control the emergence of resistance to existing drugs. In this regard, a natural product derived synthetic analogs of febrifugine containing quinazolinone scaffold can be considered best. Therefore, quinazolinones are potential compounds in seeking for novel drugs that act against the malarial pathogen. Hence, in this review compounds containing quinazolinone structure and possessing antimalarial activities are covered.

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Phthalazine – Wikipedia,
Phthalazine | C8H6N88 – PubChem

253-52-1, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.253-52-1, Name is Phthalazine, molecular formula is C8H6N2. In a Article, authors is Shilcrat£¬once mentioned of 253-52-1

Heteroarylation of 6-aryl-2,3-dihydroimidazo[2,1-b]thiazole with N- (ethoxycarbonyl)heteroaromatic salts

The ethyl chloroformate salts of a variety of benzo-fused six membered pi- deficient heteroaromatics, including quinoline, isoquinoline, 4- chloroquinoline, 3-bromoquinoline, phthalazine, and quinazoline, reacted with 6-aryl-2,3-dihydroimidazo[2,1-b]thiazole at the 5-position. The dihydroheteroaromatic adducts were oxidized by o-chloranil, sulfur, or electrochemical methodology to form the 5-heteroaromatic-6-aryl-2,3- dihydroimidazo[2,1-b]thiazoles, 10-15. In each example, the regiochemistry of addition to the heteroaromatic ring was established.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.253-52-1. In my other articles, you can also check out more blogs about 253-52-1

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Phthalazine – Wikipedia,
Phthalazine | C8H6N406 – PubChem

Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 253-52-1, Name is Phthalazine, molecular formula is C8H6N2, 253-52-1, In a Article, authors is Obach, R. Scott£¬once mentioned of 253-52-1

Human Liver Aldehyde Oxidase: Inhibition by 239 Drugs

The authors tested 239 frequently used drugs and other compounds for their potential to inhibit the drug-metabolizing enzyme, aldehyde oxidase, in human liver cytosol. A sensitive, moderate throughput HPLC-MS assay was developed for 1-phthalazinone, the aldehyde oxidase-catalyzed product of phthalazine oxidation. Inhibition of this activity was examined for the 239 drugs and other compounds of interest at a test concentration of 50 muM. Thirty-six compounds exhibited greater than 80% inhibition and were further examined for measurement of IC50. The most potent inhibitor observed was the selective estrogen receptor modulator, raloxifene (IC50 = 2.9 nM), and tamoxifen, estradiol, and ethinyl estradiol were also potent inhibitors. Other classes of drugs that demonstrated inhibition of aldehyde oxidase included phenothiazines, tricyclic antidepressants, tricyclic atypical antipsychotic agents, and dihydropyridine calcium channel blockers, along with some other drugs, including loratadine, cyclobenzaprine, amodiaquine, maprotiline, ondansetron, propafenone, domperidone, quinacrine, ketoconazole, verapamil, tacrine, and salmeterol. These findings are discussed in context to potential drug interactions that could be observed between these agents and drugs for which aldehyde oxidase is involved in metabolism and warrant investigation of the possibility of clinical drug interactions mediated by inhibition of this enzyme.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.253-52-1. In my other articles, you can also check out more blogs about 253-52-1

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Phthalazine – Wikipedia,
Phthalazine | C8H6N324 – PubChem

Let¡¯s face it, organic chemistry can seem difficult to learn. Especially from a beginner¡¯s point of view. Like 253-52-1, Name is Phthalazine. In a document type is Article, introducing its new discovery., 253-52-1

Study of aldehyde oxidase with phthalazine as substrate using both off-line and on-line capillary electrophoresis

An optimized and economical capillary electrophoretic method for both off-line and on-line study of the enzyme aldehyde oxidase and its substrate phthalazine was developed. The separation of the substrate phthalazine and its metabolite 1-phthalazinone was achieved using micellar electrokinetic chromatography (MEKC) with sodium dodecyl sulphate in the background electrolyte (BGE). The BGE consists of 25 mM sodium phosphate buffer containing 50 mM sodium dodecyl sulphate at pH 7.4. A bare-fused-silica capillary with a capillary length of 40 cm, 50 mum ID and effective length of 30 cm was used to develop the capillary electrophoresis method. Improved separation conditions were elaborated and the separation method was validated based on the ICH and EMA guidelines. The limit of detection for phthalazine and 1-phthalazinone was 8 muM and 3 muM, respectively. The limit of quantification was 25 muM for phthalazine and 10 muM for 1-phthalazinone. The linearity of the detector response was checked for 1-phthalazinone at nine different concentrations in the range 10?500 muM and the determination coefficient was 0.9994. Accuracy was tested by comparing the corrected peak area of 1-phthalazinone reference solution at 20 muM and 50 muM with the corrected peak area of 20 muM and 50 muM 1-phthalazinone in the presence of human liver cytosol (HLC). Accuracy values of +5.3% and -2.5% were obtained at 20 muM and 50 muM, respectively. The on-line enzymatic reaction was successful with the application of the method of transverse diffusion of laminar flow profiles (TDLFP), which enables the mixing as well as separation of the enzyme and substrate inside the nanoliter-scale capillary. TDLFP is examined to be precise when performing 5 consecutive injections, with a relative standard deviation of 7.16% which is within the limitation of EMA standards. This miniaturized and low-cost incubation and separation method could be further introduced into industry and extended to other substrates.

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Phthalazine – Wikipedia,
Phthalazine | C8H6N196 – PubChem

3682-14-2, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.3682-14-2, Name is 6-Amino-2,3-dihydrophthalazine-1,4-dione, molecular formula is C8H7N3O2. In a Article, authors is Rinaldi, Manuela£¬once mentioned of 3682-14-2

Differential effects of alpha1-acid glycoprotein on bovine neutrophil respiratory burst activity and IL-8 production

During bacterial-mediated diseases, neutrophils (PMNs) play a critical role in defending the host against invading pathogens. PMN production of reactive oxygen species (ROS) contributes to the bactericidal capabilities of these cells. ROS are produced intracellularly and can be released extracellularly. The aberrant extracellular release of ROS, however, has been reported to induce injury to host tissues during mastitis and other inflammatory-mediated diseases of cattle. The acute phase response, which occurs shortly after infection or tissue injury, is characterized by the induction of a large number of plasma proteins referred to as acute phase proteins (APP). alpha1-Acid glycoprotein (AGP) is an APP that increases in response to infection or injury in cattle and humans. The precise function of AGP is unknown, but it has been reported to possess anti-inflammatory properties. The objective of this study was to evaluate the effects of bovine AGP on PMN pro-inflammatory responses, including respiratory burst activity and cytokine production. Bovine AGP dose-dependently inhibited zymosan-induced PMN extracellular release of superoxide anion and hydrogen peroxide without affecting the capacity of PMN to engulf and kill Staphylococcus aureus. Moreover, AGP exerted its effect on ROS production regardless of whether PMNs were exposed to AGP prior to or after activation. In contrast to respiratory burst activity, AGP enhanced PMN production of IL-8. The precise mechanism by which AGP regulates PMN functions remains unknown, but data presented in this study suggest that AGP may have a complex role by differentially regulating PMN pro-inflammatory activities.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 3682-14-2

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Phthalazine – Wikipedia,
Phthalazine | C8H6N626 – PubChem

253-52-1, Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 253-52-1, Name is Phthalazine

Synthesis, crystal structure, and luminescent properties of a new modification of the zinc(II) dichloride complex with phthalazine

The coordination compound [ZnCl2(Phtz)2] has been synthesized by the reaction of ZnCl2 with phthalazine (Phtz, L, C8H6N2) in an ethanol solution. Its crystal structure has been determined: crystals are triclinic, space group P 0000000, a = 7.346(1) A, b = 8.095(1) A, c = 14.275(1) A, alpha = 85.63(1), beta = 75.75(1), gamma = 88.43(1), V = 820.4(2) A3, rhocalc = 1.605 g/cm3, Z = 2. The zinc atom is tetrahedrally coordinated to two crystallographically nonequivalent chlorine atoms and two nitrogen atoms of the ligands L (Zn(1)?N(1), 2.036(4) A; Zn(1)?N(3), 2.043(4) A; Zn(1)?Cl(1), 2.225(2) A; Zn(1)?Cl(2), 2.220(2) A; angles NZnN, 106.1(2); ClZnCl, 116.47(7)). The complexes are combined into a 1D supramolecular structure by nonclassical hydrogen bonds C?H¡¤¡¤¡¤Cl and pi?pi-stacking interaction between centrosymmetric pairs of aromatic rings of one of the independent ligands. The compounds [CdI2(Phtz)] and [HgBr2(Phtz)] have also been synthesized, and their luminescent properties have been studied.

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Phthalazine – Wikipedia,
Phthalazine | C8H6N240 – PubChem

253-52-1, Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 253-52-1, Name is Phthalazine, molecular formula is C8H6N2. In a Conference Paper, authors is Muniz-Miranda£¬once mentioned of 253-52-1

SERS intensities of benzodiazines adsorbed on silver nanoparticles

SERS excitation profiles of benzodiazines adsorbed on silver sols have been investigated and related to the surface plasmon resonances in the UV-Visible absorption spectra. Despite the existence of metal-ligand chemical bonds, evidenced by the occurrence of strong Ag-N stretching modes, spectral data can be interpreted in terms of enhancement due to the electromagnetic mechanism.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. 253-52-1, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 253-52-1, in my other articles.

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Phthalazine – Wikipedia,
Phthalazine | C8H6N305 – PubChem

3682-14-2, Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. 3682-14-2, Name is 6-Amino-2,3-dihydrophthalazine-1,4-dione,introducing its new discovery.

Seroprevalences of autoantibodies and anti-infectious antibodies among Ghana?s healthy population

Autoantibodies, which are antibodies that target self-epitopes, have considerable diagnostic, prognostic and predictive value in specific autoimmune diseases. Various infectious agents have been linked via numerous mechanisms to the formation of different autoantibodies. Therefore, estimating the prevalence of autoantibodies and anti-infectious antibodies in different populations is of high importance. Different genetic and environmental pressures, such as these found in Ghana?s different geographical provinces, may affect the prevalence of autoantibodies. In this study, we assessed the seroprevalence of a diverse panel of autoantibodies and anti-infectious antibodies among the healthy Ghanaian population and investigated possible environmental and genetic predispositions for autoantibodies and autoimmunity. The sera of 406 healthy individuals were obtained from Greater Accra, Upper West, Eastern and Volta regions. Multiplexed assay and chemiluminescent immunoassay techniques were utilized to assess the presence of a panel of autoantibodies and anti-infectious antibodies. We found a high prevalence of anti-HSV-1 IgG (91?100%), anti-EBNA IgG (81?93%) and anti-EBV-VCA IgG (97?100%) antibodies. The prevalence of ANA (at least one of: anti-dsDNA; anti-chromatin; anti-ribosomal-P; anti-Ro/SSA; anti-La/SSB; anti-centromere B; anti-Sm; anti-Sm/RNP; anti-Scl-70; anti-Jo1; anti-DFS70) was estimated at 14%. An inverse association between anti-HSV-2 antibodies and ANA (p = 0.044; adjusted OR = 0.398; CI [0.162?0.975]) was found, after adjusting for differences in gender, age, and familial history of autoimmune diseases. A trend towards reduced seroprevalence of anti-dsDNA antibodies among subjects who were positive for anti-HSV-2 antibodies was also noted (p = 0.1). In conclusion, the inverse association between anti-HSV-2 antibodies and ANA positivity suggests a possible protective role of HSV-2 infection against autoimmunity.

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Phthalazine – Wikipedia,
Phthalazine | C8H6N584 – PubChem

Because a catalyst decreases the height of the energy barrier, 253-52-1, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.253-52-1, Name is Phthalazine, molecular formula is C8H6N2. In a article£¬once mentioned of 253-52-1

Selectivity/specificity improvement strategies in surface-enhanced raman spectroscopy analysis

Surface-enhanced Raman spectroscopy (SERS) is a powerful technique for the discrimination, identification, and potential quantification of certain compounds/organisms. However, its real application is challenging due to the multiple interference from the complicated detection matrix. Therefore, selective/specific detection is crucial for the real application of SERS technique. We summarize in this review five selective/specific detection techniques (chemical reaction, antibody, aptamer, molecularly imprinted polymers and microfluidics), which can be applied for the rapid and reliable selective/specific detection when coupled with SERS technique.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. 253-52-1, In my other articles, you can also check out more blogs about 253-52-1

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Phthalazine – Wikipedia,
Phthalazine | C8H6N470 – PubChem

In heterogeneous catalysis, the catalyst is in a different phase from the reactants. 253-52-1, At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 253-52-1, name is Phthalazine. In an article£¬Which mentioned a new discovery about 253-52-1

Synthesis, structures and properties of the dinuclear copper(II) complexes triply bridged by two oximato and one pyrazolato or one phthalazine

The triply (two oximato and one pyrazolato or one phthalazine) bridged dinuclear copper(II) complexes [Cu2(L1)2(pz)]ClO4 (1) and [Cu2(L1)2(phta)] (ClO4)2 (2) (HL1 = 2-[2-(alpha-pyridyl)ethyl]imino-3-butanone oxime, pz = pyrazolate anion, phta = phthalazine) were synthesized and characterized; the crystal structures of 1 and 2 were determined by X-ray crystallography. Magnetic susceptibility measurements from liquid helium temperature to room temperature showed a weak antiferromagnetic exchange coupling between two copper(II) ions (2J = -17 cm-1) for l, on the other hand, a very strong antiferromagnetic interaction for 2 was observed (2J = -760 cm-1).

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 253-52-1 is helpful to your research. 253-52-1

Reference£º
Phthalazine – Wikipedia,
Phthalazine | C8H6N495 – PubChem