Tag: M.W:100-200

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.119-39-1,Phthalazin-1(2H)-one,as a common compound, the synthetic route is as follows.

To a round bottom flask containing DMF (10 mL) under an atmosphere of argon was added, phthalazone (300 mg, 2.05 mmol). To solution was then cooled to 0C before sodium hydride (60% in dispersion oil, 61 mg, 2.53 mmol) was added portion wise iodomethane (119 m L, 1.92 mmol). The reaction was stirred overnight before the solvent was removed in vacuo and the crude material purified directly via flash column chromatography using -pentane: EtOAc (10:1) affording 2-2-Mcthylphthalazin- 1 (2H)-onc as a white solid (210 mg, 1.31 mmol, 64%). 3H NMR (400 MHz, CDCb) d = 8.42 – 8.38 (m, 1H), 8.12 (s, 1H), 7.81 – 7.70 (m, 2H), 7.69 – 7.65 (m, 1H), 3.83 (s, 3H); 13C NMR (100 MHz, CDCb) d = 159.7, 137.6, 133.0, 131.6, 129.8, 127.8, 126.5, 126.0, 39.5. The data is in accordance with known literature (Outerbridge, V.M., Landge, S.M., Tamaki, H. & Torok, B. Microwave-Promoted Solid-Acid Catalyzed One-Pot Synthesis of Phthalazinones. Synthesis 11, 1801-1806, 2009)., 119-39-1

As the paragraph descriping shows that 119-39-1 is playing an increasingly important role.

Reference£º
Patent; OXFORD UNIVERSITY INNOVATION LIMITED; GOUVERNEUR, Veronique; CORNELISSEN, Bart; WILSON, Thomas Charles; (152 pag.)WO2019/186135; (2019); A1;,
Phthalazine – Wikipedia
Phthalazine | C8H6N2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.253-52-1,Phthalazine,as a common compound, the synthetic route is as follows.

General procedure: CuSCN (121 mg, 1.00 mmol) was suspended in 20 mL deionized water containing 146 mg (1.5 mmol) KSCN and 0.5 mL 17 M NH3 (8.5 mmol) under Ar purge. Qox (70 mg, 0.54 mmol) was added to the suspension, which quickly took on a red-orange color. The suspension was refluxed for 72 h. The red solid product was collected via filtration, washed with deionized water, and dried under vacuum (123 mg, 66percent).

253-52-1, 253-52-1 Phthalazine 9207, aphthalazine compound, is more and more widely used in various fields.

Reference£º
Article; Ayala, Gerardo; Tronic, Tristan A.; Pike, Robert D.; Polyhedron; vol. 115; (2016); p. 257 – 263;,
Phthalazine – Wikipedia
Phthalazine | C8H6N2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.119-39-1,Phthalazin-1(2H)-one,as a common compound, the synthetic route is as follows.

Example 1. 2-(4-Bromobutyl)-1(2H)-phthalazinone . Small portions (2.5 g, 60 mmol) of a dispersion of 60% NaH in mineral oil were added over a solution of 1(2H)-phthalazinone (7.3 g, 50 mmol) in dimethylformamide (100 mL) cooled to 0C. The reaction mixture was left to reach room temperature and kept stirred for an hour. 1,4-dibromobutane (18 mL, 150 mmol) was then added at a time and the reaction mixture was stirred, at room temperature, for 4 hours. The reaction mixture was poured over cnished ice, extracted with ethyl ether (twice), and the organic extracts were dried over anhydrous Na2SO4and concentrated to dryness. The excess dibromobutane was eliminated by distillation and the obtained residue was purified by flash chromatography (CH2Cl2), yielding an oil (11.6 g, yield: 83%) identified on the basis of its spectroscopic data as the title product, 119-39-1

The synthetic route of 119-39-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; FABRICA ESPANOLA DE PRODUCTOS, QUIMICOS Y FARMACEUTICOS, S.A. (FAES); EP875512; (1998); A2;,
Phthalazine – Wikipedia
Phthalazine | C8H6N2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.253-52-1,Phthalazine,as a common compound, the synthetic route is as follows.

3-(2-Bromoacetyl)-2H-chromen-2-one (2.67 g, 10 mmol)and 1.3 g phthalazine (10 mmol) were refluxed understirring in 60 cm3 ethyl acetate for 4 h. The whiteprecipitate formed was removed by filtration and washedwith chloroform on the filter paper to obtain 3d as whitepowder. Yield: 3.771 g (95 percent); m.p.: 244?245 C; 1HNMR (DMSO-d6, 300 MHz): d = 6.60 (s, 2H, CH2),7.49?7.54 (m, 1H, H-Coum), 7.59 (d, J = 8.4 Hz, 1H,H-Coum), 7.86?7.91 (m, 1H, H-Coum), 8.09 (dd, J = 7.7,1.5 Hz, 1H, H-Coum), 8.50?8.55 (m, 1H, H-6), 8.61?8.70(m, 1H, H-7), 8.71 (d, J = 7.7 Hz, 1H, H-5), 8.71 (d,J = 7.9 Hz, 1H, H-8), 8.98 (s, 1H, H-Coum), 10.23 (s, 1H,H-4), 10.76 (s, 1H, H-1) ppm; 13C NMR (DMSO-d6,75 MHz): d = 72.2 (CH2), 117.4 (C-Coum), 126.8 (CCoum),129.6 (Pht), 131.8 (C-Coum), 132.5 (C-Coum),136.8 (Pht), 137.6 (Pht), 140.9 (Pht), 118.9, 122.5, 128.1,128.4, 155.8, 159.6 (C4a, C-8a, 4 Cq-Coum), 150.4 (CCoum),154.4 (C-4), 155.7 (C-1), 186.3 (CO-Coum) ppm.

253-52-1, As the paragraph descriping shows that 253-52-1 is playing an increasingly important role.

Reference£º
Article; Popa, Marcel M.; Georgescu, Emilian; Draghici, Constantin; Georgescu, Florentina; Dumitrascu, Florea; Dumitrescu, Denisa; Monatshefte fur Chemie; vol. 146; 12; (2015); p. 2029 – 2040;,
Phthalazine – Wikipedia
Phthalazine | C8H6N2 – PubChem

As a common heterocyclic compound, it belongs to phthalazine compound, name is Phthalazine, and cas is 253-52-1, its synthesis route is as follows.,253-52-1

3-(2-Bromoacetyl)-2H-chromen-2-one (2.67 g, 10 mmol)and 1.3 g phthalazine (10 mmol) were refluxed understirring in 60 cm3 ethyl acetate for 4 h. The whiteprecipitate formed was removed by filtration and washedwith chloroform on the filter paper to obtain 3d as whitepowder. Yield: 3.771 g (95 percent); m.p.: 244?245 C; 1HNMR (DMSO-d6, 300 MHz): d = 6.60 (s, 2H, CH2),7.49?7.54 (m, 1H, H-Coum), 7.59 (d, J = 8.4 Hz, 1H,H-Coum), 7.86?7.91 (m, 1H, H-Coum), 8.09 (dd, J = 7.7,1.5 Hz, 1H, H-Coum), 8.50?8.55 (m, 1H, H-6), 8.61?8.70(m, 1H, H-7), 8.71 (d, J = 7.7 Hz, 1H, H-5), 8.71 (d,J = 7.9 Hz, 1H, H-8), 8.98 (s, 1H, H-Coum), 10.23 (s, 1H,H-4), 10.76 (s, 1H, H-1) ppm; 13C NMR (DMSO-d6,75 MHz): d = 72.2 (CH2), 117.4 (C-Coum), 126.8 (CCoum),129.6 (Pht), 131.8 (C-Coum), 132.5 (C-Coum),136.8 (Pht), 137.6 (Pht), 140.9 (Pht), 118.9, 122.5, 128.1,128.4, 155.8, 159.6 (C4a, C-8a, 4 Cq-Coum), 150.4 (CCoum),154.4 (C-4), 155.7 (C-1), 186.3 (CO-Coum) ppm.

With the rapid development of chemical substances, we look forward to future research findings about Phthalazine

Reference£º
Article; Popa, Marcel M.; Georgescu, Emilian; Draghici, Constantin; Georgescu, Florentina; Dumitrascu, Florea; Dumitrescu, Denisa; Monatshefte fur Chemie; vol. 146; 12; (2015); p. 2029 – 2040;,
Phthalazine – Wikipedia
Phthalazine | C8H6N2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.253-52-1,Phthalazine,as a common compound, the synthetic route is as follows.

General procedure: Phthalazine (1) (91 mg, 0.70 mmol), 1,1-dicyanoalkene 2(0.70 mmol), and isocyanide 3 (0.70 mmol) were dissolvedin acetonitrile (1 ml). After that, distilled water(0.05?0.1 ml) was added to the reaction mixture up tovisible turbidity and stirred at 25?30¡ãC for 12?18 h. Thereaction mixture was evaporated to dryness and product 4was purified by crystallization from ethanol., 253-52-1

The synthetic route of 253-52-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Mironov, Maxim A.; Shulepov, Iliya D.; Kozhikhova, Ksenia V.; Ivantsova, Maria N.; Tokareva, Maria I.; Chemistry of Heterocyclic Compounds; vol. 53; 4; (2017); p. 430 – 433; Khim. Geterotsikl. Soedin.; vol. 53; 4; (2017); p. 430 – 433,4;,
Phthalazine – Wikipedia
Phthalazine | C8H6N2 – PubChem

Name is Phthalazine, as a common heterocyclic compound, it belongs to phthalazine compound, and cas is 253-52-1, its synthesis route is as follows.,253-52-1

General procedure: In a Schlenk tube charged with a stirring bar, the air-stable bidentate Lewis acid catalyst B (5.00 mol percent) and the stated solvent were added under N2. Then, the phthalazine (1.00 equiv), dienophile (2.00 equiv; for enamines, generated in situ from aldehyde and amine) were added subsequently. The reaction mixture was stirred at the given temperature. After the reaction was finished, the solvent was removed. The remaining residue was purified by flash column chromatography over SiO2 to obtain the product.

With the complex challenges of chemical substances, we look forward to future research findings about Phthalazine

Reference£º
Article; Hong, Longcheng; Ahles, Sebastian; Heindl, Andreas H.; Tietcha, Gastelle; Petrov, Andrey; Lu, Zhenpin; Logemann, Christian; Wegner, Hermann A.; Beilstein Journal of Organic Chemistry; vol. 14; (2018); p. 618 – 625;,
Phthalazine – Wikipedia
Phthalazine | C8H6N2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.119-39-1,Phthalazin-1(2H)-one,as a common compound, the synthetic route is as follows.

Weigh 0.324g of commercial compound C1a dissolved in 3ml DMF,60% NaH 0.16g was added under ice bath.Stir for 30 minutes and add 0.591 g of ethyl 4-(bromomethyl)benzoate.Stir for 1 hour at room temperature. Pour the reaction mixture into 100ml of crushed ice.Extract several times with ethyl acetate, combine the organic layers, and evaporate.Light yellow solid (Intermediate C1b).Dissolve this intermediate in 10 ml of THF and add 2.9 ml of 8N NaOH.Return overnight. The reaction solution was diluted with water, and the aqueous layer was washed with ethyl acetate.The aqueous layer was adjusted to pH 6 with 6N HCl, precipitated and filtered.The precipitate is washed with water and dried to give a beige product C1c, 119-39-1

119-39-1 Phthalazin-1(2H)-one 8394, aphthalazine compound, is more and more widely used in various fields.

Reference£º
Patent; Chinese Academy Of Sciences Shanghai Pharmaceutical Institute; Shen Jingkang; Xiong Bing; Zhao Lele; Li Jia; Geng Meiyu; Ma Lanping; Chen Danqi; Su Mingbo; Zhou Yubo; Hu Xiaobei; Liu Hongchun; Shen Aijun; (54 pag.)CN107879975; (2018); A;,
Phthalazine – Wikipedia
Phthalazine | C8H6N2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.253-52-1,Phthalazine,as a common compound, the synthetic route is as follows.

General procedure: Phthalazine (1) (91 mg, 0.70 mmol), 1,1-dicyanoalkene 2(0.70 mmol), and isocyanide 3 (0.70 mmol) were dissolvedin acetonitrile (1 ml). After that, distilled water(0.05?0.1 ml) was added to the reaction mixture up tovisible turbidity and stirred at 25?30¡ãC for 12?18 h. Thereaction mixture was evaporated to dryness and product 4was purified by crystallization from ethanol., 253-52-1

253-52-1 Phthalazine 9207, aphthalazine compound, is more and more widely used in various fields.

Reference£º
Article; Mironov, Maxim A.; Shulepov, Iliya D.; Kozhikhova, Ksenia V.; Ivantsova, Maria N.; Tokareva, Maria I.; Chemistry of Heterocyclic Compounds; vol. 53; 4; (2017); p. 430 – 433; Khim. Geterotsikl. Soedin.; vol. 53; 4; (2017); p. 430 – 433,4;,
Phthalazine – Wikipedia
Phthalazine | C8H6N2 – PubChem

As a common heterocyclic compound, it belongs to quinuclidine compound,Quinuclidine-4-carboxylic acid hydrochloride,40117-63-3,Molecular formula: C8H14ClNO20,mainly used in chemical industry, its synthesis route is as follows.,253-52-1

General procedure: To a stirred solution of furan (1.20 g,17.6 mmol) in dry THF (20 mL) was added dropwise n-butyllithium (2.5 M in hexanes, 7.30 mL,18.3 mmol) over a period of 30 min at ?78 ¡ãC. The solution was warmed to ?25 ¡ãC, and stirring wascontinued at this temperature for 30 min. The reaction mixture was cooled back to ?78 ¡ãC, and asolution of 1 (2.00 g, 15.3 mmol) in dry THF (20 mL) was added dropwise over 30 min. The reaction mixture was stirred at this temperature for 2 h. The mixture was poured into saturated NH4Cl(100 mL) and extracted with ethyl acetate (3 ¡Á 50 mL). The combined organic extracts were thenwashed with saturated NaCl (50 mL), dried (MgSO4), filtered, and concentrated under vacuum toafford 3f as a light brown oil. The crude product 3f was dissolved in DCM (30 mL), and triethylamine(2.37 g, 3.26 mL, 23.4 mmol) was added, followed by dropwise addition of acryloyl chloride (1.59 g,1.43 mL, 17.6 mmol) at 0 ¡ãC. The reaction mixture was stirred at 0 ¡ãC for 2 h. The reaction was thenquenched with saturated NaCl (25 mL), and the organic layer was separated. The aqueous layer wasextracted with DCM (2 ¡Á 30 mL), and the combined organic extracts were washed with saturated NaCl(50 mL), dried (MgSO4), filtered, and concentrated to afford the crude product. The product waspurified on a silica gel column eluted with hexanes?EtOAc (7:3) to afford 4f (2.66 g, 60percent) as a yellowliquid.

With the synthetic route has been constantly updated, we look forward to future research findings about Phthalazine,belong phthalazine compound

Reference£º
Article; Nammalwar, Baskar; Muddala, N.Prasad; Bourne, Christina R.; Henry, Mary; Bourne, Philip C.; Bunce, Richard A.; Barrow, Esther W.; Berlin, K.Darrell; Barrow, William W.; Molecules; vol. 19; 3; (2014); p. 3231 – 3246;,
Phthalazine – Wikipedia
Phthalazine | C8H6N2 – PubChem