Tag: M.W:100-200

Redox catalysis has been broadly utilized in electrochemical synthesis due to its kinetic advantages over direct electrolysis. 613-45-6, Name is 2,4-Dimethoxybenzaldehyde, molecular formula is , belongs to phthalazine compound. In a document, author is Romero, Angel H., Quality Control of 2,4-Dimethoxybenzaldehyde.

A series of six 3-aryl-6-(N-methylpiperazin)-1,2,4-triazolo[3,4-a]phthalazines were prepared through a facile and efficient one-pot copper-catalyzed procedure from 4-chloro-1-phthalazinyl-arylhydrazones with relatively good yields (62-83%). The one-pot copper-catalytic procedure consists of two simultaneous reactions: (i) a direct intramolecular dehydrogentaive cyclization between ylidenic carbon and adjacent pyrazine nitrogen to form 1,2,4-triazolo ring and, (ii) a direct N-amination on carbon-chlorine bond. Then, an in vitro anticancer evaluation was performed for the synthesized compounds against five selected human cancer cells (A549, MCF-7, SKBr3, PC-3 and HeLa). The nitro-derivatives were significantly more active against cancer strains than against the rest of tested compounds. Specifically, compound 8d was identified as the most promising anticancer agent with significant biological responses and low relative toxicities on human dermis fibroblast. The cytotoxic effect of compound 8d was more significant on PC3, MCF-7 and SKBr3 cancer cells with low-micromolar IC50 value ranging from 0.11 to 0.59 mu M, superior to Adriamycin drug. Mechanistic experimental and theoretical studies demonstrated that compounds 8d act as a K+ channel inhibitor in cancer models. Further molecular docking studies suggest that the EGFR Tyrosine Kinase enzyme may be a potential target for the most active 3-aryl-6-(N-methylpiperazin)-1,2,4-triazolo[3,4-a]phthalazines.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 613-45-6 is helpful to your research. COA of Formula: https://www.ambeed.com/products/613-45-6.html.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

The prevalence of solvent effects in heterogeneous catalysis in condensed media has motivated developing quantitative kinetic, and theoretical assessments of solvent structures and their interactions with reaction intermediates and transition states. 5267-64-1, Name is D-Penylalaninol, molecular formula is C9H13NO, belongs to phthalazine compound. In a document, author is Li Jiali, introduce the new discover, HPLC of Formula: https://www.ambeed.com/products/5267-64-1.html.

In this paper, a series of 6-substituted-pyrido[3,2-e][1,2,4] triazolo[4,3-a] pyrazine derivatives have been synthesized. Their anticonvulsant activity and neurotoxicity in mice were evaluated by maximal electroshock (MES) and rotarod test, respectively. The structures were confirmed by H-1 NMR, C-13 NMR, MS and HRMS. The experimental results show that 6-phenoxypyrido[3,2-e][1,2,4] triazolo[4,3-a]pyrazine (5g) was safer than the reference drug, carbamazepine, with ED50 value of 93.9 mg.kg(-1) and protective index (PI) value of 24.3, which was a potential anti-epilepsy candidate compound.

Interested yet? Read on for other articles about 5267-64-1, you can contact me at any time and look forward to more communication. Category: phthalazines.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

HPLC of Formula: https://www.ambeed.com/products/90-64-2.html, In classical electrochemical theory, both the electron transfer rate and the adsorption of reactants at the electrode control the electrochemical reaction. 90-64-2, Name is 2-Hydroxy-2-phenylacetic acid, SMILES is C1=CC=CC=C1C(C(O)=O)O, belongs to phthalazine compound. In a article, author is Atashkar, Bahareh, introduce new discover of the category.

Here, the application of guanidine supported on magnetic nanoparticles Fe3O4 (MNPs-guanidine) as a novel magnetically separable base nanocatalyst is described. We have investigated the application of this new catalyst for the synthesis of 2H-indazolo[2,1-b]phthalazine-trione derivatives from the three-component, one-pot condensation reaction of phthalhydrazide, cyclic 1,3-dicarbonyl, and aromatic aldehydes under solvent-free conditions. The products were obtained in short reaction times with good to high yields. The supported catalyst could be simply separated and recovered from the reaction mixture with the assistance of an external magnet and reused 18 times with little loss of activity.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 90-64-2. Product Details of 90-64-2.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

The dynamic chemical diversity of the numerous elements, ions and molecules that constitute the basis of life provides wide challenges and opportunities for research. In an article, author is Kashanna, Jajula, once mentioned the application of 643-79-8, Name is Benzene-1,2-dicarboxaldehyde, molecular formula is C8H6O2, molecular weight is 134.132, MDL number is MFCD00003335, category is phthalazine. Now introduce a scientific discovery about this category, Reference of 643-79-8.

Novel 2,3-dihydrofuran derivatives were synthesized through a tandem Knoevenagel-Michael cyclization in good yield by reacting alpha-tosyloxy ketone, 5,5-dimethyl-1,3-cyclohexanedione, and various aldehydes in the presence of phthalazine in acetonitrile. These compounds were subjected to in vitro antibacterial screening against eight micro-organisms by using diffusion method and also in vitro cytotoxicity screening against four human cancerous cell lines by applying MTT assay. Some of the compounds showed impressive activities.

Electric Literature of 643-79-8, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 643-79-8.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

The dynamic chemical diversity of the numerous elements, ions and molecules that constitute the basis of life provides wide challenges and opportunities for research. In an article, author is Wang, Chenglin, once mentioned the application of 103-36-6, Name is Ethyl cinnamate, molecular formula is C11H12O2, molecular weight is 176.21, MDL number is MFCD00009189, category is phthalazine. Now introduce a scientific discovery about this category, Application In Synthesis of Ethyl cinnamate.

We report herein the design and synthesis of a series of structural modified dimethylpyridazine compounds as novel hedgehog signaling pathway inhibitors. The bicyclic phthalazine core and 4-methylamino- piperidine moiety of Taladegib were replaced with dimethylpyridazine and different azacycle building blocks, respectively. The in vitro Gli-luciferase assay results demonstrate that the new scaffold still retained potent inhibitory potency. Piperidin-4-amine moiety was found to be the best linker between pharmacophores dimethylpyridazine and fluorine substituted benzoyl group. Furthermore, the optimization of 1-methyl-1H-pyrazol and 4-fluoro-2-(trifluoromethyl) benzamide by different aliphatic or aromatic rings were also investigated and the SAR were described. Several new derivatives were found to show potent Hh signaling inhibitory activity with nanomolar IC50 values. Among these compounds, compound 11c showed the highest inhibitory potency with an IC50 value of 2.33 nM, which was comparable to the lead compound Taladegib. In vivo efficacy of 11c in a ptch(+/)-p53(-/-) mouse medulloblastoma allograft model also indicated encouraging results. (C) 2018 Elsevier Ltd. All rights reserved.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 103-36-6. Application In Synthesis of Ethyl cinnamate.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Name: Pathalic acid, Academic researchers, R&D teams, teachers, students, policy makers and the media all rely on us to share knowledge that is reliable, accurate and cutting-edge. 88-99-3, Name is Pathalic acid, SMILES is O=C(O)C1=CC=CC=C1C(O)=O, belongs to phthalazine compound. In a article, author is Zhao, Xiao-Na, introduce new discover of the category.

A highly efficient magnetic CoFe2O4 chitosan sulfonic acid nanoparticle (CoFe2O4-CS-SO3H) was prepared and applied for one-pot, four-component synthesis of 2H-indazolo[2,1-b]phthalazine-triones by condensation of phthalic anhydride, hydrazinium hydroxide, 1,3-cyclohexanedione and aldehydes under solvent-free conditions at 80 degrees C. The magnetic nanocatalyst could be readily recovered by applying an external magnet and recycled several times without significant loss of its catalytic activity.

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 88-99-3 help many people in the next few years. Computed Properties of https://www.ambeed.com/products/88-99-3.html.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Formula: https://www.ambeed.com/products/5267-64-1.html, Academic researchers, R&D teams, teachers, students, policy makers and the media all rely on us to share knowledge that is reliable, accurate and cutting-edge. 5267-64-1, Name is D-Penylalaninol, SMILES is OC[C@H](N)CC1=CC=CC=C1, belongs to phthalazine compound. In a article, author is Roy, Soumya S., introduce new discover of the category.

Signal Amplification by Reversible Exchange (SABRE) is an inexpensive and simple hyperpolarization technique that is capable of boosting nuclear magnetic resonance sensitivity by several orders of magnitude. It utilizes the reversible binding of para-hydrogen, as hydride ligands, and a substrate of interest to a metal catalyst to allow for polarization transfer from para-hydrogen into substrate nuclear spins. While the resulting nuclear spin populations can be dramatically larger than those normally created, their lifetime sets a strict upper limit on the experimental timeframe. Consequently, short nuclear spin lifetimes are a challenge for hyperpolarized metabolic imaging. In this report, we demonstrate how both hyperpolarization and long nuclear spin lifetime can be simultaneously achieved in nitrogen-15 containing derivatives of pyridazine and phthalazine by SABRE. These substrates were chosen to reflect two distinct classes of N-15(2)-coupled species that differ according to their chemical symmetry and thereby achieve different nuclear spin lifetimes. The pyridazine derivative proves to exhibit a signal lifetime of similar to 2.5 min and can be produced with a signal enhancement of similar to 2700. In contrast, while the phthalazine derivative yields a superior 15 000-fold N-15 signal enhancement at 11.7 T, it has a much shorter signal lifetime.

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Researchers are common within chemical engineering and are often tasked with creating and developing new chemical techniques, frequently combining other advanced and emerging scientific areas. SDS of cas: 775-12-2, 775-12-2, Name is Diphenylsilane, SMILES is C1([SiH2]C2=CC=CC=C2)=CC=CC=C1, in an article , author is Gharib, Ali, once mentioned of 775-12-2.

Efficient synthesis of 2H-indazolo[2,1-b]phthalazine-1,6,11(13H)-trione derivatives was achieved by one-pot three-component condensation reaction of phthalhydrazide, dimedone, and aromatic aldehydes under solvent-free conditions. Good to excellent yields were obtained at short reaction times on the reusable silica supported Preyssler heteropolyacid catalyst.

Interested yet? Keep reading other articles of 775-12-2, you can contact me at any time and look forward to more communication. SDS of cas: 775-12-2.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

The dynamic chemical diversity of the numerous elements, ions and molecules that constitute the basis of life provides wide challenges and opportunities for research. In an article, author is Genovino, Julien, once mentioned the application of 643-79-8, Name is Benzene-1,2-dicarboxaldehyde, molecular formula is C8H6O2, molecular weight is 134.132, MDL number is MFCD00003335, category is phthalazine. Now introduce a scientific discovery about this category, HPLC of Formula: https://www.ambeed.com/products/643-79-8.html.

The isolation, quantitation, and characterization of drug metabolites in biological fluids remain challenging. Rapid access to oxidized drugs could facilitate metabolite identification and enable early pharmacology and toxicity studies. Herein, we compared biotransformations to classical and new chemical C-H oxidation methods using oxcarbazepine, naproxen, and an early compound hit (phthalazine 1). These studies illustrated the low preparative efficacy of biotransformations and the inability of chemical methods to oxidize complex pharmaceuticals. We also disclose an aerobic catalytic protocole (CuI/air) to oxidize tertiary amines and benzylic CH’s in drugs. The reaction tolerates a broad range of functionalities and displays a high level of chemoselectivity, which is not generally explained by the strength of the C-H bonds but by the individual structural chemotype. This study represents a first step toward establishing a chemical toolkit (chemotransformations) that can selectively oxidize C-H bonds in complex pharmaceuticals and rapidly deliver drug metabolites.

Interested yet? Read on for other articles about 643-79-8, you can contact me at any time and look forward to more communication. Application In Synthesis of Benzene-1,2-dicarboxaldehyde.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

The dynamic chemical diversity of the numerous elements, ions and molecules that constitute the basis of life provides wide challenges and opportunities for research. In an article, author is Hashemzadeh, Alireza, once mentioned the application of 619-67-0, Name is 4-Hydrazinylbenzoic acid, molecular formula is C7H8N2O2, molecular weight is 152.15, MDL number is MFCD00007581, category is phthalazine. Now introduce a scientific discovery about this category, Quality Control of 4-Hydrazinylbenzoic acid.

A magnetic inorganic-organic catalyst, PTA@Fe3O4/EN-MIL-101 (EN = ethylenediamine, PTA = phosphotungstic acid) was fabricated and characterized by XRD, HRTEM, FESEM, UV-vis, TGA-DTA, FT-IR, XPS and porosimetry. PTA retained the parent Keggin structure upon dispersion throughout the amine-functionalized chromium terephthalate metal-organic framework, over which magnetic Fe3O4 nanoparticles were previously introduced. The resulting composite heterogeneous solid acid was an active catalyst for the one-pot synthesis of diverse 2H-indazolo[2,1-b] phthalazine-triones in good -> excellent yields under mild, solventless condition, and offers facile separation and excellent recyclability. (C) 2017 Elsevier B.V. All rights reserved.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 619-67-0, in my other articles. Recommanded Product: 4-Hydrazinylbenzoic acid.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem