Tag: M.W:100-200

Name: 2-Oxo-2-phenylacetic acid, As a society publisher, everything we do is to support the scientific community – so you can trust us to always act in your best interests, and get your work the international recognition that it deserves. 611-73-4, Name is 2-Oxo-2-phenylacetic acid, SMILES is O=C(O)C(C1=CC=CC=C1)=O, belongs to phthalazine compound. In a article, author is Eswararao, S., V, introduce new discover of the category.

1H-pyrazolo[1,2-b]phthalazine-5,10-diones (5) and 2H-indazolo[2,1-b]phthalazine-1,6,11(13H)-triones (7) have been synthesized by one pot, four-component method. To synthesise them phthalic anhydride (1), hydrazine hydrate (2), benzaldehydes (3) and malononitrile (4a) /ethyl cynoacetate (4b) /dimedone (6) in refluxing water for 1-1.5 h in the presence of InCl3 as a catalyst yielding 75-85%. These reactions have an easy workup, provides excellent yields, and uses water as the solvent which is considered to be relatively environmentally benign. The structures of the products were established from their spectral properties IR, H-1-NMR, C-13-NMR & Mass spectroscopy.

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Quality Control of 4-Methoxythiophenol, Reactions catalyzed within inorganic and organic materials and at electrochemical interfaces commonly occur at high coverage and in condensed media, causing turnover rates to depend strongly on interfacial structure and composition. 696-63-9, Name is 4-Methoxythiophenol, SMILES is SC1=CC=C(OC)C=C1, belongs to phthalazine compound. In a article, author is Reddy, Mudumala Veeranarayana, introduce new discover of the category.

A simple, efficient, and green practical approach to 1H-pyrazolo[1,2-b]phthalazine-5,10-diones from phthalhydrazide, aldehydes, and malononitrile/ethyl cyanoacetate has been developed that uses inexpensive and readily available InCl3 as a catalyst in solvent-free one-pot three-component cyclo condensation reaction. This method should provide high yields, shorter reaction time, easy work-up, purification of products by nonchromatographic method, and cleaner reaction. It is a new strategy for N-fused heterocycles synthesis, which haswider application in organic and medicinal chemistry. (c) 2013 Elsevier Ltd. All rights reserved.

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Some examples of the diverse research done by chemistry experts include discovery of new medicines and vaccines, improving understanding of environmental issues, and development of new chemical products and materials. 775-12-2, Name is Diphenylsilane, molecular formula is C12H12Si, COA of Formula: https://www.ambeed.com/products/775-12-2.html, belongs to phthalazine compound, is a common compound. In a patnet, author is Seo, Dong Wan, once mentioned the new application about 775-12-2.

Phosphoric acid-doped sulfonated poly(tetra phenyl phthalazine ether sulfone) (PA-SPTPPES) copolymers were successfully synthesized by the 4,4′-dihydroxydiphenylsulfone with 1,2-bis(4-fluorobenzoyl)-3,4,5,6-tetraphenylbenzene (BFBTPB) and 4,4′-difluorodiphenylsulfone in sulfolane. Poly(tetra phenyl phthalazine ether sulfone)s (PTPPESs) were prepared via an intramolecular ring-closure reaction of dibenzoylbenzene of precursor and hydrazine. The sulfonated poly(tetra phenyl phthalazine ether sulfone) (SPTPPES) membranes were obtained by sulfonation under concentrated sulfuric acid, and followed phosphoric acid-doped by immersion in phosphoric acid. Different contents of doped and sulfonated unit of PA-SPTPPES (10, 15, 20 mol% of BFBTPB) were studied by FT-IR, H-1 NMR spectroscopy, and thermo gravimetric analysis (TGA). The ion exchange capacity (IEC) and proton conductivity of SPTPPESs and PA-SPTPPESs were evaluated with increase of degree of sulfonation and doping level. The PA-SPTPPESs membranes exhibit proton conductivities (80 degrees C, relative humidity 30%) of 41.3 similar to 74.1 mS/cm and the maximum power densities of PA-SPTPPES 10, 15, and 20 were about 294, 350, and 403 mW/cm(2). Copyright (C) 2013, Hydrogen Energy Publications, LLC. Published by Elsevier Ltd. All rights reserved.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 775-12-2. COA of Formula: https://www.ambeed.com/products/775-12-2.html.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Researchers are common within chemical engineering and are often tasked with creating and developing new chemical techniques, frequently combining other advanced and emerging scientific areas. Computed Properties of https://www.ambeed.com/products/2935-35-5.html, 2935-35-5, Name is H-Phg-OH, SMILES is O=C(O)[C@@H](N)C1=CC=CC=C1, in an article , author is Moustafa, Ahmed H., once mentioned of 2935-35-5.

A series of N-alkylphthalazinone were synthesized by the reaction of phthalazin-1(2H)-one derivatives 1a-c with alkylating agents namely, propargyl, allyl bromide, epichlorohydrin, 1,3-dichloro-2-propanol, 4-bromobutylacetate, and 1-(bromomethoxy) ethyl acetate to give the corresponding N-alkylphthalazinone 2a-c, 3a-c, 5a-c, 6a-c, 7a-c, and 9a-c. Alkylation of phthalazin-1(2H)-thione to give a series from S-alkylphthalazine 12-14 and thioglycosides 15 and 17 was performed. Deprotection of compounds 7a-c, 9a-c, 15, and 17 resulted in the formation of the corresponding products 8a-c, 10a-c, 16, and 18. The structure of newly synthesized compounds was assigned by IR, H-1, C-13 NMR, and elemental analysis. Some of these compounds were screened for antiviral and antimicrobial activity.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 2935-35-5. Computed Properties of https://www.ambeed.com/products/2935-35-5.html.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Chemical engineers work across a number of sectors, processes differ within each of these areas, but chemistry and chemical engineering roles are found throughout, creation and manufacturing process of chemical products and materials. Quality Control of 2,6-Difluoroaniline, 5509-65-9, Name is 2,6-Difluoroaniline, SMILES is C1=CC=C(C(=C1F)N)F, in an article , author is El-Gazzar, Marwa G., once mentioned of 5509-65-9.

Aims and Objective: A series of novel phthalazine derivatives was synthesized with versatile, readily accessible electrophilic and nucleophilic reagents. The newly synthesized compounds were confirmed by the results of spectroscopic measurements. Hence, their potential clinical application investigated in particular for cancer treatment. Materials and Methods: The newly synthesized compounds were characterized by spectroscopic measurements and were tested for their in vitro anticancer activity by MTT assay against human liver cancer cell line. Docking study of all the synthesized compounds was performed within the active site of the enzyme VEGFR-2 (Vascular Endothelial Growth Factor Receptor-2). Results: The quinazoline derivative 12 emerged as the most potent compound in this study with an IC50 value of 5.4 mu M. Docking study showed that the synthesized compounds were fit in the VEGFR-2 active site almost at the same position of sorafenib and vatalanib with comparable docking scores (-15.20 to -8.92 was kcal/mol). Conclusion: we have synthesized a novel series of phthalazine derivatives and evaluated their potential anticancer activity against HEPG2 cell line. The quinazoline derivative 12 emerged as the most potent compound in this study with an IC50 value of 5.4 mu M. The SAR and docking studies pointed out that rigidification of the structure resulted in better activity and better binding within the active site of VEGFR-2 as in compounds 3, 5, 6 and 12. These results introduced new phthalazine derivatives having promising activity which could lead to the development of more potent anticancer agents.

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Chemical engineers ensure the efficiency and safety of chemical processes, adapt the chemical make-up of products to meet environmental or economic needs, and apply new technologies to improve existing processes. 1571-08-0, Name is Methyl 4-formylbenzoate, SMILES is C1=C(C(OC)=O)C=CC(=C1)C=O, belongs to phthalazine compound. In a document, author is Saha, Mithu, introduce the new discover, Application In Synthesis of Methyl 4-formylbenzoate.

A nickel nanoparticle (NPs) catalyzed one-pot three component reaction of phthalhydrazide, dimedone and aryl aldehydes under solvent free conditions has been reported. The present approach offers the advantages of simple methodology, clean and mild reaction conditions, short reaction time, low environmental impact, high yield, and excellent purity. The synthesized compounds (2H-indazolo[2,1-b] phthalazine-trione) are found to be suitable candidates for efficient fluorogenic assays to monitor bio-chemical environments.

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Name: Ethyl benzoylformate, While the job of a research scientist varies, most chemistry careers in research are based in laboratories, where research is conducted by teams following scientific methods and standards. 1603-79-8, Name is Ethyl benzoylformate, SMILES is CCOC(=O)C(=O)C1=CC=CC=C1, belongs to phthalazine compound. In a article, author is Mourad, Asmaa Kamal, introduce new discover of the category.

Phthalazine and phthalazinone derivatives are important owing to their significant biological activities and pharmacological properties. Herein, a benzoic acid derivative (2), a benzoxazin-1-one derivative (3), and an oxophthalazin-2(1H)-yl)acetohydrazide (13) are utilized as precursors to construct a novel series of phthalazinones bearing various valuable functional groups in excellent yields via several simple and promising approaches. Finally, the antimicrobial activity of the newly synthesized phthalazines is screened against different microbial strains; namely, Gram-negative and Gram-positive bacteria utilizing Amoxicillin as a standard drug.

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Category: phthalazines, Career opportunities within science and technology are seeing unprecedented growth across the world, and those who study chemistry or another natural science at university now have increasingly better career prospects. 103-45-7, Name is Phenethyl acetate, SMILES is CC(OCCC1=CC=CC=C1)=O, belongs to phthalazine compound. In a article, author is Bodman, Samantha E., introduce new discover of the category.

The reaction of ligands based on 3,6-di(2-pyridyl)pyridazine with symmetrical carbocyclic rings fused to the pyridazine ring; 7,10-di(2-pyridyl)-8,9-diazafluoranthene (L-1), 1,4-di(2-pyridyl)-6,7,8,9-tetrahydro-5H-cyclo-hepta[d]pyridazine (L-2), 1,4-di(2-pyridyl)-5,6,7,8-tetrahydro-phthalazine (L-3), 1,4-di(2-pyridyl)-6,7-dihydro-5H-cyclo-penta[d]pyridazine (L-4) with silver salts gave a series of complexes (1-7). Characterisation of these using single crystal X-ray structure determination clearly showed that the steric bulk of the carbocycle affects the degree to which pyridine groups remain co-planar with pyridizine, and hence their ability to chelate. The more hindered ligands L-1-L-3 form a mixture of bischelating and tetrabridging, while the least hindered (L-4) was able to chelate exclusively. In the case of L-4, the nature of the anion and solvent were also able to affect the outcome of the reaction, with tetrafluoroborate giving the first example of a 4,5-substituted 3,6-di(2-pyridyl) pyridazine ring forming a [2 x 2]-grid.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 103-45-7. Category: phthalazines.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

With the volume and accessibility of scientific research increasing across the world, it has never been more important to continue building the reputation for quality and ethical publishing we’ve spent the past two centuries establishing. 89797-68-2, Name is 5-(Ethylthio)-1H-tetrazole, SMILES is CCSC1=NN=NN1, in an article , author is Xu, Xianlin, once mentioned of 89797-68-2, HPLC of Formula: https://www.ambeed.com/products/89797-68-2.html.

High temperature-resistant separation membranes are widely considered in various fields. However, incompetent support layer limits the performance of high temperature-resistant membranes severely. In this work, a homogeneous composite nonwoven support (HCNS) is developed by wet-laid and hot-pressing technology using undrawn polyethylene terephthalate fibers as bonding fibers. The significance of hot-pressing parameters on the performances of the HCNS is investigated, and quadratic regression models are established. The HCNS exhibits a smooth surface (roughness of 118 nm) and a porous structure (porosity of 21.06% and pore size of 6.548 mu m) with a mechanical property (tensile index of 45.80 N m g(-1)). The ultrafiltration membranes supported by the HCNS are prepared from poly(phthalazine ether sulfone ketone), which demonstrates high permeance, high rejection rate, and long-term stability at raised operation temperature, thereby suggesting the potential application of HCNS in high-temperature filtration.

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Chemistry involves the study of all things chemical – chemical processes, chemical compositions and chemical manipulation – in order to better understand the way in which materials are structured, how they change and how they react in certain situations. , Application In Synthesis of H-Phg-OH, 2935-35-5, Name is H-Phg-OH, molecular formula is C8H9NO2, belongs to phthalazine compound. In a document, author is Eswararao, S., V, introduce the new discover.

1H-pyrazolo[1,2-b]phthalazine-5,10-diones (5) and 2H-indazolo[2,1-b]phthalazine-1,6,11(13H)-triones (7) have been synthesized by one pot, four-component method. To synthesise them phthalic anhydride (1), hydrazine hydrate (2), benzaldehydes (3) and malononitrile (4a) /ethyl cynoacetate (4b) /dimedone (6) in refluxing water for 1-1.5 h in the presence of InCl3 as a catalyst yielding 75-85%. These reactions have an easy workup, provides excellent yields, and uses water as the solvent which is considered to be relatively environmentally benign. The structures of the products were established from their spectral properties IR, H-1-NMR, C-13-NMR & Mass spectroscopy.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 2935-35-5 is helpful to your research. Application In Synthesis of H-Phg-OH.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem