Tag: M.W:100-200

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 140-75-0, Name is (4-Fluorophenyl)methanamine, molecular formula is C7H8FN. In an article, author is Kidwai, Mazaahir,once mentioned of 140-75-0, Formula: https://www.ambeed.com/products/140-75-0.html.

A new green protocol has been developed for the synthesis of 2H-indazolo[2,1-b]phthalazine-triones via one-pot, three-component condensation reaction of aromatic aldehydes with 1,3-dicarbonyl compounds and phthalhydrazide using reusable dodecylphosphonic acid (DPA) as heterogeneous solid acid catalyst under solvent-free conditions. This protocol provides a novel and improved method for obtaining 2H-indazolo[2,1-b]phthalazine-triones in terms of good yields with little catalyst loading. (C) 2012 Elsevier Ltd. All rights reserved.

If you’re interested in learning more about 140-75-0. The above is the message from the blog manager. Formula: https://www.ambeed.com/products/140-75-0.html.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Let’s face it, organic chemistry can seem difficult to learn, Recommanded Product: 2-Hydroxy-2-phenylacetic acid, Especially from a beginner’s point of view. Like 90-64-2, Name is 2-Hydroxy-2-phenylacetic acid, molecular formula is phthalazine, belongs to phthalazine compound. In a document, author is Iravani, Nasir, introducing its new discovery.

A novel heteropolyanion-based Bronsted acidic ionic liquid material [PhBS](3)PW12O40, butane mono-sulfoacid-functionalized phenanthrolinum salt of phosphortungstate catalyst (PhBS-PW), was synthesized and well characterized with FTIR, H-1 and C-13 NMR, electro-spray ionization mass spectrometry (ESI-MS), EDX and TG analysis techniques. The new prepared catalyst was used for the efficient one-pot synthesis of 2H-indazolo[2,1-b]phthalazine-trione derivatives from a three-component condensation reaction between aromatic aldehydes, dimedone, and phthalhydrazide in H2O under thermal conditions. This green approach has several advantages such as short reaction times, clean reaction profiles, and simple experimental and workup procedures. Moreover, the catalyst can be easily recovered and reused at least nine times with only slight reduction in its catalytic activity with no leaching amount of catalyst into the reaction mixture. These economical factors (time, cost, waste, etc.) for this three-component reaction hold promise for the future of organic synthesis. Graphic abstract In this work we introduced a new efficient Bronsted acidic ionic liquid (BAIL) and then its catalytic activities have been considered in the three-component synthesis of 2H-indazolo[2,1-b]phthalazine-triones via the domino Knoevenagel condensation/Michael addition/intramolecular cyclodehydration sequence in water under reflux condition. [GRAPHICS] .

If you are hungry for even more, make sure to check my other article about 90-64-2, Recommanded Product: 2-Hydroxy-2-phenylacetic acid.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, such as the rate of change in the concentration of reactants or products with time. 140-75-0, Name is (4-Fluorophenyl)methanamine, formurla is C7H8FN. In a document, author is Shaterian, Hamid Reza, introducing its new discovery. SDS of cas: 140-75-0.

A new four-component synthesis of 1H-pyrazolo[1,2-b]phthalazine-5,10-dione derivatives using three weak basic ionic liquids such as 1,8-diazabicyclo[5.4.0]-undec-7-en-8-ium acetate, pyrrolidinium formate, and pyrrolidinium acetate as efficient catalysts for condensation reaction of hydrazine monohydrate, phthalic anhydride, malononitrile or ethyl cyanoacetate, and aromatic aldehydes under ambient and solvent-free conditions in excellent yields is described. (C) 2012 Elsevier B.V. All rights reserved.

If you are hungry for even more, make sure to check my other article about 140-75-0, SDS of cas: 140-75-0.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Chemistry, like all the natural sciences, begins with the direct observation of nature— in this case, of matter.5267-64-1, Name is D-Penylalaninol, SMILES is OC[C@H](N)CC1=CC=CC=C1, belongs to phthalazine compound. In a document, author is Katsuma, Yuhei, introduce the new discover, Formula: https://www.ambeed.com/products/5267-64-1.html.

The diboration of the C equivalent to N bond in organic nitriles, and the N=N bond in azobenzene and pyridazine, by the highly Lewis-acidic tetra(o-tolyl)diborane(4) are reported. In the reactions with nitriles, azobenzene, and pyridazine, the addition of diborane(4) to the C equivalent to N and N=N bonds was observed. Conversely, the N=N bond in phthalazine was cleaved by an addition/rearomatization sequence.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 5267-64-1 is helpful to your research. Formula: https://www.ambeed.com/products/5267-64-1.html.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 875-74-1, Name is H-D-Phg-OH, molecular formula is C8H9NO2. In an article, author is Xue, Jie,once mentioned of 875-74-1, Quality Control of H-D-Phg-OH.

Despite the great potential for applications spanning, from military night-vision displays and information-secured devices to civilian medical diagnostics and phototherapy, the development of highly efficient, stable, and low-cost near-infrared (NIR) emitting lumophores is still a formidable challenge. Herein, we report two novel NIR-emitting homoleptic facial Ir(III) complexes based on extended pi-conjugated benzo[g]phthalazine ligands, namely, tris[1,4-di(thiophen-2-yl)benzo(g]phthalazine] (Ir(dtbpa)(3), 1) and tris[1-(2,4-bis(trifluoromethyl)pheny1)-4-(thiophen-2-y1)-benzo[g]phthalazine] iridium(III) (Ir(Ftbpa)(3), 2). Actually, these two ligarids not only enable simple one-pot synthesis of homoleptic Ir(III) complexes without any catalyst under mild conditions, but also contribute to intense NIR-emission with high photoluminescence quantum yield up to 5.2% at 824 nm for 1 and 17.3% at 765 nm for 2 respectively. Single-crystal structure of 1 demonstrates desired facial form with short Ir-N and Ir-C bonds because of strong coordination and small steric hindrance of those highly conjugated C<^>N=N ligands. Importantly, the incorporation Of CF3 groups in 2 further leads to high thermal stability and a good ability to sublime, thus resulting in ultrapurity for highly efficient NIR-organic light-emitting diodes (NIR-OLEDs) with a high maximum external quantum efficiency of 4.5% at 760 run and small efficiency roll-off remaining of 3.5% at 100 mA. cm(-2), values which rank with those of the most efficient NIR-OLEDs with small roll-off and peak emission over 750 nm. Notably, the content percentages of the noble metal in these two complexes, (similar to 10% Ir) are markedly lower by about two-thirds than that of typical green-emitting tris(2-phenylpyridine)iridium (similar to 30% Ir). The findings may provide a new strategy to develop robust NIR emitters and achieve high efficiency, small roll-off, and low cost simultaneously in NIR-OLEDs for practical applications.

If you’re interested in learning more about 875-74-1. The above is the message from the blog manager. Quality Control of H-D-Phg-OH.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Chemistry can be defined as the study of matter and the changes it undergoes. You’ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology. 619-67-0, Name is 4-Hydrazinylbenzoic acid, molecular formula is , belongs to phthalazine compound. In a document, author is Shirini, Farhad, Computed Properties of https://www.ambeed.com/products/619-67-0.html.

This article describe the applicability of 1,4-disulfopiperazine-1,4-diium chloride ([Piper-(SO3H)(2)].2Cl) as a green, versatile and Bronsted acidic ionic catalyst in the promotion of the synthesis of phthalazine derivatives via one-pot three component reaction between aromatic aldehydes, 1,3-diketone derivatives and phthalhydrazide under solvent-free reaction conditions. The main advantages of this method are: (1) simplicity of the procedure, (2) solvent-free conditions, (3) availability of the starting materials, (4) high reaction rates and excellent yields, (5) reusability of the catalyst and (6) no column chromatographic of the products.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 619-67-0, in my other articles. Computed Properties of https://www.ambeed.com/products/619-67-0.html.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Chemistry is an experimental science, Formula: https://www.ambeed.com/products/1603-79-8.html, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 1603-79-8, Name is Ethyl benzoylformate, molecular formula is C10H10O3, belongs to phthalazine compound. In a document, author is Soliman, Saied M..

A new Schiff base derived from the antihypertensive hydralazine (LH) and its Co(III) complexes [CoL2] X*4H(2)O, where X = NO3 (1) or Cl (2), were synthesized and characterized using FTIR, UV-Vis,H-1 NMR spectroscopy as well as thermal analysis. The crystal structures of the three compounds have been determined using single crystal X-ray diffraction technique. The two complexes structure is strictly divided in a highly ordered part of the [CoL2](+) units and a disordered section containing the anions and sixteen crystal water molecules per unit cell. In the complexes, the two ligand anions (L-) chelate to the Co(III) through the nitrogen atoms in a tridentate meridional manner. The pyridine and phthalazine rings showed deviations from co-planarity in all compounds which attributed to the crystal packing effects as revealed by analysis of their molecular packing using Hirshfeld analysis and further supported by DFT calculations. The optimized structure of the [CoL2] NO3 as a model showed no co-planarity of the two rings while perfectly planar ligand units were predicted in the [CoL2](+) cation indicating that the intermolecular interactions with the nitrate counter anion have a major role in the deviations of the two ring moieties from planarity. The ligand anion (L-) optimized structure using B97D function which include dispersion model showed similar results while the functions (B3LYP and mPW1PW91) which include no dispersion model predicted perfectly planar arrangement. Atoms in molecules (AIM) studies predicted the strength of the Co-N interactions is in the order, Co-N(azomethine) > Co-N(phthalazine) > Co-N(pyridine) which are generally stronger in 2 than 1. The developmental toxicity of LH and its complexes were tested in zebrafish embryos. The ligand itself was very toxic with LC50 of just 2 mu M as compared to its metal complexes, whereas, at sub-lethal concentration the ligand perturbed the neurogenesis in zebrafish embryos. (C) 2017 Elsevier B.V. All rights reserved.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 1603-79-8, in my other articles. Formula: https://www.ambeed.com/products/1603-79-8.html.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

In an article, author is El-Gazzar, Marwa G., once mentioned the application of 5509-65-9, Formula: https://www.ambeed.com/products/5509-65-9.html, Name is 2,6-Difluoroaniline, molecular formula is C6H5F2N, molecular weight is 129.11, MDL number is MFCD00007655, category is phthalazine. Now introduce a scientific discovery about this category.

Aims and Objective: A series of novel phthalazine derivatives was synthesized with versatile, readily accessible electrophilic and nucleophilic reagents. The newly synthesized compounds were confirmed by the results of spectroscopic measurements. Hence, their potential clinical application investigated in particular for cancer treatment. Materials and Methods: The newly synthesized compounds were characterized by spectroscopic measurements and were tested for their in vitro anticancer activity by MTT assay against human liver cancer cell line. Docking study of all the synthesized compounds was performed within the active site of the enzyme VEGFR-2 (Vascular Endothelial Growth Factor Receptor-2). Results: The quinazoline derivative 12 emerged as the most potent compound in this study with an IC50 value of 5.4 mu M. Docking study showed that the synthesized compounds were fit in the VEGFR-2 active site almost at the same position of sorafenib and vatalanib with comparable docking scores (-15.20 to -8.92 was kcal/mol). Conclusion: we have synthesized a novel series of phthalazine derivatives and evaluated their potential anticancer activity against HEPG2 cell line. The quinazoline derivative 12 emerged as the most potent compound in this study with an IC50 value of 5.4 mu M. The SAR and docking studies pointed out that rigidification of the structure resulted in better activity and better binding within the active site of VEGFR-2 as in compounds 3, 5, 6 and 12. These results introduced new phthalazine derivatives having promising activity which could lead to the development of more potent anticancer agents.

If you are interested in 5509-65-9, you can contact me at any time and look forward to more communication. Formula: https://www.ambeed.com/products/5509-65-9.html.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Reactions catalyzed within inorganic and organic materials and at electrochemical interfaces commonly occur at high coverage and in condensed media, causing turnover rates to depend strongly on interfacial structure and composition, 613-45-6, Name is 2,4-Dimethoxybenzaldehyde, SMILES is O=CC1=CC=C(OC)C=C1OC, in an article , author is Mohamadpour, Farzaneh, once mentioned of 613-45-6, Product Details of 613-45-6.

An efficient and convenient zinc acetate dihydrate (Zn(OAc)(2)center dot 2H(2)O) catalyzed synthesis of 1H-pyrazolo[1,2-b]phthalazine-5,10-dione derivatives has been accomplished via one-pot four-condensation of phthalic anhydride, hydrazine monohydrate, aromatic aldehydes derivatives and malononitrile under solvent-free conditions. The notable advantages of the present procedure are: operational simplicity, eco-friendly, environmentally benign nature, low-cost and non-toxic catalyst, no necessity of chromatographic purification steps, short reaction times and good to high yields.

But sometimes, even after several years of basic chemistry education, it is not easy to form a clear picture on how they govern reactivity! 613-45-6, you can contact me at any time and look forward to more communication. Product Details of 613-45-6.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Chemistry is traditionally divided into organic and inorganic chemistry. The former is the study of compounds containing at least one carbon-hydrogen bonds. 613-45-6, Name is 2,4-Dimethoxybenzaldehyde, molecular formula is C9H10O3, belongs to phthalazine compound, is a common compound. In a patnet, author is Hemdan, Magdy M., once mentioned the new application about 613-45-6, Recommanded Product: 613-45-6.

A convenient synthesis has been achieved of 11 substituted phthalazines starting from the condensation of 2-(p-toluoyl) benzoic acid with hydrazine and some of its simple congeners, H2NNHR. Four of the phthalazines showed activity as inhibitors of the corrosion of steel immersed in 5 M HCl solutions.

We’ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, 613-45-6. The above is the message from the blog manager. Recommanded Product: 613-45-6.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem