Tag: M.W:100-200

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, such as the rate of change in the concentration of reactants or products with time. 104-53-0, Name is 3-Phenylpropanal, formurla is C9H10O. In a document, author is Zhu, Mingfei, introducing its new discovery. Recommanded Product: 104-53-0.

Inhibition of aberrant Hedgehog (Hh) pathway had been proved to be a promising therapeutic intervention in cancers like basal cell carcinoma (BCC), medulloblastoma (MB), and so on. Two drugs (Vismodegib, Sonidegib) were approved to treat BCC and more inhibitors are in clinical investigation. However, the adverse effects and drug resistance restricted the use of Hh inhibitors. In the present study, 61 synthesized compounds containing central backbone of phthalazine or dimethylpyridazine were screened as candidates of new Hh signaling inhibitors by performing dual luciferase reporter assay. Among the compounds, L-4 exhibited an IC50 value of 2.33 nM in the Shh-Light II assay. L-4 strongly inhibited the Hh pathway in vitro and blocked the Hh pathway by antagonizing the smoothened receptor (Smo). Remarkably, L-4 could significantly suppress the Hh pathway activity provoked by Smo mutant (D473H) which showed strong resistant properties to existing drugs such as Vismodegib. Orally administered L-4 exhibited prominent dose-dependent anti-tumor efficacy in vivo in Ptch+/-; p53-/- MB allograft model. Furthermore, L-4 showed good tolerance in acute toxicity test using ICR mice. These evidences indicated that L-4 was a potent, well-tolerated, orally active inhibitor of Hedgehog pathway, and might be a promising candidate in development of Hh-targeted anti-cancer drugs.

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 104-53-0 help many people in the next few years. Recommanded Product: 104-53-0.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Application of 875-74-1, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C–H bond functionalisation has revolutionised modern synthetic chemistry. 875-74-1, Name is H-D-Phg-OH, SMILES is O=C(O)[C@H](N)C1=CC=CC=C1, belongs to phthalazine compound. In a article, author is Soltanzadeh, Zahra, introduce new discover of the category.

In this paper, C-N bond formation between 2,3-dihydrophthalazine-1(4H),4-dione (phthalhydrazide) and alpha,beta-unsaturated esters was investigated and a new series of phthalazine derivatives was synthesized using an efficient and simple method under solvent-free conditions. An aza-Michael addition of phthalhydrazide to both acrylic and fumaric esters led to N-monosubstituted phthalhydrazides (as mono-Michael adduct) in the presence of tetrabutylammonium bromide as a high polar media, and 1,4-diaza-bicyclo[2,2,2] octane as an available organic base. In this reaction, the N1,N2-bis-Michael adduct was not observed at all. Also, reactions were performed at 90 degrees C and yields of products were good to excellent.

Application of 875-74-1, Consequently, the presence of a catalyst will permit a system to reach equilibrium more quickly, but it has no effect on the position of the equilibrium as reflected in the value of its equilibrium constant.I hope my blog about 875-74-1 is helpful to your research.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Reference of 88-44-8, As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 88-44-8, Name is 4-Aminotoluene-3-sulfonic acid, SMILES is O=S(C1=CC(C)=CC=C1N)(O)=O, belongs to phthalazine compound. In a article, author is Li Jiali, introduce new discover of the category.

In this paper, a series of 6-substituted-pyrido[3,2-e][1,2,4] triazolo[4,3-a] pyrazine derivatives have been synthesized. Their anticonvulsant activity and neurotoxicity in mice were evaluated by maximal electroshock (MES) and rotarod test, respectively. The structures were confirmed by H-1 NMR, C-13 NMR, MS and HRMS. The experimental results show that 6-phenoxypyrido[3,2-e][1,2,4] triazolo[4,3-a]pyrazine (5g) was safer than the reference drug, carbamazepine, with ED50 value of 93.9 mg.kg(-1) and protective index (PI) value of 24.3, which was a potential anti-epilepsy candidate compound.

Reference of 88-44-8, One of the oldest and most widely used commercial enzyme inhibitors is aspirin, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 88-44-8.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Electric Literature of 89-86-1, Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, 89-86-1, Name is 2,4-Dihydroxybenzoic acid, SMILES is O=C(O)C1=CC=C(O)C=C1O, belongs to phthalazine compound. In a article, author is Ghorbani-Vaghei, Ramin, introduce new discover of the category.

A series of 1H-pyrazolo[1,2-b]phthalazine-5,10-diones were obtained from aldehydes, phthalhydrazide and malononitrile in good to excellent yields at 80-100 degrees C under solvent-free conditions by proceeding through a simple, mild and efficient procedure utilizing N, N, N’, N’-tetrabromobenzene-1,3-disulfonamide [TBBDA] and poly(N-bromo-N-ethylbenzene-1,3-disulfonamide) [PBBS] as catalysts.

Electric Literature of 89-86-1, One of the oldest and most widely used commercial enzyme inhibitors is aspirin, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 89-86-1.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Reference of 767-00-0, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C–H bond functionalisation has revolutionised modern synthetic chemistry. 767-00-0, Name is 4-Hydroxybenzonitrile, SMILES is OC1=CC=C(C=C1)C#N, belongs to phthalazine compound. In a article, author is Li, Guifei, introduce new discover of the category.

An efficient rhodium-catalyzed tandem C-H bond olefination and annulation approach was developed to afford 1,2-dihydrophthalazines in good to excellent yields from easily accessible sulfonylhydrazones and alkenes.

Reference of 767-00-0, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. I hope my blog about 767-00-0 is helpful to your research.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Electric Literature of 89797-68-2, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C–H bond functionalisation has revolutionised modern synthetic chemistry. 89797-68-2, Name is 5-(Ethylthio)-1H-tetrazole, SMILES is CCSC1=NN=NN1, belongs to phthalazine compound. In a article, author is Esmaeilpour, Mohsen, introduce new discover of the category.

In this paper, we adopt a facile method to prepare a type of porous silica nanoparticles (n-SiO2) from tetraethyl orthosilicate as the source of silica. Then, dendritic polymer supported on nanosilica with surface amino groups was fabricated. Finally, H3PW12O40 nanoparticles (PWA(n)) were synthesized by the treatment of H3PW12O40 powder with n-Octane as solvent by a solvothermal method and then immobilized onto the dendrimer polymer functionalized nanosilica. The synthesized nanostructures were characterized by fourier transform infrared (FT-IR), X-ray diffraction (XRD), thermogravimetric analysis (TGA), dynamic light scattering (DLS), N-2 adsorption-desorption isotherm analysis, UV-Vis and elemental analysis. The morphology of the catalyst was characterized using transmission electron microscopes (TEM). The acidity of the catalyst was determined by FTIR pyridine adsorption spectroscopy. Then, this catalytic system was used as an efficient catalyst for the synthesis of 2H-indazolo[2,1-b]phthalazine-triones via multi-component and one-pot reactions of various aldehydes, phthalic anhydride, hydrazinium hydroxide, and dimedone under thermal solvent-free conditions or ultrasound irradiation at room temperature. Also, the catalyst can be easily recovered and reused for six consecutive reaction cycles without significant loss of activity.

Electric Literature of 89797-68-2, Because enzymes can increase reaction rates by enormous factors and tend to be very specific, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 89797-68-2.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Chemistry, like all the natural sciences, Quality Control of Diphenylsulfane, begins with the direct observation of nature— in this case, of matter.139-66-2, Name is Diphenylsulfane, SMILES is C1(SC2=CC=CC=C2)=CC=CC=C1, belongs to phthalazine compound. In a document, author is Thangadurai, T. Daniel, introduce the new discover.

New hydrophilic fluorescent selective ion sensor based on phenazine and phthalazine moieties, 1,1′-(phenazine-2,3-diyl)-bis(3-(1,4-dihydroxyphthalazin-6-yl)urea) (1), has been designed, synthesized and characterized. Interestingly, sensor 1 exhibits prominent turn-on and turn-off’ fluorogenic signaling at 580 nm towards Fe2+ & AcO- and Sr2+ & Cu2+, respectively. The fluorescence titration experiments shed light on the nature of the interaction between 1 and guest molecules (Fe2+, Sr2+, Cu2+ and AcO-), which divulge that 1 is flexible enough to orient itself according to the size of the guest molecule. Water mediated excited-state intramolecular proton transfer (ESIPT) and photo-induced electron transfer (PET) mechanisms are responsible for the dual behavior of 1, which binds with guest molecules in 1:1 stoichiometry, Based on the significant duplex fluorescence response of 1, a molecular logic gate keypad lock with sixteen on passwords for a storage system has been developed. (C) 2018 Elsevier B.V. All rights reserved.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 139-66-2. Quality Control of Diphenylsulfane.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Chemistry is traditionally divided into organic and inorganic chemistry. The former is the study of compounds containing at least one carbon-hydrogen bonds. 104-53-0, Name is 3-Phenylpropanal, molecular formula is C9H10O, belongs to phthalazine compound, is a common compound. In a patnet, author is Hiiuk, Volodymyr M., once mentioned the new application about 104-53-0, Quality Control of 3-Phenylpropanal.

Two new 2D spin-crossover (SCO) analogues of Hofmann clathrates of composition [Fe(phth)(2)M-II(CN)(4)] (where phth = phthalazine; M-II = Pd, Pt) have been synthesized and their structures and switchable behaviour have been characterized. Single-crystal X-ray analysis reveals that the Pt and Pd derivatives contain Fe-II centres equatorially surrounded by four equivalent mu(4)-[M-II(CN)(4)](2-) groups. Two crystallographically equivalent phthalazine (phth) ligands occupy the axial positions of each Fe-II site, completing its octahedral coordination environment. The stabilization of these structures is realized via supramolecular C-HM interactions and pi-pi stacking. Temperature-dependent magnetic susceptibility measurements showed that Pt (T-1/2 down arrow = 211 K and T-1/2 up arrow = 218 K) and Pd (T-1/2 down arrow = 202 K and T-1/2 up arrow = 207 K) derivatives display cooperative spin crossover with narrow thermal hysteresis loops. In addition, spin crossover in these complexes was characterized by optical measurements, differential scanning calorimetry, and IR and Raman spectroscopy. This research shows that the use of phthalazine leads to the production of new SCO systems with attractive transition characteristics and opens up new perspectives for the design of switchable complexes based on fused bicyclic azine ligands.

We’ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, 104-53-0. The above is the message from the blog manager. Quality Control of 3-Phenylpropanal.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Reference of 1821-12-1, Catalysts allow a reaction to proceed via a pathway that has a lower activation energy than the uncatalyzed reaction. 1821-12-1, Name is 4-Phenylbutanoic acid, SMILES is O=C(O)CCCC1=CC=CC=C1, belongs to phthalazine compound. In a article, author is Goli-Jolodar, Omid, introduce new discover of the category.

In this work, O-sulfonated poly(vinylpyrrolidonium) hydrogen sulfate ([PVP-SO3H]HSO4) has been prepared as a powerful recyclable solid acid catalyst and characterized using a variety of techniques including elemental analysis, FT-IR, TGA, SEM, XRD, pH analysis and Hammett acidity function. After preparation and identification the mentioned solid acid with wide acidic functional group sites, is utilized as a highly efficient catalyst for the synthesis of tetrahydrobenzimidazo[2,1-b]quinazolin-1(2H)-ones, 1-(benzothiazolylamino)phenylmethyl-2-naphthols and 2H-indazolo[2,1-b] phthalazine-1,6,11(13H)-triones in the absence of solvent. These eco-friendly protocols offer some advantages such as green and cost-effective procedures with excellent yields, shorter reaction times, simpler work-up, recovery, and reusability of a metal-free solid acid heterogeneous catalyst.

Reference of 1821-12-1, Consequently, the presence of a catalyst will permit a system to reach equilibrium more quickly, but it has no effect on the position of the equilibrium as reflected in the value of its equilibrium constant.I hope my blog about 1821-12-1 is helpful to your research.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

In an article, author is Maleki, Behrooz, once mentioned the application of 88-44-8, Application In Synthesis of 4-Aminotoluene-3-sulfonic acid, Name is 4-Aminotoluene-3-sulfonic acid, molecular formula is C7H9NO3S, molecular weight is 187.2163, MDL number is MFCD00007908, category is phthalazine. Now introduce a scientific discovery about this category.

The rapid and environmental synthetic route to produce 1H-indazolo[1,2-b] phthalazine-1,6,11-triones and 1H-pyrazolo[1,2-b]phthalazine-5,10-diones derivatives have been developed via multicomponent and one-pot reactions of various aldehydes, cyclic or acyclic 1,3-diketones with: i) phthalhydrazide or ii) phthalic anhydride-hydrazinium hydroxide using wet 2,4,6-trichlorotriazine (TCT) as catalyst under solvent-free conditions. Simple and mild reaction conditions, the use of a cheap catalyst and easy workup and isolation are notable features of this method.

If you are interested in 88-44-8, you can contact me at any time and look forward to more communication. Application In Synthesis of 4-Aminotoluene-3-sulfonic acid.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem